PT900225E - Alquil-4-silil-fenois e esteres destes como agentes antiateroscleroticos - Google Patents

Alquil-4-silil-fenois e esteres destes como agentes antiateroscleroticos

Info

Publication number
PT900225E
PT900225E PT97907998T PT97907998T PT900225E PT 900225 E PT900225 E PT 900225E PT 97907998 T PT97907998 T PT 97907998T PT 97907998 T PT97907998 T PT 97907998T PT 900225 E PT900225 E PT 900225E
Authority
PT
Portugal
Prior art keywords
acetyclerotic
phenois
silyl
esters
alkyl
Prior art date
Application number
PT97907998T
Other languages
English (en)
Inventor
Paul S Wright
Roger A Parker
Kim S Chen
Steven J Busch
Michael J Edwards
James E Matt Jr
Mark J Vaal
Mark T Yates
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of PT900225E publication Critical patent/PT900225E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT97907998T 1996-04-30 1997-03-03 Alquil-4-silil-fenois e esteres destes como agentes antiateroscleroticos PT900225E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/637,968 US5608095A (en) 1996-04-30 1996-04-30 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents

Publications (1)

Publication Number Publication Date
PT900225E true PT900225E (pt) 2002-06-28

Family

ID=24558107

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97907998T PT900225E (pt) 1996-04-30 1997-03-03 Alquil-4-silil-fenois e esteres destes como agentes antiateroscleroticos

Country Status (19)

Country Link
US (1) US5608095A (pt)
EP (1) EP0900225B1 (pt)
JP (1) JP4309473B2 (pt)
KR (1) KR100503181B1 (pt)
CN (1) CN1216993A (pt)
AR (1) AR006890A1 (pt)
AT (1) ATE212639T1 (pt)
AU (1) AU711322B2 (pt)
BR (1) BR9709190A (pt)
CA (1) CA2251991C (pt)
DE (1) DE69710191T2 (pt)
DK (1) DK0900225T3 (pt)
ES (1) ES2167716T3 (pt)
IL (1) IL126758A0 (pt)
NO (1) NO985039L (pt)
PT (1) PT900225E (pt)
TW (1) TW474940B (pt)
WO (1) WO1997041129A1 (pt)
ZA (1) ZA973503B (pt)

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US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
AU2209097A (en) * 1996-04-30 1997-11-19 Hoechst Marion Roussel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols
JP3930056B2 (ja) 1997-05-14 2007-06-13 アセロジエニクス・インコーポレイテツド Ｖｃａｍ−１発現を阻害する化合物および方法
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
CA2295232A1 (en) * 1997-06-25 1998-12-30 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[ (dimethyl-4-methoxyphenylsilyl) -methyloxy]phenol and 2,6-di-t-butyl-4-[ (dimethyl-2-methoxy-phenylsilyl) -methyloxy]phenol
AU8282798A (en) * 1997-07-01 1999-01-25 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
AU1911200A (en) * 1998-11-09 2000-05-29 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6020383A (en) * 1999-01-11 2000-02-01 Eastman Chemicals Company Method for reducing blood cholesterol and/or blood triglycerides
BR0115474A (pt) 2000-11-17 2006-01-31 Idenix Cayman Ltd Composição e método para inibição da transmissão de hiv que usam 6-benzil-4-oxopirimidinas substituìdas aplicada por via tópica
US20030064967A1 (en) * 2001-04-11 2003-04-03 Jayraz Luchoomun Methods to increase plasma HDL cholesterol levels and improve HDL functionality with probucol monoesters
US20030153536A1 (en) * 2001-10-25 2003-08-14 Mitchell Glass Compounds and methods of treating transplant rejection
EP1451138A4 (en) * 2001-11-09 2005-06-15 Atherogenics Inc METHOD FOR REVERTING AND PREVENTING THE PROCESS OF CARDIOVASCULAR DISEASES
HUP0500165A2 (en) * 2001-12-19 2006-09-28 Atherogenics Inc Chalcone derivatives and their use to treat diseases
JP4467429B2 (ja) * 2002-07-12 2010-05-26 アセロジエニクス・インコーポレイテツド 低溶解性プロブコールエステル類およびエーテル類の新規な塩形態
WO2004024094A2 (en) * 2002-09-13 2004-03-25 Samford University Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
US7273948B2 (en) * 2003-01-13 2007-09-25 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
WO2004108094A2 (en) * 2003-06-06 2004-12-16 Atherogenics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005039596A1 (en) * 2003-10-17 2005-05-06 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
WO2005102323A2 (en) 2004-04-20 2005-11-03 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US20060063828A1 (en) * 2004-06-28 2006-03-23 Weingarten M D 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
US20060058268A1 (en) * 2004-07-01 2006-03-16 Sundell Cynthia L Compounds and methods for treating diabetic vascular diseases
WO2008118948A1 (en) * 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
EP2558433B1 (en) * 2010-04-15 2014-06-18 Merck Patent GmbH Process for the preparation of hydroquinones
CN109641004A (zh) * 2016-07-08 2019-04-16 燕财成有限公司 实体癌治疗剂

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US3862332A (en) * 1967-05-11 1975-01-21 Dow Chemical Co Method of lowering serum cholesterol
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US5112870A (en) * 1990-05-09 1992-05-12 Merrell Dow Pharmaceuticals Inc. Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis
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Also Published As

Publication number Publication date
NO985039D0 (no) 1998-10-29
ATE212639T1 (de) 2002-02-15
AU711322B2 (en) 1999-10-14
JP4309473B2 (ja) 2009-08-05
BR9709190A (pt) 1999-08-10
US5608095A (en) 1997-03-04
JP2001509782A (ja) 2001-07-24
AU1985497A (en) 1997-11-19
KR20000065101A (ko) 2000-11-06
ZA973503B (en) 1997-10-30
AR006890A1 (es) 1999-09-29
CN1216993A (zh) 1999-05-19
DE69710191T2 (de) 2002-07-25
ES2167716T3 (es) 2002-05-16
CA2251991A1 (en) 1997-11-06
DK0900225T3 (da) 2002-05-13
TW474940B (en) 2002-02-01
EP0900225A1 (en) 1999-03-10
DE69710191D1 (de) 2002-03-14
EP0900225B1 (en) 2002-01-30
IL126758A0 (en) 1999-08-17
CA2251991C (en) 2002-05-14
KR100503181B1 (ko) 2006-03-03
NO985039L (no) 1998-12-21
WO1997041129A1 (en) 1997-11-06

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