BR0215312A - Uso de um composto, método para inibir a aurora quinase em um animal de sangue quente, composto, composição farmacêutica, e, processo para a preparação de um composto - Google Patents
Uso de um composto, método para inibir a aurora quinase em um animal de sangue quente, composto, composição farmacêutica, e, processo para a preparação de um compostoInfo
- Publication number
- BR0215312A BR0215312A BR0215312-2A BR0215312A BR0215312A BR 0215312 A BR0215312 A BR 0215312A BR 0215312 A BR0215312 A BR 0215312A BR 0215312 A BR0215312 A BR 0215312A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- aurora kinase
- preparing
- pharmaceutical composition
- inhibiting aurora
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01403357.5 | 2001-12-24 | ||
EP01403357 | 2001-12-24 | ||
PCT/GB2002/005845 WO2003055491A1 (en) | 2001-12-24 | 2002-12-20 | Substituted quinazoline derivatives as inhibitors of aurora kinases |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0215312A true BR0215312A (pt) | 2004-12-07 |
BRPI0215312B1 BRPI0215312B1 (pt) | 2018-03-27 |
BRPI0215312B8 BRPI0215312B8 (pt) | 2021-05-25 |
Family
ID=8183051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0215312A BRPI0215312B8 (pt) | 2001-12-24 | 2002-12-20 | composto, uso de um composto, composição farmacêutica, e processo para a preparação de um composto |
Country Status (32)
Country | Link |
---|---|
US (2) | US7402585B2 (pt) |
EP (1) | EP1463506B1 (pt) |
JP (1) | JP4498741B2 (pt) |
KR (1) | KR101029281B1 (pt) |
CN (1) | CN100491372C (pt) |
AR (1) | AR038052A1 (pt) |
AT (1) | ATE446093T1 (pt) |
AU (1) | AU2002353196B2 (pt) |
BR (1) | BRPI0215312B8 (pt) |
CA (1) | CA2471577C (pt) |
CY (1) | CY1109681T1 (pt) |
DE (1) | DE60234125D1 (pt) |
DK (1) | DK1463506T3 (pt) |
ES (1) | ES2333702T3 (pt) |
HK (1) | HK1076598A1 (pt) |
HU (1) | HU229477B1 (pt) |
IL (1) | IL162541A0 (pt) |
IS (1) | IS2758B (pt) |
MX (1) | MXPA04006260A (pt) |
MY (1) | MY141739A (pt) |
NO (1) | NO328159B1 (pt) |
NZ (1) | NZ533440A (pt) |
PL (1) | PL211694B1 (pt) |
PT (1) | PT1463506E (pt) |
RU (1) | RU2323215C2 (pt) |
SA (1) | SA03230531B1 (pt) |
SI (1) | SI1463506T1 (pt) |
TW (1) | TWI335818B (pt) |
UA (1) | UA82058C2 (pt) |
UY (1) | UY27604A1 (pt) |
WO (1) | WO2003055491A1 (pt) |
ZA (1) | ZA200404923B (pt) |
Families Citing this family (81)
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WO2002036587A2 (en) | 2000-11-01 | 2002-05-10 | Cor Therapeutics, Inc. | Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides |
ES2333702T3 (es) * | 2001-12-24 | 2010-02-26 | Astrazeneca Ab | Derivados de quinazolina sustituidos que actuan como unhibidores de cinasas aurora. |
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SI1578755T1 (sl) * | 2002-12-24 | 2007-12-31 | Astrazeneca Ab | Fosfonooksi kinazolinski derivati in njihova farmacevtska uporaba |
CA2522079A1 (en) | 2003-04-16 | 2004-11-04 | Astrazeneca Ab | Quinazoline derivatives for treatment of cancer |
US20060135541A1 (en) * | 2003-06-02 | 2006-06-22 | Astrazeneca Ab | (3-((Quinazolin-4-yl) amino)-1h-pyrazol-1-yl)acetamide derivatives and related compounds as aurora kinase inhibitors for the treatment of proliferative diseases such as cancer |
TW200505452A (en) * | 2003-06-17 | 2005-02-16 | Astrazeneca Ab | Chemical compounds |
US20060178318A1 (en) * | 2003-07-03 | 2006-08-10 | Shubha Anand | Use of aurora kinase inhibitors for reducing the resistance of cancer cells |
PT1660090E (pt) * | 2003-08-14 | 2013-01-11 | Array Biopharma Inc | Análogos de quinazolina como inibidores de tirosina-cinases recetoras |
DK2210607T3 (da) | 2003-09-26 | 2011-12-12 | Exelixis Inc | N-[3-fluor-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorphenyl)cyclopropan-1,1-dicarboxamid til behandling af kræft |
JP4845736B2 (ja) * | 2003-10-14 | 2011-12-28 | アリゾナ ボード オブ リージェンツ オン ビハーフ ザ ユニバーシティー オブ アリゾナ | プロテインキナーゼ阻害剤 |
US20090099165A1 (en) | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
EP1694686A1 (en) * | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinase inhibitors |
WO2005105788A1 (en) * | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Indole derivatives and use thereof as kinase inhibitors |
NZ550796A (en) | 2004-05-06 | 2010-07-30 | Warner Lambert Co | 4-phenylamino-quinazolin-6-yl-amides |
EP1768984B1 (en) * | 2004-07-16 | 2010-10-20 | Sunesis Pharmaceuticals, Inc. | Thienopyrimidines useful as aurora kinase inhibitors |
EP1778669A2 (en) * | 2004-08-18 | 2007-05-02 | Takeda San Diego, Inc. | Kinase inhibitors |
TW200624431A (en) * | 2004-09-24 | 2006-07-16 | Hoffmann La Roche | Phthalazinone derivatives, their manufacture and use as pharmaceutical agents |
AU2005293336B2 (en) | 2004-10-12 | 2009-05-28 | Astrazeneca Ab | Quinazoline derivatives |
ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
CA2587427A1 (en) | 2004-11-17 | 2006-05-26 | Miikana Therapeutics, Inc. | Kinase inhibitors |
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ES2545382T3 (es) | 2005-04-28 | 2015-09-10 | Mitsubishi Tanabe Pharma Corporation | Derivado de cianopiridina y su uso como medicamento |
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AU2006272876A1 (en) | 2005-07-22 | 2007-02-01 | Sunesis Pharmaceuticals, Inc. | Pyrazolo pyrimidines useful as aurora kinase inhibitors |
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US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
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US7560551B2 (en) | 2006-01-23 | 2009-07-14 | Amgen Inc. | Aurora kinase modulators and method of use |
US7868177B2 (en) | 2006-02-24 | 2011-01-11 | Amgen Inc. | Multi-cyclic compounds and method of use |
JP2009528336A (ja) * | 2006-03-02 | 2009-08-06 | アストラゼネカ アクチボラグ | キノリン誘導体 |
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GB0609621D0 (en) * | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Novel co-crystal |
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US20100022404A1 (en) | 2006-10-05 | 2010-01-28 | Shinichi Hasako | Gene/protein marker for prediction or diagnosis of pharmacological efficacy of aurora a inhibitor |
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GEP20135728B (en) | 2006-10-09 | 2013-01-25 | Takeda Pharmaceuticals Co | Kinase inhibitors |
JP5516397B2 (ja) | 2007-04-05 | 2014-06-11 | アムジエン・インコーポレーテツド | オーロラキナーゼ調節物質及び使用方法 |
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KR101699991B1 (ko) * | 2009-02-11 | 2017-01-26 | 메르크 파텐트 게엠베하 | 신규의 아미노 아자헤테로시클릭 카르복사미드 |
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KR101940340B1 (ko) | 2011-03-04 | 2019-01-18 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 키나제 억제제로서의 아미노-퀴놀린 |
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LT3122358T (lt) | 2014-03-26 | 2021-04-12 | Astex Therapeutics Ltd. | Egfr ir cmet inhibitorių deriniai, skirti vėžio gydymui |
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US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
HRP20220012T1 (hr) | 2015-09-23 | 2022-04-01 | Janssen Pharmaceutica Nv | Bi-heteroaril supstituirani 1,4-benzodiazepini i njihova upotreba za liječenje raka |
CN108026095B (zh) | 2015-09-23 | 2021-07-27 | 詹森药业有限公司 | 新化合物 |
CN112939948B (zh) * | 2019-12-11 | 2022-05-17 | 苏州美诺医药科技有限公司 | 新型含喹唑啉类化合物及其中间体与应用 |
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-
2002
- 2002-12-20 ES ES02788214T patent/ES2333702T3/es not_active Expired - Lifetime
- 2002-12-20 MX MXPA04006260A patent/MXPA04006260A/es active IP Right Grant
- 2002-12-20 PL PL371253A patent/PL211694B1/pl unknown
- 2002-12-20 CA CA2471577A patent/CA2471577C/en not_active Expired - Lifetime
- 2002-12-20 EP EP02788214A patent/EP1463506B1/en not_active Expired - Lifetime
- 2002-12-20 PT PT02788214T patent/PT1463506E/pt unknown
- 2002-12-20 UA UA20040706026A patent/UA82058C2/uk unknown
- 2002-12-20 CN CNB028283058A patent/CN100491372C/zh not_active Expired - Lifetime
- 2002-12-20 JP JP2003556068A patent/JP4498741B2/ja not_active Expired - Lifetime
- 2002-12-20 DE DE60234125T patent/DE60234125D1/de not_active Expired - Lifetime
- 2002-12-20 SI SI200230864T patent/SI1463506T1/sl unknown
- 2002-12-20 HU HU0402454A patent/HU229477B1/hu unknown
- 2002-12-20 IL IL16254102A patent/IL162541A0/xx unknown
- 2002-12-20 AT AT02788214T patent/ATE446093T1/de active
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- 2002-12-20 RU RU2004122926/04A patent/RU2323215C2/ru active
- 2002-12-20 KR KR1020047010003A patent/KR101029281B1/ko active IP Right Grant
- 2002-12-20 WO PCT/GB2002/005845 patent/WO2003055491A1/en active Application Filing
- 2002-12-20 BR BRPI0215312A patent/BRPI0215312B8/pt not_active IP Right Cessation
- 2002-12-20 AU AU2002353196A patent/AU2002353196B2/en not_active Expired
- 2002-12-20 US US10/499,684 patent/US7402585B2/en not_active Expired - Lifetime
- 2002-12-20 DK DK02788214T patent/DK1463506T3/da active
- 2002-12-23 AR ARP020105081A patent/AR038052A1/es active IP Right Grant
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- 2002-12-24 UY UY27604A patent/UY27604A1/es not_active Application Discontinuation
- 2002-12-24 TW TW091137139A patent/TWI335818B/zh not_active IP Right Cessation
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2003
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2004
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- 2004-06-22 ZA ZA2004/04923A patent/ZA200404923B/en unknown
- 2004-07-23 NO NO20043158A patent/NO328159B1/no not_active IP Right Cessation
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2005
- 2005-09-28 HK HK05108559.1A patent/HK1076598A1/xx not_active IP Right Cessation
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2008
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2009
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