DK1044977T3 - Camptothecinderivater med antitumoraktivitet - Google Patents

Camptothecinderivater med antitumoraktivitet

Info

Publication number
DK1044977T3
DK1044977T3 DK99830124T DK99830124T DK1044977T3 DK 1044977 T3 DK1044977 T3 DK 1044977T3 DK 99830124 T DK99830124 T DK 99830124T DK 99830124 T DK99830124 T DK 99830124T DK 1044977 T3 DK1044977 T3 DK 1044977T3
Authority
DK
Denmark
Prior art keywords
antitumor activity
camptothecin derivatives
camptothecin
derivatives
antitumor
Prior art date
Application number
DK99830124T
Other languages
English (en)
Inventor
Sergio Penco
Lucio Merlini
Paolo C O Sigma-Tau Carminati
Franco C O Sigma-Tau In Zunino
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK1044977T3 publication Critical patent/DK1044977T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
DK99830124T 1999-03-09 1999-03-09 Camptothecinderivater med antitumoraktivitet DK1044977T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99830124A EP1044977B1 (en) 1999-03-09 1999-03-09 Camptothecin derivatives having antitumor activity

Publications (1)

Publication Number Publication Date
DK1044977T3 true DK1044977T3 (da) 2002-07-08

Family

ID=8243303

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99830124T DK1044977T3 (da) 1999-03-09 1999-03-09 Camptothecinderivater med antitumoraktivitet

Country Status (39)

Country Link
US (2) US6242457B1 (da)
EP (1) EP1044977B1 (da)
JP (1) JP4610743B2 (da)
KR (1) KR100702085B1 (da)
CN (1) CN1139592C (da)
AR (1) AR022860A1 (da)
AT (1) ATE216998T1 (da)
AU (1) AU774174B2 (da)
BG (1) BG65032B1 (da)
BR (1) BR0008840B1 (da)
CA (1) CA2362760C (da)
CO (1) CO5180590A1 (da)
CZ (1) CZ304465B6 (da)
DE (1) DE69901379T2 (da)
DK (1) DK1044977T3 (da)
EA (1) EA003605B1 (da)
EE (1) EE04679B1 (da)
EG (1) EG23999A (da)
ES (1) ES2175919T3 (da)
HK (1) HK1031222A1 (da)
HR (1) HRP20010667B1 (da)
HU (1) HU229506B1 (da)
IL (2) IL144958A0 (da)
IS (1) IS2003B (da)
ME (2) MEP4008A (da)
MX (1) MXPA01009081A (da)
NO (1) NO328363B1 (da)
NZ (1) NZ513393A (da)
PE (1) PE20001485A1 (da)
PL (1) PL222208B1 (da)
PT (1) PT1044977E (da)
RS (1) RS50405B (da)
SI (1) SI1044977T1 (da)
SK (1) SK287561B6 (da)
TN (1) TNSN00045A1 (da)
TR (1) TR200102603T2 (da)
TW (1) TWI272272B (da)
WO (1) WO2000053607A1 (da)
ZA (1) ZA200107408B (da)

Families Citing this family (39)

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ES2295005T3 (es) 1999-01-13 2008-04-16 Alchemia Oncology Pty Limited Uso de hialuronano para la preparacion de un medicamento para la mejora de la eficacia de farmacos citotoxicos.
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
FR2794123B1 (fr) * 1999-05-28 2001-07-27 Aventis Pharma Sa Preparation de derives de la camptothecine et de la nothapodytine
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
US20040029906A1 (en) * 2001-07-31 2004-02-12 Michael Christman Inhibitors of dna polymerase sigma
US20050042303A1 (en) * 2001-08-27 2005-02-24 Brown Tracey Jean Therapeutic protocols
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
ITRM20020305A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
EP1732554A2 (en) * 2004-03-26 2006-12-20 Novartis AG Treatment regimen for camptothecin derivatives
RU2408387C2 (ru) 2004-04-27 2011-01-10 Веллстат Байолоджикс Корпорейшн Лечение злокачественного новообразования с применением вирусов и камптотецинов
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
RU2400232C2 (ru) * 2004-12-15 2010-09-27 Новартис Аг Комбинации терапевтических агентов для лечения рака
KR101355121B1 (ko) * 2004-12-21 2014-01-24 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. 캄토테신의 입체선택적 방법 및 결정성 형태
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
ATE540698T1 (de) 2005-07-14 2012-01-15 Wellstat Biologics Corp Krebsbehandlung mit viren, fluoropyrimidinen und camptothecinen
EP1912658B1 (en) * 2005-07-27 2017-01-25 Alchemia Oncology Pty Limited Therapeutic protocols using hyaluronan
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
MX2008001970A (es) * 2005-08-10 2008-03-24 Novartis Ag Formulaciones para 7-(t-butoxi)iminometil camptotecin.
AU2006289651B2 (en) * 2005-09-07 2012-07-26 Alchemia Oncology Pty Limited Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment
SI1962850T1 (sl) 2005-12-21 2012-06-29 Sigma Tau Ind Farmaceuti Zdravljenje tumorjev, odpornih proti zdravilom
WO2007098091A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs
WO2007113687A2 (en) 2006-03-30 2007-10-11 Diatos S.A. Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
EP2107903A1 (en) * 2007-02-01 2009-10-14 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Pharmaceutical composition comprising a campothecin derivative
WO2008098701A1 (en) * 2007-02-13 2008-08-21 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
JP5765937B2 (ja) * 2007-08-01 2015-08-19 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ 小児腫瘍の治療
EP2096113A1 (en) * 2008-02-05 2009-09-02 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 9-substituted camptothecin derivatives as antitumor compounds
TWI482621B (zh) 2009-12-23 2015-05-01 Sigma Tau Ind Farmaceuti 青蒿素基藥物與其他化學治療劑的抗癌組合物
CA2995029C (en) 2015-09-25 2022-10-25 Zy Therapeutics Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
DE69233169T2 (de) * 1991-11-15 2004-05-27 Smithkline Beecham Corp. Cisplatin und Topotecan enthaltende Zusammensetzung als antitumor.
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
PT925301E (pt) * 1996-08-19 2004-08-31 Bionumerik Pharmaceuticals Inc Derivados altamente lipofilos de camptotecina

Also Published As

Publication number Publication date
NZ513393A (en) 2003-04-29
IS6031A (is) 2001-07-31
TR200102603T2 (tr) 2002-01-21
SK287561B6 (sk) 2011-02-04
EP1044977B1 (en) 2002-05-02
YU64301A (sh) 2005-07-19
PL355094A1 (en) 2004-03-22
ME00017B (me) 2010-06-10
EA003605B1 (ru) 2003-06-26
NO20014128L (no) 2001-08-24
EP1044977A1 (en) 2000-10-18
DE69901379D1 (de) 2002-06-06
JP2002539128A (ja) 2002-11-19
TNSN00045A1 (fr) 2005-11-10
IS2003B (is) 2005-04-15
EA200100954A1 (ru) 2002-04-25
CN1139592C (zh) 2004-02-25
PL222208B1 (pl) 2016-07-29
KR100702085B1 (ko) 2007-04-02
HK1031222A1 (en) 2001-06-08
AU774174B2 (en) 2004-06-17
CZ20013077A3 (cs) 2002-01-16
IL144958A0 (en) 2002-06-30
NO20014128D0 (no) 2001-08-24
PE20001485A1 (es) 2000-12-07
ES2175919T3 (es) 2002-11-16
KR20010102519A (ko) 2001-11-15
BR0008840B1 (pt) 2011-12-27
MEP4008A (xx) 2010-02-10
EG23999A (en) 2008-03-19
CZ304465B6 (cs) 2014-05-21
RS50405B (sr) 2009-12-31
HUP0200210A2 (hu) 2002-05-29
ATE216998T1 (de) 2002-05-15
HRP20010667B1 (en) 2003-06-30
EE200100466A (et) 2002-12-16
BG65032B1 (bg) 2006-12-29
MXPA01009081A (es) 2002-08-30
JP4610743B2 (ja) 2011-01-12
US20010008939A1 (en) 2001-07-19
DE69901379T2 (de) 2002-11-07
TWI272272B (en) 2007-02-01
SI1044977T1 (en) 2002-08-31
CN1343209A (zh) 2002-04-03
AU3160400A (en) 2000-09-28
SK11642001A3 (sk) 2002-01-07
BR0008840A (pt) 2002-01-08
HU229506B1 (en) 2014-01-28
US6242457B1 (en) 2001-06-05
US6589939B2 (en) 2003-07-08
BG105810A (en) 2002-06-28
CO5180590A1 (es) 2002-07-30
IL144958A (en) 2009-08-03
ZA200107408B (en) 2002-05-29
NO328363B1 (no) 2010-02-01
PT1044977E (pt) 2002-09-30
AR022860A1 (es) 2002-09-04
EE04679B1 (et) 2006-08-15
CA2362760A1 (en) 2000-09-14
WO2000053607A1 (en) 2000-09-14
HUP0200210A3 (en) 2004-03-29
HRP20010667A2 (en) 2002-08-31
CA2362760C (en) 2009-08-18

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