JPS5630998A - 1-n-(l-4-amino-2-hydroxybutyryl)derivative of 6'-c-alkyl-3'-deoxykanamycin b or 6'-c-alkyl-3',4-dideoxykanamycin b - Google Patents

1-n-(l-4-amino-2-hydroxybutyryl)derivative of 6'-c-alkyl-3'-deoxykanamycin b or 6'-c-alkyl-3',4-dideoxykanamycin b

Info

Publication number
JPS5630998A
JPS5630998A JP10729879A JP10729879A JPS5630998A JP S5630998 A JPS5630998 A JP S5630998A JP 10729879 A JP10729879 A JP 10729879A JP 10729879 A JP10729879 A JP 10729879A JP S5630998 A JPS5630998 A JP S5630998A
Authority
JP
Japan
Prior art keywords
alkyl
amino
deoxykanamycin
formula
dideoxykanamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10729879A
Other languages
Japanese (ja)
Other versions
JPS631950B2 (en
Inventor
Hamao Umezawa
Shinichi Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP10729879A priority Critical patent/JPS5630998A/en
Publication of JPS5630998A publication Critical patent/JPS5630998A/en
Publication of JPS631950B2 publication Critical patent/JPS631950B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:The titled compound shown by the formula I (R is hydroxyl or H; one of R1 and R2 is H, and the other is 1W6C alkyl) and its acid addition salt.
EXAMPLE: 1-N-( L-4-Amino-2-hydroxybutyryl )-6'( R )-C-methyl-3'-deoxykanamycin B.
USE: An antibacterial agent effective against a resistant bacterium, sensitive bacterium, etc.
PROCESS: An amino group of a 6'-C-alkyl-3'-deoxykanamycin B or 6'-C-alkyl-3', 4'-dideoxykanamycin B shown by the formula II or their derivative wherein 4 amino groups except the amino group in the 1st position, and, if necessary, hydroxyl groups, are at least partially protected by protecting groups is acylated by L-4- amino-2-hydroxybutyric acid. The protecting groups of the reaction product are removed conventionally to give a compound shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP10729879A 1979-08-24 1979-08-24 1-n-(l-4-amino-2-hydroxybutyryl)derivative of 6'-c-alkyl-3'-deoxykanamycin b or 6'-c-alkyl-3',4-dideoxykanamycin b Granted JPS5630998A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10729879A JPS5630998A (en) 1979-08-24 1979-08-24 1-n-(l-4-amino-2-hydroxybutyryl)derivative of 6'-c-alkyl-3'-deoxykanamycin b or 6'-c-alkyl-3',4-dideoxykanamycin b

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10729879A JPS5630998A (en) 1979-08-24 1979-08-24 1-n-(l-4-amino-2-hydroxybutyryl)derivative of 6'-c-alkyl-3'-deoxykanamycin b or 6'-c-alkyl-3',4-dideoxykanamycin b

Publications (2)

Publication Number Publication Date
JPS5630998A true JPS5630998A (en) 1981-03-28
JPS631950B2 JPS631950B2 (en) 1988-01-14

Family

ID=14455544

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10729879A Granted JPS5630998A (en) 1979-08-24 1979-08-24 1-n-(l-4-amino-2-hydroxybutyryl)derivative of 6'-c-alkyl-3'-deoxykanamycin b or 6'-c-alkyl-3',4-dideoxykanamycin b

Country Status (1)

Country Link
JP (1) JPS5630998A (en)

Also Published As

Publication number Publication date
JPS631950B2 (en) 1988-01-14

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