HK1090633A1 - Process of preparing esters and ethers of probucol and derivatives thereof - Google Patents
Process of preparing esters and ethers of probucol and derivatives thereofInfo
- Publication number
- HK1090633A1 HK1090633A1 HK06111244.5A HK06111244A HK1090633A1 HK 1090633 A1 HK1090633 A1 HK 1090633A1 HK 06111244 A HK06111244 A HK 06111244A HK 1090633 A1 HK1090633 A1 HK 1090633A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- probucol
- ethers
- derivatives
- preparing esters
- esters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43966503P | 2003-01-13 | 2003-01-13 | |
PCT/US2004/000805 WO2004062622A2 (en) | 2003-01-13 | 2004-01-13 | Process of preparing esters and ethers of probucol and derivatives thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1090633A1 true HK1090633A1 (en) | 2006-12-29 |
Family
ID=32713499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06111244.5A HK1090633A1 (en) | 2003-01-13 | 2006-10-12 | Process of preparing esters and ethers of probucol and derivatives thereof |
Country Status (12)
Country | Link |
---|---|
US (2) | US7273948B2 (es) |
EP (1) | EP1594824A4 (es) |
JP (1) | JP4550800B2 (es) |
CN (2) | CN100548950C (es) |
AU (1) | AU2004204824B2 (es) |
BR (1) | BRPI0406738A (es) |
CA (1) | CA2512980A1 (es) |
HK (1) | HK1090633A1 (es) |
IL (1) | IL169662A (es) |
MX (1) | MXPA05007548A (es) |
SG (1) | SG142207A1 (es) |
WO (1) | WO2004062622A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4467429B2 (ja) * | 2002-07-12 | 2010-05-26 | アセロジエニクス・インコーポレイテツド | 低溶解性プロブコールエステル類およびエーテル類の新規な塩形態 |
BRPI0406738A (pt) * | 2003-01-13 | 2005-12-20 | Atherogenics Inc | Processo de preparação de ésteres e éteres de probucol e derivados desse |
US7294736B2 (en) * | 2004-04-09 | 2007-11-13 | Cambrex Charles City, Inc. | Process for preparation of probucol derivatives |
US20070260087A1 (en) | 2004-04-20 | 2007-11-08 | Atherogenics, Inc. | Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof |
EP1768660A4 (en) * | 2004-07-01 | 2009-05-13 | Atherogenics Inc | COMPOUNDS AND METHODS FOR TREATING DIABETIC VASCULAR DISEASES |
US20060194981A1 (en) * | 2005-02-26 | 2006-08-31 | Jass Paul A | Process for preparation of probucol derivatives |
MX2007013081A (es) * | 2005-04-21 | 2008-01-18 | Atherogenics Inc | Procesos para la separacion de derivados de probucol. |
US20070275174A1 (en) * | 2006-05-24 | 2007-11-29 | Hanson Eric L | Fishing fly and fly fishing line with fluorocarbon coating |
CN105001129B (zh) * | 2015-08-18 | 2017-06-16 | 齐鲁安替(临邑)制药有限公司 | 一种高收率普罗布考精制析晶方法 |
CN111434647A (zh) * | 2019-01-14 | 2020-07-21 | 中国科学院上海药物研究所 | 普罗布考单琥珀酸酯的多晶型 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3576883A (en) * | 1969-06-30 | 1971-04-27 | Consolidation Coal Co | Alkylidenedithiobisphenols |
FR2130975A5 (en) | 1971-03-29 | 1972-11-10 | Aries Robert | Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics |
FR2133024A5 (en) | 1971-04-06 | 1972-11-24 | Aries Robert | Bis-(4-nicotinoyloxyphenylthio) propanes - with hypocholesterolaemic and hypolipaemic activity |
FR2134810A5 (en) | 1971-04-21 | 1972-12-08 | Aries Robert | Bis-(3-alkyl-5-t-alkyl-4-(thiazole-5-carboxy)phenylthio) alcanes - - with hypocholesterolaemic and hypolipaemic activity |
FR2140771A5 (en) | 1971-06-07 | 1973-01-19 | Aries Robert | Tetralinyl phenoxy alkanoic esters - of bis hydroxyphenylthio alkanes, hypolipemics etc |
FR2140769A5 (en) | 1971-06-07 | 1973-01-19 | Aries Robert | Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents |
FR2168137A1 (en) | 1972-01-17 | 1973-08-31 | Dynachim Sarl | Bis 4-hydroxyphenylthioalkane esters - with hypocholesterolaemic and hypolipaemic activities |
US3952064A (en) * | 1973-03-12 | 1976-04-20 | Crown Zellerbach Corporation | Process for producing mercaptophenols |
US4752616A (en) * | 1987-06-29 | 1988-06-21 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use |
JPH01283261A (ja) * | 1988-05-07 | 1989-11-14 | Sanshin Chem Ind Co Ltd | アルキル化方法 |
DE3929913A1 (de) * | 1989-09-08 | 1991-04-04 | Hoechst Ag | 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte |
US5155250A (en) * | 1990-07-05 | 1992-10-13 | Merrell Dow Pharmaceuticals Inc. | 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents |
FR2666583B1 (fr) * | 1990-09-06 | 1994-09-09 | Adir | Nouveaux derives du spiro [4.5] decane, leur procede de preparation et leurs compositions pharmaceutiques les renfermant. |
US5262439A (en) | 1992-04-30 | 1993-11-16 | The Regents Of The University Of California | Soluble analogs of probucol |
US5380747A (en) | 1992-10-30 | 1995-01-10 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
US5821260A (en) | 1992-10-30 | 1998-10-13 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
FR2704224B1 (fr) * | 1993-04-20 | 1995-08-25 | Adir | Nouveaux acides et esters phénoxy isobutyriques substitués. |
US5792787A (en) | 1995-06-07 | 1998-08-11 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
FR2738817B1 (fr) | 1995-09-14 | 1997-10-17 | Adir | Nouveaux acides et esters 2,2-dimethyl-omega-phenoxy alcanoiques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5608095A (en) * | 1996-04-30 | 1997-03-04 | Hoechst Marion Roussel, Inc. | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
PL194329B1 (pl) | 1997-05-14 | 2007-05-31 | Atherogenics Inc | Zastosowanie monoestru probukolu kwasu bursztynowego lub jego farmaceutycznie dopuszczalnej soli dowytwarzania leku do leczenia choroby, której mediatorem jest VCAM-1 |
US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
WO1999024400A1 (en) * | 1997-11-10 | 1999-05-20 | Vyrex Corporation | Probucol esters and uses thereof |
JP3344331B2 (ja) | 1998-09-30 | 2002-11-11 | 日本電気株式会社 | 不揮発性半導体記憶装置 |
AU4765101A (en) | 2000-03-21 | 2001-10-03 | Atherogenics Inc | Thioketals and thioethers for inhibiting the expression of vcam-1 |
US6323359B1 (en) | 2000-05-02 | 2001-11-27 | Salsbury Chemicals, Inc. | Process for preparing probucol derivatives |
EP1385501A2 (en) * | 2001-04-11 | 2004-02-04 | Atherogenics, Inc. | Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality |
US6806381B2 (en) * | 2001-11-02 | 2004-10-19 | Bristol-Myers Squibb Company | Process for the preparation of aniline-derived thyroid receptor ligands |
BRPI0406738A (pt) * | 2003-01-13 | 2005-12-20 | Atherogenics Inc | Processo de preparação de ésteres e éteres de probucol e derivados desse |
US20060025481A1 (en) | 2004-02-09 | 2006-02-02 | Strange Matthew L | Process for preparation of probucol derivatives and polymorphic forms thereof |
US20070260087A1 (en) | 2004-04-20 | 2007-11-08 | Atherogenics, Inc. | Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof |
-
2004
- 2004-01-13 BR BR0406738-0A patent/BRPI0406738A/pt not_active IP Right Cessation
- 2004-01-13 CN CNB2004800062657A patent/CN100548950C/zh not_active Expired - Fee Related
- 2004-01-13 WO PCT/US2004/000805 patent/WO2004062622A2/en active Application Filing
- 2004-01-13 EP EP04701812A patent/EP1594824A4/en not_active Withdrawn
- 2004-01-13 SG SG200705127-9A patent/SG142207A1/en unknown
- 2004-01-13 JP JP2006500935A patent/JP4550800B2/ja not_active Expired - Fee Related
- 2004-01-13 US US10/757,664 patent/US7273948B2/en not_active Expired - Fee Related
- 2004-01-13 AU AU2004204824A patent/AU2004204824B2/en not_active Ceased
- 2004-01-13 CN CNA2008102158866A patent/CN101391972A/zh active Pending
- 2004-01-13 CA CA002512980A patent/CA2512980A1/en not_active Abandoned
- 2004-01-13 MX MXPA05007548A patent/MXPA05007548A/es active IP Right Grant
-
2005
- 2005-07-13 IL IL169662A patent/IL169662A/en not_active IP Right Cessation
-
2006
- 2006-10-12 HK HK06111244.5A patent/HK1090633A1/xx not_active IP Right Cessation
-
2007
- 2007-09-13 US US11/854,939 patent/US7622604B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7273948B2 (en) | 2007-09-25 |
US7622604B2 (en) | 2009-11-24 |
MXPA05007548A (es) | 2005-10-20 |
US20080009642A1 (en) | 2008-01-10 |
US20040204485A1 (en) | 2004-10-14 |
WO2004062622A2 (en) | 2004-07-29 |
CN100548950C (zh) | 2009-10-14 |
CN101391972A (zh) | 2009-03-25 |
JP2006516569A (ja) | 2006-07-06 |
WO2004062622A3 (en) | 2004-12-02 |
BRPI0406738A (pt) | 2005-12-20 |
AU2004204824A1 (en) | 2004-07-29 |
JP4550800B2 (ja) | 2010-09-22 |
EP1594824A4 (en) | 2007-04-04 |
CN1759084A (zh) | 2006-04-12 |
AU2004204824B2 (en) | 2010-12-23 |
IL169662A (en) | 2011-10-31 |
SG142207A1 (en) | 2008-05-28 |
EP1594824A2 (en) | 2005-11-16 |
CA2512980A1 (en) | 2004-07-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20140113 |