DE69225601T2 - Azabicycloarylacetylen- und arylenynoxine als cholinergische mittel und verfahren zur behandlung - Google Patents

Azabicycloarylacetylen- und arylenynoxine als cholinergische mittel und verfahren zur behandlung

Info

Publication number
DE69225601T2
DE69225601T2 DE69225601T DE69225601T DE69225601T2 DE 69225601 T2 DE69225601 T2 DE 69225601T2 DE 69225601 T DE69225601 T DE 69225601T DE 69225601 T DE69225601 T DE 69225601T DE 69225601 T2 DE69225601 T2 DE 69225601T2
Authority
DE
Germany
Prior art keywords
synoxins
azabicycloarylacetylene
arylene
treating
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69225601T
Other languages
English (en)
Other versions
DE69225601D1 (de
Inventor
David Lauffer
Walter Moos
Michael Pavia
Haile Tecle
Anthony Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE69225601D1 publication Critical patent/DE69225601D1/de
Application granted granted Critical
Publication of DE69225601T2 publication Critical patent/DE69225601T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Indole Compounds (AREA)
DE69225601T 1991-10-16 1992-10-09 Azabicycloarylacetylen- und arylenynoxine als cholinergische mittel und verfahren zur behandlung Expired - Fee Related DE69225601T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/778,412 US5306718A (en) 1990-03-06 1991-10-16 Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment
PCT/US1992/008642 WO1993008192A1 (en) 1991-10-16 1992-10-09 Azabicyclo arylacetylene and arylenyne oximes as cholinergic agents and methods of treatment

Publications (2)

Publication Number Publication Date
DE69225601D1 DE69225601D1 (de) 1998-06-25
DE69225601T2 true DE69225601T2 (de) 1998-12-17

Family

ID=25113261

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69225601T Expired - Fee Related DE69225601T2 (de) 1991-10-16 1992-10-09 Azabicycloarylacetylen- und arylenynoxine als cholinergische mittel und verfahren zur behandlung

Country Status (17)

Country Link
US (2) US5306718A (de)
EP (1) EP0608336B1 (de)
JP (1) JP3367670B2 (de)
KR (1) KR100241479B1 (de)
AT (1) ATE166354T1 (de)
AU (1) AU658685B2 (de)
CA (1) CA2115443C (de)
DE (1) DE69225601T2 (de)
DK (1) DK0608336T3 (de)
ES (1) ES2119823T3 (de)
FI (1) FI106797B (de)
NO (1) NO302072B1 (de)
NZ (1) NZ244726A (de)
PH (1) PH31431A (de)
PT (1) PT100961B (de)
WO (1) WO1993008192A1 (de)
ZA (1) ZA927973B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346911A (en) * 1990-03-06 1994-09-13 Warner-Lambert Company Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment
US5514812A (en) * 1994-06-10 1996-05-07 Warner-Lambert Company Preparation of stereochemically pure oximes with muscarinic activity
AUPM910994A0 (en) * 1994-10-28 1994-11-24 Commonwealth Scientific And Industrial Research Organisation Bisallyloxyimides
US5534522A (en) * 1995-06-07 1996-07-09 Warner-Lambert Company (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
US6168912B1 (en) 1996-01-23 2001-01-02 Martek Biosciences Corporation Method and kit for making a multidimensional combinatorial chemical library
NZ335784A (en) * 1997-01-27 2000-12-22 Warner Lambert Co Process for isolation of (z)-azabicyclo oxime ethers by reacting an O-substituted hydroxylamine with an azabicycloketone
US6924313B1 (en) 1999-09-23 2005-08-02 Pfizer Inc. Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US6521607B1 (en) * 1999-09-23 2003-02-18 Pharmacia Corporation (R)-chiral halogenated substituted N-phenoxy N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
KR100465277B1 (ko) * 2002-01-24 2005-01-13 한국과학기술연구원 신규한 옥심계 아자 두 고리 화합물 및 그 제조방법
EP3827747A1 (de) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharmainformatiksystem
EP2063905B1 (de) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
IL295075A (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3371094A (en) * 1961-08-08 1968-02-27 Sterling Drug Inc N-(amidoximino-lower-alkyl)-and n-amidino-n-[(1-piperidyl)-lower-alkyl]amines
US3502692A (en) * 1962-06-13 1970-03-24 American Cyanamid Co Cyclic nitroxides and process for preparing same
DE2019536A1 (de) * 1970-04-23 1971-11-11 Basf Ag Oximcarbamate
DE2552176A1 (de) * 1975-11-21 1977-06-02 Hoechst Ag Neue piperidin-derivate, ihre herstellung und verwendung
US4341795A (en) * 1975-12-01 1982-07-27 Union Carbide Corporation Asymmetrical bis-carbamate compounds
US4710508A (en) * 1986-12-08 1987-12-01 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
NZ226000A (en) * 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
US4937239A (en) * 1989-02-13 1990-06-26 Warner-Lambert Company Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents
IL97266A0 (en) * 1990-03-06 1992-05-25 Warner Lambert Co Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE69225601D1 (de) 1998-06-25
EP0608336B1 (de) 1998-05-20
NO941365L (no) 1994-04-15
AU2783592A (en) 1993-05-21
JP3367670B2 (ja) 2003-01-14
JPH07500337A (ja) 1995-01-12
EP0608336A1 (de) 1994-08-03
CA2115443C (en) 2003-05-13
KR100241479B1 (ko) 2000-03-02
PH31431A (en) 1998-11-03
ES2119823T3 (es) 1998-10-16
WO1993008192A1 (en) 1993-04-29
NO302072B1 (no) 1998-01-19
FI941699A0 (fi) 1994-04-13
PT100961B (pt) 1999-07-30
FI106797B (fi) 2001-04-12
PT100961A (pt) 1993-11-30
NO941365D0 (no) 1994-04-15
DK0608336T3 (da) 1999-01-18
FI941699A (fi) 1994-04-13
US5306718A (en) 1994-04-26
NZ244726A (en) 1995-09-26
US5482938A (en) 1996-01-09
ZA927973B (en) 1994-04-15
ATE166354T1 (de) 1998-06-15
CA2115443A1 (en) 1993-04-29
AU658685B2 (en) 1995-04-27

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee