ATE166354T1 - Azabicycloarylacetylen- und arylenynoxine als cholinergische mittel und verfahren zur behandlung - Google Patents
Azabicycloarylacetylen- und arylenynoxine als cholinergische mittel und verfahren zur behandlungInfo
- Publication number
- ATE166354T1 ATE166354T1 AT92921974T AT92921974T ATE166354T1 AT E166354 T1 ATE166354 T1 AT E166354T1 AT 92921974 T AT92921974 T AT 92921974T AT 92921974 T AT92921974 T AT 92921974T AT E166354 T1 ATE166354 T1 AT E166354T1
- Authority
- AT
- Austria
- Prior art keywords
- azabicycloarylacetylene
- arylenynoxines
- treatment
- methods
- azabicyclo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Carbon And Carbon Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/778,412 US5306718A (en) | 1990-03-06 | 1991-10-16 | Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE166354T1 true ATE166354T1 (de) | 1998-06-15 |
Family
ID=25113261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92921974T ATE166354T1 (de) | 1991-10-16 | 1992-10-09 | Azabicycloarylacetylen- und arylenynoxine als cholinergische mittel und verfahren zur behandlung |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5306718A (de) |
| EP (1) | EP0608336B1 (de) |
| JP (1) | JP3367670B2 (de) |
| KR (1) | KR100241479B1 (de) |
| AT (1) | ATE166354T1 (de) |
| AU (1) | AU658685B2 (de) |
| CA (1) | CA2115443C (de) |
| DE (1) | DE69225601T2 (de) |
| DK (1) | DK0608336T3 (de) |
| ES (1) | ES2119823T3 (de) |
| FI (1) | FI106797B (de) |
| NO (1) | NO302072B1 (de) |
| NZ (1) | NZ244726A (de) |
| PH (1) | PH31431A (de) |
| PT (1) | PT100961B (de) |
| WO (1) | WO1993008192A1 (de) |
| ZA (1) | ZA927973B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5346911A (en) * | 1990-03-06 | 1994-09-13 | Warner-Lambert Company | Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment |
| US5514812A (en) * | 1994-06-10 | 1996-05-07 | Warner-Lambert Company | Preparation of stereochemically pure oximes with muscarinic activity |
| AUPM910994A0 (en) * | 1994-10-28 | 1994-11-24 | Commonwealth Scientific And Industrial Research Organisation | Bisallyloxyimides |
| US5534522A (en) * | 1995-06-07 | 1996-07-09 | Warner-Lambert Company | (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent |
| US6168912B1 (en) | 1996-01-23 | 2001-01-02 | Martek Biosciences Corporation | Method and kit for making a multidimensional combinatorial chemical library |
| US6121459A (en) * | 1997-01-27 | 2000-09-19 | Warner-Lambert Company | Single pot process for producing (Z)-azabicyclo oxime ethers |
| US6924313B1 (en) | 1999-09-23 | 2005-08-02 | Pfizer Inc. | Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| US6544974B2 (en) * | 1999-09-23 | 2003-04-08 | G.D. Searle & Co. | (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesteryl ester transfer protein activity |
| CA2450073C (en) | 2001-07-25 | 2017-08-29 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| KR100465277B1 (ko) * | 2002-01-24 | 2005-01-13 | 한국과학기술연구원 | 신규한 옥심계 아자 두 고리 화합물 및 그 제조방법 |
| EP2671508B1 (de) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-Informatiksystem |
| JP2010503710A (ja) | 2006-09-18 | 2010-02-04 | ラプトール ファーマシューティカル インコーポレイテッド | 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置 |
| ES2919563T3 (es) | 2009-02-20 | 2022-07-27 | Enhanx Biopharm Inc | Sistema de administración de medicamentos a base de glutatión |
| KR20180114970A (ko) | 2009-05-06 | 2018-10-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3479346A (en) * | 1961-08-08 | 1969-11-18 | Sterling Drug Inc | N-acyl-n- (and n,n-bis-) ((1-piperidyl)-lower-alkyl)amines |
| US3502692A (en) * | 1962-06-13 | 1970-03-24 | American Cyanamid Co | Cyclic nitroxides and process for preparing same |
| DE2019536A1 (de) * | 1970-04-23 | 1971-11-11 | Basf Ag | Oximcarbamate |
| DE2552176A1 (de) * | 1975-11-21 | 1977-06-02 | Hoechst Ag | Neue piperidin-derivate, ihre herstellung und verwendung |
| US4341795A (en) * | 1975-12-01 | 1982-07-27 | Union Carbide Corporation | Asymmetrical bis-carbamate compounds |
| US4710508A (en) * | 1986-12-08 | 1987-12-01 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
| NZ226000A (en) * | 1987-09-10 | 1991-06-25 | Merck Sharp & Dohme | Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions |
| US4937239A (en) * | 1989-02-13 | 1990-06-26 | Warner-Lambert Company | Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents |
| IL97266A0 (en) * | 1990-03-06 | 1992-05-25 | Warner Lambert Co | Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them |
-
1991
- 1991-10-16 US US07/778,412 patent/US5306718A/en not_active Expired - Fee Related
-
1992
- 1992-10-09 AT AT92921974T patent/ATE166354T1/de not_active IP Right Cessation
- 1992-10-09 KR KR1019940701231A patent/KR100241479B1/ko not_active Expired - Fee Related
- 1992-10-09 DE DE69225601T patent/DE69225601T2/de not_active Expired - Fee Related
- 1992-10-09 JP JP50773793A patent/JP3367670B2/ja not_active Expired - Fee Related
- 1992-10-09 DK DK92921974T patent/DK0608336T3/da active
- 1992-10-09 ES ES92921974T patent/ES2119823T3/es not_active Expired - Lifetime
- 1992-10-09 AU AU27835/92A patent/AU658685B2/en not_active Ceased
- 1992-10-09 EP EP92921974A patent/EP0608336B1/de not_active Expired - Lifetime
- 1992-10-09 WO PCT/US1992/008642 patent/WO1993008192A1/en not_active Ceased
- 1992-10-09 CA CA002115443A patent/CA2115443C/en not_active Expired - Fee Related
- 1992-10-14 PH PH45704A patent/PH31431A/en unknown
- 1992-10-14 NZ NZ244726A patent/NZ244726A/en unknown
- 1992-10-15 ZA ZA927973A patent/ZA927973B/xx unknown
- 1992-10-15 PT PT100961A patent/PT100961B/pt active IP Right Grant
-
1994
- 1994-02-01 US US08/189,620 patent/US5482938A/en not_active Expired - Fee Related
- 1994-04-13 FI FI941699A patent/FI106797B/fi active
- 1994-04-15 NO NO941365A patent/NO302072B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT100961B (pt) | 1999-07-30 |
| DE69225601T2 (de) | 1998-12-17 |
| NO941365D0 (no) | 1994-04-15 |
| FI106797B (fi) | 2001-04-12 |
| DE69225601D1 (de) | 1998-06-25 |
| US5306718A (en) | 1994-04-26 |
| DK0608336T3 (da) | 1999-01-18 |
| EP0608336A1 (de) | 1994-08-03 |
| ES2119823T3 (es) | 1998-10-16 |
| NZ244726A (en) | 1995-09-26 |
| AU2783592A (en) | 1993-05-21 |
| NO941365L (no) | 1994-04-15 |
| US5482938A (en) | 1996-01-09 |
| KR100241479B1 (ko) | 2000-03-02 |
| FI941699A0 (fi) | 1994-04-13 |
| CA2115443A1 (en) | 1993-04-29 |
| EP0608336B1 (de) | 1998-05-20 |
| AU658685B2 (en) | 1995-04-27 |
| CA2115443C (en) | 2003-05-13 |
| ZA927973B (en) | 1994-04-15 |
| JPH07500337A (ja) | 1995-01-12 |
| WO1993008192A1 (en) | 1993-04-29 |
| FI941699L (fi) | 1994-04-13 |
| NO302072B1 (no) | 1998-01-19 |
| PT100961A (pt) | 1993-11-30 |
| PH31431A (en) | 1998-11-03 |
| JP3367670B2 (ja) | 2003-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |