BR0008840A - Derivados de camptotecina tendo atividade antitumoral - Google Patents

Derivados de camptotecina tendo atividade antitumoral

Info

Publication number
BR0008840A
BR0008840A BR0008840-4A BR0008840A BR0008840A BR 0008840 A BR0008840 A BR 0008840A BR 0008840 A BR0008840 A BR 0008840A BR 0008840 A BR0008840 A BR 0008840A
Authority
BR
Brazil
Prior art keywords
antitumor activity
formula
camptothecin derivatives
camptothecin
derivatives
Prior art date
Application number
BR0008840-4A
Other languages
English (en)
Other versions
BR0008840B1 (pt
Inventor
Sergio Penco
Lucio Merlini
Franco Zunino
Paolo Carminati
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of BR0008840A publication Critical patent/BR0008840A/pt
Publication of BR0008840B1 publication Critical patent/BR0008840B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE CAMPTOTECINA TENDO ATIVIDADE ANTITUMORAL". São revelados derivados de camptotecina de camptotecina de fórmula (I), em que os grupos R~ 1~, R~ 2~ e R~ 3~ são como definidos na descrição. Os de fórmula (1) são dotados de atividade antitumoral e apresentam um bom índice terapêutico. Também são revelados processos para a preparação dos compostos de fórmula (I) e seu uso na preparação de medicamentos úteis no tratamento de tumores, infecções virais e anti-plasmodium falciparum.
BRPI0008840-4A 1999-03-09 2000-03-08 derivados de camptotecina, processos para a sua preparaÇço, composiÇço farmacÊutica que os compreende e uso dos mesmos. BR0008840B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99830124A EP1044977B1 (en) 1999-03-09 1999-03-09 Camptothecin derivatives having antitumor activity
PCT/EP2000/001570 WO2000053607A1 (en) 1999-03-09 2000-03-08 Camptothecin derivatives having antitumor activity

Publications (2)

Publication Number Publication Date
BR0008840A true BR0008840A (pt) 2002-01-08
BR0008840B1 BR0008840B1 (pt) 2011-12-27

Family

ID=8243303

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0008840-4A BR0008840B1 (pt) 1999-03-09 2000-03-08 derivados de camptotecina, processos para a sua preparaÇço, composiÇço farmacÊutica que os compreende e uso dos mesmos.

Country Status (39)

Country Link
US (2) US6242457B1 (pt)
EP (1) EP1044977B1 (pt)
JP (1) JP4610743B2 (pt)
KR (1) KR100702085B1 (pt)
CN (1) CN1139592C (pt)
AR (1) AR022860A1 (pt)
AT (1) ATE216998T1 (pt)
AU (1) AU774174B2 (pt)
BG (1) BG65032B1 (pt)
BR (1) BR0008840B1 (pt)
CA (1) CA2362760C (pt)
CO (1) CO5180590A1 (pt)
CZ (1) CZ304465B6 (pt)
DE (1) DE69901379T2 (pt)
DK (1) DK1044977T3 (pt)
EA (1) EA003605B1 (pt)
EE (1) EE04679B1 (pt)
EG (1) EG23999A (pt)
ES (1) ES2175919T3 (pt)
HK (1) HK1031222A1 (pt)
HR (1) HRP20010667B1 (pt)
HU (1) HU229506B1 (pt)
IL (2) IL144958A0 (pt)
IS (1) IS2003B (pt)
ME (2) MEP4008A (pt)
MX (1) MXPA01009081A (pt)
NO (1) NO328363B1 (pt)
NZ (1) NZ513393A (pt)
PE (1) PE20001485A1 (pt)
PL (1) PL222208B1 (pt)
PT (1) PT1044977E (pt)
RS (1) RS50405B (pt)
SI (1) SI1044977T1 (pt)
SK (1) SK287561B6 (pt)
TN (1) TNSN00045A1 (pt)
TR (1) TR200102603T2 (pt)
TW (1) TWI272272B (pt)
WO (1) WO2000053607A1 (pt)
ZA (1) ZA200107408B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ512676A (en) 1999-01-13 2003-01-31 Meditech Res Ltd A composition and method for the enhancement of the efficacy of drugs
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
FR2794123B1 (fr) * 1999-05-28 2001-07-27 Aventis Pharma Sa Preparation de derives de la camptothecine et de la nothapodytine
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US20040029906A1 (en) * 2001-07-31 2004-02-12 Michael Christman Inhibitors of dna polymerase sigma
EP1427447A4 (en) * 2001-08-27 2007-05-23 Alchemia Oncology Ltd IMPROVED THERAPEUTIC PROTOCOLS
WO2003033525A1 (en) * 2001-10-12 2003-04-24 Debio Recherche Pharmacuetique S.A. Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
ITRM20020305A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
CN101480395A (zh) * 2004-03-26 2009-07-15 诺瓦提斯公司 喜树碱衍生物以固定给药方案治疗增生性疾病的用途
KR20070008710A (ko) 2004-04-27 2007-01-17 웰스테트 바이올로직스 코포레이션 바이러스 및 캄토테신을 이용한 암치료 방법
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
ITRM20040242A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
EP1827437B1 (en) 2004-12-15 2011-11-02 Novartis AG Combinations of therapeutic agents for treating cancer
DK1828196T3 (da) 2004-12-21 2012-11-26 Sigma Tau Ind Farmaceuti Stereospecifik fremgangsmåde og krystallinske former af en camptothecin
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
NZ562951A (en) 2005-07-14 2011-09-30 Wellstat Biologics Corp Cancer treatment using a Newcastle disease virus, a fluoropyrimidine and a camptothecin combination
AU2006274509B2 (en) * 2005-07-27 2012-01-19 Alchemia Oncology Pty Limited Therapeutic protocols using hyaluronan
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
US20080213385A1 (en) * 2005-08-10 2008-09-04 Oskar Kalb Formulations for 7- (T-Butoxy) Iminomethyl Camptothecin
EP2772260A3 (en) * 2005-09-07 2014-10-15 Alchemia Oncology Pty Limited Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment
JP5657205B2 (ja) * 2005-12-21 2015-01-21 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ 薬物耐性腫瘍の治療
WO2007098091A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs
AU2007232206B2 (en) 2006-03-30 2013-04-04 Drais Pharmaceuticals, Inc. Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
WO2008094959A1 (en) * 2007-02-01 2008-08-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Pharmaceutical composition comprising a campothecin derivative
WO2008098701A1 (en) * 2007-02-13 2008-08-21 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
JP5765937B2 (ja) * 2007-08-01 2015-08-19 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニＳｉｇｍａ−Ｔａｕ Ｉｎｄｕｓｔｒｉｅ Ｆａｒｍａｃｅｕｔｉｃｈｅ Ｒｉｕｎｉｔｅ Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ 小児腫瘍の治療
EP2096113A1 (en) 2008-02-05 2009-09-02 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 9-substituted camptothecin derivatives as antitumor compounds
TWI482621B (zh) 2009-12-23 2015-05-01 Sigma Tau Ind Farmaceuti 青蒿素基藥物與其他化學治療劑的抗癌組合物
JP6877049B2 (ja) 2015-09-25 2021-05-26 ゼットワイ セラピューティクス インク．Ｚｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 多糖類−ビタミン共役体を含む粒状物に基づく薬物製剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
ATE247471T1 (de) * 1991-11-15 2003-09-15 Smithkline Beecham Corp Cisplatin und topotecan enthaltende zusammensetzung als antitumor.
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
JP4364305B2 (ja) * 1996-08-19 2009-11-18 バイオニューメリック ファーマシューティカルズ インク 極めて脂肪親和性のカンプトテシン誘導体

Also Published As

Publication number Publication date
RS50405B (sr) 2009-12-31
AU774174B2 (en) 2004-06-17
ME00017B (me) 2010-06-10
CN1343209A (zh) 2002-04-03
CA2362760A1 (en) 2000-09-14
ZA200107408B (en) 2002-05-29
MEP4008A (xx) 2010-02-10
CZ20013077A3 (cs) 2002-01-16
IL144958A0 (en) 2002-06-30
EE04679B1 (et) 2006-08-15
WO2000053607A1 (en) 2000-09-14
EP1044977A1 (en) 2000-10-18
TR200102603T2 (tr) 2002-01-21
ES2175919T3 (es) 2002-11-16
PE20001485A1 (es) 2000-12-07
JP4610743B2 (ja) 2011-01-12
KR100702085B1 (ko) 2007-04-02
EE200100466A (et) 2002-12-16
IS6031A (is) 2001-07-31
PL355094A1 (en) 2004-03-22
JP2002539128A (ja) 2002-11-19
TWI272272B (en) 2007-02-01
NO20014128L (no) 2001-08-24
EA200100954A1 (ru) 2002-04-25
NO20014128D0 (no) 2001-08-24
HRP20010667B1 (en) 2003-06-30
KR20010102519A (ko) 2001-11-15
HU229506B1 (en) 2014-01-28
BG105810A (en) 2002-06-28
BR0008840B1 (pt) 2011-12-27
CO5180590A1 (es) 2002-07-30
TNSN00045A1 (fr) 2005-11-10
YU64301A (sh) 2005-07-19
US6589939B2 (en) 2003-07-08
CA2362760C (en) 2009-08-18
DE69901379D1 (de) 2002-06-06
SK287561B6 (sk) 2011-02-04
ATE216998T1 (de) 2002-05-15
HRP20010667A2 (en) 2002-08-31
HK1031222A1 (en) 2001-06-08
US20010008939A1 (en) 2001-07-19
DE69901379T2 (de) 2002-11-07
SI1044977T1 (en) 2002-08-31
NZ513393A (en) 2003-04-29
DK1044977T3 (da) 2002-07-08
SK11642001A3 (sk) 2002-01-07
NO328363B1 (no) 2010-02-01
PT1044977E (pt) 2002-09-30
HUP0200210A2 (hu) 2002-05-29
CZ304465B6 (cs) 2014-05-21
PL222208B1 (pl) 2016-07-29
EG23999A (en) 2008-03-19
EA003605B1 (ru) 2003-06-26
MXPA01009081A (es) 2002-08-30
HUP0200210A3 (en) 2004-03-29
US6242457B1 (en) 2001-06-05
IS2003B (is) 2005-04-15
EP1044977B1 (en) 2002-05-02
CN1139592C (zh) 2004-02-25
IL144958A (en) 2009-08-03
AU3160400A (en) 2000-09-28
AR022860A1 (es) 2002-09-04
BG65032B1 (bg) 2006-12-29

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/12/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 19A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2504 DE 02-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.