DK0608336T3 - Azabicycloarylacetylen- og -arylenynoximer som cholinerge midler og fremgangsmåde til behandling - Google Patents
Azabicycloarylacetylen- og -arylenynoximer som cholinerge midler og fremgangsmåde til behandlingInfo
- Publication number
- DK0608336T3 DK0608336T3 DK92921974T DK92921974T DK0608336T3 DK 0608336 T3 DK0608336 T3 DK 0608336T3 DK 92921974 T DK92921974 T DK 92921974T DK 92921974 T DK92921974 T DK 92921974T DK 0608336 T3 DK0608336 T3 DK 0608336T3
- Authority
- DK
- Denmark
- Prior art keywords
- nynoxymes
- azabicycloaryl
- arylene
- acetylene
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Carbon And Carbon Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/778,412 US5306718A (en) | 1990-03-06 | 1991-10-16 | Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment |
PCT/US1992/008642 WO1993008192A1 (en) | 1991-10-16 | 1992-10-09 | Azabicyclo arylacetylene and arylenyne oximes as cholinergic agents and methods of treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0608336T3 true DK0608336T3 (da) | 1999-01-18 |
Family
ID=25113261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92921974T DK0608336T3 (da) | 1991-10-16 | 1992-10-09 | Azabicycloarylacetylen- og -arylenynoximer som cholinerge midler og fremgangsmåde til behandling |
Country Status (17)
Country | Link |
---|---|
US (2) | US5306718A (da) |
EP (1) | EP0608336B1 (da) |
JP (1) | JP3367670B2 (da) |
KR (1) | KR100241479B1 (da) |
AT (1) | ATE166354T1 (da) |
AU (1) | AU658685B2 (da) |
CA (1) | CA2115443C (da) |
DE (1) | DE69225601T2 (da) |
DK (1) | DK0608336T3 (da) |
ES (1) | ES2119823T3 (da) |
FI (1) | FI106797B (da) |
NO (1) | NO302072B1 (da) |
NZ (1) | NZ244726A (da) |
PH (1) | PH31431A (da) |
PT (1) | PT100961B (da) |
WO (1) | WO1993008192A1 (da) |
ZA (1) | ZA927973B (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5346911A (en) * | 1990-03-06 | 1994-09-13 | Warner-Lambert Company | Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment |
US5514812A (en) * | 1994-06-10 | 1996-05-07 | Warner-Lambert Company | Preparation of stereochemically pure oximes with muscarinic activity |
AUPM910994A0 (en) * | 1994-10-28 | 1994-11-24 | Commonwealth Scientific And Industrial Research Organisation | Bisallyloxyimides |
US5534522A (en) * | 1995-06-07 | 1996-07-09 | Warner-Lambert Company | (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent |
US6168912B1 (en) | 1996-01-23 | 2001-01-02 | Martek Biosciences Corporation | Method and kit for making a multidimensional combinatorial chemical library |
AU741566B2 (en) * | 1997-01-27 | 2001-12-06 | Warner-Lambert Company | Single pot process for producing (Z)-azabicyclo oxime ethers |
US6924313B1 (en) | 1999-09-23 | 2005-08-02 | Pfizer Inc. | Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
US6677341B2 (en) * | 1999-09-23 | 2004-01-13 | Pharmacia Corporation | (R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
KR100465277B1 (ko) * | 2002-01-24 | 2005-01-13 | 한국과학기술연구원 | 신규한 옥심계 아자 두 고리 화합물 및 그 제조방법 |
EP2392258B1 (en) | 2005-04-28 | 2014-10-08 | Proteus Digital Health, Inc. | Pharma-informatics system |
US8795627B2 (en) | 2007-03-21 | 2014-08-05 | Raptor Pharmaceuticals Inc. | Treatment of liver disorders by administration of RAP conjugates |
AU2010216512B2 (en) | 2009-02-20 | 2016-06-30 | 2-Bbb Medicines B.V. | Glutathione-based drug delivery system |
WO2010129819A2 (en) | 2009-05-06 | 2010-11-11 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3479346A (en) * | 1961-08-08 | 1969-11-18 | Sterling Drug Inc | N-acyl-n- (and n,n-bis-) ((1-piperidyl)-lower-alkyl)amines |
US3502692A (en) * | 1962-06-13 | 1970-03-24 | American Cyanamid Co | Cyclic nitroxides and process for preparing same |
DE2019536A1 (de) * | 1970-04-23 | 1971-11-11 | Basf Ag | Oximcarbamate |
DE2552176A1 (de) * | 1975-11-21 | 1977-06-02 | Hoechst Ag | Neue piperidin-derivate, ihre herstellung und verwendung |
US4341795A (en) * | 1975-12-01 | 1982-07-27 | Union Carbide Corporation | Asymmetrical bis-carbamate compounds |
US4710508A (en) * | 1986-12-08 | 1987-12-01 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
NZ226000A (en) * | 1987-09-10 | 1991-06-25 | Merck Sharp & Dohme | Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions |
US4937239A (en) * | 1989-02-13 | 1990-06-26 | Warner-Lambert Company | Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents |
IL97266A0 (en) * | 1990-03-06 | 1992-05-25 | Warner Lambert Co | Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them |
-
1991
- 1991-10-16 US US07/778,412 patent/US5306718A/en not_active Expired - Fee Related
-
1992
- 1992-10-09 DK DK92921974T patent/DK0608336T3/da active
- 1992-10-09 WO PCT/US1992/008642 patent/WO1993008192A1/en active IP Right Grant
- 1992-10-09 AU AU27835/92A patent/AU658685B2/en not_active Ceased
- 1992-10-09 AT AT92921974T patent/ATE166354T1/de not_active IP Right Cessation
- 1992-10-09 DE DE69225601T patent/DE69225601T2/de not_active Expired - Fee Related
- 1992-10-09 KR KR1019940701231A patent/KR100241479B1/ko not_active IP Right Cessation
- 1992-10-09 JP JP50773793A patent/JP3367670B2/ja not_active Expired - Fee Related
- 1992-10-09 ES ES92921974T patent/ES2119823T3/es not_active Expired - Lifetime
- 1992-10-09 CA CA002115443A patent/CA2115443C/en not_active Expired - Fee Related
- 1992-10-09 EP EP92921974A patent/EP0608336B1/en not_active Expired - Lifetime
- 1992-10-14 PH PH45704A patent/PH31431A/en unknown
- 1992-10-14 NZ NZ244726A patent/NZ244726A/en unknown
- 1992-10-15 PT PT100961A patent/PT100961B/pt active IP Right Grant
- 1992-10-15 ZA ZA927973A patent/ZA927973B/xx unknown
-
1994
- 1994-02-01 US US08/189,620 patent/US5482938A/en not_active Expired - Fee Related
- 1994-04-13 FI FI941699A patent/FI106797B/fi active
- 1994-04-15 NO NO941365A patent/NO302072B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2115443C (en) | 2003-05-13 |
DE69225601T2 (de) | 1998-12-17 |
AU658685B2 (en) | 1995-04-27 |
EP0608336A1 (en) | 1994-08-03 |
PH31431A (en) | 1998-11-03 |
AU2783592A (en) | 1993-05-21 |
FI941699A (fi) | 1994-04-13 |
ES2119823T3 (es) | 1998-10-16 |
US5306718A (en) | 1994-04-26 |
NZ244726A (en) | 1995-09-26 |
NO302072B1 (no) | 1998-01-19 |
ATE166354T1 (de) | 1998-06-15 |
KR100241479B1 (ko) | 2000-03-02 |
JP3367670B2 (ja) | 2003-01-14 |
JPH07500337A (ja) | 1995-01-12 |
EP0608336B1 (en) | 1998-05-20 |
US5482938A (en) | 1996-01-09 |
PT100961A (pt) | 1993-11-30 |
DE69225601D1 (de) | 1998-06-25 |
CA2115443A1 (en) | 1993-04-29 |
ZA927973B (en) | 1994-04-15 |
NO941365L (no) | 1994-04-15 |
PT100961B (pt) | 1999-07-30 |
NO941365D0 (no) | 1994-04-15 |
FI106797B (fi) | 2001-04-12 |
FI941699A0 (fi) | 1994-04-13 |
WO1993008192A1 (en) | 1993-04-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0608336T3 (da) | Azabicycloarylacetylen- og -arylenynoximer som cholinerge midler og fremgangsmåde til behandling | |
CA2037541A1 (en) | Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment | |
DE59308619D1 (de) | Germicide wirkstoffkombinationen | |
ZA917744B (en) | Fused ring analogs of nitrogen containing nonaromatic heterocycles. | |
NZ506574A (en) | Cyclic amino derivative having a sulphinyl, sulphonyl or disulphanyl group useful in the treatment of thrombosis or embolism | |
MX9800411A (es) | Compuestos quimicos. | |
DK0463969T3 (da) | Hidtil ukendte 4-aminosmørsyreforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske præparater, som indeholder dem | |
DE69433148D1 (de) | Tricyclische kondensierte heterocyclische Verbindungen zur Behandlung von seniler Demenz | |
DK0677116T3 (da) | Fremgangsmåde til fremstilling af immunosuppressive midler og en ny mikroorganismeart til anvendelse deri | |
DE69427517D1 (de) | Tetracyclische kondensierte heterocyclische Verbindungen zur Behandlung von seniler Demenz | |
CA2241845A1 (en) | 4,5-dihydronaphth[1,2-c]isoxazoles and derivatives thereof having cns activity | |
MY108849A (en) | Novel compound | |
EA199900684A1 (ru) | Производные иминоазаантрациклинона для лечения амилоидоза | |
ES2102774T3 (es) | Indolsulfonamidas como agentes antitumorales. | |
DE3770433D1 (de) | 4-oxo-1,3-benzodioxan-derivat. | |
TH13390EX (th) | อนุพันธ์ของอินโดลและอินดาโซลสำหรับใช้รักษาและ ป้องกันผิดปกติเกี่ยวกับสมองใหญ่, การเตรียมและ การใช้สารเหล่านั้น | |
EA200200574A1 (ru) | НОВЫЕ ЦИКЛИЧЕСКИЕ α-АМИНО-γ-ГИДРОКСИАМИДНЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, ИХ СОДЕРЖАЩИЕ |