HUP0105142A2 - 4-oxo-1,4-dihidro-3-kinolin-karboxamid-származékok, mint vírusellenes hatóanyagok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

4-oxo-1,4-dihidro-3-kinolin-karboxamid-származékok, mint vírusellenes hatóanyagok és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0105142A2
HUP0105142A2 HU0105142A HUP0105142A HUP0105142A2 HU P0105142 A2 HUP0105142 A2 HU P0105142A2 HU 0105142 A HU0105142 A HU 0105142A HU P0105142 A HUP0105142 A HU P0105142A HU P0105142 A2 HUP0105142 A2 HU P0105142A2
Authority
HU
Hungary
Prior art keywords
formula
group
antiviral agents
quinolinecarboxamides
dihydro
Prior art date
Application number
HU0105142A
Other languages
English (en)
Inventor
Mark E. Schnute
Allen Scott
Joseph Walter Strohbach
Suvit Thaisrivongs
Steven Ronald Turner
Valerie A. Vaillancourt
Original Assignee
Pharmacia & Upjohn Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co. filed Critical Pharmacia & Upjohn Co.
Publication of HUP0105142A2 publication Critical patent/HUP0105142A2/hu
Publication of HUP0105142A3 publication Critical patent/HUP0105142A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A tal lm ny (I) ltal nos képletű vegyületekre és azok gyógy szatilagelfogadható sóira vonatkozik - a képletben R1 jelentése 1-7 szénatomosalkilcsoport, amely adott esetbenszubsztitu lva van hidroxilcsoporttalvagy NR4R5 ltal nos képletű csoporttal; R2 jelentése 1-7 szénatomosalkilcsoport, amely szubsztitu lva van hidroxilcsoporttal vagy NR4R5ltal nos képletű csoporttal; R3 jelentése H, F vagy 1-7 szénatomosalkoxicsoport; R4 és R5 jelentése a szomszédos nitrogénatommal együtt5- vagy 6-tagú heterociklusos csoport, amely nitrogén, oxigén és kénk"zül kiv lasztott 1-3 heteroatomot tartalmaz, ahol a kénatomszubsztitu lva lehet egy vagy két oxigénatommal -. Az (I) ltal nosképletű vegyületek vírusellenes hatóanyagokként alkalmazhatók. Ó
HU0105142A 1999-01-08 1999-12-22 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents HUP0105142A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11511399P 1999-01-08 1999-01-08
US13839099P 1999-06-09 1999-06-09
US14061499P 1999-06-23 1999-06-23
PCT/US1999/027959 WO2000040563A1 (en) 1999-01-08 1999-12-22 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents

Publications (2)

Publication Number Publication Date
HUP0105142A2 true HUP0105142A2 (hu) 2002-04-29
HUP0105142A3 HUP0105142A3 (en) 2002-05-28

Family

ID=27381602

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105142A HUP0105142A3 (en) 1999-01-08 1999-12-22 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents

Country Status (28)

Country Link
US (1) US6248736B1 (hu)
EP (1) EP1140851B1 (hu)
JP (1) JP2002534417A (hu)
KR (1) KR20010101428A (hu)
CN (1) CN1132818C (hu)
AT (1) ATE275134T1 (hu)
AU (1) AU2158300A (hu)
BR (1) BR9916781A (hu)
CA (1) CA2353634A1 (hu)
CO (1) CO5150150A1 (hu)
CZ (1) CZ20012458A3 (hu)
DE (1) DE69919897T2 (hu)
EA (1) EA004043B1 (hu)
ES (1) ES2228162T3 (hu)
HK (1) HK1041879A1 (hu)
HU (1) HUP0105142A3 (hu)
ID (1) ID29452A (hu)
IL (1) IL144170A0 (hu)
MY (1) MY118904A (hu)
NO (1) NO320396B1 (hu)
NZ (1) NZ512823A (hu)
PE (1) PE20001337A1 (hu)
PL (1) PL348769A1 (hu)
PT (1) PT1140851E (hu)
SK (1) SK8312001A3 (hu)
TR (1) TR200101893T2 (hu)
TW (1) TW593281B (hu)
WO (1) WO2000040563A1 (hu)

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CA2433467A1 (en) 2001-03-01 2002-09-12 Joseph W. Strohbach Substituted quinolinecarboxamides as antiviral agents
WO2003020728A1 (en) 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS
AR038294A1 (es) 2002-01-14 2005-01-12 Upjohn Co Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales
AR038117A1 (es) 2002-01-14 2004-12-29 Upjohn Co Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida
AR038118A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales
WO2004019932A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
US20040176366A1 (en) * 2002-08-30 2004-09-09 Wathen Michael W Method of preventing or treating atherosclerosis or restenosis
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CN103068804B (zh) * 2010-08-27 2015-08-19 格吕伦塔尔有限公司 作为kcnq2/3调节剂的取代的2-氧基-喹啉-3-甲酰胺
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CA2888210C (en) 2012-10-16 2021-02-09 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of ror-gamma-t
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Also Published As

Publication number Publication date
PT1140851E (pt) 2004-12-31
HK1041879A1 (en) 2002-07-26
SK8312001A3 (en) 2001-12-03
EP1140851B1 (en) 2004-09-01
NO320396B1 (no) 2005-11-28
NO20013379L (no) 2001-07-06
DE69919897T2 (de) 2005-09-08
CA2353634A1 (en) 2000-07-13
EP1140851A1 (en) 2001-10-10
JP2002534417A (ja) 2002-10-15
ID29452A (id) 2001-08-30
PL348769A1 (en) 2002-06-17
IL144170A0 (en) 2002-05-23
ES2228162T3 (es) 2005-04-01
CZ20012458A3 (cs) 2001-12-12
NZ512823A (en) 2003-10-31
CN1132818C (zh) 2003-12-31
MY118904A (en) 2005-02-28
CN1332729A (zh) 2002-01-23
AU2158300A (en) 2000-07-24
ATE275134T1 (de) 2004-09-15
EA004043B1 (ru) 2003-12-25
DE69919897D1 (en) 2004-10-07
CO5150150A1 (es) 2002-04-29
BR9916781A (pt) 2001-12-04
EA200100755A1 (ru) 2001-12-24
TW593281B (en) 2004-06-21
KR20010101428A (ko) 2001-11-14
HUP0105142A3 (en) 2002-05-28
WO2000040563A1 (en) 2000-07-13
TR200101893T2 (tr) 2001-11-21
PE20001337A1 (es) 2000-11-23
NO20013379D0 (no) 2001-07-06
US6248736B1 (en) 2001-06-19

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