FR2130975A5 - Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics - Google Patents

Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics

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Publication number
FR2130975A5
FR2130975A5 FR7110910A FR7110910A FR2130975A5 FR 2130975 A5 FR2130975 A5 FR 2130975A5 FR 7110910 A FR7110910 A FR 7110910A FR 7110910 A FR7110910 A FR 7110910A FR 2130975 A5 FR2130975 A5 FR 2130975A5
Authority
FR
France
Prior art keywords
substits
substd
alkyl
hypolipemics
phenoxyalkanoyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7110910A
Other languages
French (fr)
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Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR7110910A priority Critical patent/FR2130975A5/en
Application granted granted Critical
Publication of FR2130975A5 publication Critical patent/FR2130975A5/en
Expired legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Title cpds. are of formula (I) where R = 1-3 opt. substits. selected from alkyl, alkenyl, CF3, cycloalkyl, cycloalkenyl, aryl, aralkyl aralkenyl, halo, alkoxy, alkylthio, aryloxy, aralkoxy arylthio, and aralkylthio or R may be a gp. -CH=CH-CH=CH- joined to two vicinal C atoms of the benzene ring to form a naphthalene gp. which may be substd. by one or two of the above substits. and when one of these substits. is cyclohexyl or cyclohexenyl it may be substd. by OH or =O and/or alkyl or alkenyl, A = divalent satd. or ethylenically unsatd. hydrocarbon residue with 1-18C, opt. substd. by =O or OH or phenyl alkylphenyl, aralkylphenyl, arylphenyl, acylphenyl, alkoxyphenyl or halophenyl gp. R1 = H or lower alkyl R2 = Me or Et, R3 = t-amyl or t-butyl; R4 = lower alkyl.
FR7110910A 1971-03-29 1971-03-29 Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics Expired FR2130975A5 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7110910A FR2130975A5 (en) 1971-03-29 1971-03-29 Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7110910A FR2130975A5 (en) 1971-03-29 1971-03-29 Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics

Publications (1)

Publication Number Publication Date
FR2130975A5 true FR2130975A5 (en) 1972-11-10

Family

ID=9074280

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7110910A Expired FR2130975A5 (en) 1971-03-29 1971-03-29 Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics

Country Status (1)

Country Link
FR (1) FR2130975A5 (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0637959A1 (en) * 1992-04-30 1995-02-15 The Regents Of The University Of California Soluble analogs of probucol
US6121319A (en) * 1997-05-14 2000-09-19 Atherogenics, Inc. Monoesters of probucol for the treatment of cardiovascular and inflammatory disease
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6852878B2 (en) 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
US6881860B2 (en) 2000-04-11 2005-04-19 Atherogenics, Inc. Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
US6960683B2 (en) 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
US7071158B2 (en) 1997-07-01 2006-07-04 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
US7271274B2 (en) 2004-04-20 2007-09-18 Ahterogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US7273948B2 (en) 2003-01-13 2007-09-25 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US7294737B2 (en) 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
WO2008118948A1 (en) 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
US7687659B2 (en) 2005-04-21 2010-03-30 Salutria Pharmaceuticals Llc Process for the separation of probucol derivatives
US7897776B2 (en) 2007-04-23 2011-03-01 Salutria Pharmaceuticals Llc Sulfonamide containing compounds for treatment of inflammatory disorders

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0637959A1 (en) * 1992-04-30 1995-02-15 The Regents Of The University Of California Soluble analogs of probucol
EP0637959A4 (en) * 1992-04-30 1995-03-29 Univ California Soluble analogs of probucol.
EP1161946A3 (en) * 1992-04-30 2003-12-10 AtheroGenics, Inc. Soluble analogs of probucol
US6121319A (en) * 1997-05-14 2000-09-19 Atherogenics, Inc. Monoesters of probucol for the treatment of cardiovascular and inflammatory disease
US6147250A (en) * 1997-05-14 2000-11-14 Atherogenics, Inc. Compounds and methods for the inhibition of the expression of VCAM-1
US6548699B1 (en) 1997-05-14 2003-04-15 Atherogenics, Inc. Compounds and methods for the inhibition of the expression of VCAM-1
US6617352B2 (en) 1997-05-14 2003-09-09 Atherogenics, Inc. Compounds and methods for the inhibition of the expression of VCAM-1
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6828447B2 (en) 1997-05-14 2004-12-07 Atherogenics, Inc. Compounds and methods for the inhibition of the expression of VCAM-1
US7375252B2 (en) 1997-05-14 2008-05-20 Atherogenics, Inc. Compounds and method for the inhibition of the expression of VCAM-1
US7189870B2 (en) 1997-05-14 2007-03-13 Atherogenic, Inc. Compounds and methods for the inhibition of the expression of VCAM-1
US7087645B2 (en) 1997-05-14 2006-08-08 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US7071158B2 (en) 1997-07-01 2006-07-04 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
US6852878B2 (en) 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
US7183317B2 (en) 2000-04-11 2007-02-27 Atherogenics, Inc. Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
US6881860B2 (en) 2000-04-11 2005-04-19 Atherogenics, Inc. Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
US7371895B2 (en) 2002-07-12 2008-05-13 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
US6960683B2 (en) 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
US7622604B2 (en) 2003-01-13 2009-11-24 Salutria Pharmaceuticals Llc Process of preparing esters and ethers of probucol and derivatives thereof
US7273948B2 (en) 2003-01-13 2007-09-25 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US7294737B2 (en) 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US7271274B2 (en) 2004-04-20 2007-09-18 Ahterogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US7687659B2 (en) 2005-04-21 2010-03-30 Salutria Pharmaceuticals Llc Process for the separation of probucol derivatives
WO2008118948A1 (en) 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
US8252840B2 (en) 2007-03-26 2012-08-28 Salutria Pharmaceuticals Llc Methods of derivatives of probucol for the treatment of type II diabetes
US7897776B2 (en) 2007-04-23 2011-03-01 Salutria Pharmaceuticals Llc Sulfonamide containing compounds for treatment of inflammatory disorders

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