ES2119823T3 - Oximas de arilenina y arilacetileno azabiciclo utilizadas como agentes colinergicos y metodos de tratamiento. - Google Patents

Oximas de arilenina y arilacetileno azabiciclo utilizadas como agentes colinergicos y metodos de tratamiento.

Info

Publication number
ES2119823T3
ES2119823T3 ES92921974T ES92921974T ES2119823T3 ES 2119823 T3 ES2119823 T3 ES 2119823T3 ES 92921974 T ES92921974 T ES 92921974T ES 92921974 T ES92921974 T ES 92921974T ES 2119823 T3 ES2119823 T3 ES 2119823T3
Authority
ES
Spain
Prior art keywords
oximes
azabicicl
arylenine
arylacetylene
treatment methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92921974T
Other languages
English (en)
Inventor
David Jeffrey Lauffer
Walter Hamilton Moos Moos
Michael Raymond Pavia
Haile Tecle
Anthony Jerome Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2119823T3 publication Critical patent/ES2119823T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

NITROGENO UTIL FARMACEUTICAMENTE QUE CONTIENE COMPUESTOS DE OXIMA CICLICA SUSTITUIDA LOS CUALES SON OXIMAS [2.2.1] DE AZABICICLO ARILACETILENO Y ARILENINO DE FORMULA (I) QUE SON UTILES PARA ALIVIAR EL DOLOR Y PARA TRATAR EL DECAIMIENTO COGNITIVO SE DESCRIBEN; COMPOSICIONES FARMACEUTICAS Y UN METODO DE FABRICACION SON TAMBIEN DESCRITOS. EN LA FORMULA (I), R SELECCIONA ENTRE EL GRUPO (IIA) Y EL (IIB).
ES92921974T 1991-10-16 1992-10-09 Oximas de arilenina y arilacetileno azabiciclo utilizadas como agentes colinergicos y metodos de tratamiento. Expired - Lifetime ES2119823T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/778,412 US5306718A (en) 1990-03-06 1991-10-16 Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment

Publications (1)

Publication Number Publication Date
ES2119823T3 true ES2119823T3 (es) 1998-10-16

Family

ID=25113261

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92921974T Expired - Lifetime ES2119823T3 (es) 1991-10-16 1992-10-09 Oximas de arilenina y arilacetileno azabiciclo utilizadas como agentes colinergicos y metodos de tratamiento.

Country Status (17)

Country Link
US (2) US5306718A (es)
EP (1) EP0608336B1 (es)
JP (1) JP3367670B2 (es)
KR (1) KR100241479B1 (es)
AT (1) ATE166354T1 (es)
AU (1) AU658685B2 (es)
CA (1) CA2115443C (es)
DE (1) DE69225601T2 (es)
DK (1) DK0608336T3 (es)
ES (1) ES2119823T3 (es)
FI (1) FI106797B (es)
NO (1) NO302072B1 (es)
NZ (1) NZ244726A (es)
PH (1) PH31431A (es)
PT (1) PT100961B (es)
WO (1) WO1993008192A1 (es)
ZA (1) ZA927973B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346911A (en) * 1990-03-06 1994-09-13 Warner-Lambert Company Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment
US5514812A (en) * 1994-06-10 1996-05-07 Warner-Lambert Company Preparation of stereochemically pure oximes with muscarinic activity
AUPM910994A0 (en) * 1994-10-28 1994-11-24 Commonwealth Scientific And Industrial Research Organisation Bisallyloxyimides
US5534522A (en) * 1995-06-07 1996-07-09 Warner-Lambert Company (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
US6168912B1 (en) 1996-01-23 2001-01-02 Martek Biosciences Corporation Method and kit for making a multidimensional combinatorial chemical library
CA2270884A1 (en) * 1997-01-27 1998-07-30 Haile Tecle Single pot process for producing (z)-azabicyclo oxime ethers
US6924313B1 (en) 1999-09-23 2005-08-02 Pfizer Inc. Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US6521607B1 (en) * 1999-09-23 2003-02-18 Pharmacia Corporation (R)-chiral halogenated substituted N-phenoxy N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
KR100465277B1 (ko) * 2002-01-24 2005-01-13 한국과학기술연구원 신규한 옥심계 아자 두 고리 화합물 및 그 제조방법
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3479346A (en) * 1961-08-08 1969-11-18 Sterling Drug Inc N-acyl-n- (and n,n-bis-) ((1-piperidyl)-lower-alkyl)amines
US3502692A (en) * 1962-06-13 1970-03-24 American Cyanamid Co Cyclic nitroxides and process for preparing same
DE2019536A1 (de) * 1970-04-23 1971-11-11 Basf Ag Oximcarbamate
DE2552176A1 (de) * 1975-11-21 1977-06-02 Hoechst Ag Neue piperidin-derivate, ihre herstellung und verwendung
US4341795A (en) * 1975-12-01 1982-07-27 Union Carbide Corporation Asymmetrical bis-carbamate compounds
US4710508A (en) * 1986-12-08 1987-12-01 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
NZ226000A (en) * 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
US4937239A (en) * 1989-02-13 1990-06-26 Warner-Lambert Company Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents
IL97266A0 (en) * 1990-03-06 1992-05-25 Warner Lambert Co Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CA2115443A1 (en) 1993-04-29
WO1993008192A1 (en) 1993-04-29
PT100961A (pt) 1993-11-30
US5306718A (en) 1994-04-26
ATE166354T1 (de) 1998-06-15
KR100241479B1 (ko) 2000-03-02
FI941699A0 (fi) 1994-04-13
DK0608336T3 (da) 1999-01-18
AU2783592A (en) 1993-05-21
DE69225601D1 (de) 1998-06-25
CA2115443C (en) 2003-05-13
NZ244726A (en) 1995-09-26
FI106797B (fi) 2001-04-12
PH31431A (en) 1998-11-03
FI941699A (fi) 1994-04-13
NO941365L (no) 1994-04-15
JP3367670B2 (ja) 2003-01-14
JPH07500337A (ja) 1995-01-12
US5482938A (en) 1996-01-09
NO302072B1 (no) 1998-01-19
DE69225601T2 (de) 1998-12-17
PT100961B (pt) 1999-07-30
NO941365D0 (no) 1994-04-15
ZA927973B (en) 1994-04-15
EP0608336A1 (en) 1994-08-03
EP0608336B1 (en) 1998-05-20
AU658685B2 (en) 1995-04-27

Similar Documents

Publication Publication Date Title
CA2037541A1 (en) Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment
ES2119823T3 (es) Oximas de arilenina y arilacetileno azabiciclo utilizadas como agentes colinergicos y metodos de tratamiento.
ZA917744B (en) Fused ring analogs of nitrogen containing nonaromatic heterocycles.
CA2155104A1 (en) Heterocyclic-substituted alkyl amide acat inhibitors
IL108731A (en) 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
CO4810230A1 (es) Nuevos derivados del 19-nor-pregneno
CA2212326A1 (en) O-carbamoyl-(d)-phenylalanilol compounds and process for preparing the same
DE69427517D1 (de) Tetracyclische kondensierte heterocyclische Verbindungen zur Behandlung von seniler Demenz
DE69727305D1 (de) Verwendung neurogen-entzuendungshemmender verbindungen und zusammensetzungen
TW333532B (en) Benzopyrans
CA2241845A1 (en) 4,5-dihydronaphth[1,2-c]isoxazoles and derivatives thereof having cns activity
IE780064L (en) Pharmaceutically active amines disubstituted by heterocyclic¹groups
DE69725133D1 (de) Als entzündungshemmende mittel nützliche dihydrobenzofurane und verwandte verbindungen
DE3263490D1 (en) Process for the n-alkylation of organic nitrogen compounds
ES2102774T3 (es) Indolsulfonamidas como agentes antitumorales.
NO933162D0 (no) Heterosykliske forbindelser samt fremgangsm}te for fremstilling av slike
TH13390EX (th) อนุพันธ์ของอินโดลและอินดาโซลสำหรับใช้รักษาและ ป้องกันผิดปกติเกี่ยวกับสมองใหญ่, การเตรียมและ การใช้สารเหล่านั้น
EA200200574A1 (ru) НОВЫЕ ЦИКЛИЧЕСКИЕ α-АМИНО-γ-ГИДРОКСИАМИДНЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ИХ СОДЕРЖАЩИЕ

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 608336

Country of ref document: ES