CO5180590A1 - Derivados de camptotecina que tienen actividad anti tumores - Google Patents

Derivados de camptotecina que tienen actividad anti tumores

Info

Publication number
CO5180590A1
CO5180590A1 CO00016957A CO00016957A CO5180590A1 CO 5180590 A1 CO5180590 A1 CO 5180590A1 CO 00016957 A CO00016957 A CO 00016957A CO 00016957 A CO00016957 A CO 00016957A CO 5180590 A1 CO5180590 A1 CO 5180590A1
Authority
CO
Colombia
Prior art keywords
derivatives
camptotechine
formula
tumors
compounds
Prior art date
Application number
CO00016957A
Other languages
English (en)
Inventor
Paolo Carminati
Sergio Penco
Lucio Merlini
Franco Zunino
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of CO5180590A1 publication Critical patent/CO5180590A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se divulgan derivados de camptotecina de camptotecina de fórmula (I)<EMI FILE="00016957_1" ID="1" IMF=JPEG >donde los grupos R1, R2, y R3 son como se definió en la descripción.Los compuestos de fórmula (I) están dotados con actividad anti-tumores y muestran un buen índice terapéutico.También se divulgan procesos para la preparación de los compuestos de fórmula (I) y su uso en la preparación de medicamentos útiles en el tratamiento de tumores, infecciones virales y antiplasmodium alciparum.
CO00016957A 1999-03-09 2000-03-08 Derivados de camptotecina que tienen actividad anti tumores CO5180590A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99830124A EP1044977B1 (en) 1999-03-09 1999-03-09 Camptothecin derivatives having antitumor activity

Publications (1)

Publication Number Publication Date
CO5180590A1 true CO5180590A1 (es) 2002-07-30

Family

ID=8243303

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00016957A CO5180590A1 (es) 1999-03-09 2000-03-08 Derivados de camptotecina que tienen actividad anti tumores

Country Status (39)

Country Link
US (2) US6242457B1 (es)
EP (1) EP1044977B1 (es)
JP (1) JP4610743B2 (es)
KR (1) KR100702085B1 (es)
CN (1) CN1139592C (es)
AR (1) AR022860A1 (es)
AT (1) ATE216998T1 (es)
AU (1) AU774174B2 (es)
BG (1) BG65032B1 (es)
BR (1) BR0008840B1 (es)
CA (1) CA2362760C (es)
CO (1) CO5180590A1 (es)
CZ (1) CZ304465B6 (es)
DE (1) DE69901379T2 (es)
DK (1) DK1044977T3 (es)
EA (1) EA003605B1 (es)
EE (1) EE04679B1 (es)
EG (1) EG23999A (es)
ES (1) ES2175919T3 (es)
HK (1) HK1031222A1 (es)
HR (1) HRP20010667B1 (es)
HU (1) HU229506B1 (es)
IL (2) IL144958A0 (es)
IS (1) IS2003B (es)
ME (2) MEP4008A (es)
MX (1) MXPA01009081A (es)
NO (1) NO328363B1 (es)
NZ (1) NZ513393A (es)
PE (1) PE20001485A1 (es)
PL (1) PL222208B1 (es)
PT (1) PT1044977E (es)
RS (1) RS50405B (es)
SI (1) SI1044977T1 (es)
SK (1) SK287561B6 (es)
TN (1) TNSN00045A1 (es)
TR (1) TR200102603T2 (es)
TW (1) TWI272272B (es)
WO (1) WO2000053607A1 (es)
ZA (1) ZA200107408B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
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NZ512676A (en) 1999-01-13 2003-01-31 Meditech Res Ltd A composition and method for the enhancement of the efficacy of drugs
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
FR2794123B1 (fr) * 1999-05-28 2001-07-27 Aventis Pharma Sa Preparation de derives de la camptothecine et de la nothapodytine
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
US20040029906A1 (en) * 2001-07-31 2004-02-12 Michael Christman Inhibitors of dna polymerase sigma
CN1578677A (zh) * 2001-08-27 2005-02-09 美迪泰克研究有限公司 改良的治疗方案
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
ITRM20020305A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
ITRM20030344A1 (it) 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
WO2005092302A2 (en) * 2004-03-26 2005-10-06 Novartis Ag Use of camptothecin derivates for the treatment of proliferative diseases in a fixed dosing regimen
CN1946421B (zh) 2004-04-27 2013-07-17 威尔斯达特生物制剂公司 使用病毒和喜树碱进行的癌症治疗
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
EP1827437B1 (en) * 2004-12-15 2011-11-02 Novartis AG Combinations of therapeutic agents for treating cancer
AU2005318227B2 (en) 2004-12-21 2011-08-18 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Stereoselective process and crystalline forms of a camptothecin
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
RU2435586C2 (ru) 2005-07-14 2011-12-10 Веллстат Байолоджикс Корпорейшн Лечение рака с применением вирусов, фторпиримидинов и камптотецинов
CN103784960A (zh) * 2005-07-27 2014-05-14 阿尔卡米亚肿瘤学股份有限公司 使用乙酰透明质酸的治疗方案
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
CA2617873A1 (en) * 2005-08-10 2007-02-15 Novartis Ag Formulations for 7-(t-butoxy)iminomethyl camptothecin
US8623354B2 (en) * 2005-09-07 2014-01-07 Alchemia Oncology Pty Limited Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment
JP5657205B2 (ja) 2005-12-21 2015-01-21 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ 薬物耐性腫瘍の治療
CN101421282B (zh) * 2006-02-17 2013-08-14 俄勒冈州由俄勒冈州立大学代表高等教育委员会行使 用长春花生物碱n-氧化物和类似物治疗过度增殖性疾病
AU2007232206B2 (en) 2006-03-30 2013-04-04 Drais Pharmaceuticals, Inc. Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
CN101652125A (zh) * 2007-02-01 2010-02-17 希格马托制药工业公司 包含喜树碱衍生物的药物组合物
US8853233B2 (en) * 2007-02-13 2014-10-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
EA015933B1 (ru) * 2007-08-01 2011-12-30 Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. Лечение детских опухолей
EP2096113A1 (en) * 2008-02-05 2009-09-02 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 9-substituted camptothecin derivatives as antitumor compounds
TWI482621B (zh) 2009-12-23 2015-05-01 Sigma Tau Ind Farmaceuti 青蒿素基藥物與其他化學治療劑的抗癌組合物
AU2016326747A1 (en) 2015-09-25 2018-03-01 Zy Therapeutics Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
NZ245112A (en) * 1991-11-15 1995-07-26 Smithkline Beecham Corp Pharmaceutical composition comprising a camptothecin analog and a platinum coordination compound
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
KR100516593B1 (ko) * 1996-08-19 2005-09-22 바이오누머릭 파마슈티칼스, 인코포레이티드 고 친유성 캠프토테신 유도체

Also Published As

Publication number Publication date
SK287561B6 (sk) 2011-02-04
JP4610743B2 (ja) 2011-01-12
NO328363B1 (no) 2010-02-01
ATE216998T1 (de) 2002-05-15
EP1044977A1 (en) 2000-10-18
TWI272272B (en) 2007-02-01
SI1044977T1 (en) 2002-08-31
DK1044977T3 (da) 2002-07-08
EA200100954A1 (ru) 2002-04-25
HRP20010667A2 (en) 2002-08-31
RS50405B (sr) 2009-12-31
BR0008840A (pt) 2002-01-08
SK11642001A3 (sk) 2002-01-07
KR100702085B1 (ko) 2007-04-02
ME00017B (me) 2010-06-10
HU229506B1 (en) 2014-01-28
US6242457B1 (en) 2001-06-05
PL355094A1 (en) 2004-03-22
CZ304465B6 (cs) 2014-05-21
EG23999A (en) 2008-03-19
ZA200107408B (en) 2002-05-29
EE04679B1 (et) 2006-08-15
YU64301A (sh) 2005-07-19
AU3160400A (en) 2000-09-28
AR022860A1 (es) 2002-09-04
BR0008840B1 (pt) 2011-12-27
CN1343209A (zh) 2002-04-03
TNSN00045A1 (fr) 2005-11-10
HRP20010667B1 (en) 2003-06-30
IL144958A (en) 2009-08-03
HUP0200210A2 (hu) 2002-05-29
US6589939B2 (en) 2003-07-08
BG65032B1 (bg) 2006-12-29
IS2003B (is) 2005-04-15
EE200100466A (et) 2002-12-16
HK1031222A1 (en) 2001-06-08
IS6031A (is) 2001-07-31
NZ513393A (en) 2003-04-29
US20010008939A1 (en) 2001-07-19
ES2175919T3 (es) 2002-11-16
AU774174B2 (en) 2004-06-17
DE69901379T2 (de) 2002-11-07
NO20014128D0 (no) 2001-08-24
PE20001485A1 (es) 2000-12-07
CA2362760C (en) 2009-08-18
WO2000053607A1 (en) 2000-09-14
TR200102603T2 (tr) 2002-01-21
CA2362760A1 (en) 2000-09-14
IL144958A0 (en) 2002-06-30
BG105810A (en) 2002-06-28
CZ20013077A3 (cs) 2002-01-16
DE69901379D1 (de) 2002-06-06
EP1044977B1 (en) 2002-05-02
CN1139592C (zh) 2004-02-25
JP2002539128A (ja) 2002-11-19
MXPA01009081A (es) 2002-08-30
HUP0200210A3 (en) 2004-03-29
KR20010102519A (ko) 2001-11-15
PT1044977E (pt) 2002-09-30
MEP4008A (xx) 2010-02-10
EA003605B1 (ru) 2003-06-26
PL222208B1 (pl) 2016-07-29
NO20014128L (no) 2001-08-24

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