HK1090633A1 - Process of preparing esters and ethers of probucol and derivatives thereof - Google Patents

Process of preparing esters and ethers of probucol and derivatives thereof

Info

Publication number
HK1090633A1
HK1090633A1 HK06111244.5A HK06111244A HK1090633A1 HK 1090633 A1 HK1090633 A1 HK 1090633A1 HK 06111244 A HK06111244 A HK 06111244A HK 1090633 A1 HK1090633 A1 HK 1090633A1
Authority
HK
Hong Kong
Prior art keywords
probucol
ethers
derivatives
preparing esters
esters
Prior art date
Application number
HK06111244.5A
Other languages
English (en)
Inventor
M David Weingarten
James A Sikorski
Original Assignee
Salutria Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salutria Pharmaceuticals Llc filed Critical Salutria Pharmaceuticals Llc
Publication of HK1090633A1 publication Critical patent/HK1090633A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
HK06111244.5A 2003-01-13 2006-10-12 Process of preparing esters and ethers of probucol and derivatives thereof HK1090633A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43966503P 2003-01-13 2003-01-13
PCT/US2004/000805 WO2004062622A2 (en) 2003-01-13 2004-01-13 Process of preparing esters and ethers of probucol and derivatives thereof

Publications (1)

Publication Number Publication Date
HK1090633A1 true HK1090633A1 (en) 2006-12-29

Family

ID=32713499

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06111244.5A HK1090633A1 (en) 2003-01-13 2006-10-12 Process of preparing esters and ethers of probucol and derivatives thereof

Country Status (12)

Country Link
US (2) US7273948B2 (xx)
EP (1) EP1594824A4 (xx)
JP (1) JP4550800B2 (xx)
CN (2) CN100548950C (xx)
AU (1) AU2004204824B2 (xx)
BR (1) BRPI0406738A (xx)
CA (1) CA2512980A1 (xx)
HK (1) HK1090633A1 (xx)
IL (1) IL169662A (xx)
MX (1) MXPA05007548A (xx)
SG (1) SG142207A1 (xx)
WO (1) WO2004062622A2 (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4467429B2 (ja) * 2002-07-12 2010-05-26 アセロジエニクス・インコーポレイテツド 低溶解性プロブコールエステル類およびエーテル類の新規な塩形態
BRPI0406738A (pt) * 2003-01-13 2005-12-20 Atherogenics Inc Processo de preparação de ésteres e éteres de probucol e derivados desse
US7294736B2 (en) * 2004-04-09 2007-11-13 Cambrex Charles City, Inc. Process for preparation of probucol derivatives
US20070260087A1 (en) 2004-04-20 2007-11-08 Atherogenics, Inc. Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof
EP1768660A4 (en) * 2004-07-01 2009-05-13 Atherogenics Inc COMPOUNDS AND METHODS FOR TREATING DIABETIC VASCULAR DISEASES
US20060194981A1 (en) * 2005-02-26 2006-08-31 Jass Paul A Process for preparation of probucol derivatives
MX2007013081A (es) * 2005-04-21 2008-01-18 Atherogenics Inc Procesos para la separacion de derivados de probucol.
US20070275174A1 (en) * 2006-05-24 2007-11-29 Hanson Eric L Fishing fly and fly fishing line with fluorocarbon coating
CN105001129B (zh) * 2015-08-18 2017-06-16 齐鲁安替（临邑）制药有限公司 一种高收率普罗布考精制析晶方法
CN111434647A (zh) * 2019-01-14 2020-07-21 中国科学院上海药物研究所 普罗布考单琥珀酸酯的多晶型

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576883A (en) * 1969-06-30 1971-04-27 Consolidation Coal Co Alkylidenedithiobisphenols
FR2130975A5 (en) 1971-03-29 1972-11-10 Aries Robert Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics
FR2133024A5 (en) 1971-04-06 1972-11-24 Aries Robert Bis-(4-nicotinoyloxyphenylthio) propanes - with hypocholesterolaemic and hypolipaemic activity
FR2134810A5 (en) 1971-04-21 1972-12-08 Aries Robert Bis-(3-alkyl-5-t-alkyl-4-(thiazole-5-carboxy)phenylthio) alcanes - - with hypocholesterolaemic and hypolipaemic activity
FR2140771A5 (en) 1971-06-07 1973-01-19 Aries Robert Tetralinyl phenoxy alkanoic esters - of bis hydroxyphenylthio alkanes, hypolipemics etc
FR2140769A5 (en) 1971-06-07 1973-01-19 Aries Robert Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents
FR2168137A1 (en) 1972-01-17 1973-08-31 Dynachim Sarl Bis 4-hydroxyphenylthioalkane esters - with hypocholesterolaemic and hypolipaemic activities
US3952064A (en) * 1973-03-12 1976-04-20 Crown Zellerbach Corporation Process for producing mercaptophenols
US4752616A (en) * 1987-06-29 1988-06-21 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use
JPH01283261A (ja) * 1988-05-07 1989-11-14 Sanshin Chem Ind Co Ltd アルキル化方法
DE3929913A1 (de) * 1989-09-08 1991-04-04 Hoechst Ag 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
FR2666583B1 (fr) * 1990-09-06 1994-09-09 Adir Nouveaux derives du spiro [4.5] decane, leur procede de preparation et leurs compositions pharmaceutiques les renfermant.
US5262439A (en) 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
US5380747A (en) 1992-10-30 1995-01-10 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5821260A (en) 1992-10-30 1998-10-13 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
FR2704224B1 (fr) * 1993-04-20 1995-08-25 Adir Nouveaux acides et esters phénoxy isobutyriques substitués.
US5792787A (en) 1995-06-07 1998-08-11 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
FR2738817B1 (fr) 1995-09-14 1997-10-17 Adir Nouveaux acides et esters 2,2-dimethyl-omega-phenoxy alcanoiques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
PL194329B1 (pl) 1997-05-14 2007-05-31 Atherogenics Inc Zastosowanie monoestru probukolu kwasu bursztynowego lub jego farmaceutycznie dopuszczalnej soli dowytwarzania leku do leczenia choroby, której mediatorem jest VCAM-1
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
WO1999024400A1 (en) * 1997-11-10 1999-05-20 Vyrex Corporation Probucol esters and uses thereof
JP3344331B2 (ja) 1998-09-30 2002-11-11 日本電気株式会社 不揮発性半導体記憶装置
AU4765101A (en) 2000-03-21 2001-10-03 Atherogenics Inc Thioketals and thioethers for inhibiting the expression of vcam-1
US6323359B1 (en) 2000-05-02 2001-11-27 Salsbury Chemicals, Inc. Process for preparing probucol derivatives
EP1385501A2 (en) * 2001-04-11 2004-02-04 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
US6806381B2 (en) * 2001-11-02 2004-10-19 Bristol-Myers Squibb Company Process for the preparation of aniline-derived thyroid receptor ligands
BRPI0406738A (pt) * 2003-01-13 2005-12-20 Atherogenics Inc Processo de preparação de ésteres e éteres de probucol e derivados desse
US20060025481A1 (en) 2004-02-09 2006-02-02 Strange Matthew L Process for preparation of probucol derivatives and polymorphic forms thereof
US20070260087A1 (en) 2004-04-20 2007-11-08 Atherogenics, Inc. Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof

Also Published As

Publication number Publication date
US7273948B2 (en) 2007-09-25
US7622604B2 (en) 2009-11-24
MXPA05007548A (es) 2005-10-20
US20080009642A1 (en) 2008-01-10
US20040204485A1 (en) 2004-10-14
WO2004062622A2 (en) 2004-07-29
CN100548950C (zh) 2009-10-14
CN101391972A (zh) 2009-03-25
JP2006516569A (ja) 2006-07-06
WO2004062622A3 (en) 2004-12-02
BRPI0406738A (pt) 2005-12-20
AU2004204824A1 (en) 2004-07-29
JP4550800B2 (ja) 2010-09-22
EP1594824A4 (en) 2007-04-04
CN1759084A (zh) 2006-04-12
AU2004204824B2 (en) 2010-12-23
IL169662A (en) 2011-10-31
SG142207A1 (en) 2008-05-28
EP1594824A2 (en) 2005-11-16
CA2512980A1 (en) 2004-07-29

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140113