TR200101893T2 - Antiviral maddeler olarak 4-okso-1,4 dihidro -3- kuinolinkarboksamitler. - Google Patents

Antiviral maddeler olarak 4-okso-1,4 dihidro -3- kuinolinkarboksamitler.

Info

Publication number
TR200101893T2
TR200101893T2 TR2001/01893T TR200101893T TR200101893T2 TR 200101893 T2 TR200101893 T2 TR 200101893T2 TR 2001/01893 T TR2001/01893 T TR 2001/01893T TR 200101893 T TR200101893 T TR 200101893T TR 200101893 T2 TR200101893 T2 TR 200101893T2
Authority
TR
Turkey
Prior art keywords
quinolinecarboxamides
dihydro
oxo
formula
antiviral agents
Prior art date
Application number
TR2001/01893T
Other languages
English (en)
Inventor
Ronald Turner Steven
Walter Strohbach Joseph
Thaisrivongs Suvit
A. Vaillancourt Valerie
E. Schnute Mark
Scott Allen
Original Assignee
Pharmacia & Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company
Publication of TR200101893T2 publication Critical patent/TR200101893T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Formül I bir bilesik, (FORMÜL) burada, R1 istege bagli olarak hidroksi veya NR4R5 ile ikameli C1-7 alkildir; R2 hidroksi veya NR4R5 ile ikameli C1-7 alkildir; R3H, F veya C1-7 alkoksidir; R4 ve R5 N ile birlikte azot, oksijen ve kükürtten olusan gruptan seçilmis 1-3 heteroatoma sahip 5 veya 6 unsurlu heteroksiklik bir yarimdir, burada kükürt bir (1) veya iki (2) oksijen atomu ile ikame edilebilir; ve bunun farmasötik açidan kabul edilebilir bir tuzdur. Mevcut bulusa mahsus formül I bilesikler intiviral maddeler olarak faydalidirlar.
TR2001/01893T 1999-01-08 1999-12-22 Antiviral maddeler olarak 4-okso-1,4 dihidro -3- kuinolinkarboksamitler. TR200101893T2 (tr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11511399P 1999-01-08 1999-01-08
US13839099P 1999-06-09 1999-06-09
US14061499P 1999-06-23 1999-06-23

Publications (1)

Publication Number Publication Date
TR200101893T2 true TR200101893T2 (tr) 2001-11-21

Family

ID=27381602

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01893T TR200101893T2 (tr) 1999-01-08 1999-12-22 Antiviral maddeler olarak 4-okso-1,4 dihidro -3- kuinolinkarboksamitler.

Country Status (28)

Country Link
US (1) US6248736B1 (tr)
EP (1) EP1140851B1 (tr)
JP (1) JP2002534417A (tr)
KR (1) KR20010101428A (tr)
CN (1) CN1132818C (tr)
AT (1) ATE275134T1 (tr)
AU (1) AU2158300A (tr)
BR (1) BR9916781A (tr)
CA (1) CA2353634A1 (tr)
CO (1) CO5150150A1 (tr)
CZ (1) CZ20012458A3 (tr)
DE (1) DE69919897T2 (tr)
EA (1) EA004043B1 (tr)
ES (1) ES2228162T3 (tr)
HK (1) HK1041879A1 (tr)
HU (1) HUP0105142A3 (tr)
ID (1) ID29452A (tr)
IL (1) IL144170A0 (tr)
MY (1) MY118904A (tr)
NO (1) NO320396B1 (tr)
NZ (1) NZ512823A (tr)
PE (1) PE20001337A1 (tr)
PL (1) PL348769A1 (tr)
PT (1) PT1140851E (tr)
SK (1) SK8312001A3 (tr)
TR (1) TR200101893T2 (tr)
TW (1) TW593281B (tr)
WO (1) WO2000040563A1 (tr)

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US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
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AR038117A1 (es) 2002-01-14 2004-12-29 Upjohn Co Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida
AR038118A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales
AR038294A1 (es) 2002-01-14 2005-01-12 Upjohn Co Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales
AU2003262947A1 (en) * 2002-08-30 2004-03-19 Pharmacia And Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2004019933A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
CN100375742C (zh) * 2002-11-20 2008-03-19 日本烟草产业株式会社 4-氧代喹啉化合物及其用途
DK1564210T5 (da) 2002-11-20 2010-05-03 Japan Tobacco Inc 4-Oxoquinolinforbindelser og anvendelse deraf som HIV-integraseinhibitorer
CA2530352A1 (en) 2003-07-24 2005-02-03 Astellas Pharma Inc. Quinolone derivative or salt thereof
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AU2007223260C1 (en) * 2006-03-06 2011-02-03 Japan Tobacco Inc. Method for producing 4-oxoquinoline compound
DE102008036099B4 (de) 2008-08-04 2014-02-13 Steag Power Saar Gmbh Entstickungsanlage
LT2821400T (lt) 2009-03-20 2018-02-12 Vertex Pharmaceuticals Incorporated Cistinės fibrozės transmembraninio laidumo reguliatoriaus moduliatorių gamybos būdas
WO2011004389A2 (en) 2009-06-18 2011-01-13 Matrix Laboratories Ltd An improved process for the preparation of elvitegravir
CN103068804B (zh) * 2010-08-27 2015-08-19 格吕伦塔尔有限公司 作为kcnq2/3调节剂的取代的2-氧基-喹啉-3-甲酰胺
CN109966264A (zh) 2012-02-27 2019-07-05 沃泰克斯药物股份有限公司 药物组合物及其施用
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US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
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Also Published As

Publication number Publication date
NZ512823A (en) 2003-10-31
HK1041879A1 (en) 2002-07-26
CA2353634A1 (en) 2000-07-13
EA004043B1 (ru) 2003-12-25
IL144170A0 (en) 2002-05-23
US6248736B1 (en) 2001-06-19
KR20010101428A (ko) 2001-11-14
ID29452A (id) 2001-08-30
NO320396B1 (no) 2005-11-28
JP2002534417A (ja) 2002-10-15
CN1132818C (zh) 2003-12-31
NO20013379L (no) 2001-07-06
EP1140851B1 (en) 2004-09-01
PE20001337A1 (es) 2000-11-23
SK8312001A3 (en) 2001-12-03
EP1140851A1 (en) 2001-10-10
CO5150150A1 (es) 2002-04-29
CZ20012458A3 (cs) 2001-12-12
EA200100755A1 (ru) 2001-12-24
CN1332729A (zh) 2002-01-23
NO20013379D0 (no) 2001-07-06
PL348769A1 (en) 2002-06-17
ATE275134T1 (de) 2004-09-15
HUP0105142A2 (hu) 2002-04-29
WO2000040563A1 (en) 2000-07-13
AU2158300A (en) 2000-07-24
MY118904A (en) 2005-02-28
HUP0105142A3 (en) 2002-05-28
ES2228162T3 (es) 2005-04-01
PT1140851E (pt) 2004-12-31
DE69919897T2 (de) 2005-09-08
BR9916781A (pt) 2001-12-04
TW593281B (en) 2004-06-21
DE69919897D1 (en) 2004-10-07

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