PT1017675E - Derivados da camtotecina altamente lipofilos - Google Patents
Derivados da camtotecina altamente lipofilosInfo
- Publication number
- PT1017675E PT1017675E PT98904990T PT98904990T PT1017675E PT 1017675 E PT1017675 E PT 1017675E PT 98904990 T PT98904990 T PT 98904990T PT 98904990 T PT98904990 T PT 98904990T PT 1017675 E PT1017675 E PT 1017675E
- Authority
- PT
- Portugal
- Prior art keywords
- derivatives
- lipofilos
- campotecin
- derivatives highly
- substitution
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 abstract 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Silicon Polymers (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3714897P | 1997-02-14 | 1997-02-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1017675E true PT1017675E (pt) | 2006-09-29 |
Family
ID=21892705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98904990T PT1017675E (pt) | 1997-02-14 | 1998-02-11 | Derivados da camtotecina altamente lipofilos |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1017675B1 (pt) |
| JP (2) | JP4311765B2 (pt) |
| AT (1) | ATE329903T1 (pt) |
| AU (1) | AU6272598A (pt) |
| CA (1) | CA2280905C (pt) |
| DE (1) | DE69834923T2 (pt) |
| DK (1) | DK1017675T3 (pt) |
| ES (1) | ES2262223T3 (pt) |
| PT (1) | PT1017675E (pt) |
| WO (1) | WO1998035940A1 (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136978A (en) * | 1993-06-30 | 2000-10-24 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| US6743917B2 (en) | 1993-06-30 | 2004-06-01 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| US6150343A (en) | 1993-06-30 | 2000-11-21 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| FR2790261B1 (fr) * | 1999-02-26 | 2004-09-10 | Sod Conseils Rech Applic | Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation |
| WO1998035940A1 (en) * | 1997-02-14 | 1998-08-20 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
| US6057303A (en) * | 1998-10-20 | 2000-05-02 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic Camptothecin derivatives |
| US6207832B1 (en) | 1999-04-09 | 2001-03-27 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| WO2000066127A1 (en) * | 1999-05-04 | 2000-11-09 | Bionumerik Pharmaceuticals, Inc. | Novel highly lipophilic camptothecin analogs |
| US6350756B1 (en) * | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
| US6855720B2 (en) | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| US6372906B1 (en) | 2001-04-12 | 2002-04-16 | University Of Pittsburgh | Synthesis of silyl camptothecins and silyl homocamptothecins |
| US6723853B2 (en) | 2001-08-27 | 2004-04-20 | University Of Pittsburgh | Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins |
| KR100895746B1 (ko) | 2001-11-30 | 2009-04-30 | 추가이 세이야쿠 가부시키가이샤 | 헥사사이클릭 화합물 |
| AU2003243380A1 (en) | 2002-06-03 | 2003-12-19 | California Pacific Medical Center | Nitrogen-based homo-camptothecin derivatives |
| EP1393719A1 (en) * | 2002-08-23 | 2004-03-03 | Munich Biotech AG | Camptothecin-carboxylate formulations |
| US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
| MXPA06006710A (es) * | 2003-12-17 | 2006-08-31 | Bionumerik Pharmaceuticals Inc | Formulaciones farmaceuticas de camptotecinas y proceso para su elaboracion. |
| NZ550665A (en) | 2004-04-09 | 2010-05-28 | Chugai Pharmaceutical Co Ltd | Novel water-soluble prodrugs of camptothecin derivatives |
| ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
| TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
| US7875602B2 (en) | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
| US7786134B2 (en) | 2005-12-16 | 2010-08-31 | Sonus Pharmaceuticals, Inc. | Lipophilic anticancer drug compounds, compositions and related methods |
| MX2009001505A (es) * | 2006-08-11 | 2009-03-25 | Christus Stehlin Foundation Fo | Metodos para hacer esteres de camptotecinas. |
| EP2586463B1 (en) | 2010-06-11 | 2016-08-17 | Japan Science and Technology Agency | Pharmaceutical multimeric particles, and manufacturing method for same |
| US9556192B2 (en) | 2012-10-30 | 2017-01-31 | Nerviano Medical Sciences S.R.L. | Functionalized 9-bromo-camptothecin derivatives |
| FR3029637B1 (fr) | 2014-12-05 | 2018-01-05 | Universite De Strasbourg | Microdispositif de detection de composes organiques volatils et methode de detection d'au moins un compose organique volatil compris dans un echantillon gazeux |
| CN111194341B (zh) | 2018-09-14 | 2022-09-23 | 美国陶氏有机硅公司 | 压敏粘合剂及其制备和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| US5446047A (en) * | 1992-07-23 | 1995-08-29 | Sloan-Kettering Institute For Cancer Research | Camptothecin analogues |
| US5468754A (en) * | 1994-04-19 | 1995-11-21 | Bionumerik Pharmaceuticals, Inc. | 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof |
| GB9510716D0 (en) * | 1995-05-26 | 1995-07-19 | Pharmacia Spa | Substituted camptothecin derivatives and process for their preparation |
| WO1998035940A1 (en) * | 1997-02-14 | 1998-08-20 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
-
1998
- 1998-02-11 WO PCT/US1998/002375 patent/WO1998035940A1/en active IP Right Grant
- 1998-02-11 DK DK98904990T patent/DK1017675T3/da active
- 1998-02-11 JP JP53583598A patent/JP4311765B2/ja not_active Expired - Lifetime
- 1998-02-11 AU AU62725/98A patent/AU6272598A/en not_active Abandoned
- 1998-02-11 DE DE69834923T patent/DE69834923T2/de not_active Expired - Lifetime
- 1998-02-11 PT PT98904990T patent/PT1017675E/pt unknown
- 1998-02-11 EP EP98904990A patent/EP1017675B1/en not_active Expired - Lifetime
- 1998-02-11 AT AT98904990T patent/ATE329903T1/de active
- 1998-02-11 CA CA002280905A patent/CA2280905C/en not_active Expired - Lifetime
- 1998-02-11 ES ES98904990T patent/ES2262223T3/es not_active Expired - Lifetime
-
2009
- 2009-03-02 JP JP2009047622A patent/JP5264561B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2262223T3 (es) | 2006-11-16 |
| JP4311765B2 (ja) | 2009-08-12 |
| JP2009149680A (ja) | 2009-07-09 |
| EP1017675B1 (en) | 2006-06-14 |
| WO1998035940A1 (en) | 1998-08-20 |
| AU6272598A (en) | 1998-09-08 |
| DK1017675T3 (da) | 2006-10-16 |
| DE69834923D1 (en) | 2006-07-27 |
| ATE329903T1 (de) | 2006-07-15 |
| CA2280905A1 (en) | 1998-08-20 |
| EP1017675A4 (en) | 2001-08-22 |
| DE69834923T2 (de) | 2006-10-19 |
| JP2001511807A (ja) | 2001-08-14 |
| EP1017675A1 (en) | 2000-07-12 |
| CA2280905C (en) | 2006-08-29 |
| JP5264561B2 (ja) | 2013-08-14 |
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