SG142207A1 - Process of preparing esters and ethers of probucol and derivatives thereof - Google Patents
Process of preparing esters and ethers of probucol and derivatives thereofInfo
- Publication number
- SG142207A1 SG142207A1 SG200705127-9A SG2007051279A SG142207A1 SG 142207 A1 SG142207 A1 SG 142207A1 SG 2007051279 A SG2007051279 A SG 2007051279A SG 142207 A1 SG142207 A1 SG 142207A1
- Authority
- SG
- Singapore
- Prior art keywords
- probucol
- ethers
- derivative
- derivatives
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43966503P | 2003-01-13 | 2003-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG142207A1 true SG142207A1 (en) | 2008-05-28 |
Family
ID=32713499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200705127-9A SG142207A1 (en) | 2003-01-13 | 2004-01-13 | Process of preparing esters and ethers of probucol and derivatives thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7273948B2 (es) |
| EP (1) | EP1594824A4 (es) |
| JP (1) | JP4550800B2 (es) |
| CN (2) | CN101391972A (es) |
| AU (1) | AU2004204824B2 (es) |
| BR (1) | BRPI0406738A (es) |
| CA (1) | CA2512980A1 (es) |
| HK (1) | HK1090633A1 (es) |
| IL (1) | IL169662A (es) |
| MX (1) | MXPA05007548A (es) |
| SG (1) | SG142207A1 (es) |
| WO (1) | WO2004062622A2 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4467429B2 (ja) * | 2002-07-12 | 2010-05-26 | アセロジエニクス・インコーポレイテツド | 低溶解性プロブコールエステル類およびエーテル類の新規な塩形態 |
| US7273948B2 (en) * | 2003-01-13 | 2007-09-25 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
| US7294736B2 (en) * | 2004-04-09 | 2007-11-13 | Cambrex Charles City, Inc. | Process for preparation of probucol derivatives |
| US7294737B2 (en) | 2004-04-20 | 2007-11-13 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
| JP2008505097A (ja) * | 2004-07-01 | 2008-02-21 | アセロジエニクス・インコーポレイテツド | 糖尿病性血管疾患を治療するための化合物および方法 |
| US20060194981A1 (en) * | 2005-02-26 | 2006-08-31 | Jass Paul A | Process for preparation of probucol derivatives |
| SG161305A1 (en) * | 2005-04-21 | 2010-05-27 | Atherogenics Inc | Process for the separation of probucol derivatives |
| US20070275174A1 (en) * | 2006-05-24 | 2007-11-29 | Hanson Eric L | Fishing fly and fly fishing line with fluorocarbon coating |
| CN105001129B (zh) * | 2015-08-18 | 2017-06-16 | 齐鲁安替（临邑）制药有限公司 | 一种高收率普罗布考精制析晶方法 |
| CN111434647A (zh) * | 2019-01-14 | 2020-07-21 | 中国科学院上海药物研究所 | 普罗布考单琥珀酸酯的多晶型 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3576883A (en) | 1969-06-30 | 1971-04-27 | Consolidation Coal Co | Alkylidenedithiobisphenols |
| FR2130975A5 (en) | 1971-03-29 | 1972-11-10 | Aries Robert | Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics |
| FR2133024A5 (en) | 1971-04-06 | 1972-11-24 | Aries Robert | Bis-(4-nicotinoyloxyphenylthio) propanes - with hypocholesterolaemic and hypolipaemic activity |
| FR2134810A5 (en) | 1971-04-21 | 1972-12-08 | Aries Robert | Bis-(3-alkyl-5-t-alkyl-4-(thiazole-5-carboxy)phenylthio) alcanes - - with hypocholesterolaemic and hypolipaemic activity |
| FR2140769A5 (en) | 1971-06-07 | 1973-01-19 | Aries Robert | Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents |
| FR2140771A5 (en) | 1971-06-07 | 1973-01-19 | Aries Robert | Tetralinyl phenoxy alkanoic esters - of bis hydroxyphenylthio alkanes, hypolipemics etc |
| FR2168137A1 (en) | 1972-01-17 | 1973-08-31 | Dynachim Sarl | Bis 4-hydroxyphenylthioalkane esters - with hypocholesterolaemic and hypolipaemic activities |
| US3952064A (en) | 1973-03-12 | 1976-04-20 | Crown Zellerbach Corporation | Process for producing mercaptophenols |
| US4752616A (en) | 1987-06-29 | 1988-06-21 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use |
| JPH01283261A (ja) * | 1988-05-07 | 1989-11-14 | Sanshin Chem Ind Co Ltd | アルキル化方法 |
| DE3929913A1 (de) | 1989-09-08 | 1991-04-04 | Hoechst Ag | 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte |
| US5155250A (en) | 1990-07-05 | 1992-10-13 | Merrell Dow Pharmaceuticals Inc. | 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents |
| FR2666583B1 (fr) | 1990-09-06 | 1994-09-09 | Adir | Nouveaux derives du spiro [4.5] decane, leur procede de preparation et leurs compositions pharmaceutiques les renfermant. |
| US5262439A (en) * | 1992-04-30 | 1993-11-16 | The Regents Of The University Of California | Soluble analogs of probucol |
| US5380747A (en) * | 1992-10-30 | 1995-01-10 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
| US5783596A (en) * | 1992-10-30 | 1998-07-21 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
| FR2704224B1 (fr) | 1993-04-20 | 1995-08-25 | Adir | Nouveaux acides et esters phénoxy isobutyriques substitués. |
| US5792787A (en) * | 1995-06-07 | 1998-08-11 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
| FR2738817B1 (fr) | 1995-09-14 | 1997-10-17 | Adir | Nouveaux acides et esters 2,2-dimethyl-omega-phenoxy alcanoiques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5608095A (en) | 1996-04-30 | 1997-03-04 | Hoechst Marion Roussel, Inc. | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
| EA009370B1 (ru) * | 1997-05-14 | 2007-12-28 | Атеродженикс, Инк. | Соединение и фармацевтическая композиция для ингибирования экспрессии vcam-1 |
| US6670398B2 (en) * | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| WO1999024400A1 (en) * | 1997-11-10 | 1999-05-20 | Vyrex Corporation | Probucol esters and uses thereof |
| JP3344331B2 (ja) | 1998-09-30 | 2002-11-11 | 日本電気株式会社 | 不揮発性半導体記憶装置 |
| CA2403823A1 (en) | 2000-03-21 | 2001-09-27 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of vcam-1 |
| US6323359B1 (en) | 2000-05-02 | 2001-11-27 | Salsbury Chemicals, Inc. | Process for preparing probucol derivatives |
| CA2444429A1 (en) * | 2001-04-11 | 2002-11-07 | Atherogenics, Inc. | Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality |
| US6806381B2 (en) * | 2001-11-02 | 2004-10-19 | Bristol-Myers Squibb Company | Process for the preparation of aniline-derived thyroid receptor ligands |
| US7273948B2 (en) * | 2003-01-13 | 2007-09-25 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
| US20060025481A1 (en) * | 2004-02-09 | 2006-02-02 | Strange Matthew L | Process for preparation of probucol derivatives and polymorphic forms thereof |
| US7294737B2 (en) * | 2004-04-20 | 2007-11-13 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
-
2004
- 2004-01-13 US US10/757,664 patent/US7273948B2/en not_active Expired - Fee Related
- 2004-01-13 WO PCT/US2004/000805 patent/WO2004062622A2/en active Application Filing
- 2004-01-13 BR BR0406738-0A patent/BRPI0406738A/pt not_active IP Right Cessation
- 2004-01-13 AU AU2004204824A patent/AU2004204824B2/en not_active Ceased
- 2004-01-13 SG SG200705127-9A patent/SG142207A1/en unknown
- 2004-01-13 CA CA002512980A patent/CA2512980A1/en not_active Abandoned
- 2004-01-13 JP JP2006500935A patent/JP4550800B2/ja not_active Expired - Fee Related
- 2004-01-13 MX MXPA05007548A patent/MXPA05007548A/es active IP Right Grant
- 2004-01-13 CN CNA2008102158866A patent/CN101391972A/zh active Pending
- 2004-01-13 EP EP04701812A patent/EP1594824A4/en not_active Withdrawn
- 2004-01-13 CN CNB2004800062657A patent/CN100548950C/zh not_active Expired - Fee Related
-
2005
- 2005-07-13 IL IL169662A patent/IL169662A/en not_active IP Right Cessation
-
2006
- 2006-10-12 HK HK06111244.5A patent/HK1090633A1/xx not_active IP Right Cessation
-
2007
- 2007-09-13 US US11/854,939 patent/US7622604B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1594824A4 (en) | 2007-04-04 |
| HK1090633A1 (en) | 2006-12-29 |
| CN100548950C (zh) | 2009-10-14 |
| JP4550800B2 (ja) | 2010-09-22 |
| AU2004204824A1 (en) | 2004-07-29 |
| MXPA05007548A (es) | 2005-10-20 |
| US7622604B2 (en) | 2009-11-24 |
| AU2004204824B2 (en) | 2010-12-23 |
| WO2004062622A3 (en) | 2004-12-02 |
| CN101391972A (zh) | 2009-03-25 |
| IL169662A (en) | 2011-10-31 |
| WO2004062622A2 (en) | 2004-07-29 |
| CA2512980A1 (en) | 2004-07-29 |
| EP1594824A2 (en) | 2005-11-16 |
| US7273948B2 (en) | 2007-09-25 |
| BRPI0406738A (pt) | 2005-12-20 |
| US20080009642A1 (en) | 2008-01-10 |
| CN1759084A (zh) | 2006-04-12 |
| US20040204485A1 (en) | 2004-10-14 |
| JP2006516569A (ja) | 2006-07-06 |
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