CN1139592C - 喜树碱衍生物,其制备用途以及中间体 - Google Patents
喜树碱衍生物,其制备用途以及中间体 Download PDFInfo
- Publication number
- CN1139592C CN1139592C CNB008047804A CN00804780A CN1139592C CN 1139592 C CN1139592 C CN 1139592C CN B008047804 A CNB008047804 A CN B008047804A CN 00804780 A CN00804780 A CN 00804780A CN 1139592 C CN1139592 C CN 1139592C
- Authority
- CN
- China
- Prior art keywords
- compound
- group
- iminomethyl
- camptothecin
- camptothecine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
药物(10im) | 持续性 |
喜树碱 | 16 |
拓扑替康(Topotecan) | 16 |
CPT181 | 28 |
CPT184 | 72 |
CPT172 | 80 |
Claims (14)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99830124.6 | 1999-03-09 | ||
EP99830124A EP1044977B1 (en) | 1999-03-09 | 1999-03-09 | Camptothecin derivatives having antitumor activity |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1343209A CN1343209A (zh) | 2002-04-03 |
CN1139592C true CN1139592C (zh) | 2004-02-25 |
Family
ID=8243303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008047804A Expired - Fee Related CN1139592C (zh) | 1999-03-09 | 2000-03-08 | 喜树碱衍生物,其制备用途以及中间体 |
Country Status (39)
Country | Link |
---|---|
US (2) | US6242457B1 (zh) |
EP (1) | EP1044977B1 (zh) |
JP (1) | JP4610743B2 (zh) |
KR (1) | KR100702085B1 (zh) |
CN (1) | CN1139592C (zh) |
AR (1) | AR022860A1 (zh) |
AT (1) | ATE216998T1 (zh) |
AU (1) | AU774174B2 (zh) |
BG (1) | BG65032B1 (zh) |
BR (1) | BR0008840B1 (zh) |
CA (1) | CA2362760C (zh) |
CO (1) | CO5180590A1 (zh) |
CZ (1) | CZ304465B6 (zh) |
DE (1) | DE69901379T2 (zh) |
DK (1) | DK1044977T3 (zh) |
EA (1) | EA003605B1 (zh) |
EE (1) | EE04679B1 (zh) |
EG (1) | EG23999A (zh) |
ES (1) | ES2175919T3 (zh) |
HK (1) | HK1031222A1 (zh) |
HR (1) | HRP20010667B1 (zh) |
HU (1) | HU229506B1 (zh) |
IL (2) | IL144958A0 (zh) |
IS (1) | IS2003B (zh) |
ME (2) | MEP4008A (zh) |
MX (1) | MXPA01009081A (zh) |
NO (1) | NO328363B1 (zh) |
NZ (1) | NZ513393A (zh) |
PE (1) | PE20001485A1 (zh) |
PL (1) | PL222208B1 (zh) |
PT (1) | PT1044977E (zh) |
RS (1) | RS50405B (zh) |
SI (1) | SI1044977T1 (zh) |
SK (1) | SK287561B6 (zh) |
TN (1) | TNSN00045A1 (zh) |
TR (1) | TR200102603T2 (zh) |
TW (1) | TWI272272B (zh) |
WO (1) | WO2000053607A1 (zh) |
ZA (1) | ZA200107408B (zh) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1140198B1 (en) | 1999-01-13 | 2007-10-31 | Alchemia Oncology Pty Limited | Use of hyaluronan for the manufacture of a medicament for the enhancement of the efficacy of cytotoxic drugs |
US7105492B2 (en) | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
FR2794123B1 (fr) * | 1999-05-28 | 2001-07-27 | Aventis Pharma Sa | Preparation de derives de la camptothecine et de la nothapodytine |
US6352996B1 (en) * | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
US20040029906A1 (en) * | 2001-07-31 | 2004-02-12 | Michael Christman | Inhibitors of dna polymerase sigma |
US20050042303A1 (en) * | 2001-08-27 | 2005-02-24 | Brown Tracey Jean | Therapeutic protocols |
WO2003033525A1 (en) * | 2001-10-12 | 2003-04-24 | Debio Recherche Pharmacuetique S.A. | Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament |
ITRM20020305A1 (it) | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Camptotecine con anello lattonico modificato. |
ITRM20020306A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
ITRM20030344A1 (it) * | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
CN1929842A (zh) * | 2004-03-26 | 2007-03-14 | 诺瓦提斯公司 | 喜树碱衍生物以固定给药方案治疗增生性疾病的用途 |
JP5170741B2 (ja) | 2004-04-27 | 2013-03-27 | ウェルスタット バイオロジクス コーポレイション | ウイルスおよびカンプトテシン類を使用する癌の処置 |
ITRM20040241A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 20 con antagonisti delle integrine. |
ITRM20040242A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
ITRM20040288A1 (it) * | 2004-06-11 | 2004-09-11 | Sigma Tau Ind Farmaceuti | Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero. |
CN100334089C (zh) * | 2004-07-21 | 2007-08-29 | 王洋 | 一种9-硝基喜树碱的生产方法 |
GT200500310A (es) * | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
BRPI0515774A (pt) * | 2004-12-15 | 2008-08-05 | Novartis Ag | combinações de agentes terapêuticos para o tratamento de cáncer |
DK1828196T3 (da) | 2004-12-21 | 2012-11-26 | Sigma Tau Ind Farmaceuti | Stereospecifik fremgangsmåde og krystallinske former af en camptothecin |
SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
EP1907015B1 (en) | 2005-07-14 | 2012-01-11 | Wellstat Biologics Corporation | Cancer treatment using viruses, fluoropyrimidines and camptothecins |
CA2616607C (en) * | 2005-07-27 | 2015-06-02 | Alchemia Oncology Pty Limited | Therapeutic protocols using hyaluronan |
ITRM20050418A1 (it) * | 2005-08-04 | 2007-02-05 | Sigma Tau Ind Farmaceuti | Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina. |
MX2008001970A (es) * | 2005-08-10 | 2008-03-24 | Novartis Ag | Formulaciones para 7-(t-butoxi)iminometil camptotecin. |
MY149606A (en) * | 2005-09-07 | 2013-09-13 | Alchemia Oncology Pty Ltd | Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment |
ES2382819T3 (es) * | 2005-12-21 | 2012-06-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Tratamiento de tumores resistentes a fármacos |
EP1989212B1 (en) | 2006-02-17 | 2013-06-19 | Cascade Prodrug Inc. | Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs |
US8410045B2 (en) | 2006-03-30 | 2013-04-02 | Drais Pharmaceuticals, Inc. | Camptothecin-peptide conjugates and pharmaceutical compositions containing the same |
KR20090115856A (ko) * | 2007-02-01 | 2009-11-09 | 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. | 캄포테신 유도체를 함유하는 약학적 조성물 |
EP2120948A1 (en) * | 2007-02-13 | 2009-11-25 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives |
JP5765937B2 (ja) * | 2007-08-01 | 2015-08-19 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニSigma−Tau Industrie Farmaceutiche Riunite Societa Per Azioni | 小児腫瘍の治療 |
EP2096113A1 (en) * | 2008-02-05 | 2009-09-02 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | 9-substituted camptothecin derivatives as antitumor compounds |
TWI482621B (zh) | 2009-12-23 | 2015-05-01 | Sigma Tau Ind Farmaceuti | 青蒿素基藥物與其他化學治療劑的抗癌組合物 |
US10517961B2 (en) | 2015-09-25 | 2019-12-31 | ZY Therapeutics, Inc. | Drug formulation based on particulates comprising polysaccharide-vitamin conjugate |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
WO1993009782A1 (en) * | 1991-11-15 | 1993-05-27 | Smithkline Beecham Corporation | Combination chemotherapy |
US5614529A (en) * | 1994-09-22 | 1997-03-25 | Research Triangle Institute | Inhibition of plasmodia parasites by camptothecin compounds |
US5972955A (en) * | 1995-06-06 | 1999-10-26 | Dr. Reddy's Research Foundation | Water soluble C-ring analogues of 20(S)-camptothecin |
GB9512670D0 (en) * | 1995-06-21 | 1995-08-23 | Sod Conseils Rech Applic | Camptothecin analogues |
IT1282673B1 (it) * | 1996-02-23 | 1998-03-31 | Ist Naz Stud Cura Dei Tumori | Derivati della camptotecina e loro uso come agenti antitumorali |
BR9711319B1 (pt) * | 1996-08-19 | 2009-08-11 | derivados de camptotecina altamente lipofìlicos. |
-
1999
- 1999-03-09 AT AT99830124T patent/ATE216998T1/de active
- 1999-03-09 DK DK99830124T patent/DK1044977T3/da active
- 1999-03-09 ES ES99830124T patent/ES2175919T3/es not_active Expired - Lifetime
- 1999-03-09 SI SI9930010T patent/SI1044977T1/xx unknown
- 1999-03-09 EP EP99830124A patent/EP1044977B1/en not_active Expired - Lifetime
- 1999-03-09 PT PT99830124T patent/PT1044977E/pt unknown
- 1999-03-09 DE DE69901379T patent/DE69901379T2/de not_active Expired - Lifetime
-
2000
- 2000-02-22 US US09/507,928 patent/US6242457B1/en not_active Expired - Lifetime
- 2000-03-07 TW TW089104090A patent/TWI272272B/zh not_active IP Right Cessation
- 2000-03-07 EG EG20000293A patent/EG23999A/xx active
- 2000-03-08 KR KR1020017011336A patent/KR100702085B1/ko not_active IP Right Cessation
- 2000-03-08 MX MXPA01009081A patent/MXPA01009081A/es unknown
- 2000-03-08 ME MEP-40/08A patent/MEP4008A/xx unknown
- 2000-03-08 RS YUP-643/01A patent/RS50405B/sr unknown
- 2000-03-08 ME MEP-2008-40A patent/ME00017B/me unknown
- 2000-03-08 CN CNB008047804A patent/CN1139592C/zh not_active Expired - Fee Related
- 2000-03-08 WO PCT/EP2000/001570 patent/WO2000053607A1/en active IP Right Grant
- 2000-03-08 JP JP2000604043A patent/JP4610743B2/ja not_active Expired - Fee Related
- 2000-03-08 HU HU0200210A patent/HU229506B1/hu not_active IP Right Cessation
- 2000-03-08 PL PL355094A patent/PL222208B1/pl unknown
- 2000-03-08 SK SK1164-2001A patent/SK287561B6/sk not_active IP Right Cessation
- 2000-03-08 EE EEP200100466A patent/EE04679B1/xx not_active IP Right Cessation
- 2000-03-08 NZ NZ513393A patent/NZ513393A/xx not_active IP Right Cessation
- 2000-03-08 TN TNTNSN00045A patent/TNSN00045A1/fr unknown
- 2000-03-08 IL IL14495800A patent/IL144958A0/xx unknown
- 2000-03-08 BR BRPI0008840-4A patent/BR0008840B1/pt not_active IP Right Cessation
- 2000-03-08 CZ CZ2001-3077A patent/CZ304465B6/cs not_active IP Right Cessation
- 2000-03-08 CA CA002362760A patent/CA2362760C/en not_active Expired - Fee Related
- 2000-03-08 PE PE2000000206A patent/PE20001485A1/es not_active Application Discontinuation
- 2000-03-08 CO CO00016957A patent/CO5180590A1/es active IP Right Grant
- 2000-03-08 AR ARP000101013A patent/AR022860A1/es not_active Application Discontinuation
- 2000-03-08 TR TR2001/02603T patent/TR200102603T2/xx unknown
- 2000-03-08 EA EA200100954A patent/EA003605B1/ru not_active IP Right Cessation
- 2000-03-08 AU AU31604/00A patent/AU774174B2/en not_active Ceased
- 2000-11-29 HK HK00107660A patent/HK1031222A1/xx not_active IP Right Cessation
- 2000-12-22 US US09/741,818 patent/US6589939B2/en not_active Expired - Lifetime
-
2001
- 2001-07-31 IS IS6031A patent/IS2003B/is unknown
- 2001-08-10 BG BG105810A patent/BG65032B1/bg unknown
- 2001-08-16 IL IL144958A patent/IL144958A/en not_active IP Right Cessation
- 2001-08-24 NO NO20014128A patent/NO328363B1/no not_active IP Right Cessation
- 2001-09-07 ZA ZA200107408A patent/ZA200107408B/xx unknown
- 2001-09-10 HR HR960321A patent/HRP20010667B1/xx not_active IP Right Cessation
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CI01 | Publication of corrected invention patent application |
Correction item: Denomination of Invention Correct: Camptothecin derivatives, process for their preparation and their use and intermediates False: Camptothecin derivatives, their preparation, use and intermediates Number: 8 Page: 381 Volume: 20 |
|
CI03 | Correction of invention patent |
Correction item: Denomination of Invention Correct: Camptothecin derivatives, process for their preparation and their use and intermediates False: Camptothecin derivatives, their preparation, use and intermediates Number: 8 Page: The title page Volume: 20 |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTION NAME; FROM: CAMPTOTHECIN DERIVATIVES, PREPARING USE AND INTERMEDIATE BODY TO: CAMPTOTHECIN DERIVATIVES, PREPARATION METHOD AND THE USE AND INTERMEDIATE BODY |
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ERR | Gazette correction |
Free format text: CORRECT: INVENTION NAME; FROM: CAMPTOTHECIN DERIVATIVES, PREPARING USE AND INTERMEDIATE BODY TO: CAMPTOTHECIN DERIVATIVES, PREPARATION METHOD AND THE USE AND INTERMEDIATE BODY |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040225 Termination date: 20180308 |
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CF01 | Termination of patent right due to non-payment of annual fee |