FR2140769A5 - Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents - Google Patents

Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents

Info

Publication number
FR2140769A5
FR2140769A5 FR7120544A FR7120544A FR2140769A5 FR 2140769 A5 FR2140769 A5 FR 2140769A5 FR 7120544 A FR7120544 A FR 7120544A FR 7120544 A FR7120544 A FR 7120544A FR 2140769 A5 FR2140769 A5 FR 2140769A5
Authority
FR
France
Prior art keywords
benzofuryloxy
derivs
lower alkyl
alkanoic
tert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7120544A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR7120544A priority Critical patent/FR2140769A5/en
Application granted granted Critical
Publication of FR2140769A5 publication Critical patent/FR2140769A5/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Abstract

Cpds. are of formula (I): (where B = straight or branched, satd or ethylenic divalent hydrocarbon of 1-5C; R1 = H or lower alkyl, R2 = methyl or ethyl, R3 = tert. amyl or tert. butyl, R4 = lower alkyl, X = H or lower alkyl). The cpds. are prepd. by esterification of the bis-(4-hydroxy phenyl thio)alkane with the appropriate benzofuryloxy alkanoic acid or its derivs. In an example 268g bis 2,2-(3,5-di tert butyl-4-hydroxy phenylthio)propane was treated with 253g. (2-methyl-5-benzofuran)-2-oxy-2-methyl propionyl chloride in triethylamine and benzene to give corresp. (I).
FR7120544A 1971-06-07 1971-06-07 Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents Expired FR2140769A5 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7120544A FR2140769A5 (en) 1971-06-07 1971-06-07 Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7120544A FR2140769A5 (en) 1971-06-07 1971-06-07 Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents

Publications (1)

Publication Number Publication Date
FR2140769A5 true FR2140769A5 (en) 1973-01-19

Family

ID=9078216

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7120544A Expired FR2140769A5 (en) 1971-06-07 1971-06-07 Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents

Country Status (1)

Country Link
FR (1) FR2140769A5 (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6121319A (en) * 1997-05-14 2000-09-19 Atherogenics, Inc. Monoesters of probucol for the treatment of cardiovascular and inflammatory disease
US6323359B1 (en) * 2000-05-02 2001-11-27 Salsbury Chemicals, Inc. Process for preparing probucol derivatives
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6852878B2 (en) 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
US6881860B2 (en) 2000-04-11 2005-04-19 Atherogenics, Inc. Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
US6960683B2 (en) 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
US7071158B2 (en) 1997-07-01 2006-07-04 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
US7166605B2 (en) 2002-03-22 2007-01-23 Nicox, S.A. Probucol nitro-derivatives
US7271274B2 (en) 2004-04-20 2007-09-18 Ahterogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US7273948B2 (en) 2003-01-13 2007-09-25 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US7294737B2 (en) 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
WO2008118948A1 (en) 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
US7687659B2 (en) 2005-04-21 2010-03-30 Salutria Pharmaceuticals Llc Process for the separation of probucol derivatives
US7897776B2 (en) 2007-04-23 2011-03-01 Salutria Pharmaceuticals Llc Sulfonamide containing compounds for treatment of inflammatory disorders

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087645B2 (en) 1997-05-14 2006-08-08 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6828447B2 (en) 1997-05-14 2004-12-07 Atherogenics, Inc. Compounds and methods for the inhibition of the expression of VCAM-1
US6121319A (en) * 1997-05-14 2000-09-19 Atherogenics, Inc. Monoesters of probucol for the treatment of cardiovascular and inflammatory disease
US6147250A (en) * 1997-05-14 2000-11-14 Atherogenics, Inc. Compounds and methods for the inhibition of the expression of VCAM-1
US6602914B2 (en) 1997-05-14 2003-08-05 Atherogenics, Inc. Compounds and methods for the inhibition of the expression of VCAM-1
US6617352B2 (en) 1997-05-14 2003-09-09 Atherogenics, Inc. Compounds and methods for the inhibition of the expression of VCAM-1
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6548699B1 (en) 1997-05-14 2003-04-15 Atherogenics, Inc. Compounds and methods for the inhibition of the expression of VCAM-1
US7189870B2 (en) 1997-05-14 2007-03-13 Atherogenic, Inc. Compounds and methods for the inhibition of the expression of VCAM-1
US7375252B2 (en) 1997-05-14 2008-05-20 Atherogenics, Inc. Compounds and method for the inhibition of the expression of VCAM-1
US7071158B2 (en) 1997-07-01 2006-07-04 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
US6852878B2 (en) 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
US6881860B2 (en) 2000-04-11 2005-04-19 Atherogenics, Inc. Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
US7183317B2 (en) 2000-04-11 2007-02-27 Atherogenics, Inc. Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
US6323359B1 (en) * 2000-05-02 2001-11-27 Salsbury Chemicals, Inc. Process for preparing probucol derivatives
US7166605B2 (en) 2002-03-22 2007-01-23 Nicox, S.A. Probucol nitro-derivatives
US7371895B2 (en) 2002-07-12 2008-05-13 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
US6960683B2 (en) 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
US7273948B2 (en) 2003-01-13 2007-09-25 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US7622604B2 (en) 2003-01-13 2009-11-24 Salutria Pharmaceuticals Llc Process of preparing esters and ethers of probucol and derivatives thereof
US7271274B2 (en) 2004-04-20 2007-09-18 Ahterogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US7294737B2 (en) 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US7687659B2 (en) 2005-04-21 2010-03-30 Salutria Pharmaceuticals Llc Process for the separation of probucol derivatives
US8252840B2 (en) 2007-03-26 2012-08-28 Salutria Pharmaceuticals Llc Methods of derivatives of probucol for the treatment of type II diabetes
WO2008118948A1 (en) 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
US7897776B2 (en) 2007-04-23 2011-03-01 Salutria Pharmaceuticals Llc Sulfonamide containing compounds for treatment of inflammatory disorders

Similar Documents

Publication Publication Date Title
FR2140769A5 (en) Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents
SE7601755L (en) USE OF PERFLUORAL CANCULPHONAMIDES AND / OR AMMONIUM SALTS OF PERFLUORAL CANCULPHONIC ACIDS AND / OR CYCLIMMONIUM SALTS OF PERFLUORAL CANCULPHONIC ACIDS AS FORMSLEPLO MOLE MOLES
FR2140771A5 (en) Tetralinyl phenoxy alkanoic esters - of bis hydroxyphenylthio alkanes, hypolipemics etc
FR2134810A5 (en) Bis-(3-alkyl-5-t-alkyl-4-(thiazole-5-carboxy)phenylthio) alcanes - - with hypocholesterolaemic and hypolipaemic activity
GB1396628A (en) Diene sulphones
FR2445355A1 (en) Storage stable UV-hardenable epoxy-silane compsn. - contg. di:aryl-iodonium salt as catalyst for prodn. of coating, photoresist insulator, sealant etc.
GB1160403A (en) Substituted 4-Nitropyrazoles
ES514824A0 (en) "PROCEDURE OF PREPARATION OF URSODESOXICOLICO ACID".
GB1060576A (en) Aromatic polyquinazolinediones
GB1206359A (en) Method for production of aminoalkyl fumarates
GB741007A (en) Improvements relating to triorganosilylbenzamides
ATE18205T1 (en) N-SULFENYLATED PHENETHYLSULFONAMIDES.
GB1058111A (en) Improvements in or relating to the purification of gelatin
GB1167202A (en) Hydroxy-Substituted Thio-Ethers.
ES402285A1 (en) A method of inducing fibrinolysis
ES386460A1 (en) N-sulfonyl-indole-3-acetamides
FR2071042A5 (en) 1-phenyl-1-substd-2,2-dihaloethyl esters - active as insecticides - and herbicides
GB1352089A (en) Bis-styryltriazoles their use for the optical brightening of organic materials and processes for their manufacture
GB1015786A (en) New 2-chloro-thiazole compounds
ES375396A1 (en) Epoxyethylphosphonic acid derivatives
FR2276812A1 (en) 1-Ethyl-4-(halophenyl)benzenes - with antithrombotic and antiinflammatory activity
GB848370A (en) Diaryldisulfides containing arylsulfonoxy groups
GB966795A (en) Hard synthetic waxes, their production and their conversion to emulsifiable syntheticwaxes
GB1414424A (en) Bisphenol derivative
GB1500023A (en) Manufacture of 1-aryl-3-carboxy-pyrazolid-5-ones

Legal Events

Date Code Title Description
ST Notification of lapse