FR2130975A5 - Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics - Google Patents
Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemicsInfo
- Publication number
- FR2130975A5 FR2130975A5 FR7110910A FR7110910A FR2130975A5 FR 2130975 A5 FR2130975 A5 FR 2130975A5 FR 7110910 A FR7110910 A FR 7110910A FR 7110910 A FR7110910 A FR 7110910A FR 2130975 A5 FR2130975 A5 FR 2130975A5
- Authority
- FR
- France
- Prior art keywords
- substits
- substd
- alkyl
- hypolipemics
- phenoxyalkanoyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Title cpds. are of formula (I) where R = 1-3 opt. substits. selected from alkyl, alkenyl, CF3, cycloalkyl, cycloalkenyl, aryl, aralkyl aralkenyl, halo, alkoxy, alkylthio, aryloxy, aralkoxy arylthio, and aralkylthio or R may be a gp. -CH=CH-CH=CH- joined to two vicinal C atoms of the benzene ring to form a naphthalene gp. which may be substd. by one or two of the above substits. and when one of these substits. is cyclohexyl or cyclohexenyl it may be substd. by OH or =O and/or alkyl or alkenyl, A = divalent satd. or ethylenically unsatd. hydrocarbon residue with 1-18C, opt. substd. by =O or OH or phenyl alkylphenyl, aralkylphenyl, arylphenyl, acylphenyl, alkoxyphenyl or halophenyl gp. R1 = H or lower alkyl R2 = Me or Et, R3 = t-amyl or t-butyl; R4 = lower alkyl.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7110910A FR2130975A5 (en) | 1971-03-29 | 1971-03-29 | Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7110910A FR2130975A5 (en) | 1971-03-29 | 1971-03-29 | Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2130975A5 true FR2130975A5 (en) | 1972-11-10 |
Family
ID=9074280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7110910A Expired FR2130975A5 (en) | 1971-03-29 | 1971-03-29 | Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2130975A5 (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0637959A1 (en) * | 1992-04-30 | 1995-02-15 | The Regents Of The University Of California | Soluble analogs of probucol |
US6121319A (en) * | 1997-05-14 | 2000-09-19 | Atherogenics, Inc. | Monoesters of probucol for the treatment of cardiovascular and inflammatory disease |
US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
US6852878B2 (en) | 1998-05-14 | 2005-02-08 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of VCAM-1 |
US6881860B2 (en) | 2000-04-11 | 2005-04-19 | Atherogenics, Inc. | Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality |
US6960683B2 (en) | 2002-07-12 | 2005-11-01 | Atherogenics, Inc. | Salt forms of poorly soluble probucol esters and ethers |
US7071158B2 (en) | 1997-07-01 | 2006-07-04 | Atherogenics, Inc. | Antioxidant enhancement of therapy for hyperproliferative conditions |
US7271274B2 (en) | 2004-04-20 | 2007-09-18 | Ahterogenics, Inc. | Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease |
US7273948B2 (en) | 2003-01-13 | 2007-09-25 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
US7294737B2 (en) | 2004-04-20 | 2007-11-13 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
WO2008118948A1 (en) | 2007-03-26 | 2008-10-02 | Atherogenics, Inc. | Methods and compositions of derivatives of probucol for the treatment of diabetes |
US7687659B2 (en) | 2005-04-21 | 2010-03-30 | Salutria Pharmaceuticals Llc | Process for the separation of probucol derivatives |
US7897776B2 (en) | 2007-04-23 | 2011-03-01 | Salutria Pharmaceuticals Llc | Sulfonamide containing compounds for treatment of inflammatory disorders |
-
1971
- 1971-03-29 FR FR7110910A patent/FR2130975A5/en not_active Expired
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0637959A1 (en) * | 1992-04-30 | 1995-02-15 | The Regents Of The University Of California | Soluble analogs of probucol |
EP0637959A4 (en) * | 1992-04-30 | 1995-03-29 | Univ California | Soluble analogs of probucol. |
EP1161946A3 (en) * | 1992-04-30 | 2003-12-10 | AtheroGenics, Inc. | Soluble analogs of probucol |
US6121319A (en) * | 1997-05-14 | 2000-09-19 | Atherogenics, Inc. | Monoesters of probucol for the treatment of cardiovascular and inflammatory disease |
US6147250A (en) * | 1997-05-14 | 2000-11-14 | Atherogenics, Inc. | Compounds and methods for the inhibition of the expression of VCAM-1 |
US6548699B1 (en) | 1997-05-14 | 2003-04-15 | Atherogenics, Inc. | Compounds and methods for the inhibition of the expression of VCAM-1 |
US6617352B2 (en) | 1997-05-14 | 2003-09-09 | Atherogenics, Inc. | Compounds and methods for the inhibition of the expression of VCAM-1 |
US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
US6828447B2 (en) | 1997-05-14 | 2004-12-07 | Atherogenics, Inc. | Compounds and methods for the inhibition of the expression of VCAM-1 |
US7375252B2 (en) | 1997-05-14 | 2008-05-20 | Atherogenics, Inc. | Compounds and method for the inhibition of the expression of VCAM-1 |
US7189870B2 (en) | 1997-05-14 | 2007-03-13 | Atherogenic, Inc. | Compounds and methods for the inhibition of the expression of VCAM-1 |
US7087645B2 (en) | 1997-05-14 | 2006-08-08 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
US7071158B2 (en) | 1997-07-01 | 2006-07-04 | Atherogenics, Inc. | Antioxidant enhancement of therapy for hyperproliferative conditions |
US6852878B2 (en) | 1998-05-14 | 2005-02-08 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of VCAM-1 |
US7183317B2 (en) | 2000-04-11 | 2007-02-27 | Atherogenics, Inc. | Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality |
US6881860B2 (en) | 2000-04-11 | 2005-04-19 | Atherogenics, Inc. | Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality |
US7371895B2 (en) | 2002-07-12 | 2008-05-13 | Atherogenics, Inc. | Salt forms of poorly soluble probucol esters and ethers |
US6960683B2 (en) | 2002-07-12 | 2005-11-01 | Atherogenics, Inc. | Salt forms of poorly soluble probucol esters and ethers |
US7622604B2 (en) | 2003-01-13 | 2009-11-24 | Salutria Pharmaceuticals Llc | Process of preparing esters and ethers of probucol and derivatives thereof |
US7273948B2 (en) | 2003-01-13 | 2007-09-25 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
US7294737B2 (en) | 2004-04-20 | 2007-11-13 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
US7271274B2 (en) | 2004-04-20 | 2007-09-18 | Ahterogenics, Inc. | Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease |
US7687659B2 (en) | 2005-04-21 | 2010-03-30 | Salutria Pharmaceuticals Llc | Process for the separation of probucol derivatives |
WO2008118948A1 (en) | 2007-03-26 | 2008-10-02 | Atherogenics, Inc. | Methods and compositions of derivatives of probucol for the treatment of diabetes |
US8252840B2 (en) | 2007-03-26 | 2012-08-28 | Salutria Pharmaceuticals Llc | Methods of derivatives of probucol for the treatment of type II diabetes |
US7897776B2 (en) | 2007-04-23 | 2011-03-01 | Salutria Pharmaceuticals Llc | Sulfonamide containing compounds for treatment of inflammatory disorders |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |