AR006890A1 - Compuestos alquil-4-silil-fenoles y esteres de los mismos como agentes antiateroscleroticos - Google Patents

Compuestos alquil-4-silil-fenoles y esteres de los mismos como agentes antiateroscleroticos

Info

Publication number
AR006890A1
AR006890A1 ARP970101749A ARP970101749A AR006890A1 AR 006890 A1 AR006890 A1 AR 006890A1 AR P970101749 A ARP970101749 A AR P970101749A AR P970101749 A ARP970101749 A AR P970101749A AR 006890 A1 AR006890 A1 AR 006890A1
Authority
AR
Argentina
Prior art keywords
alkyl
silyl
esters
same
hydrogen
Prior art date
Application number
ARP970101749A
Other languages
English (en)
Original Assignee
Hoechst Marion Roussell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussell Inc filed Critical Hoechst Marion Roussell Inc
Publication of AR006890A1 publication Critical patent/AR006890A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Los alquil-4-silil-fenoles y ésteres de los mismos como agentes antiateroscleróticos tienen la fórmula (I), donde R1 y R6 son cada unoindependientemente alquilo C1-C6; R2, R3 y R4 son cada uno independientemente hidrógeno o alquilo C1-C6; R es hidrógeno o -C(O)-(CH2)m-Q, donde Q eshidrógeno o -COOH y m es un entero 1, 2, 3 o 4; Z es tio, oxi o un grupo metileno; A es un grupo alquileno C1-C4; R5 y R7 son cada unoindependientemente un alquilo C1-C6 o -(CH2)n-(Ar) donde n es un entero 0, 1, 2 o 3; y Ar es fenilo o naftilo sin sustituir o sustituido con uno a tressustituyentes seleccionados del grupo formado por hidroxi, metoxi, etoxi, halógeno, trifluormetilo, alquilo C1-C6, o -NR8R9, donde R8 y R9 son cada unoindependientemente hidrógeno o alquilo C1-C6; con la condición de que cuando R2 y al menos uno de R5 o R7 es alquilo C1-C6, y Ar no está sustituido contrifluormetilo o -NR8R9, entonces R sea -C(O)-(CH2)m-Q; y pueden ser una sal farmacéuticamente aceptable de los mismos.
ARP970101749A 1996-04-30 1997-04-29 Compuestos alquil-4-silil-fenoles y esteres de los mismos como agentes antiateroscleroticos AR006890A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/637,968 US5608095A (en) 1996-04-30 1996-04-30 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents

Publications (1)

Publication Number Publication Date
AR006890A1 true AR006890A1 (es) 1999-09-29

Family

ID=24558107

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101749A AR006890A1 (es) 1996-04-30 1997-04-29 Compuestos alquil-4-silil-fenoles y esteres de los mismos como agentes antiateroscleroticos

Country Status (19)

Country Link
US (1) US5608095A (es)
EP (1) EP0900225B1 (es)
JP (1) JP4309473B2 (es)
KR (1) KR100503181B1 (es)
CN (1) CN1216993A (es)
AR (1) AR006890A1 (es)
AT (1) ATE212639T1 (es)
AU (1) AU711322B2 (es)
BR (1) BR9709190A (es)
CA (1) CA2251991C (es)
DE (1) DE69710191T2 (es)
DK (1) DK0900225T3 (es)
ES (1) ES2167716T3 (es)
IL (1) IL126758A0 (es)
NO (1) NO985039L (es)
PT (1) PT900225E (es)
TW (1) TW474940B (es)
WO (1) WO1997041129A1 (es)
ZA (1) ZA973503B (es)

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IL126744A0 (en) * 1996-04-30 1999-08-17 Hoechst Marion Roussel Inc Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-Di-alkyl-4-silyl-phenols
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US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
AU8282798A (en) * 1997-07-01 1999-01-25 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
WO2000028332A1 (en) * 1998-11-09 2000-05-18 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6020383A (en) * 1999-01-11 2000-02-01 Eastman Chemicals Company Method for reducing blood cholesterol and/or blood triglycerides
CA2428753C (en) 2000-11-17 2013-05-21 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
JP4334233B2 (ja) * 2001-04-11 2009-09-30 アセロジエニクス・インコーポレイテツド プロブコールモノエステルによって血漿ｈｄｌコレステロールレベルを上昇させ、ｈｄｌの機能性を改善するための方法
CN100512809C (zh) * 2001-10-25 2009-07-15 阿特罗吉尼克斯公司 化合物在制备用于慢性移植排斥的药物中的用途
KR20050044352A (ko) * 2001-11-09 2005-05-12 아테로제닉스, 인코포레이티드 심혈관 병리의 역전 및 예방 방법
RU2004121898A (ru) * 2001-12-19 2006-01-20 Атеродженикс, Инк. (Us) Производные халкона и их применение для лечения заболеваний
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MXPA05007548A (es) * 2003-01-13 2005-10-20 Atherogenics Inc Procedimiento para preparar esteres y eteres de probucol y derivados del mismo.
US7173129B2 (en) * 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005039596A1 (en) * 2003-10-17 2005-05-06 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
WO2005102323A2 (en) 2004-04-20 2005-11-03 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
WO2006004903A2 (en) * 2004-06-28 2006-01-12 Atherogenics, Inc. 1,2-bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
CA2571589A1 (en) * 2004-07-01 2006-01-19 Atherogenics, Inc. Compounds and methods for treating diabetic vascular diseases
AU2008230861A1 (en) * 2007-03-26 2008-10-02 Salutria Pharmaceuticals, Llc Methods and compositions of derivatives of probucol for the treatment of diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
JP5778755B2 (ja) * 2010-04-15 2015-09-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ヒドロキノンの製造方法
CN109641004A (zh) 2016-07-08 2019-04-16 燕财成有限公司 实体癌治疗剂

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Also Published As

Publication number Publication date
BR9709190A (pt) 1999-08-10
AU1985497A (en) 1997-11-19
JP2001509782A (ja) 2001-07-24
ES2167716T3 (es) 2002-05-16
EP0900225A1 (en) 1999-03-10
ZA973503B (en) 1997-10-30
CA2251991C (en) 2002-05-14
IL126758A0 (en) 1999-08-17
AU711322B2 (en) 1999-10-14
CN1216993A (zh) 1999-05-19
DE69710191D1 (de) 2002-03-14
NO985039L (no) 1998-12-21
EP0900225B1 (en) 2002-01-30
NO985039D0 (no) 1998-10-29
DK0900225T3 (da) 2002-05-13
ATE212639T1 (de) 2002-02-15
PT900225E (pt) 2002-06-28
TW474940B (en) 2002-02-01
KR100503181B1 (ko) 2006-03-03
CA2251991A1 (en) 1997-11-06
JP4309473B2 (ja) 2009-08-05
DE69710191T2 (de) 2002-07-25
WO1997041129A1 (en) 1997-11-06
US5608095A (en) 1997-03-04
KR20000065101A (ko) 2000-11-06

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