MX9205311A - Nuevos taxanos substituidos y composiciones farmaceuticas que los contienen - Google Patents

Nuevos taxanos substituidos y composiciones farmaceuticas que los contienen

Info

Publication number
MX9205311A
MX9205311A MX9205311A MX9205311A MX9205311A MX 9205311 A MX9205311 A MX 9205311A MX 9205311 A MX9205311 A MX 9205311A MX 9205311 A MX9205311 A MX 9205311A MX 9205311 A MX9205311 A MX 9205311A
Authority
MX
Mexico
Prior art keywords
contain
pharmaceutical compositions
new substituted
substituted taxanes
phenyl
Prior art date
Application number
MX9205311A
Other languages
English (en)
Inventor
Robert A Holton
Ronald J Biediger
Hossain Nadizadeh
Seokchan Kim
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State filed Critical Univ Florida State
Publication of MX9205311A publication Critical patent/MX9205311A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Toys (AREA)
  • Holo Graphy (AREA)

Abstract

Un derivado del taxano de la fórmula (III) en donde R1 y R3 se seleccionan independientemente del grupo que consiste de fenilo, naftaleno, C6H5CHCH-, y no obstante, con la condición de que R1 y R3 no sean ambos fenilo, Q es CH3-, (CH3)3C-, CH3O-, Cl, Br, F, NO2, Z es -OT1, T1 es hidrógeno, un grupo de protección del hidroxilo o COT2, T2 es H, un alquilo de C1-C6, alquenilo de C1-C6, alquinilo de C1-C6 o un arilo monocíclico, Ac es acetilo, y E1 y E2 se seleccionan independientemente de hidrógeno y de los grupos funcionales que aumentan la solubilidad al agua de los derivados de los taxanos que son útiles como agentes antitumorales.
MX9205311A 1991-09-23 1992-09-18 Nuevos taxanos substituidos y composiciones farmaceuticas que los contienen MX9205311A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76380591A 1991-09-23 1991-09-23
US07/863,451 US5250683A (en) 1991-09-23 1992-04-03 Certain substituted taxanes and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
MX9205311A true MX9205311A (es) 1993-07-01

Family

ID=27117342

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9205311A MX9205311A (es) 1991-09-23 1992-09-18 Nuevos taxanos substituidos y composiciones farmaceuticas que los contienen

Country Status (14)

Country Link
US (1) US5250683A (es)
EP (1) EP0534709B1 (es)
JP (1) JP3182231B2 (es)
AT (1) ATE231139T1 (es)
AU (1) AU655493B2 (es)
CA (2) CA2077394C (es)
DE (1) DE69232895T2 (es)
DK (1) DK0534709T3 (es)
ES (1) ES2191005T3 (es)
FI (1) FI113173B (es)
HU (1) HU215110B (es)
MX (1) MX9205311A (es)
NO (1) NO305205B1 (es)
NZ (1) NZ244457A (es)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
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ZA926829B (en) * 1991-09-23 1993-03-15 Univ Florida State Novel substituted taxanes and pharmaceutical compositions containing them.
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5243045A (en) * 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US6005138A (en) * 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
DE69329304T2 (de) * 1992-01-15 2001-01-04 E.R. Squibb & Sons, Inc. Enzymatische Verfahren zur Resolution von Enantiomeren-Mischungen nützlich wie Zwischenprodukte zur Herstellung von Taxanen
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FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
IL108316A (en) * 1993-01-15 2006-10-31 Univ Florida State History of C-10 Texan and pharmaceuticals containing them
DE69432140T2 (de) * 1993-03-05 2003-07-31 Florida State University, Tallahassee Verfahren zur Herstellung von 9-Desoxotaxanen
US6710191B2 (en) 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
DE69434374T2 (de) * 1993-03-22 2005-11-24 Florida State University, Tallahassee Taxane mit Furyl oder Thienyl enthaltender substituierter Seitenkette
IT1261667B (it) * 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
PT982302E (pt) * 1993-06-11 2004-07-30 Upjohn Co Utilizacao de delta 6,7-taxois antineoplasicos e composicoes farmaceuticas que os contem
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US5807888A (en) * 1995-12-13 1998-09-15 Xechem International, Inc. Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
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US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
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Family Cites Families (9)

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FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
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Also Published As

Publication number Publication date
DE69232895D1 (de) 2003-02-20
HU9203024D0 (en) 1992-12-28
CA2077394A1 (en) 1993-03-24
HUT63155A (en) 1993-07-28
NO923679D0 (no) 1992-09-22
FI924228A0 (fi) 1992-09-21
CA2221190C (en) 2002-02-12
AU2212492A (en) 1993-03-25
JPH06199824A (ja) 1994-07-19
NZ244457A (en) 1995-03-28
AU655493B2 (en) 1994-12-22
EP0534709B1 (en) 2003-01-15
ATE231139T1 (de) 2003-02-15
FI924228A (fi) 1993-03-24
NO305205B1 (no) 1999-04-19
ES2191005T3 (es) 2003-09-01
DK0534709T3 (da) 2003-05-12
HU215110B (hu) 1998-12-28
FI113173B (fi) 2004-03-15
NO923679L (no) 1993-03-24
CA2077394C (en) 1999-04-06
EP0534709A1 (en) 1993-03-31
US5250683A (en) 1993-10-05
JP3182231B2 (ja) 2001-07-03
CA2221190A1 (en) 1993-03-24
DE69232895T2 (de) 2003-07-31

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