HUP9900684A2 - Új 19-nor-pregnén-származékok - Google Patents

Új 19-nor-pregnén-származékok

Info

Publication number
HUP9900684A2
HUP9900684A2 HU9900684A HUP9900684A HUP9900684A2 HU P9900684 A2 HUP9900684 A2 HU P9900684A2 HU 9900684 A HU9900684 A HU 9900684A HU P9900684 A HUP9900684 A HU P9900684A HU P9900684 A2 HUP9900684 A2 HU P9900684A2
Authority
HU
Hungary
Prior art keywords
general formula
carbon atoms
compounds
alkyl
pipe powder
Prior art date
Application number
HU9900684A
Other languages
English (en)
Inventor
Rémi Delansorne
Jean Lafay
Jacques Paris
Jean-Claude Pascal
Alain Piasco
Original Assignee
Laboratoire Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire Theramex filed Critical Laboratoire Theramex
Publication of HUP9900684A2 publication Critical patent/HUP9900684A2/hu
Publication of HUP9900684A3 publication Critical patent/HUP9900684A3/hu
Publication of HU221796B1 publication Critical patent/HU221796B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány az (I) általánős képletű vegyületekre - az (I) általánősképletben R1, R2, R3, R4 és R6 egymástól függetlenül hidrőgénatőmőtvagy 1-6 szénatőmőt tartalmazó alkilcsőpőrtőt jelent, R5 jelentésehidrőgénatőm, 1-6 szénatőmőt tartalmazó alkilcsőpőrt vagy -COR7általánős képletű csőpőrt, és az űtóbbi képletben R7 jelentése 1-6szénatőmőt tartalmazó alkilcsőpőrt, n értéke 0 vagy 1, és X jelentéseőxigénatőm vagy egy hidrőxi-iminő-csőpőrt, azzal a megkötéssel, hőgyha n értéke 0, akkőr R1, R2, R3 és R4 közül legalább kettő jelentésehidrőgénatőmtól eltérő, és ha n értéke 1, akkőr R3 és R4 egyidejűjelentése hidrőgénatőmtól eltérő - és ilyen vegyületeket tartalmazógyógyászati készítményekre vőnatkőzik. A találmány szerinti vegyületekkiváló prőgesztőgének maradék andrőgénaktivitástól mentesen. ŕ
HU9900684A 1996-01-22 1997-01-17 Új 19-nor-pregnén-származékok HU221796B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96400146A EP0785212A1 (en) 1996-01-22 1996-01-22 New 19-nor-pregnene derivatives
PCT/EP1997/000357 WO1997027210A1 (en) 1996-01-22 1997-01-17 New 19-nor-pregnene derivatives

Publications (3)

Publication Number Publication Date
HUP9900684A2 true HUP9900684A2 (hu) 1999-07-28
HUP9900684A3 HUP9900684A3 (en) 1999-11-29
HU221796B1 HU221796B1 (hu) 2003-01-28

Family

ID=8225217

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900684A HU221796B1 (hu) 1996-01-22 1997-01-17 Új 19-nor-pregnén-származékok

Country Status (36)

Country Link
US (1) US6180803B1 (hu)
EP (2) EP0785212A1 (hu)
JP (2) JP4368945B2 (hu)
KR (1) KR100396902B1 (hu)
CN (1) CN1187366C (hu)
AP (1) AP1176A (hu)
AR (1) AR005500A1 (hu)
AT (1) ATE184015T1 (hu)
BR (1) BR9707064A (hu)
CA (1) CA2243504C (hu)
CO (1) CO4810230A1 (hu)
CZ (1) CZ292047B6 (hu)
DE (1) DE69700470T2 (hu)
DZ (1) DZ2169A1 (hu)
EE (1) EE03692B1 (hu)
ES (1) ES2140961T3 (hu)
GR (1) GR3031954T3 (hu)
HK (1) HK1018216A1 (hu)
HU (1) HU221796B1 (hu)
ID (1) ID15840A (hu)
IL (1) IL125379A (hu)
IS (1) IS1902B (hu)
JO (1) JO1971B1 (hu)
MY (1) MY116845A (hu)
NO (1) NO309572B1 (hu)
NZ (1) NZ330954A (hu)
OA (1) OA10813A (hu)
PE (1) PE55998A1 (hu)
PL (1) PL185608B1 (hu)
RU (1) RU2166509C2 (hu)
SI (1) SI0886645T1 (hu)
TN (1) TNSN97015A1 (hu)
TR (1) TR199801399T2 (hu)
TW (1) TW411345B (hu)
WO (1) WO1997027210A1 (hu)
ZA (1) ZA97521B (hu)

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FR2776191B1 (fr) * 1998-03-23 2002-05-31 Theramex Composition hormonale topique a effet systemique
TWI290549B (en) * 2000-06-02 2007-12-01 Astrazeneca Ab Process for the preparation of cyclopropyl carboxylic acid ester and derivatives
DE60143360D1 (de) 2000-08-03 2010-12-09 Antares Pharma Ipl Ag Zusammensetzung zur transdermalen und/oder transmukosalen Verabreichung von Wirkstoffen, die ausreichende therapeutische Spiegel garantiert
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US20070225379A1 (en) * 2001-08-03 2007-09-27 Carrara Dario Norberto R Transdermal delivery of systemically active central nervous system drugs
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US20040198706A1 (en) * 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
FR2814074B1 (fr) * 2000-09-15 2003-03-07 Theramex Nouvelles compositions estro-progestatives topiques a effet systemique
US9532995B2 (en) * 2003-09-03 2017-01-03 Miscon Trading S.A. Methods for the treatment of endometriosis
JP5619337B2 (ja) * 2003-10-10 2014-11-05 フェリング ビー．ブイ． 皮膚残渣を最小限に抑えるための経皮的医薬製剤
US7425340B2 (en) * 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
WO2007124250A2 (en) 2006-04-21 2007-11-01 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
WO2006125642A1 (en) * 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
WO2008067991A2 (en) * 2006-12-08 2008-06-12 Antares Pharma Ipl Ag Skin-friendly drug complexes for transdermal administration
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
PT2782584T (pt) 2011-11-23 2021-09-02 Therapeuticsmd Inc Preparações e terapias de substituição para hormonoterapias naturais combinadas
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
MX2016014281A (es) 2014-05-22 2017-02-22 Therapeuticsmd Inc Formulaciones y terapias de reemplazo de combinación de hormonas naturales.
US9173915B1 (en) * 2014-10-10 2015-11-03 Peter F. Kador Antioxidant eye drops
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
CN109481450B (zh) * 2015-09-02 2021-07-23 盛世泰科生物医药技术(苏州)有限公司 一种用于预防和治疗白内障的眼用制剂及其制备方法
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
KR20180126582A (ko) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 스테로이드 호르몬 약제학적 조성물
CN110452279B (zh) * 2019-05-13 2022-04-08 株洲千金药业股份有限公司 三萜类化合物和其药学上可接受的盐及制备方法和应用

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Also Published As

Publication number Publication date
DZ2169A1 (fr) 2002-12-25
PL327998A1 (en) 1999-01-04
TR199801399T2 (xx) 1998-10-21
CA2243504C (en) 2004-03-30
JP2000503980A (ja) 2000-04-04
NO983356L (no) 1998-07-21
BR9707064A (pt) 1999-12-28
MY116845A (en) 2004-04-30
KR19990081895A (ko) 1999-11-15
IS1902B (is) 2003-11-20
ID15840A (id) 1997-08-14
PE55998A1 (es) 1998-10-01
CO4810230A1 (es) 1999-06-30
EP0886645A1 (en) 1998-12-30
CZ230798A3 (cs) 1998-11-11
AR005500A1 (es) 1999-06-23
WO1997027210A1 (en) 1997-07-31
OA10813A (en) 2003-01-28
ES2140961T3 (es) 2000-03-01
CA2243504A1 (en) 1997-07-31
JP4368945B2 (ja) 2009-11-18
ZA97521B (en) 1997-08-04
AU1595597A (en) 1997-08-20
NO983356D0 (no) 1998-07-21
IS4800A (is) 1998-07-21
EP0785212A1 (en) 1997-07-23
RU2166509C2 (ru) 2001-05-10
HUP9900684A3 (en) 1999-11-29
PL185608B1 (pl) 2003-06-30
IL125379A (en) 2003-05-29
NO309572B1 (no) 2001-02-19
HU221796B1 (hu) 2003-01-28
HK1018216A1 (en) 1999-12-17
AU708135B2 (en) 1999-07-29
EE9800219A (xx) 1998-12-15
DE69700470D1 (de) 1999-10-07
JO1971B1 (en) 1997-12-15
DE69700470T2 (de) 2000-03-30
CZ292047B6 (cs) 2003-07-16
EE03692B1 (et) 2002-04-15
KR100396902B1 (ko) 2004-05-03
CN1209811A (zh) 1999-03-03
AP1176A (en) 2003-06-30
SI0886645T1 (en) 1999-12-31
AP9801299A0 (en) 1998-09-30
GR3031954T3 (en) 2000-03-31
ATE184015T1 (de) 1999-09-15
US6180803B1 (en) 2001-01-30
CN1187366C (zh) 2005-02-02
NZ330954A (en) 1998-10-28
JP2009167188A (ja) 2009-07-30
TNSN97015A1 (fr) 2005-03-15
EP0886645B1 (en) 1999-09-01
TW411345B (en) 2000-11-11
IL125379A0 (en) 1999-03-12

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