ES2175919T3 - Derivados del camptothecin con actividad antitumoral. - Google Patents
Derivados del camptothecin con actividad antitumoral.Info
- Publication number
- ES2175919T3 ES2175919T3 ES99830124T ES99830124T ES2175919T3 ES 2175919 T3 ES2175919 T3 ES 2175919T3 ES 99830124 T ES99830124 T ES 99830124T ES 99830124 T ES99830124 T ES 99830124T ES 2175919 T3 ES2175919 T3 ES 2175919T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- group
- linear
- branched alkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos de **fórmula**, en donde R1 es un grupo -C(R5)=N-O(n) R4, en donde R4 es un alquilo lineal o ramificado de 1 a 8 átomos de carbono, ó un grupo alquenilo lineal o ramicado de 1 a 8 átomos de carbono, ó cicloalquilo de 3 a10 átomos de carbono, ó un grupo cicloalquilo de 3 a 10 átomos de carbono alquilo lineal o ramificado de 1 a 8 átomos de carbono, ó arilo de 6 a14 átomos de carbono, ó un grupo arilo de 6 a 14 átomos de carbono alquilo lineal o ramificado de 1 a 8 átomos de carbono, o un grupo heterocíclico ó un heterociclo alquilo lineal o ramificado de 1 a 8 átomos de carbono, conteniendo dicho grupo heterocíclico por lo menos un heteroátomo seleccionado del grupo formado por el átomo de nitrógeno, opcionalmente substituido con un grupo alquilode 1 a 8 átomos de carbono, y/o oxígeno y/o azufre; dicho alquilo, alquenilo, cicloalquilo, cicloalquilalquilo, arilo, aril-alquilo, grupos heterocíclicos o heterociclo-alquilo, estando opcionalmente substituidos con uno o más grupos seleccionados del grupo formado por: halógeno, hidroxilo, alquilo de 1 a 8 átomos de carbono, alcoxilo de 1 a 8 átomos de carbono, fenilo, ciano, nitro, -NR6R7, en donde R6 y R7, iguales o diferentes entre sí, son hidrógeno, alquilo lineal o ramificado de 1 a 8 átomos de carbono; el grupo -COOH ó unéster farmacéuticamente aceptable del mismo; o el grupo CONR8R9, en donde R8 y R9 iguales o diferentes entre sí, son hidrógeno, alquilo lineal o ramificado de 1 a 8 átomos de carbono, fenilo; o R4 es un grupo aroilo de 6 a 10 átomos de carbono, o un grupo arilsulfonilo de 6 a 10 átomos de carbono, opcionalmente substituido con uno o más grupos seleccionados del grupo formado por: halógeno, hidroxilo, alquilo lineal o ramificado de 1 a 8 átomos de carbono, alcoxilo lineal o ramificado de 1 a 8 átomos de carbono, fenilo, ciano, nitro, -NR10R11, en donde R10 y R11, iguales o diferentes entre sí, son hidrógeno, alquilo lineal o ramificado de 1 a 8 átomos de carbono; R4 es un grupo poliaminoalquilo de fórmula -(CH2)m-NR12-(CH2)p-NR13-(CH2)q-NH2, en donde m, p son un número entero de 2 a 6, y q es un número entero de 0 a 6, ambos incluidos, y R12 y R13 son un grupo alquilo lineal o ramificado de 1 a 8 átomos de carbono; o R4 es un grupo glicosilo seleccionado entre 6-D-galactosilo, 6-D-glucosilo; n es el número 1; R5 es hidrógeno,alquilolinealo ramificado de 1 a 8 átomos de carbono, alquenilo lineal o ramificado de 1 a 8 átomos de carbono, cicloalquilo de 3 a 10 átomos de carbono, cicloalquilo de 3 a 10 átomos de carbono-alquilolinealo ramificado de 1 a 8 átomos de carbono, arilo de 6 a 14 átomos de carbono, arilo de 6 a 14 átomos de carbono alquilo lineal o ramificado de 1 a 8 átomos de carbono; R2 y R3, iguales o diferentes entre sí, son hidrógeno, hidroxilo, alcoxilo lineal o ramificado de 1 a 8 átomos de carbono; sus óxidos N1, sus isómeros únicos, en particular los isómeros s y n y anti del grupo -C(R5)=N-O(n) R4, sus posibles enantiómeros, diastereoisómeros y mezclas relativas, y salesfarmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99830124A EP1044977B1 (en) | 1999-03-09 | 1999-03-09 | Camptothecin derivatives having antitumor activity |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2175919T3 true ES2175919T3 (es) | 2002-11-16 |
Family
ID=8243303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99830124T Expired - Lifetime ES2175919T3 (es) | 1999-03-09 | 1999-03-09 | Derivados del camptothecin con actividad antitumoral. |
Country Status (39)
Country | Link |
---|---|
US (2) | US6242457B1 (es) |
EP (1) | EP1044977B1 (es) |
JP (1) | JP4610743B2 (es) |
KR (1) | KR100702085B1 (es) |
CN (1) | CN1139592C (es) |
AR (1) | AR022860A1 (es) |
AT (1) | ATE216998T1 (es) |
AU (1) | AU774174B2 (es) |
BG (1) | BG65032B1 (es) |
BR (1) | BR0008840B1 (es) |
CA (1) | CA2362760C (es) |
CO (1) | CO5180590A1 (es) |
CZ (1) | CZ304465B6 (es) |
DE (1) | DE69901379T2 (es) |
DK (1) | DK1044977T3 (es) |
EA (1) | EA003605B1 (es) |
EE (1) | EE04679B1 (es) |
EG (1) | EG23999A (es) |
ES (1) | ES2175919T3 (es) |
HK (1) | HK1031222A1 (es) |
HR (1) | HRP20010667B1 (es) |
HU (1) | HU229506B1 (es) |
IL (2) | IL144958A0 (es) |
IS (1) | IS2003B (es) |
ME (2) | MEP4008A (es) |
MX (1) | MXPA01009081A (es) |
NO (1) | NO328363B1 (es) |
NZ (1) | NZ513393A (es) |
PE (1) | PE20001485A1 (es) |
PL (1) | PL222208B1 (es) |
PT (1) | PT1044977E (es) |
RS (1) | RS50405B (es) |
SI (1) | SI1044977T1 (es) |
SK (1) | SK287561B6 (es) |
TN (1) | TNSN00045A1 (es) |
TR (1) | TR200102603T2 (es) |
TW (1) | TWI272272B (es) |
WO (1) | WO2000053607A1 (es) |
ZA (1) | ZA200107408B (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ512676A (en) | 1999-01-13 | 2003-01-31 | Meditech Res Ltd | A composition and method for the enhancement of the efficacy of drugs |
US7105492B2 (en) * | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
FR2794123B1 (fr) * | 1999-05-28 | 2001-07-27 | Aventis Pharma Sa | Preparation de derives de la camptothecine et de la nothapodytine |
US6352996B1 (en) * | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
US20040029906A1 (en) * | 2001-07-31 | 2004-02-12 | Michael Christman | Inhibitors of dna polymerase sigma |
CN1578677A (zh) * | 2001-08-27 | 2005-02-09 | 美迪泰克研究有限公司 | 改良的治疗方案 |
WO2003033525A1 (en) * | 2001-10-12 | 2003-04-24 | Debio Recherche Pharmacuetique S.A. | Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament |
ITRM20020305A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Camptotecine con anello lattonico modificato. |
ITRM20020306A1 (it) * | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
FR2852606A1 (fr) * | 2003-03-18 | 2004-09-24 | Inst Nat Sante Rech Med | Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie |
US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
ITRM20030344A1 (it) | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
WO2005092302A2 (en) * | 2004-03-26 | 2005-10-06 | Novartis Ag | Use of camptothecin derivates for the treatment of proliferative diseases in a fixed dosing regimen |
CN1946421B (zh) | 2004-04-27 | 2013-07-17 | 威尔斯达特生物制剂公司 | 使用病毒和喜树碱进行的癌症治疗 |
ITRM20040242A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine. |
ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
ITRM20040241A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 20 con antagonisti delle integrine. |
ITRM20040288A1 (it) * | 2004-06-11 | 2004-09-11 | Sigma Tau Ind Farmaceuti | Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero. |
CN100334089C (zh) * | 2004-07-21 | 2007-08-29 | 王洋 | 一种9-硝基喜树碱的生产方法 |
GT200500310A (es) * | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
EP1827437B1 (en) * | 2004-12-15 | 2011-11-02 | Novartis AG | Combinations of therapeutic agents for treating cancer |
AU2005318227B2 (en) | 2004-12-21 | 2011-08-18 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Stereoselective process and crystalline forms of a camptothecin |
SA06270147B1 (ar) | 2005-06-09 | 2009-12-22 | نوفارتيس ايه جي | عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين |
RU2435586C2 (ru) | 2005-07-14 | 2011-12-10 | Веллстат Байолоджикс Корпорейшн | Лечение рака с применением вирусов, фторпиримидинов и камптотецинов |
CN103784960A (zh) * | 2005-07-27 | 2014-05-14 | 阿尔卡米亚肿瘤学股份有限公司 | 使用乙酰透明质酸的治疗方案 |
ITRM20050418A1 (it) * | 2005-08-04 | 2007-02-05 | Sigma Tau Ind Farmaceuti | Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina. |
CA2617873A1 (en) * | 2005-08-10 | 2007-02-15 | Novartis Ag | Formulations for 7-(t-butoxy)iminomethyl camptothecin |
US8623354B2 (en) * | 2005-09-07 | 2014-01-07 | Alchemia Oncology Pty Limited | Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment |
JP5657205B2 (ja) | 2005-12-21 | 2015-01-21 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニSigma−Tau Industrie Farmaceutiche Riunite Societa Per Azioni | 薬物耐性腫瘍の治療 |
CN101421282B (zh) * | 2006-02-17 | 2013-08-14 | 俄勒冈州由俄勒冈州立大学代表高等教育委员会行使 | 用长春花生物碱n-氧化物和类似物治疗过度增殖性疾病 |
AU2007232206B2 (en) | 2006-03-30 | 2013-04-04 | Drais Pharmaceuticals, Inc. | Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same |
CN101652125A (zh) * | 2007-02-01 | 2010-02-17 | 希格马托制药工业公司 | 包含喜树碱衍生物的药物组合物 |
US8853233B2 (en) * | 2007-02-13 | 2014-10-07 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives |
EA015933B1 (ru) * | 2007-08-01 | 2011-12-30 | Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. | Лечение детских опухолей |
EP2096113A1 (en) * | 2008-02-05 | 2009-09-02 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | 9-substituted camptothecin derivatives as antitumor compounds |
TWI482621B (zh) | 2009-12-23 | 2015-05-01 | Sigma Tau Ind Farmaceuti | 青蒿素基藥物與其他化學治療劑的抗癌組合物 |
AU2016326747A1 (en) | 2015-09-25 | 2018-03-01 | Zy Therapeutics Inc. | Drug formulation based on particulates comprising polysaccharide-vitamin conjugate |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
NZ245112A (en) * | 1991-11-15 | 1995-07-26 | Smithkline Beecham Corp | Pharmaceutical composition comprising a camptothecin analog and a platinum coordination compound |
US5614529A (en) * | 1994-09-22 | 1997-03-25 | Research Triangle Institute | Inhibition of plasmodia parasites by camptothecin compounds |
US5972955A (en) * | 1995-06-06 | 1999-10-26 | Dr. Reddy's Research Foundation | Water soluble C-ring analogues of 20(S)-camptothecin |
GB9512670D0 (en) * | 1995-06-21 | 1995-08-23 | Sod Conseils Rech Applic | Camptothecin analogues |
IT1282673B1 (it) * | 1996-02-23 | 1998-03-31 | Ist Naz Stud Cura Dei Tumori | Derivati della camptotecina e loro uso come agenti antitumorali |
KR100516593B1 (ko) * | 1996-08-19 | 2005-09-22 | 바이오누머릭 파마슈티칼스, 인코포레이티드 | 고 친유성 캠프토테신 유도체 |
-
1999
- 1999-03-09 SI SI9930010T patent/SI1044977T1/xx unknown
- 1999-03-09 AT AT99830124T patent/ATE216998T1/de active
- 1999-03-09 PT PT99830124T patent/PT1044977E/pt unknown
- 1999-03-09 EP EP99830124A patent/EP1044977B1/en not_active Expired - Lifetime
- 1999-03-09 ES ES99830124T patent/ES2175919T3/es not_active Expired - Lifetime
- 1999-03-09 DE DE69901379T patent/DE69901379T2/de not_active Expired - Lifetime
- 1999-03-09 DK DK99830124T patent/DK1044977T3/da active
-
2000
- 2000-02-22 US US09/507,928 patent/US6242457B1/en not_active Expired - Lifetime
- 2000-03-07 EG EG20000293A patent/EG23999A/xx active
- 2000-03-07 TW TW089104090A patent/TWI272272B/zh not_active IP Right Cessation
- 2000-03-08 TN TNTNSN00045A patent/TNSN00045A1/fr unknown
- 2000-03-08 MX MXPA01009081A patent/MXPA01009081A/es unknown
- 2000-03-08 EE EEP200100466A patent/EE04679B1/xx not_active IP Right Cessation
- 2000-03-08 WO PCT/EP2000/001570 patent/WO2000053607A1/en active IP Right Grant
- 2000-03-08 HU HU0200210A patent/HU229506B1/hu not_active IP Right Cessation
- 2000-03-08 SK SK1164-2001A patent/SK287561B6/sk not_active IP Right Cessation
- 2000-03-08 ME MEP-40/08A patent/MEP4008A/xx unknown
- 2000-03-08 RS YUP-643/01A patent/RS50405B/sr unknown
- 2000-03-08 PE PE2000000206A patent/PE20001485A1/es not_active Application Discontinuation
- 2000-03-08 IL IL14495800A patent/IL144958A0/xx unknown
- 2000-03-08 EA EA200100954A patent/EA003605B1/ru not_active IP Right Cessation
- 2000-03-08 KR KR1020017011336A patent/KR100702085B1/ko not_active IP Right Cessation
- 2000-03-08 CZ CZ2001-3077A patent/CZ304465B6/cs not_active IP Right Cessation
- 2000-03-08 ME MEP-2008-40A patent/ME00017B/me unknown
- 2000-03-08 CO CO00016957A patent/CO5180590A1/es active IP Right Grant
- 2000-03-08 NZ NZ513393A patent/NZ513393A/xx not_active IP Right Cessation
- 2000-03-08 AR ARP000101013A patent/AR022860A1/es not_active Application Discontinuation
- 2000-03-08 BR BRPI0008840-4A patent/BR0008840B1/pt not_active IP Right Cessation
- 2000-03-08 TR TR2001/02603T patent/TR200102603T2/xx unknown
- 2000-03-08 PL PL355094A patent/PL222208B1/pl unknown
- 2000-03-08 AU AU31604/00A patent/AU774174B2/en not_active Ceased
- 2000-03-08 JP JP2000604043A patent/JP4610743B2/ja not_active Expired - Fee Related
- 2000-03-08 CN CNB008047804A patent/CN1139592C/zh not_active Expired - Fee Related
- 2000-03-08 CA CA002362760A patent/CA2362760C/en not_active Expired - Fee Related
- 2000-11-29 HK HK00107660A patent/HK1031222A1/xx not_active IP Right Cessation
- 2000-12-22 US US09/741,818 patent/US6589939B2/en not_active Expired - Lifetime
-
2001
- 2001-07-31 IS IS6031A patent/IS2003B/is unknown
- 2001-08-10 BG BG105810A patent/BG65032B1/bg unknown
- 2001-08-16 IL IL144958A patent/IL144958A/en not_active IP Right Cessation
- 2001-08-24 NO NO20014128A patent/NO328363B1/no not_active IP Right Cessation
- 2001-09-07 ZA ZA200107408A patent/ZA200107408B/xx unknown
- 2001-09-10 HR HR960321A patent/HRP20010667B1/xx not_active IP Right Cessation
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