EA200100954A1 - Производные камптотецина, обладающие противоопухолевой активностью - Google Patents
Производные камптотецина, обладающие противоопухолевой активностьюInfo
- Publication number
- EA200100954A1 EA200100954A1 EA200100954A EA200100954A EA200100954A1 EA 200100954 A1 EA200100954 A1 EA 200100954A1 EA 200100954 A EA200100954 A EA 200100954A EA 200100954 A EA200100954 A EA 200100954A EA 200100954 A1 EA200100954 A1 EA 200100954A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- camptotecine
- formula
- tumor activity
- possessing anti
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Раскрыты производные камптотецина формулы I, в которой группы R, Rи Rтакие, как определены в описании. Соединения формулы I обладают противоопухолевой активностью и имеют хороший терапевтический индекс. Раскрыты также способы получения соединений формулы I и их применение для приготовления лекарственных препаратов, которые полезны для лечения опухолей, вирусных инфекций и против Plasmodium falciparum.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99830124A EP1044977B1 (en) | 1999-03-09 | 1999-03-09 | Camptothecin derivatives having antitumor activity |
PCT/EP2000/001570 WO2000053607A1 (en) | 1999-03-09 | 2000-03-08 | Camptothecin derivatives having antitumor activity |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200100954A1 true EA200100954A1 (ru) | 2002-04-25 |
EA003605B1 EA003605B1 (ru) | 2003-06-26 |
Family
ID=8243303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100954A EA003605B1 (ru) | 1999-03-09 | 2000-03-08 | Производные камптотецина, обладающие противоопухолевой активностью |
Country Status (39)
Country | Link |
---|---|
US (2) | US6242457B1 (ru) |
EP (1) | EP1044977B1 (ru) |
JP (1) | JP4610743B2 (ru) |
KR (1) | KR100702085B1 (ru) |
CN (1) | CN1139592C (ru) |
AR (1) | AR022860A1 (ru) |
AT (1) | ATE216998T1 (ru) |
AU (1) | AU774174B2 (ru) |
BG (1) | BG65032B1 (ru) |
BR (1) | BR0008840B1 (ru) |
CA (1) | CA2362760C (ru) |
CO (1) | CO5180590A1 (ru) |
CZ (1) | CZ304465B6 (ru) |
DE (1) | DE69901379T2 (ru) |
DK (1) | DK1044977T3 (ru) |
EA (1) | EA003605B1 (ru) |
EE (1) | EE04679B1 (ru) |
EG (1) | EG23999A (ru) |
ES (1) | ES2175919T3 (ru) |
HK (1) | HK1031222A1 (ru) |
HR (1) | HRP20010667B1 (ru) |
HU (1) | HU229506B1 (ru) |
IL (2) | IL144958A0 (ru) |
IS (1) | IS2003B (ru) |
ME (2) | ME00017B (ru) |
MX (1) | MXPA01009081A (ru) |
NO (1) | NO328363B1 (ru) |
NZ (1) | NZ513393A (ru) |
PE (1) | PE20001485A1 (ru) |
PL (1) | PL222208B1 (ru) |
PT (1) | PT1044977E (ru) |
RS (1) | RS50405B (ru) |
SI (1) | SI1044977T1 (ru) |
SK (1) | SK287561B6 (ru) |
TN (1) | TNSN00045A1 (ru) |
TR (1) | TR200102603T2 (ru) |
TW (1) | TWI272272B (ru) |
WO (1) | WO2000053607A1 (ru) |
ZA (1) | ZA200107408B (ru) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4790911B2 (ja) | 1999-01-13 | 2011-10-12 | アルケミア オンコロジー ピーティワイ リミテッド | 薬物の効力を増強するための組成物および方法 |
US7105492B2 (en) * | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
FR2794123B1 (fr) * | 1999-05-28 | 2001-07-27 | Aventis Pharma Sa | Preparation de derives de la camptothecine et de la nothapodytine |
US6352996B1 (en) * | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
US20040029906A1 (en) * | 2001-07-31 | 2004-02-12 | Michael Christman | Inhibitors of dna polymerase sigma |
CA2458856C (en) * | 2001-08-27 | 2011-02-15 | Meditech Research Limited | Improved therapeutic protocols |
WO2003033525A1 (en) * | 2001-10-12 | 2003-04-24 | Debio Recherche Pharmacuetique S.A. | Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament |
ITRM20020305A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Camptotecine con anello lattonico modificato. |
ITRM20020306A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
ITRM20030344A1 (it) | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
RU2006137657A (ru) * | 2004-03-26 | 2008-05-10 | Новартис АГ (CH) | Применение производных камптотецина для лечения пролиферативных заболеваний с использованием схемы лечения с фиксированной дозой |
NZ550430A (en) | 2004-04-27 | 2009-06-26 | Wellstat Biologics Corp | Cancer treatment using viruses and camptothecins |
ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
ITRM20040242A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
ITRM20040241A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 20 con antagonisti delle integrine. |
ITRM20040288A1 (it) * | 2004-06-11 | 2004-09-11 | Sigma Tau Ind Farmaceuti | Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero. |
CN100334089C (zh) * | 2004-07-21 | 2007-08-29 | 王洋 | 一种9-硝基喜树碱的生产方法 |
GT200500310A (es) * | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
NZ555370A (en) * | 2004-12-15 | 2010-03-26 | Sigma Tau Ind Farmaceuti | Combinations of therapeutic agents for treating cancer |
CA2590756C (en) | 2004-12-21 | 2014-09-02 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Stereoselective process and crystalline forms of a camptothecin |
SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
MX2007015407A (es) | 2005-07-14 | 2008-02-19 | Wellstat Biologics Corp | Tratamiento del cancer utilizando virus, fluoropirimidinas y camptotecinas. |
AU2006274509B2 (en) * | 2005-07-27 | 2012-01-19 | Alchemia Oncology Pty Limited | Therapeutic protocols using hyaluronan |
ITRM20050418A1 (it) * | 2005-08-04 | 2007-02-05 | Sigma Tau Ind Farmaceuti | Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina. |
KR20080034149A (ko) * | 2005-08-10 | 2008-04-18 | 노파르티스 아게 | 7-(t-부톡시)이미노메틸 캄토테신에 대한 제형 |
CN101287475B (zh) * | 2005-09-07 | 2012-11-14 | 阿尔卡米亚肿瘤学股份有限公司 | 包含透明质酸和治疗抗体的治疗组合物以及制药用途 |
ES2382819T3 (es) * | 2005-12-21 | 2012-06-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Tratamiento de tumores resistentes a fármacos |
CA2642717C (en) * | 2006-02-17 | 2015-08-18 | Novacea, Inc. | Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs |
WO2007113687A2 (en) | 2006-03-30 | 2007-10-11 | Diatos S.A. | Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same |
EP2107903A1 (en) * | 2007-02-01 | 2009-10-14 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Pharmaceutical composition comprising a campothecin derivative |
US8853233B2 (en) * | 2007-02-13 | 2014-10-07 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives |
WO2009015981A2 (en) * | 2007-08-01 | 2009-02-05 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Treatment of pediatric tumors |
EP2096113A1 (en) | 2008-02-05 | 2009-09-02 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | 9-substituted camptothecin derivatives as antitumor compounds |
TWI482621B (zh) | 2009-12-23 | 2015-05-01 | Sigma Tau Ind Farmaceuti | 青蒿素基藥物與其他化學治療劑的抗癌組合物 |
JP6877049B2 (ja) | 2015-09-25 | 2021-05-26 | ゼットワイ セラピューティクス インク.Zy Therapeutics Inc. | 多糖類−ビタミン共役体を含む粒状物に基づく薬物製剤 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
PT101061B (pt) * | 1991-11-15 | 1999-07-30 | Smithkline Beckman Corp | Composicoes farmaceuticas contendo anagolos da camptotecina e um composto de coordenacao de platina e seu uso na inibicao do crescimento de celulas tumorais |
US5614529A (en) * | 1994-09-22 | 1997-03-25 | Research Triangle Institute | Inhibition of plasmodia parasites by camptothecin compounds |
US5972955A (en) * | 1995-06-06 | 1999-10-26 | Dr. Reddy's Research Foundation | Water soluble C-ring analogues of 20(S)-camptothecin |
GB9512670D0 (en) * | 1995-06-21 | 1995-08-23 | Sod Conseils Rech Applic | Camptothecin analogues |
IT1282673B1 (it) * | 1996-02-23 | 1998-03-31 | Ist Naz Stud Cura Dei Tumori | Derivati della camptotecina e loro uso come agenti antitumorali |
DK0925301T3 (da) * | 1996-08-19 | 2004-07-12 | Bionumerik Pharmaceuticals Inc | Höjlipofile camptothecinderivater |
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1999
- 1999-03-09 DE DE69901379T patent/DE69901379T2/de not_active Expired - Lifetime
- 1999-03-09 DK DK99830124T patent/DK1044977T3/da active
- 1999-03-09 AT AT99830124T patent/ATE216998T1/de active
- 1999-03-09 PT PT99830124T patent/PT1044977E/pt unknown
- 1999-03-09 SI SI9930010T patent/SI1044977T1/xx unknown
- 1999-03-09 ES ES99830124T patent/ES2175919T3/es not_active Expired - Lifetime
- 1999-03-09 EP EP99830124A patent/EP1044977B1/en not_active Expired - Lifetime
-
2000
- 2000-02-22 US US09/507,928 patent/US6242457B1/en not_active Expired - Lifetime
- 2000-03-07 TW TW089104090A patent/TWI272272B/zh not_active IP Right Cessation
- 2000-03-07 EG EG20000293A patent/EG23999A/xx active
- 2000-03-08 PE PE2000000206A patent/PE20001485A1/es not_active Application Discontinuation
- 2000-03-08 TN TNTNSN00045A patent/TNSN00045A1/fr unknown
- 2000-03-08 SK SK1164-2001A patent/SK287561B6/sk not_active IP Right Cessation
- 2000-03-08 CA CA002362760A patent/CA2362760C/en not_active Expired - Fee Related
- 2000-03-08 BR BRPI0008840-4A patent/BR0008840B1/pt not_active IP Right Cessation
- 2000-03-08 PL PL355094A patent/PL222208B1/pl unknown
- 2000-03-08 HU HU0200210A patent/HU229506B1/hu not_active IP Right Cessation
- 2000-03-08 CO CO00016957A patent/CO5180590A1/es active IP Right Grant
- 2000-03-08 AU AU31604/00A patent/AU774174B2/en not_active Ceased
- 2000-03-08 ME MEP-2008-40A patent/ME00017B/me unknown
- 2000-03-08 WO PCT/EP2000/001570 patent/WO2000053607A1/en active IP Right Grant
- 2000-03-08 KR KR1020017011336A patent/KR100702085B1/ko not_active IP Right Cessation
- 2000-03-08 EA EA200100954A patent/EA003605B1/ru not_active IP Right Cessation
- 2000-03-08 MX MXPA01009081A patent/MXPA01009081A/es unknown
- 2000-03-08 NZ NZ513393A patent/NZ513393A/xx not_active IP Right Cessation
- 2000-03-08 AR ARP000101013A patent/AR022860A1/es not_active Application Discontinuation
- 2000-03-08 IL IL14495800A patent/IL144958A0/xx unknown
- 2000-03-08 RS YUP-643/01A patent/RS50405B/sr unknown
- 2000-03-08 CZ CZ2001-3077A patent/CZ304465B6/cs not_active IP Right Cessation
- 2000-03-08 CN CNB008047804A patent/CN1139592C/zh not_active Expired - Fee Related
- 2000-03-08 TR TR2001/02603T patent/TR200102603T2/xx unknown
- 2000-03-08 JP JP2000604043A patent/JP4610743B2/ja not_active Expired - Fee Related
- 2000-03-08 EE EEP200100466A patent/EE04679B1/xx not_active IP Right Cessation
- 2000-03-08 ME MEP-40/08A patent/MEP4008A/xx unknown
- 2000-11-29 HK HK00107660A patent/HK1031222A1/xx not_active IP Right Cessation
- 2000-12-22 US US09/741,818 patent/US6589939B2/en not_active Expired - Lifetime
-
2001
- 2001-07-31 IS IS6031A patent/IS2003B/is unknown
- 2001-08-10 BG BG105810A patent/BG65032B1/bg unknown
- 2001-08-16 IL IL144958A patent/IL144958A/en not_active IP Right Cessation
- 2001-08-24 NO NO20014128A patent/NO328363B1/no not_active IP Right Cessation
- 2001-09-07 ZA ZA200107408A patent/ZA200107408B/xx unknown
- 2001-09-10 HR HR960321A patent/HRP20010667B1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |