ATE216998T1 - Camptothecin-derivate mit antitumor-wirkung - Google Patents
Camptothecin-derivate mit antitumor-wirkungInfo
- Publication number
- ATE216998T1 ATE216998T1 AT99830124T AT99830124T ATE216998T1 AT E216998 T1 ATE216998 T1 AT E216998T1 AT 99830124 T AT99830124 T AT 99830124T AT 99830124 T AT99830124 T AT 99830124T AT E216998 T1 ATE216998 T1 AT E216998T1
- Authority
- AT
- Austria
- Prior art keywords
- tumor effect
- camptothecin derivatives
- camptothecin
- derivatives
- tumor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99830124A EP1044977B1 (de) | 1999-03-09 | 1999-03-09 | Camptothecin-Derivate mit Antitumor-Wirkung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE216998T1 true ATE216998T1 (de) | 2002-05-15 |
Family
ID=8243303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99830124T ATE216998T1 (de) | 1999-03-09 | 1999-03-09 | Camptothecin-derivate mit antitumor-wirkung |
Country Status (39)
Country | Link |
---|---|
US (2) | US6242457B1 (de) |
EP (1) | EP1044977B1 (de) |
JP (1) | JP4610743B2 (de) |
KR (1) | KR100702085B1 (de) |
CN (1) | CN1139592C (de) |
AR (1) | AR022860A1 (de) |
AT (1) | ATE216998T1 (de) |
AU (1) | AU774174B2 (de) |
BG (1) | BG65032B1 (de) |
BR (1) | BR0008840B1 (de) |
CA (1) | CA2362760C (de) |
CO (1) | CO5180590A1 (de) |
CZ (1) | CZ304465B6 (de) |
DE (1) | DE69901379T2 (de) |
DK (1) | DK1044977T3 (de) |
EA (1) | EA003605B1 (de) |
EE (1) | EE04679B1 (de) |
EG (1) | EG23999A (de) |
ES (1) | ES2175919T3 (de) |
HK (1) | HK1031222A1 (de) |
HR (1) | HRP20010667B1 (de) |
HU (1) | HU229506B1 (de) |
IL (2) | IL144958A0 (de) |
IS (1) | IS2003B (de) |
ME (2) | ME00017B (de) |
MX (1) | MXPA01009081A (de) |
NO (1) | NO328363B1 (de) |
NZ (1) | NZ513393A (de) |
PE (1) | PE20001485A1 (de) |
PL (1) | PL222208B1 (de) |
PT (1) | PT1044977E (de) |
RS (1) | RS50405B (de) |
SI (1) | SI1044977T1 (de) |
SK (1) | SK287561B6 (de) |
TN (1) | TNSN00045A1 (de) |
TR (1) | TR200102603T2 (de) |
TW (1) | TWI272272B (de) |
WO (1) | WO2000053607A1 (de) |
ZA (1) | ZA200107408B (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000041730A1 (en) | 1999-01-13 | 2000-07-20 | Meditech Research Limited | A composition and method for the enhancement of the efficacy of drugs |
US7105492B2 (en) * | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
FR2794123B1 (fr) * | 1999-05-28 | 2001-07-27 | Aventis Pharma Sa | Preparation de derives de la camptothecine et de la nothapodytine |
US6352996B1 (en) * | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
US20040029906A1 (en) * | 2001-07-31 | 2004-02-12 | Michael Christman | Inhibitors of dna polymerase sigma |
US20050042303A1 (en) * | 2001-08-27 | 2005-02-24 | Brown Tracey Jean | Therapeutic protocols |
WO2003033525A1 (en) * | 2001-10-12 | 2003-04-24 | Debio Recherche Pharmacuetique S.A. | Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament |
ITRM20020305A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Camptotecine con anello lattonico modificato. |
ITRM20020306A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
ITRM20030344A1 (it) * | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
WO2005092302A2 (en) * | 2004-03-26 | 2005-10-06 | Novartis Ag | Use of camptothecin derivates for the treatment of proliferative diseases in a fixed dosing regimen |
CN1946421B (zh) | 2004-04-27 | 2013-07-17 | 威尔斯达特生物制剂公司 | 使用病毒和喜树碱进行的癌症治疗 |
ITRM20040242A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
ITRM20040241A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 20 con antagonisti delle integrine. |
ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
ITRM20040288A1 (it) * | 2004-06-11 | 2004-09-11 | Sigma Tau Ind Farmaceuti | Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero. |
CN100334089C (zh) * | 2004-07-21 | 2007-08-29 | 王洋 | 一种9-硝基喜树碱的生产方法 |
GT200500310A (es) * | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
WO2006065780A2 (en) * | 2004-12-15 | 2006-06-22 | Novartis Ag | Combinations of therapeutic agents for treating cancer |
AU2005318227B2 (en) * | 2004-12-21 | 2011-08-18 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Stereoselective process and crystalline forms of a camptothecin |
SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
WO2007011601A2 (en) | 2005-07-14 | 2007-01-25 | Wellstat Biologics Corporation | Cancer treatment using viruses, fluoropyrimidines and camptothecins |
EP1912658B1 (de) * | 2005-07-27 | 2017-01-25 | Alchemia Oncology Pty Limited | Therapeutische protokolle mit hyaluronan |
ITRM20050418A1 (it) * | 2005-08-04 | 2007-02-05 | Sigma Tau Ind Farmaceuti | Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina. |
KR20080034149A (ko) * | 2005-08-10 | 2008-04-18 | 노파르티스 아게 | 7-(t-부톡시)이미노메틸 캄토테신에 대한 제형 |
CN101287475B (zh) * | 2005-09-07 | 2012-11-14 | 阿尔卡米亚肿瘤学股份有限公司 | 包含透明质酸和治疗抗体的治疗组合物以及制药用途 |
PT1962850E (pt) | 2005-12-21 | 2012-05-21 | Sigma Tau Ind Farmaceuti | Tratamento de tumores resistentes a drogas |
JP5596924B2 (ja) | 2006-02-17 | 2014-09-24 | カスケード プロドラッグ インコーポレイテッド | ビンカアルカロイドn酸化物および類似体による過剰増殖疾患の処置 |
EP1998809B1 (de) | 2006-03-30 | 2014-06-25 | Drais Pharmaceuticals, Inc. | Konjugate von camptothecin und zelldurchdringenden peptiden und deren pharmazeutische zusammensetzungen. |
AU2008210511A1 (en) * | 2007-02-01 | 2008-08-07 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Pharmaceutical composition comprising a campothecin derivative |
WO2008098701A1 (en) * | 2007-02-13 | 2008-08-21 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives |
US8829021B2 (en) | 2007-08-01 | 2014-09-09 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Treatment of pediatric tumors |
EP2096113A1 (de) | 2008-02-05 | 2009-09-02 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | 9-substituierte Camptothecin-Derivate als Antitumorverbindungen |
TWI482621B (zh) | 2009-12-23 | 2015-05-01 | Sigma Tau Ind Farmaceuti | 青蒿素基藥物與其他化學治療劑的抗癌組合物 |
KR20180058759A (ko) | 2015-09-25 | 2018-06-01 | 제트와이 테라퓨틱스 인코포레이티드 | 폴리사카라이드-비타민 접합체를 포함하는 미립자를 기재로 하는 약물 제제 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
EP1393729A3 (de) * | 1991-11-15 | 2004-03-17 | Smithkline Beecham Corporation | Kombinationschemotherapy mit Topotecan und einer Platin-Koordinationsverbindung |
US5614529A (en) * | 1994-09-22 | 1997-03-25 | Research Triangle Institute | Inhibition of plasmodia parasites by camptothecin compounds |
US5972955A (en) * | 1995-06-06 | 1999-10-26 | Dr. Reddy's Research Foundation | Water soluble C-ring analogues of 20(S)-camptothecin |
GB9512670D0 (en) * | 1995-06-21 | 1995-08-23 | Sod Conseils Rech Applic | Camptothecin analogues |
IT1282673B1 (it) * | 1996-02-23 | 1998-03-31 | Ist Naz Stud Cura Dei Tumori | Derivati della camptotecina e loro uso come agenti antitumorali |
BR9711319B1 (pt) * | 1996-08-19 | 2009-08-11 | derivados de camptotecina altamente lipofìlicos. |
-
1999
- 1999-03-09 DE DE69901379T patent/DE69901379T2/de not_active Expired - Lifetime
- 1999-03-09 EP EP99830124A patent/EP1044977B1/de not_active Expired - Lifetime
- 1999-03-09 ES ES99830124T patent/ES2175919T3/es not_active Expired - Lifetime
- 1999-03-09 DK DK99830124T patent/DK1044977T3/da active
- 1999-03-09 PT PT99830124T patent/PT1044977E/pt unknown
- 1999-03-09 AT AT99830124T patent/ATE216998T1/de active
- 1999-03-09 SI SI9930010T patent/SI1044977T1/xx unknown
-
2000
- 2000-02-22 US US09/507,928 patent/US6242457B1/en not_active Expired - Lifetime
- 2000-03-07 TW TW089104090A patent/TWI272272B/zh not_active IP Right Cessation
- 2000-03-07 EG EG20000293A patent/EG23999A/xx active
- 2000-03-08 CZ CZ2001-3077A patent/CZ304465B6/cs not_active IP Right Cessation
- 2000-03-08 SK SK1164-2001A patent/SK287561B6/sk not_active IP Right Cessation
- 2000-03-08 TR TR2001/02603T patent/TR200102603T2/xx unknown
- 2000-03-08 NZ NZ513393A patent/NZ513393A/xx not_active IP Right Cessation
- 2000-03-08 AR ARP000101013A patent/AR022860A1/es not_active Application Discontinuation
- 2000-03-08 EA EA200100954A patent/EA003605B1/ru not_active IP Right Cessation
- 2000-03-08 CA CA002362760A patent/CA2362760C/en not_active Expired - Fee Related
- 2000-03-08 ME MEP-2008-40A patent/ME00017B/me unknown
- 2000-03-08 JP JP2000604043A patent/JP4610743B2/ja not_active Expired - Fee Related
- 2000-03-08 IL IL14495800A patent/IL144958A0/xx unknown
- 2000-03-08 PE PE2000000206A patent/PE20001485A1/es not_active Application Discontinuation
- 2000-03-08 MX MXPA01009081A patent/MXPA01009081A/es unknown
- 2000-03-08 TN TNTNSN00045A patent/TNSN00045A1/fr unknown
- 2000-03-08 ME MEP-40/08A patent/MEP4008A/xx unknown
- 2000-03-08 HU HU0200210A patent/HU229506B1/hu not_active IP Right Cessation
- 2000-03-08 AU AU31604/00A patent/AU774174B2/en not_active Ceased
- 2000-03-08 EE EEP200100466A patent/EE04679B1/xx not_active IP Right Cessation
- 2000-03-08 RS YUP-643/01A patent/RS50405B/sr unknown
- 2000-03-08 CN CNB008047804A patent/CN1139592C/zh not_active Expired - Fee Related
- 2000-03-08 WO PCT/EP2000/001570 patent/WO2000053607A1/en active IP Right Grant
- 2000-03-08 PL PL355094A patent/PL222208B1/pl unknown
- 2000-03-08 CO CO00016957A patent/CO5180590A1/es active IP Right Grant
- 2000-03-08 KR KR1020017011336A patent/KR100702085B1/ko not_active IP Right Cessation
- 2000-03-08 BR BRPI0008840-4A patent/BR0008840B1/pt not_active IP Right Cessation
- 2000-11-29 HK HK00107660A patent/HK1031222A1/xx not_active IP Right Cessation
- 2000-12-22 US US09/741,818 patent/US6589939B2/en not_active Expired - Lifetime
-
2001
- 2001-07-31 IS IS6031A patent/IS2003B/is unknown
- 2001-08-10 BG BG105810A patent/BG65032B1/bg unknown
- 2001-08-16 IL IL144958A patent/IL144958A/en not_active IP Right Cessation
- 2001-08-24 NO NO20014128A patent/NO328363B1/no not_active IP Right Cessation
- 2001-09-07 ZA ZA200107408A patent/ZA200107408B/xx unknown
- 2001-09-10 HR HR960321A patent/HRP20010667B1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE216998T1 (de) | Camptothecin-derivate mit antitumor-wirkung | |
ATE304352T1 (de) | Indolyl-3-glyoxylsäure-derivate mit antitumorwirkung | |
IS5381A (is) | 4-fenyl-pyridin afleiður | |
ATE263748T1 (de) | Admantan-derivate | |
DE50010060D1 (de) | Thiazolylamid-derivate | |
IS6128A (is) | 13-Metýl-erýþrómýsín afleiður | |
DK1187814T3 (da) | 5-phenyl-pyrimidinderivater | |
DK1240157T3 (da) | Substituerede N-benzyl-indol-3-yl-glyoxylsyrederivater med antitumorvirkning | |
ATE257148T1 (de) | Propargyletherderivate | |
ATE273272T1 (de) | Mevinolinderivate | |
ATE374747T1 (de) | Monofluoralkylderivate | |
ATE293592T1 (de) | Resorcinderivate | |
ATE254598T1 (de) | 4-hydroxybiphenylhydrazid-derivate | |
DK1187815T3 (da) | 4-phenyl-pyrimidinderivater | |
TR200002893A3 (tr) | Kinolin-4-il türevleri II | |
NO20004892D0 (no) | Kinolin-4-yl-derivater I | |
DK1088818T3 (da) | Quinolin-4-yl-derivater | |
NO20020212D0 (no) | 3-amino-2-benzyl-1-fenyl-propanderivater | |
DK1189886T3 (da) | Ethansulfonyl-piperidinderivater | |
DE60001736D1 (de) | 1-trifluorotmethyl-4-hydroxy-7-piperidinyl-aminomethylchroman-derivate | |
DE50015441D1 (de) | Fadenliefergerät mit verstellbarer fadenleiteinrichtung | |
ATE269328T1 (de) | 1-cycloalkylpyrazolyl-benzoyl-derivate | |
ATE259816T1 (de) | Tricyclische benzoylcyclohexandion-derivate |