CO4810230A1 - Nuevos derivados del 19-nor-pregneno - Google Patents

Nuevos derivados del 19-nor-pregneno

Info

Publication number
CO4810230A1
CO4810230A1 CO97002478A CO97002478A CO4810230A1 CO 4810230 A1 CO4810230 A1 CO 4810230A1 CO 97002478 A CO97002478 A CO 97002478A CO 97002478 A CO97002478 A CO 97002478A CO 4810230 A1 CO4810230 A1 CO 4810230A1
Authority
CO
Colombia
Prior art keywords
pregneno
new derivatives
hydrogen
alkyl
group
Prior art date
Application number
CO97002478A
Other languages
English (en)
Inventor
Alain Piasco
Jean Lafay
Delansorne Remi
Jacques Paris
Jean Claude Pascal
Original Assignee
Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theramex filed Critical Theramex
Publication of CO4810230A1 publication Critical patent/CO4810230A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Abstract

Un compuesto de la fórmula (I):caracterizado porque:R1 , R2 , R3 , R4 y R6 representan cada uno independientemente hidrógeno o un (C1 -C6 )alquilo,R5 es hidrógeno, un (C1 -C6 )alquilo, un grupo -COR7 en dondeR7 es un (C1 -C6 )alquilo,n es cero o uno, yX es oxígeno o un grupo hidroxiimino,siempre que cuando n=0, por lo menos dos de R1 , R2 , R3 y R4 son diferentes de hidrógeno y que cuando n=1, R3 y R4 no son simultáneamente hidrógeno.
CO97002478A 1996-01-22 1997-01-21 Nuevos derivados del 19-nor-pregneno CO4810230A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96400146A EP0785212A1 (en) 1996-01-22 1996-01-22 New 19-nor-pregnene derivatives

Publications (1)

Publication Number Publication Date
CO4810230A1 true CO4810230A1 (es) 1999-06-30

Family

ID=8225217

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97002478A CO4810230A1 (es) 1996-01-22 1997-01-21 Nuevos derivados del 19-nor-pregneno

Country Status (36)

Country Link
US (1) US6180803B1 (es)
EP (2) EP0785212A1 (es)
JP (2) JP4368945B2 (es)
KR (1) KR100396902B1 (es)
CN (1) CN1187366C (es)
AP (1) AP1176A (es)
AR (1) AR005500A1 (es)
AT (1) ATE184015T1 (es)
BR (1) BR9707064A (es)
CA (1) CA2243504C (es)
CO (1) CO4810230A1 (es)
CZ (1) CZ292047B6 (es)
DE (1) DE69700470T2 (es)
DZ (1) DZ2169A1 (es)
EE (1) EE03692B1 (es)
ES (1) ES2140961T3 (es)
GR (1) GR3031954T3 (es)
HK (1) HK1018216A1 (es)
HU (1) HU221796B1 (es)
ID (1) ID15840A (es)
IL (1) IL125379A (es)
IS (1) IS1902B (es)
JO (1) JO1971B1 (es)
MY (1) MY116845A (es)
NO (1) NO309572B1 (es)
NZ (1) NZ330954A (es)
OA (1) OA10813A (es)
PE (1) PE55998A1 (es)
PL (1) PL185608B1 (es)
RU (1) RU2166509C2 (es)
SI (1) SI0886645T1 (es)
TN (1) TNSN97015A1 (es)
TR (1) TR199801399T2 (es)
TW (1) TW411345B (es)
WO (1) WO1997027210A1 (es)
ZA (1) ZA97521B (es)

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FR2776191B1 (fr) * 1998-03-23 2002-05-31 Theramex Composition hormonale topique a effet systemique
AR028110A1 (es) * 2000-06-02 2003-04-23 Astrazeneca Ab Nuevo proceso
US20070225379A1 (en) * 2001-08-03 2007-09-27 Carrara Dario Norberto R Transdermal delivery of systemically active central nervous system drugs
US20040198706A1 (en) * 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
ES2283425T3 (es) 2000-08-03 2007-11-01 Antares Pharma Ipl Ag Nueva composicion para la administracion transdermica y/o transmucosa de compuestos activos que asegura niveles terapeutiocos adecuados.
US7198801B2 (en) * 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
FR2814074B1 (fr) * 2000-09-15 2003-03-07 Theramex Nouvelles compositions estro-progestatives topiques a effet systemique
SI1660009T1 (sl) 2003-09-03 2015-07-31 Miscon Trading S.A. Metode za zdravljenje endometrioze
JP5619337B2 (ja) * 2003-10-10 2014-11-05 フェリング ビー．ブイ． 皮膚残渣を最小限に抑えるための経皮的医薬製剤
US7425340B2 (en) * 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
WO2007124250A2 (en) 2006-04-21 2007-11-01 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
WO2008067991A2 (en) * 2006-12-08 2008-06-12 Antares Pharma Ipl Ag Skin-friendly drug complexes for transdermal administration
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
HRP20211377T1 (hr) 2011-11-23 2022-01-07 Therapeuticsmd, Inc. Prirodne kombinirane hormonske supstitucijske formulacije i terapije
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
US9173915B1 (en) * 2014-10-10 2015-11-03 Peter F. Kador Antioxidant eye drops
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
CN106074568B (zh) * 2015-09-02 2021-05-14 盛世泰科生物医药技术(苏州)有限公司 一种用于预防和治疗白内障的眼用制剂及其制备方法
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
AU2017239645A1 (en) 2016-04-01 2018-10-18 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
CN110452279B (zh) * 2019-05-13 2022-04-08 株洲千金药业股份有限公司 三萜类化合物和其药学上可接受的盐及制备方法和应用

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DE1593524A1 (de) * 1951-01-28 1970-08-13 Schering Ag Verfahren zur Herstellung von 1,2alpha-Methylen-19-nor-steroiden
DE1087127B (de) * 1958-12-13 1960-08-18 Schering Ag Verfahren zur Herstellung neuer progestativ wirksamer Ester von 2-Methyl-Steroiden
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Also Published As

Publication number Publication date
IL125379A0 (en) 1999-03-12
MY116845A (en) 2004-04-30
JP2009167188A (ja) 2009-07-30
NZ330954A (en) 1998-10-28
ID15840A (id) 1997-08-14
NO983356L (no) 1998-07-21
CN1187366C (zh) 2005-02-02
AP1176A (en) 2003-06-30
KR100396902B1 (ko) 2004-05-03
BR9707064A (pt) 1999-12-28
ATE184015T1 (de) 1999-09-15
OA10813A (en) 2003-01-28
JP4368945B2 (ja) 2009-11-18
DE69700470D1 (de) 1999-10-07
PL185608B1 (pl) 2003-06-30
JO1971B1 (en) 1997-12-15
WO1997027210A1 (en) 1997-07-31
CN1209811A (zh) 1999-03-03
CZ230798A3 (cs) 1998-11-11
CZ292047B6 (cs) 2003-07-16
JP2000503980A (ja) 2000-04-04
AU708135B2 (en) 1999-07-29
IS4800A (is) 1998-07-21
KR19990081895A (ko) 1999-11-15
CA2243504C (en) 2004-03-30
PE55998A1 (es) 1998-10-01
TNSN97015A1 (fr) 2005-03-15
NO309572B1 (no) 2001-02-19
EP0886645A1 (en) 1998-12-30
HK1018216A1 (en) 1999-12-17
ZA97521B (en) 1997-08-04
NO983356D0 (no) 1998-07-21
EE03692B1 (et) 2002-04-15
HU221796B1 (hu) 2003-01-28
CA2243504A1 (en) 1997-07-31
EP0886645B1 (en) 1999-09-01
SI0886645T1 (en) 1999-12-31
TR199801399T2 (xx) 1998-10-21
RU2166509C2 (ru) 2001-05-10
IS1902B (is) 2003-11-20
US6180803B1 (en) 2001-01-30
DE69700470T2 (de) 2000-03-30
HUP9900684A2 (hu) 1999-07-28
PL327998A1 (en) 1999-01-04
AR005500A1 (es) 1999-06-23
DZ2169A1 (fr) 2002-12-25
TW411345B (en) 2000-11-11
HUP9900684A3 (en) 1999-11-29
IL125379A (en) 2003-05-29
AU1595597A (en) 1997-08-20
AP9801299A0 (en) 1998-09-30
EP0785212A1 (en) 1997-07-23
GR3031954T3 (en) 2000-03-31
EE9800219A (xx) 1998-12-15
ES2140961T3 (es) 2000-03-01

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