BR9807349A - Composto, processos para preparar um composto e para preparar 6-o-alquil eritromicina a. - Google Patents

Composto, processos para preparar um composto e para preparar 6-o-alquil eritromicina a.

Info

Publication number
BR9807349A
BR9807349A BR9807349-4A BR9807349A BR9807349A BR 9807349 A BR9807349 A BR 9807349A BR 9807349 A BR9807349 A BR 9807349A BR 9807349 A BR9807349 A BR 9807349A
Authority
BR
Brazil
Prior art keywords
preparing
compound
processes
alkyl erythromycin
alkyl
Prior art date
Application number
BR9807349-4A
Other languages
English (en)
Inventor
Yi-Yin Ku
David A Riley
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BR9807349A publication Critical patent/BR9807349A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"COMPOSTO, PROCESSOS PARA PREPARAR UM COMPOSTO E PARA PREPARAR 6-O-ALQUIL ERITROMICINA A". A invenção divulgada refere-se a novos derivados 3'-N-O, 9-O-oxima protegida, 6-O-alquil eritromicina de fórmula (I) um processo para prepará-los. A invenção também refere-se a um processo de preparar 6-O-alquil eritromicina A pela eliminação do grupo 3'-N-oxido e grupos protetores de 9-O-oxima e, opcionalmente desproteção dos grupos hidróxi nas posições 2' e 4' em condições de reação adequadas.
BR9807349-4A 1997-02-13 1998-02-03 Composto, processos para preparar um composto e para preparar 6-o-alquil eritromicina a. BR9807349A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/800,009 US5864023A (en) 1997-02-13 1997-02-13 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
PCT/US1998/001929 WO1998035976A1 (en) 1997-02-13 1998-02-03 3'-n-oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives

Publications (1)

Publication Number Publication Date
BR9807349A true BR9807349A (pt) 2000-04-25

Family

ID=25177295

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807349-4A BR9807349A (pt) 1997-02-13 1998-02-03 Composto, processos para preparar um composto e para preparar 6-o-alquil eritromicina a.

Country Status (25)

Country Link
US (1) US5864023A (pt)
EP (1) EP0966477B1 (pt)
JP (1) JP2001512456A (pt)
KR (1) KR100561326B1 (pt)
CN (1) CN1326865C (pt)
AR (1) AR012032A1 (pt)
AT (1) ATE252108T1 (pt)
AU (1) AU725274B2 (pt)
BG (1) BG64099B1 (pt)
BR (1) BR9807349A (pt)
CA (1) CA2279932C (pt)
CZ (1) CZ294481B6 (pt)
DE (1) DE69818977T2 (pt)
DK (1) DK0966477T3 (pt)
ES (1) ES2212266T3 (pt)
HU (1) HUP0001330A3 (pt)
IL (1) IL130697A0 (pt)
NO (1) NO993876D0 (pt)
NZ (1) NZ336482A (pt)
PL (1) PL187357B1 (pt)
PT (1) PT966477E (pt)
SK (1) SK284157B6 (pt)
TR (1) TR199901874T2 (pt)
WO (1) WO1998035976A1 (pt)
ZA (1) ZA98986B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100317907B1 (ko) * 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) * 1999-07-01 2001-02-05 유충식 6-오-메틸 에리트로마이신의 제조방법
KR100336447B1 (ko) * 1999-11-24 2002-05-15 민경윤 클라리스로마이신의 개선된 제조방법
HUP0204091A3 (en) * 1999-12-16 2003-05-28 Teva Pharma Processes for preparing clarithromycin polymorphs and novel polymorph iv and pharmaceutical composition containing them and their use
ES2236023T3 (es) 2000-01-11 2005-07-16 Teva Pharmaceutical Industries Ltd. Procedimiento para preparacion de polimorfos de claritromicina.
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6617436B2 (en) * 2000-02-29 2003-09-09 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
RU2230748C2 (ru) * 2000-03-15 2004-06-20 Ханми Фарм. Ко., Лтд. Способ получения кларитромицина в виде кристаллов формы ii
KR20000037126A (ko) * 2000-04-08 2000-07-05 김용규 6-메틸 에리스로마이신 ａ의 제조방법
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
EP1648407A4 (en) * 2003-07-21 2011-08-31 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, CORRESPONDING USE AND FORMULATION
JP2006528185A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
WO2005009365A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
AU2004264939A1 (en) * 2003-08-11 2005-02-24 Middlebrook Pharmaceuticals, Inc. Robust pellet
JP2007502294A (ja) 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
CA2535780A1 (en) * 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
AU2004273830B2 (en) * 2003-09-15 2011-03-24 Shionogi, Inc. Antibiotic product, use and formulation thereof
EP1701705A4 (en) * 2003-12-24 2007-08-08 Advancis Pharmaceutical Corp IMPROVED ABSORPTION OF MODIFIED RELEASE DOSAGE FORMS
AU2005269981A1 (en) * 2004-07-02 2006-02-09 Bonck, John A Tablet for pulsed delivery
US7694523B2 (en) * 2004-07-19 2010-04-13 Earthrenew, Inc. Control system for gas turbine in material treatment unit
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) * 2007-08-09 2009-02-26 Vinod Kumar Kansal Process for the preparation of clarithromycin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331803A (en) * 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
US4670549A (en) * 1985-03-18 1987-06-02 Taisho Pharmaceutical Co., Ltd. Method for selective methylation of erythromycin a derivatives
JPS61229895A (ja) * 1985-04-03 1986-10-14 Nippon Zeon Co Ltd 保護化デス−ｎ−メチルエリスロマイシン誘導体
EP0254534A3 (en) * 1986-07-24 1991-04-17 William S. Robinson Erythromycin derivatives and compositions and use for inhibiting virus replication and disease
DE3782994T2 (de) * 1986-09-18 1993-04-08 Taisho Pharmaceutical Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法

Also Published As

Publication number Publication date
PL187357B1 (pl) 2004-06-30
US5864023A (en) 1999-01-26
CN1326865C (zh) 2007-07-18
ZA98986B (en) 1998-08-05
AU725274B2 (en) 2000-10-12
PL335301A1 (en) 2000-04-10
TR199901874T2 (xx) 2000-04-21
HUP0001330A2 (hu) 2000-08-28
NZ336482A (en) 2001-02-23
JP2001512456A (ja) 2001-08-21
IL130697A0 (en) 2000-06-01
NO993876L (no) 1999-08-11
CN1246864A (zh) 2000-03-08
EP0966477A1 (en) 1999-12-29
AU6260898A (en) 1998-09-08
NO993876D0 (no) 1999-08-11
WO1998035976A1 (en) 1998-08-20
DE69818977D1 (en) 2003-11-20
KR100561326B1 (ko) 2006-03-16
CZ294481B6 (cs) 2005-01-12
ES2212266T3 (es) 2004-07-16
BG103673A (en) 2000-02-29
EP0966477B1 (en) 2003-10-15
BG64099B1 (bg) 2003-12-31
AR012032A1 (es) 2000-09-27
CA2279932A1 (en) 1998-08-20
PT966477E (pt) 2004-03-31
HUP0001330A3 (en) 2000-09-28
CA2279932C (en) 2008-04-22
ATE252108T1 (de) 2003-11-15
SK97499A3 (en) 2000-01-18
DE69818977T2 (de) 2004-08-12
SK284157B6 (sk) 2004-10-05
KR20000070985A (ko) 2000-11-25
CZ270499A3 (cs) 1999-11-17
DK0966477T3 (da) 2004-02-23

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O E 13 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.