AR012032A1 - Compuestos derivados 3'-n-oxido, 3'-n-dimetilamina, 9-oxima eritromicina a y un proceso para su preparacion - Google Patents

Compuestos derivados 3'-n-oxido, 3'-n-dimetilamina, 9-oxima eritromicina a y un proceso para su preparacion

Info

Publication number
AR012032A1
AR012032A1 ARP980100584A ARP980100584A AR012032A1 AR 012032 A1 AR012032 A1 AR 012032A1 AR P980100584 A ARP980100584 A AR P980100584A AR P980100584 A ARP980100584 A AR P980100584A AR 012032 A1 AR012032 A1 AR 012032A1
Authority
AR
Argentina
Prior art keywords
group
lower alkyl
atoms
attached
taken together
Prior art date
Application number
ARP980100584A
Other languages
English (en)
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of AR012032A1 publication Critical patent/AR012032A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un compuesto derivado de 3-N-oxido, 3-dimetilamina, 9-oxima eritromicina A, que tiene la formula (I): en donde R1 y R2 son independientemente hidrogenoo un grupo protector de hidroxi; R3 es un grupo alquilo inferior; Y es seleccionado del g rupoque consiste de: (a) una oxima que tiene la formula:N-O-R4, en donde R4 es seleccinado del grupo que consiste de: un grupo alquenilo inferior; un grupo alquilarilo; un grupo alquilarilo sustituido; ungrupo aril (alquilo inferior), o un grupo aril(alquilo inferior) sustituido; o (b) una oxima que tiene la formula (II) en donde R5 es seleccionado del grupoque consiste de: un grupo alquilo inferior; un grupo cicloalquilo, un grupo fenilo, un grupo aril (alquilo inferior), o R5 y R6, o R5 y R7y los átomos delos cuales están unidos se toman juntos para formar un anillo de 5 a 7 miembros conteniendo un átomo de oxígeno; R6 es seleccionado del grupo que consite de:un grupo alquilo inferior, un grupo alcoximetilo inferior; o R6 y R5 y losátomos a los cuales están unidos se toman juntos para formar un grupocicloalquilo de 5 a 7 miembros; y R7 es seleccionado del grupo que consiste de: un átomo de hidrogeno, un grupo alquilo inferior, un grupo fenilo, un grupoaril (alqu ilo inferior);o R7 y R5 y los átomos a los cuales están unidos se toman juntos para formar un anillo de 5 a 7 miembros conteniendo un átomo deoxígeno; o R7 y R6 y los átomos a los cuales están unidos se toman juntos para formar un grupo cicloalq uilo de 5 a 7miembros; con el requisito de que solo unpar de sustituyentes (R5 y R6), (R5 y R7), o (R6 y R7) pueden ser formados junto con los átomos a los cuales están unidos para formar un anillo como sedefine con anterioridad; y Z es hidroge no, hidroxi, ohidroxi protegido y un proceso para su preparacion. Los compuestos anteriormente descriptos se usan en
ARP980100584A 1997-02-13 1998-02-10 Compuestos derivados 3'-n-oxido, 3'-n-dimetilamina, 9-oxima eritromicina a y un proceso para su preparacion AR012032A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/800,009 US5864023A (en) 1997-02-13 1997-02-13 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives

Publications (1)

Publication Number Publication Date
AR012032A1 true AR012032A1 (es) 2000-09-27

Family

ID=25177295

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980100584A AR012032A1 (es) 1997-02-13 1998-02-10 Compuestos derivados 3'-n-oxido, 3'-n-dimetilamina, 9-oxima eritromicina a y un proceso para su preparacion

Country Status (25)

Country Link
US (1) US5864023A (es)
EP (1) EP0966477B1 (es)
JP (1) JP2001512456A (es)
KR (1) KR100561326B1 (es)
CN (1) CN1326865C (es)
AR (1) AR012032A1 (es)
AT (1) ATE252108T1 (es)
AU (1) AU725274B2 (es)
BG (1) BG64099B1 (es)
BR (1) BR9807349A (es)
CA (1) CA2279932C (es)
CZ (1) CZ294481B6 (es)
DE (1) DE69818977T2 (es)
DK (1) DK0966477T3 (es)
ES (1) ES2212266T3 (es)
HU (1) HUP0001330A3 (es)
IL (1) IL130697A0 (es)
NO (1) NO993876L (es)
NZ (1) NZ336482A (es)
PL (1) PL187357B1 (es)
PT (1) PT966477E (es)
SK (1) SK284157B6 (es)
TR (1) TR199901874T2 (es)
WO (1) WO1998035976A1 (es)
ZA (1) ZA98986B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100317907B1 (ko) * 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) * 1999-07-01 2001-02-05 유충식 6-오-메틸 에리트로마이신의 제조방법
KR100336447B1 (ko) * 1999-11-24 2002-05-15 민경윤 클라리스로마이신의 개선된 제조방법
HUP0204091A3 (en) 1999-12-16 2003-05-28 Teva Pharma Processes for preparing clarithromycin polymorphs and novel polymorph iv and pharmaceutical composition containing them and their use
IL150698A0 (en) * 2000-01-11 2003-02-12 Teva Pharma Processes for preparing clarithromycin polymorphs
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
IL151496A0 (en) * 2000-02-29 2003-04-10 Teva Pharma Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
EP1134229B1 (en) * 2000-03-15 2005-06-15 Hanmi Pharm. Co., Ltd. Method of preparing clarithromycin of form II crystals
KR20000037126A (ko) * 2000-04-08 2000-07-05 김용규 6-메틸 에리스로마이신 ａ의 제조방법
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
EP1648418A4 (en) * 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION
CA2533292C (en) * 2003-07-21 2013-12-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
JP2006528189A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質産物、その使用法および製剤
AU2004264939A1 (en) * 2003-08-11 2005-02-24 Middlebrook Pharmaceuticals, Inc. Robust pellet
JP2007502294A (ja) * 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
CA2535780A1 (en) * 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
AU2004273830B2 (en) * 2003-09-15 2011-03-24 Shionogi, Inc. Antibiotic product, use and formulation thereof
US20050142187A1 (en) * 2003-12-24 2005-06-30 Treacy Donald J.Jr. Enhanced absorption of modified release dosage forms
EP1771158A4 (en) * 2004-07-02 2008-03-12 Advancis Pharmaceutical Corp TABLET FOR PULSED DELIVERY
US7694523B2 (en) * 2004-07-19 2010-04-13 Earthrenew, Inc. Control system for gas turbine in material treatment unit
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) * 2007-08-09 2009-02-26 Vinod Kumar Kansal Process for the preparation of clarithromycin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
JPS61229895A (ja) * 1985-04-03 1986-10-14 Nippon Zeon Co Ltd 保護化デス−ｎ−メチルエリスロマイシン誘導体
EP0254534A3 (en) * 1986-07-24 1991-04-17 William S. Robinson Erythromycin derivatives and compositions and use for inhibiting virus replication and disease
DE3782994T2 (de) * 1986-09-18 1993-04-08 Taisho Pharma Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法

Also Published As

Publication number Publication date
JP2001512456A (ja) 2001-08-21
ZA98986B (en) 1998-08-05
ES2212266T3 (es) 2004-07-16
CN1246864A (zh) 2000-03-08
DK0966477T3 (da) 2004-02-23
BG64099B1 (bg) 2003-12-31
HUP0001330A3 (en) 2000-09-28
KR100561326B1 (ko) 2006-03-16
PT966477E (pt) 2004-03-31
ATE252108T1 (de) 2003-11-15
NO993876D0 (no) 1999-08-11
DE69818977D1 (en) 2003-11-20
US5864023A (en) 1999-01-26
NO993876L (no) 1999-08-11
AU6260898A (en) 1998-09-08
NZ336482A (en) 2001-02-23
BG103673A (en) 2000-02-29
CA2279932C (en) 2008-04-22
EP0966477A1 (en) 1999-12-29
KR20000070985A (ko) 2000-11-25
HUP0001330A2 (hu) 2000-08-28
EP0966477B1 (en) 2003-10-15
IL130697A0 (en) 2000-06-01
WO1998035976A1 (en) 1998-08-20
TR199901874T2 (xx) 2000-04-21
CZ294481B6 (cs) 2005-01-12
PL187357B1 (pl) 2004-06-30
BR9807349A (pt) 2000-04-25
CZ270499A3 (cs) 1999-11-17
PL335301A1 (en) 2000-04-10
SK97499A3 (en) 2000-01-18
AU725274B2 (en) 2000-10-12
SK284157B6 (sk) 2004-10-05
CA2279932A1 (en) 1998-08-20
CN1326865C (zh) 2007-07-18
DE69818977T2 (de) 2004-08-12

Similar Documents

Publication Publication Date Title
AR012032A1 (es) Compuestos derivados 3'-n-oxido, 3'-n-dimetilamina, 9-oxima eritromicina a y un proceso para su preparacion
MX9205311A (es) Nuevos taxanos substituidos y composiciones farmaceuticas que los contienen
ES2175919T3 (es) Derivados del camptothecin con actividad antitumoral.
CO4790091A1 (es) Derivados sustituidos de acido 3-sulfonil-propionico
FI930991A0 (fi) Polymerer som innehaoller diesterenheter
CO4810230A1 (es) Nuevos derivados del 19-nor-pregneno
AR011425A1 (es) Compuestos derivados de sulfamida, su uso, composiciones farmaceuticas que los comprenden y un procedimiento para preparar compuestos derivados de sulfamida
RS49906B (sr) Benzociklohepteni, postupak za njihovo dobijanje, farmaceutski preparati koji ove sadrže kao i njihova primena za izradu lekova
CO5031246A1 (es) Compuestos calciliticos
RO93855A (ro) Procedeu pentru prepararea de arilciclobutilalchilamina
MY100115A (en) Nitrogen containing heterocyclic compounds, and their production and use.
MD422C2 (ro) Derivaţi ai azolului şi compuţi intermediari pentru producerea lor
CO4910142A1 (es) Compuestos de furano nitrona
PE20000734A1 (es) Compuestos heterociclicos derivados de furopiridina y su uso terapeutico
ATE75737T1 (de) Indenothiazolderivate und verfahren zu ihrer herstellung.
EA200000389A3 (ru) Новые замещенные пиридины или пиперидины, способ их получения и содержащие их фармацевтические композиции
YU43902A (sh) Novi razgranati supstituisani amino derivati od 3-amino-1- -fenil-1h(1,2,4) triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže
ATE148128T1 (de) Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung
IE40395L (en) 2,3- dihydrobenzofuranyl -7-n-methylcarbamates;¹insecticides
ATE112769T1 (de) Benzoxazepinderivate.
NO20003604L (no) Nye tricykliske forbindelser, fremgangsmÕte ved deres fremstilling og farmasøytiske sammensetninger inneholdende dem
BG60248B2 (en) Process for the preparation of phenoxyethylamine derivatives
ES2138434T3 (es) Compuesto fluoropropeno, un insecticida que lo contiene, y un compuesto intermediario para su preparacion.
ES447751A1 (es) Procedimiento para preparar derivados de imidazolilquinazo- lina.
ATE6500T1 (de) 2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3 4-tetrahydronaphthalin, seine salze, und verfahren zu dessen herstellung.

Legal Events

Date Code Title Description
FG Grant, registration