HK1076598A1 - Substituted quinazoline derivatives as inhibitors of aurora kinases - Google Patents
Substituted quinazoline derivatives as inhibitors of aurora kinasesInfo
- Publication number
- HK1076598A1 HK1076598A1 HK05108559.1A HK05108559A HK1076598A1 HK 1076598 A1 HK1076598 A1 HK 1076598A1 HK 05108559 A HK05108559 A HK 05108559A HK 1076598 A1 HK1076598 A1 HK 1076598A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- inhibitors
- quinazoline derivatives
- aurora kinases
- substituted quinazoline
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01403357 | 2001-12-24 | ||
PCT/GB2002/005845 WO2003055491A1 (en) | 2001-12-24 | 2002-12-20 | Substituted quinazoline derivatives as inhibitors of aurora kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1076598A1 true HK1076598A1 (en) | 2006-01-20 |
Family
ID=8183051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05108559.1A HK1076598A1 (en) | 2001-12-24 | 2005-09-28 | Substituted quinazoline derivatives as inhibitors of aurora kinases |
Country Status (32)
Country | Link |
---|---|
US (2) | US7402585B2 (xx) |
EP (1) | EP1463506B1 (xx) |
JP (1) | JP4498741B2 (xx) |
KR (1) | KR101029281B1 (xx) |
CN (1) | CN100491372C (xx) |
AR (1) | AR038052A1 (xx) |
AT (1) | ATE446093T1 (xx) |
AU (1) | AU2002353196B2 (xx) |
BR (1) | BRPI0215312B8 (xx) |
CA (1) | CA2471577C (xx) |
CY (1) | CY1109681T1 (xx) |
DE (1) | DE60234125D1 (xx) |
DK (1) | DK1463506T3 (xx) |
ES (1) | ES2333702T3 (xx) |
HK (1) | HK1076598A1 (xx) |
HU (1) | HU229477B1 (xx) |
IL (1) | IL162541A0 (xx) |
IS (1) | IS2758B (xx) |
MX (1) | MXPA04006260A (xx) |
MY (1) | MY141739A (xx) |
NO (1) | NO328159B1 (xx) |
NZ (1) | NZ533440A (xx) |
PL (1) | PL211694B1 (xx) |
PT (1) | PT1463506E (xx) |
RU (1) | RU2323215C2 (xx) |
SA (1) | SA03230531B1 (xx) |
SI (1) | SI1463506T1 (xx) |
TW (1) | TWI335818B (xx) |
UA (1) | UA82058C2 (xx) |
UY (1) | UY27604A1 (xx) |
WO (1) | WO2003055491A1 (xx) |
ZA (1) | ZA200404923B (xx) |
Families Citing this family (81)
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DE60144284D1 (de) | 2000-11-01 | 2011-05-05 | Millennium Pharm Inc | Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung |
AU2002353196B2 (en) * | 2001-12-24 | 2008-01-17 | Astrazeneca Ab | Substituted quinazoline derivatives as inhibitors of aurora kinases |
EP1521747B1 (en) | 2002-07-15 | 2018-09-05 | Symphony Evolution, Inc. | Receptor-type kinase modulators and methods of use |
DE60328735D1 (de) | 2002-12-24 | 2009-09-17 | Astrazeneca Ab | Chinazolinderivate |
CN1809557B (zh) | 2003-04-16 | 2012-07-04 | 阿斯利康(瑞典)有限公司 | 化合物 |
US20060135541A1 (en) * | 2003-06-02 | 2006-06-22 | Astrazeneca Ab | (3-((Quinazolin-4-yl) amino)-1h-pyrazol-1-yl)acetamide derivatives and related compounds as aurora kinase inhibitors for the treatment of proliferative diseases such as cancer |
TW200505452A (en) * | 2003-06-17 | 2005-02-16 | Astrazeneca Ab | Chemical compounds |
WO2005002571A1 (en) * | 2003-07-03 | 2005-01-13 | Cambridge University Technical Services Ltd | Use of aurora kinase inhibitors for reducing the resistance of cancer cells |
KR101028952B1 (ko) * | 2003-08-14 | 2011-04-12 | 어레이 바이오파마 인크. | 수용체 티로신 키나아제 억제제로서의 퀴나졸린 유사체 |
ES2371383T3 (es) | 2003-09-26 | 2011-12-30 | Exelixis, Inc. | N-[3-fluoro-4-({6-(metiloxi)-7-[(3-morfolin-4-ilpropil)oxi]quinolin-4-il}oxi)fenil]-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida para el tratamiento del cáncer. |
PL1678166T3 (pl) | 2003-10-14 | 2009-12-31 | Univ Arizona | Inhibitory kinaz białkowych |
US20090099165A1 (en) | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
US7572914B2 (en) * | 2003-12-19 | 2009-08-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
JP2007533753A (ja) * | 2004-04-23 | 2007-11-22 | タケダ サン ディエゴ インコーポレイテッド | インドール誘導体及びキナーゼ阻害剤としてのその使用 |
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US7601725B2 (en) * | 2004-07-16 | 2009-10-13 | Sunesis Pharmaceuticals, Inc. | Thienopyrimidines useful as Aurora kinase inhibitors |
WO2006023931A2 (en) * | 2004-08-18 | 2006-03-02 | Takeda San Diego, Inc. | Kinase inhibitors |
TW200624431A (en) | 2004-09-24 | 2006-07-16 | Hoffmann La Roche | Phthalazinone derivatives, their manufacture and use as pharmaceutical agents |
CA2581516C (en) | 2004-10-12 | 2013-06-11 | Astrazeneca Ab | Quinazoline derivatives |
JP2008516973A (ja) | 2004-10-15 | 2008-05-22 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
BRPI0517737A (pt) | 2004-11-17 | 2008-10-21 | Miikana Therapeutics Inc | inibidores de quinase |
GB0427917D0 (en) * | 2004-12-21 | 2005-01-26 | Astrazeneca Ab | Chemical compounds |
ES2545382T3 (es) | 2005-04-28 | 2015-09-10 | Mitsubishi Tanabe Pharma Corporation | Derivado de cianopiridina y su uso como medicamento |
GB0510963D0 (en) * | 2005-05-28 | 2005-07-06 | Astrazeneca Ab | Chemical compounds |
AU2006272876A1 (en) * | 2005-07-22 | 2007-02-01 | Sunesis Pharmaceuticals, Inc. | Pyrazolo pyrimidines useful as aurora kinase inhibitors |
EP1928456B1 (en) * | 2005-09-30 | 2015-04-22 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
GB0601215D0 (en) * | 2006-01-21 | 2006-03-01 | Astrazeneca Ab | Chemical compounds |
US7560551B2 (en) | 2006-01-23 | 2009-07-14 | Amgen Inc. | Aurora kinase modulators and method of use |
BRPI0706684A2 (pt) | 2006-01-23 | 2011-04-05 | Amgen Inc | composto, medicamento, uso do medicamento, e, processo para preparar um composto |
US7868177B2 (en) | 2006-02-24 | 2011-01-11 | Amgen Inc. | Multi-cyclic compounds and method of use |
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MX2008011769A (es) * | 2006-03-20 | 2008-09-25 | Hoffmann La Roche | Derivados de ftalazinona pirazol, su fabricacion y uso como agentes farmaceuticos. |
GB0609617D0 (en) | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Process & intermediate |
GB0609621D0 (en) * | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Novel co-crystal |
CA2652634A1 (en) * | 2006-05-18 | 2007-11-29 | Amphora Discovery Corporation | Certain substituted quinolones, compositions, and uses thereof |
GB0619342D0 (en) * | 2006-09-30 | 2006-11-08 | Vernalis R&D Ltd | New chemical compounds |
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EP2223925A1 (en) * | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
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EP2465842A1 (de) * | 2010-12-17 | 2012-06-20 | Sika Technology AG | Amine mit sekundären aliphatischen Aminogruppen |
ES2609578T3 (es) | 2011-03-04 | 2017-04-21 | Glaxosmithkline Intellectual Property Development Limited | Amino-quinolinas como inhibidores de quinasa |
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GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
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WO2013143466A1 (zh) * | 2012-03-27 | 2013-10-03 | 广东东阳光药业有限公司 | 作为欧若拉激酶抑制剂的取代嘧啶衍生物 |
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GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
TWI592417B (zh) | 2012-09-13 | 2017-07-21 | 葛蘭素史克智慧財產發展有限公司 | 胺基喹唑啉激酶抑制劑之前藥 |
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CN104098551B (zh) * | 2013-04-03 | 2019-03-22 | 广东东阳光药业有限公司 | 作为欧若拉激酶抑制剂的取代喹唑啉类衍生物 |
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LT3122359T (lt) | 2014-03-26 | 2021-03-25 | Astex Therapeutics Ltd. | Fgfr inhibitoriaus ir igf1r inhibitoriaus deriniai |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
AU2015238301B2 (en) | 2014-03-26 | 2020-06-25 | Astex Therapeutics Ltd | Combinations |
NZ733950A (en) | 2014-12-23 | 2018-08-31 | Axikin Pharmaceuticals Inc | 3,5-diaminopyrazole kinase inhibitors |
JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
KR20180052631A (ko) | 2015-09-23 | 2018-05-18 | 얀센 파마슈티카 엔.브이. | 비-헤테로아릴 치환된 1,4-벤조디아제핀 및 암의 치료를 위한 이의 용도 |
ES2811845T3 (es) | 2015-09-23 | 2021-03-15 | Janssen Pharmaceutica Nv | Heterociclos tricíclicos para el tratamiento del cáncer |
CN112939948B (zh) * | 2019-12-11 | 2022-05-17 | 苏州美诺医药科技有限公司 | 新型含喹唑啉类化合物及其中间体与应用 |
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-
2002
- 2002-12-20 AU AU2002353196A patent/AU2002353196B2/en not_active Expired
- 2002-12-20 KR KR1020047010003A patent/KR101029281B1/ko active IP Right Grant
- 2002-12-20 JP JP2003556068A patent/JP4498741B2/ja not_active Expired - Lifetime
- 2002-12-20 MX MXPA04006260A patent/MXPA04006260A/es active IP Right Grant
- 2002-12-20 ES ES02788214T patent/ES2333702T3/es not_active Expired - Lifetime
- 2002-12-20 UA UA20040706026A patent/UA82058C2/uk unknown
- 2002-12-20 BR BRPI0215312A patent/BRPI0215312B8/pt not_active IP Right Cessation
- 2002-12-20 RU RU2004122926/04A patent/RU2323215C2/ru active
- 2002-12-20 SI SI200230864T patent/SI1463506T1/sl unknown
- 2002-12-20 EP EP02788214A patent/EP1463506B1/en not_active Expired - Lifetime
- 2002-12-20 HU HU0402454A patent/HU229477B1/hu unknown
- 2002-12-20 WO PCT/GB2002/005845 patent/WO2003055491A1/en active Application Filing
- 2002-12-20 IL IL16254102A patent/IL162541A0/xx unknown
- 2002-12-20 DK DK02788214T patent/DK1463506T3/da active
- 2002-12-20 PT PT02788214T patent/PT1463506E/pt unknown
- 2002-12-20 DE DE60234125T patent/DE60234125D1/de not_active Expired - Lifetime
- 2002-12-20 CA CA2471577A patent/CA2471577C/en not_active Expired - Lifetime
- 2002-12-20 NZ NZ533440A patent/NZ533440A/en not_active IP Right Cessation
- 2002-12-20 US US10/499,684 patent/US7402585B2/en not_active Expired - Lifetime
- 2002-12-20 AT AT02788214T patent/ATE446093T1/de active
- 2002-12-20 PL PL371253A patent/PL211694B1/pl unknown
- 2002-12-20 CN CNB028283058A patent/CN100491372C/zh not_active Expired - Lifetime
- 2002-12-23 AR ARP020105081A patent/AR038052A1/es active IP Right Grant
- 2002-12-23 MY MYPI20024859A patent/MY141739A/en unknown
- 2002-12-24 TW TW091137139A patent/TWI335818B/zh not_active IP Right Cessation
- 2002-12-24 UY UY27604A patent/UY27604A1/es not_active Application Discontinuation
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2003
- 2003-01-28 SA SA03230531A patent/SA03230531B1/ar unknown
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2004
- 2004-06-21 IS IS7328A patent/IS2758B/is unknown
- 2004-06-22 ZA ZA2004/04923A patent/ZA200404923B/en unknown
- 2004-07-23 NO NO20043158A patent/NO328159B1/no not_active IP Right Cessation
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2005
- 2005-09-28 HK HK05108559.1A patent/HK1076598A1/xx not_active IP Right Cessation
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2008
- 2008-05-28 US US12/128,479 patent/US20090215770A1/en not_active Abandoned
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2009
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