DK1187814T3 - 5-phenyl-pyrimidinderivater - Google Patents

5-phenyl-pyrimidinderivater

Info

Publication number
DK1187814T3
DK1187814T3 DK00935104T DK00935104T DK1187814T3 DK 1187814 T3 DK1187814 T3 DK 1187814T3 DK 00935104 T DK00935104 T DK 00935104T DK 00935104 T DK00935104 T DK 00935104T DK 1187814 T3 DK1187814 T3 DK 1187814T3
Authority
DK
Denmark
Prior art keywords
phenyl
pyrimidine derivatives
pyrimidine
derivatives
Prior art date
Application number
DK00935104T
Other languages
English (en)
Inventor
Michael Boes
Patrick Schnider
Heinz Stadler
Guido Galley
Thierry Godel
Walter Hunkeler
Torsten Hoffmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1187814T3 publication Critical patent/DK1187814T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/34One oxygen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
DK00935104T 1999-05-31 2000-05-24 5-phenyl-pyrimidinderivater DK1187814T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99110482 1999-05-31
EP00935104A EP1187814B1 (en) 1999-05-31 2000-05-24 5-phenyl-pyrimidine derivatives
PCT/EP2000/004702 WO2000073278A2 (en) 1999-05-31 2000-05-24 5-phenyl-pyrimidine derivatives

Publications (1)

Publication Number Publication Date
DK1187814T3 true DK1187814T3 (da) 2004-12-20

Family

ID=8238270

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00935104T DK1187814T3 (da) 1999-05-31 2000-05-24 5-phenyl-pyrimidinderivater

Country Status (36)

Country Link
US (1) US6756380B1 (da)
EP (1) EP1187814B1 (da)
JP (1) JP3590591B2 (da)
KR (1) KR100478369B1 (da)
CN (1) CN1187338C (da)
AR (1) AR024145A1 (da)
AT (1) ATE273962T1 (da)
AU (1) AU769265B2 (da)
BR (1) BR0011097A (da)
CA (1) CA2375670C (da)
CO (1) CO5170529A1 (da)
CZ (1) CZ20014273A3 (da)
DE (1) DE60013127T2 (da)
DK (1) DK1187814T3 (da)
ES (1) ES2225144T3 (da)
GC (1) GC0000338A (da)
HK (1) HK1046411B (da)
HR (1) HRP20010867A2 (da)
HU (1) HU225016B1 (da)
IL (2) IL146519A0 (da)
JO (1) JO2308B1 (da)
MA (1) MA26794A1 (da)
MX (1) MXPA01011704A (da)
MY (1) MY136258A (da)
NO (1) NO321334B1 (da)
NZ (1) NZ515408A (da)
PE (1) PE20010203A1 (da)
PL (1) PL353492A1 (da)
PT (1) PT1187814E (da)
RU (1) RU2244710C2 (da)
SI (1) SI1187814T1 (da)
TR (1) TR200103460T2 (da)
TW (1) TWI263638B (da)
WO (1) WO2000073278A2 (da)
YU (1) YU85001A (da)
ZA (1) ZA200109496B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ514600A0 (en) 2000-01-18 2000-02-10 James Cook University Brain injury treatment
SK17452002A3 (sk) * 2000-06-13 2003-06-03 Basf Aktiengesellschaft Fungicídne 5-fenyl substituované 2-(kyanoamino)pyrimidíny
WO2002060378A2 (en) 2000-12-21 2002-08-08 Nitromed, Inc. Substituted aryl compounds as cyclooxygenase-2 selective inhibitors, compositions and methods of use
PL375263A1 (en) 2002-07-02 2005-11-28 F.Hoffmann-La Roche Ag 2,5-substituted pyrimidine derivatives as ccr-3 receptor antagonists
JP4851337B2 (ja) * 2003-11-10 2012-01-11 シンタ ファーマシューティカルズ コーポレーション ヘテロアリールヒドラゾン化合物
JP2007217282A (ja) * 2004-03-04 2007-08-30 Astellas Pharma Inc 置換ピリミジン誘導体
AU2005304393B2 (en) * 2004-11-10 2012-09-27 Synta Pharmaceuticals Corp. IL-12 modulatory compounds
BRPI0606187A2 (pt) 2005-02-25 2009-06-09 Hoffmann La Roche comprimidos com capacidade de dispersão da substáncia do fármaco melhorada
US9013997B2 (en) 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
BR112015023267B1 (pt) 2013-03-15 2023-01-31 Epigen Biosciences, Inc Composto, e medicamento para tratar um indivíduo com doença ou condição lisofosfatídica dependente de ácido
GB201316600D0 (en) * 2013-09-18 2013-10-30 Redx Pharma Ltd Agricultural chemicals
WO2016021562A1 (ja) * 2014-08-06 2016-02-11 キッセイ薬品工業株式会社 シアノチオフェン誘導体
WO2016120355A2 (en) * 2015-01-30 2016-08-04 Basf Se Herbicidal phenylpyrimidines
CA3029873A1 (en) 2016-07-20 2018-01-25 Basf Se Herbicidal compositions comprising phenylpyrimidines
US20190161451A1 (en) 2016-07-25 2019-05-30 Basf Se Herbicidal pyrimidine compounds
EP3487848B1 (en) * 2016-07-25 2020-09-30 Basf Se Herbicidal pyrimidine compounds
EP3490985B1 (en) 2016-07-26 2020-08-05 Basf Se Herbicidal pyrimidine compounds
CN109475127A (zh) 2016-07-27 2019-03-15 巴斯夫欧洲公司 除草的嘧啶化合物
CN109561684A (zh) 2016-07-28 2019-04-02 巴斯夫欧洲公司 除草的嘧啶化合物
CA3064513A1 (en) 2017-06-14 2018-12-20 Basf Se Herbicidal pyrimidine compounds
WO2019121374A1 (en) 2017-12-20 2019-06-27 Basf Se Herbicidal pyrimidine compounds
WO2019121352A1 (en) 2017-12-20 2019-06-27 Basf Se Herbicidal pyrimidine compounds
WO2019121373A1 (en) 2017-12-20 2019-06-27 Basf Se Herbicidal pyrimidine compounds
WO2019121408A1 (en) 2017-12-20 2019-06-27 Basf Se Herbicidal pyrimidine compounds
ES2959616T3 (es) 2018-09-19 2024-02-27 Bayer Ag Hidrazidas de fenilpirimidina sustituidas con efecto herbicida

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR208171A1 (es) 1972-09-29 1976-12-09 Ciba Geigy Ag Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico
PL181214B1 (pl) 1993-12-29 2001-06-29 Merck Sharp & Dohme Podstawione związki morfolinowe, sposób ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
CA2230894A1 (en) 1995-09-01 1997-03-13 Signal Pharmaceuticals, Inc. Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions

Also Published As

Publication number Publication date
IL146519A (en) 2006-12-10
CA2375670C (en) 2009-09-29
YU85001A (sh) 2004-09-03
HK1046411B (zh) 2005-05-27
SI1187814T1 (en) 2004-12-31
NO20015701L (no) 2001-11-22
ZA200109496B (en) 2003-02-17
DE60013127T2 (de) 2005-09-08
PL353492A1 (en) 2003-11-17
AU769265B2 (en) 2004-01-22
MA26794A1 (fr) 2004-12-20
HK1046411A1 (en) 2003-01-10
ATE273962T1 (de) 2004-09-15
CZ20014273A3 (cs) 2002-05-15
WO2000073278A2 (en) 2000-12-07
JP2003500477A (ja) 2003-01-07
HRP20010867A2 (en) 2003-04-30
TR200103460T2 (tr) 2002-05-21
ES2225144T3 (es) 2005-03-16
US6756380B1 (en) 2004-06-29
WO2000073278A3 (en) 2001-07-05
CA2375670A1 (en) 2000-12-07
DE60013127D1 (de) 2004-09-23
HUP0201527A3 (en) 2005-01-28
NO20015701D0 (no) 2001-11-22
KR100478369B1 (ko) 2005-03-24
AU5070800A (en) 2000-12-18
HUP0201527A2 (en) 2002-08-28
AR024145A1 (es) 2002-09-04
MXPA01011704A (es) 2002-05-14
HU225016B1 (en) 2006-05-29
NZ515408A (en) 2004-02-27
NO321334B1 (no) 2006-04-24
RU2244710C2 (ru) 2005-01-20
PE20010203A1 (es) 2001-02-15
TWI263638B (en) 2006-10-11
BR0011097A (pt) 2002-03-19
EP1187814B1 (en) 2004-08-18
GC0000338A (en) 2007-03-31
JP3590591B2 (ja) 2004-11-17
PT1187814E (pt) 2004-10-29
JO2308B1 (en) 2005-09-12
IL146519A0 (en) 2002-07-25
CO5170529A1 (es) 2002-06-27
KR20020003399A (ko) 2002-01-12
CN1353696A (zh) 2002-06-12
MY136258A (en) 2008-09-30
CN1187338C (zh) 2005-02-02
EP1187814A2 (en) 2002-03-20

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