MXPA05007548A - Procedimiento para preparar esteres y eteres de probucol y derivados del mismo. - Google Patents
Procedimiento para preparar esteres y eteres de probucol y derivados del mismo.Info
- Publication number
- MXPA05007548A MXPA05007548A MXPA05007548A MXPA05007548A MXPA05007548A MX PA05007548 A MXPA05007548 A MX PA05007548A MX PA05007548 A MXPA05007548 A MX PA05007548A MX PA05007548 A MXPA05007548 A MX PA05007548A MX PA05007548 A MXPA05007548 A MX PA05007548A
- Authority
- MX
- Mexico
- Prior art keywords
- probucol
- derivative
- compound
- ethers
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Se puede convertir en forma eficiente un probucol o derivado de probucol hasta un monoester o monoeter de probucol haciendo reaccionar el probucol que contiene hidroxilo libre o un derivado del mismo (con lo cual se quiere decir un compuesto probucol con por lo menos un sustituyente que sea diferente de aquel en la molecula de probucol precursora pero que conserva los dos grupos hidroxilo libres) con un reactivo de Grignard o un reactivo de litio que produzca un sal de bromuro de magnesio o litio de probucol o el derivado probucol. El anion del compuesto probucol despues se hace reaccionar con un compuesto formador de ester o eter.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43966503P | 2003-01-13 | 2003-01-13 | |
PCT/US2004/000805 WO2004062622A2 (en) | 2003-01-13 | 2004-01-13 | Process of preparing esters and ethers of probucol and derivatives thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05007548A true MXPA05007548A (es) | 2005-10-20 |
Family
ID=32713499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05007548A MXPA05007548A (es) | 2003-01-13 | 2004-01-13 | Procedimiento para preparar esteres y eteres de probucol y derivados del mismo. |
Country Status (12)
Country | Link |
---|---|
US (2) | US7273948B2 (es) |
EP (1) | EP1594824A4 (es) |
JP (1) | JP4550800B2 (es) |
CN (2) | CN100548950C (es) |
AU (1) | AU2004204824B2 (es) |
BR (1) | BRPI0406738A (es) |
CA (1) | CA2512980A1 (es) |
HK (1) | HK1090633A1 (es) |
IL (1) | IL169662A (es) |
MX (1) | MXPA05007548A (es) |
SG (1) | SG142207A1 (es) |
WO (1) | WO2004062622A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4467429B2 (ja) * | 2002-07-12 | 2010-05-26 | アセロジエニクス・インコーポレイテツド | 低溶解性プロブコールエステル類およびエーテル類の新規な塩形態 |
CN100548950C (zh) * | 2003-01-13 | 2009-10-14 | 阿特罗吉尼克斯公司 | 制备普罗布考及其衍生物的酯和醚的方法 |
US7294736B2 (en) * | 2004-04-09 | 2007-11-13 | Cambrex Charles City, Inc. | Process for preparation of probucol derivatives |
WO2005102323A2 (en) * | 2004-04-20 | 2005-11-03 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
US20060058268A1 (en) * | 2004-07-01 | 2006-03-16 | Sundell Cynthia L | Compounds and methods for treating diabetic vascular diseases |
US20060194981A1 (en) * | 2005-02-26 | 2006-08-31 | Jass Paul A | Process for preparation of probucol derivatives |
EP1874725A4 (en) | 2005-04-21 | 2011-04-06 | Atherogenics Inc | PROCESS FOR SEPARATING PROBUCOL DERIVATIVES |
US20070275174A1 (en) * | 2006-05-24 | 2007-11-29 | Hanson Eric L | Fishing fly and fly fishing line with fluorocarbon coating |
CN105001129B (zh) * | 2015-08-18 | 2017-06-16 | 齐鲁安替(临邑)制药有限公司 | 一种高收率普罗布考精制析晶方法 |
CN111434647A (zh) * | 2019-01-14 | 2020-07-21 | 中国科学院上海药物研究所 | 普罗布考单琥珀酸酯的多晶型 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3576883A (en) | 1969-06-30 | 1971-04-27 | Consolidation Coal Co | Alkylidenedithiobisphenols |
FR2130975A5 (en) | 1971-03-29 | 1972-11-10 | Aries Robert | Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics |
FR2133024A5 (en) | 1971-04-06 | 1972-11-24 | Aries Robert | Bis-(4-nicotinoyloxyphenylthio) propanes - with hypocholesterolaemic and hypolipaemic activity |
FR2134810A5 (en) | 1971-04-21 | 1972-12-08 | Aries Robert | Bis-(3-alkyl-5-t-alkyl-4-(thiazole-5-carboxy)phenylthio) alcanes - - with hypocholesterolaemic and hypolipaemic activity |
FR2140769A5 (en) | 1971-06-07 | 1973-01-19 | Aries Robert | Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents |
FR2140771A5 (en) | 1971-06-07 | 1973-01-19 | Aries Robert | Tetralinyl phenoxy alkanoic esters - of bis hydroxyphenylthio alkanes, hypolipemics etc |
FR2168137A1 (en) | 1972-01-17 | 1973-08-31 | Dynachim Sarl | Bis 4-hydroxyphenylthioalkane esters - with hypocholesterolaemic and hypolipaemic activities |
US3952064A (en) | 1973-03-12 | 1976-04-20 | Crown Zellerbach Corporation | Process for producing mercaptophenols |
US4752616A (en) | 1987-06-29 | 1988-06-21 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use |
JPH01283261A (ja) * | 1988-05-07 | 1989-11-14 | Sanshin Chem Ind Co Ltd | アルキル化方法 |
DE3929913A1 (de) | 1989-09-08 | 1991-04-04 | Hoechst Ag | 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte |
US5155250A (en) | 1990-07-05 | 1992-10-13 | Merrell Dow Pharmaceuticals Inc. | 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents |
FR2666583B1 (fr) | 1990-09-06 | 1994-09-09 | Adir | Nouveaux derives du spiro [4.5] decane, leur procede de preparation et leurs compositions pharmaceutiques les renfermant. |
US5262439A (en) * | 1992-04-30 | 1993-11-16 | The Regents Of The University Of California | Soluble analogs of probucol |
US5380747A (en) | 1992-10-30 | 1995-01-10 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
US5821260A (en) | 1992-10-30 | 1998-10-13 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
FR2704224B1 (fr) | 1993-04-20 | 1995-08-25 | Adir | Nouveaux acides et esters phénoxy isobutyriques substitués. |
US5792787A (en) | 1995-06-07 | 1998-08-11 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
FR2738817B1 (fr) | 1995-09-14 | 1997-10-17 | Adir | Nouveaux acides et esters 2,2-dimethyl-omega-phenoxy alcanoiques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5608095A (en) | 1996-04-30 | 1997-03-04 | Hoechst Marion Roussel, Inc. | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
CN1275596C (zh) * | 1997-05-14 | 2006-09-20 | 阿特罗吉尼克斯公司 | 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用 |
US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
AU1387399A (en) * | 1997-11-10 | 1999-05-31 | Vyrex Corporation | Probucol esters and uses thereof |
JP3344331B2 (ja) | 1998-09-30 | 2002-11-11 | 日本電気株式会社 | 不揮発性半導体記憶装置 |
JP2003528109A (ja) | 2000-03-21 | 2003-09-24 | アセロジエニクス・インコーポレイテツド | Vcam−1の発現を阻害するためのチオケタール及びチオエーテル |
US6323359B1 (en) | 2000-05-02 | 2001-11-27 | Salsbury Chemicals, Inc. | Process for preparing probucol derivatives |
AU2002320025A1 (en) * | 2001-04-11 | 2002-11-11 | Atherogenics, Inc. | Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality |
US6806381B2 (en) * | 2001-11-02 | 2004-10-19 | Bristol-Myers Squibb Company | Process for the preparation of aniline-derived thyroid receptor ligands |
CN100548950C (zh) * | 2003-01-13 | 2009-10-14 | 阿特罗吉尼克斯公司 | 制备普罗布考及其衍生物的酯和醚的方法 |
US20060025481A1 (en) | 2004-02-09 | 2006-02-02 | Strange Matthew L | Process for preparation of probucol derivatives and polymorphic forms thereof |
WO2005102323A2 (en) | 2004-04-20 | 2005-11-03 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
-
2004
- 2004-01-13 CN CNB2004800062657A patent/CN100548950C/zh not_active Expired - Fee Related
- 2004-01-13 CN CNA2008102158866A patent/CN101391972A/zh active Pending
- 2004-01-13 JP JP2006500935A patent/JP4550800B2/ja not_active Expired - Fee Related
- 2004-01-13 US US10/757,664 patent/US7273948B2/en not_active Expired - Fee Related
- 2004-01-13 WO PCT/US2004/000805 patent/WO2004062622A2/en active Application Filing
- 2004-01-13 AU AU2004204824A patent/AU2004204824B2/en not_active Ceased
- 2004-01-13 MX MXPA05007548A patent/MXPA05007548A/es active IP Right Grant
- 2004-01-13 BR BR0406738-0A patent/BRPI0406738A/pt not_active IP Right Cessation
- 2004-01-13 CA CA002512980A patent/CA2512980A1/en not_active Abandoned
- 2004-01-13 EP EP04701812A patent/EP1594824A4/en not_active Withdrawn
- 2004-01-13 SG SG200705127-9A patent/SG142207A1/en unknown
-
2005
- 2005-07-13 IL IL169662A patent/IL169662A/en not_active IP Right Cessation
-
2006
- 2006-10-12 HK HK06111244.5A patent/HK1090633A1/xx not_active IP Right Cessation
-
2007
- 2007-09-13 US US11/854,939 patent/US7622604B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HK1090633A1 (en) | 2006-12-29 |
CN1759084A (zh) | 2006-04-12 |
WO2004062622A3 (en) | 2004-12-02 |
SG142207A1 (en) | 2008-05-28 |
CN100548950C (zh) | 2009-10-14 |
WO2004062622A2 (en) | 2004-07-29 |
EP1594824A2 (en) | 2005-11-16 |
JP2006516569A (ja) | 2006-07-06 |
CA2512980A1 (en) | 2004-07-29 |
US7273948B2 (en) | 2007-09-25 |
CN101391972A (zh) | 2009-03-25 |
IL169662A (en) | 2011-10-31 |
AU2004204824B2 (en) | 2010-12-23 |
JP4550800B2 (ja) | 2010-09-22 |
AU2004204824A1 (en) | 2004-07-29 |
US20080009642A1 (en) | 2008-01-10 |
US20040204485A1 (en) | 2004-10-14 |
EP1594824A4 (en) | 2007-04-04 |
US7622604B2 (en) | 2009-11-24 |
BRPI0406738A (pt) | 2005-12-20 |
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Legal Events
Date | Code | Title | Description |
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FG | Grant or registration |