UY27604A1 - Compuestos químicos. - Google Patents
Compuestos químicos.Info
- Publication number
- UY27604A1 UY27604A1 UY27604A UY27604A UY27604A1 UY 27604 A1 UY27604 A1 UY 27604A1 UY 27604 A UY27604 A UY 27604A UY 27604 A UY27604 A UY 27604A UY 27604 A1 UY27604 A1 UY 27604A1
- Authority
- UY
- Uruguay
- Prior art keywords
- chemical compounds
- preparation
- quinazoline derivatives
- medicament
- inhibition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
La presente invención proporciona derivados de quinazolina de fórmula (I) en la preparación de un medicamento para su uso en la inhibicón de Aurora quinasa, así como también nuevos derivados de quinazolina, procesos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01403357 | 2001-12-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY27604A1 true UY27604A1 (es) | 2003-07-31 |
Family
ID=8183051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY27604A UY27604A1 (es) | 2001-12-24 | 2002-12-24 | Compuestos químicos. |
Country Status (32)
Country | Link |
---|---|
US (2) | US7402585B2 (es) |
EP (1) | EP1463506B1 (es) |
JP (1) | JP4498741B2 (es) |
KR (1) | KR101029281B1 (es) |
CN (1) | CN100491372C (es) |
AR (1) | AR038052A1 (es) |
AT (1) | ATE446093T1 (es) |
AU (1) | AU2002353196B2 (es) |
BR (1) | BRPI0215312B8 (es) |
CA (1) | CA2471577C (es) |
CY (1) | CY1109681T1 (es) |
DE (1) | DE60234125D1 (es) |
DK (1) | DK1463506T3 (es) |
ES (1) | ES2333702T3 (es) |
HK (1) | HK1076598A1 (es) |
HU (1) | HU229477B1 (es) |
IL (1) | IL162541A0 (es) |
IS (1) | IS2758B (es) |
MX (1) | MXPA04006260A (es) |
MY (1) | MY141739A (es) |
NO (1) | NO328159B1 (es) |
NZ (1) | NZ533440A (es) |
PL (1) | PL211694B1 (es) |
PT (1) | PT1463506E (es) |
RU (1) | RU2323215C2 (es) |
SA (1) | SA03230531B1 (es) |
SI (1) | SI1463506T1 (es) |
TW (1) | TWI335818B (es) |
UA (1) | UA82058C2 (es) |
UY (1) | UY27604A1 (es) |
WO (1) | WO2003055491A1 (es) |
ZA (1) | ZA200404923B (es) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002036587A2 (en) | 2000-11-01 | 2002-05-10 | Cor Therapeutics, Inc. | Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides |
ES2333702T3 (es) * | 2001-12-24 | 2010-02-26 | Astrazeneca Ab | Derivados de quinazolina sustituidos que actuan como unhibidores de cinasas aurora. |
EP2280003B1 (en) | 2002-07-15 | 2014-04-02 | Symphony Evolution, Inc. | Process for preparing receptor-type kinase modulators |
SI1578755T1 (sl) * | 2002-12-24 | 2007-12-31 | Astrazeneca Ab | Fosfonooksi kinazolinski derivati in njihova farmacevtska uporaba |
CA2522079A1 (en) | 2003-04-16 | 2004-11-04 | Astrazeneca Ab | Quinazoline derivatives for treatment of cancer |
US20060135541A1 (en) * | 2003-06-02 | 2006-06-22 | Astrazeneca Ab | (3-((Quinazolin-4-yl) amino)-1h-pyrazol-1-yl)acetamide derivatives and related compounds as aurora kinase inhibitors for the treatment of proliferative diseases such as cancer |
TW200505452A (en) * | 2003-06-17 | 2005-02-16 | Astrazeneca Ab | Chemical compounds |
US20060178318A1 (en) * | 2003-07-03 | 2006-08-10 | Shubha Anand | Use of aurora kinase inhibitors for reducing the resistance of cancer cells |
PT1660090E (pt) * | 2003-08-14 | 2013-01-11 | Array Biopharma Inc | Análogos de quinazolina como inibidores de tirosina-cinases recetoras |
DK2210607T3 (da) | 2003-09-26 | 2011-12-12 | Exelixis Inc | N-[3-fluor-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorphenyl)cyclopropan-1,1-dicarboxamid til behandling af kræft |
JP4845736B2 (ja) * | 2003-10-14 | 2011-12-28 | アリゾナ ボード オブ リージェンツ オン ビハーフ ザ ユニバーシティー オブ アリゾナ | プロテインキナーゼ阻害剤 |
US20090099165A1 (en) | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
EP1694686A1 (en) * | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinase inhibitors |
WO2005105788A1 (en) * | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Indole derivatives and use thereof as kinase inhibitors |
NZ550796A (en) | 2004-05-06 | 2010-07-30 | Warner Lambert Co | 4-phenylamino-quinazolin-6-yl-amides |
EP1768984B1 (en) * | 2004-07-16 | 2010-10-20 | Sunesis Pharmaceuticals, Inc. | Thienopyrimidines useful as aurora kinase inhibitors |
EP1778669A2 (en) * | 2004-08-18 | 2007-05-02 | Takeda San Diego, Inc. | Kinase inhibitors |
TW200624431A (en) * | 2004-09-24 | 2006-07-16 | Hoffmann La Roche | Phthalazinone derivatives, their manufacture and use as pharmaceutical agents |
AU2005293336B2 (en) | 2004-10-12 | 2009-05-28 | Astrazeneca Ab | Quinazoline derivatives |
ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
CA2587427A1 (en) | 2004-11-17 | 2006-05-26 | Miikana Therapeutics, Inc. | Kinase inhibitors |
GB0427917D0 (en) * | 2004-12-21 | 2005-01-26 | Astrazeneca Ab | Chemical compounds |
ES2545382T3 (es) | 2005-04-28 | 2015-09-10 | Mitsubishi Tanabe Pharma Corporation | Derivado de cianopiridina y su uso como medicamento |
GB0510963D0 (en) * | 2005-05-28 | 2005-07-06 | Astrazeneca Ab | Chemical compounds |
AU2006272876A1 (en) | 2005-07-22 | 2007-02-01 | Sunesis Pharmaceuticals, Inc. | Pyrazolo pyrimidines useful as aurora kinase inhibitors |
WO2007041358A2 (en) * | 2005-09-30 | 2007-04-12 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
GB0601215D0 (en) * | 2006-01-21 | 2006-03-01 | Astrazeneca Ab | Chemical compounds |
AU2007208351C1 (en) | 2006-01-23 | 2011-07-07 | Amgen Inc. | Aurora kinase modulators and method of use |
US7560551B2 (en) | 2006-01-23 | 2009-07-14 | Amgen Inc. | Aurora kinase modulators and method of use |
US7868177B2 (en) | 2006-02-24 | 2011-01-11 | Amgen Inc. | Multi-cyclic compounds and method of use |
JP2009528336A (ja) * | 2006-03-02 | 2009-08-06 | アストラゼネカ アクチボラグ | キノリン誘導体 |
UY30183A1 (es) | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
CA2645583A1 (en) * | 2006-03-20 | 2007-09-27 | F. Hoffman-La Roche Ag | Methods of inhibiting btk and syk protein kinases |
AU2007229063A1 (en) * | 2006-03-20 | 2007-09-27 | F. Hoffmann-La Roche Ag | Phthalazinone pyrazole derivatives, their manufacture and use as pharmaceutical agents |
GB0609617D0 (en) | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Process & intermediate |
GB0609621D0 (en) * | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Novel co-crystal |
US20070287706A1 (en) * | 2006-05-18 | 2007-12-13 | Dickson John K Jr | Certain substituted quinolones, compositions, and uses thereof |
GB0619342D0 (en) * | 2006-09-30 | 2006-11-08 | Vernalis R&D Ltd | New chemical compounds |
US20100022404A1 (en) | 2006-10-05 | 2010-01-28 | Shinichi Hasako | Gene/protein marker for prediction or diagnosis of pharmacological efficacy of aurora a inhibitor |
EP2223925A1 (en) * | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
GEP20135728B (en) | 2006-10-09 | 2013-01-25 | Takeda Pharmaceuticals Co | Kinase inhibitors |
JP5516397B2 (ja) | 2007-04-05 | 2014-06-11 | アムジエン・インコーポレーテツド | オーロラキナーゼ調節物質及び使用方法 |
EP2166849A4 (en) * | 2007-06-11 | 2010-09-15 | Miikana Therapeutics Inc | SUBSTITUTED PYRAZOL COMPOUNDS |
US7968536B2 (en) | 2007-06-29 | 2011-06-28 | Millennium Pharmaceuticals, Inc. | Heterocyclic compounds useful as RAF kinase inhibitors |
EP2262796A1 (en) | 2008-03-04 | 2010-12-22 | Vitae Pharmaceuticals, Inc. | Aurora kinase inhibitors |
US8404694B2 (en) | 2008-03-20 | 2013-03-26 | Amgen Inc. | Aurora kinase modulators and method of use |
WO2010019473A1 (en) | 2008-08-14 | 2010-02-18 | Amgen Inc. | Aurora kinase modulators and methods of use |
WO2010083414A1 (en) | 2009-01-16 | 2010-07-22 | Exelixis, Inc. | Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quin0lin-4-yl] oxy}phenyl-n' - (4 -fluorophenyl) cyclopropane-1-dicarboxamide, and crystalline forms therof for the treatment of cancer |
KR101699991B1 (ko) * | 2009-02-11 | 2017-01-26 | 메르크 파텐트 게엠베하 | 신규의 아미노 아자헤테로시클릭 카르복사미드 |
UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
EP2465842A1 (de) * | 2010-12-17 | 2012-06-20 | Sika Technology AG | Amine mit sekundären aliphatischen Aminogruppen |
KR101940340B1 (ko) | 2011-03-04 | 2019-01-18 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 키나제 억제제로서의 아미노-퀴놀린 |
TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
JP6134376B2 (ja) | 2012-03-16 | 2017-05-24 | アクシキン ファーマシューティカルズ インコーポレーテッド | 3,5−ジアミノピラゾールキナーゼ阻害剤 |
WO2013143466A1 (zh) * | 2012-03-27 | 2013-10-03 | 广东东阳光药业有限公司 | 作为欧若拉激酶抑制剂的取代嘧啶衍生物 |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
AR092529A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
TW201425307A (zh) | 2012-09-13 | 2014-07-01 | Glaxosmithkline Llc | 作為激酶抑制劑之胺基-喹啉類 |
KR20150118152A (ko) * | 2013-02-21 | 2015-10-21 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 키나제 억제제로서의 퀴나졸린 |
CN104098551B (zh) * | 2013-04-03 | 2019-03-22 | 广东东阳光药业有限公司 | 作为欧若拉激酶抑制剂的取代喹唑啉类衍生物 |
GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
MY191804A (en) | 2013-09-16 | 2022-07-15 | Astrazeneca Ab | Therapeutic polymeric nanoparticles and methods of making and using same |
NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
JP6527513B2 (ja) | 2013-11-20 | 2019-06-05 | シグナルケム・ライフサイエンシーズ・コーポレイションSignalchem Lifesciences Corporation | Tamファミリーキナーゼ阻害剤としてのキナゾリン誘導体 |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
HUE053653T2 (hu) | 2014-03-26 | 2021-07-28 | Astex Therapeutics Ltd | FGFR inhibitor és IGF1R inhibitor kombinációi |
LT3122358T (lt) | 2014-03-26 | 2021-04-12 | Astex Therapeutics Ltd. | Egfr ir cmet inhibitorių deriniai, skirti vėžio gydymui |
MX2017008526A (es) | 2014-12-23 | 2017-10-25 | Axikin Pharmaceuticals Inc | Inhibidores de 3,5-diaminopirazol quinasa. |
JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
HRP20220012T1 (hr) | 2015-09-23 | 2022-04-01 | Janssen Pharmaceutica Nv | Bi-heteroaril supstituirani 1,4-benzodiazepini i njihova upotreba za liječenje raka |
CN108026095B (zh) | 2015-09-23 | 2021-07-27 | 詹森药业有限公司 | 新化合物 |
CN112939948B (zh) * | 2019-12-11 | 2022-05-17 | 苏州美诺医药科技有限公司 | 新型含喹唑啉类化合物及其中间体与应用 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL89029A (en) | 1988-01-29 | 1993-01-31 | Lilly Co Eli | Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them |
US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5721237A (en) * | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
EP0584222B1 (en) | 1991-05-10 | 1997-10-08 | Rhone-Poulenc Rorer International (Holdings) Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
TW321649B (es) | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
GB9514265D0 (en) | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
KR100860295B1 (ko) | 1998-10-08 | 2008-09-25 | 아스트라제네카 아베 | 퀴나졸린 유도체 |
GB9922171D0 (en) | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
JP4870304B2 (ja) | 1999-09-21 | 2012-02-08 | アストラゼネカ アクチボラグ | キナゾリン誘導体およびそれらの医薬品としての使用 |
GB0006864D0 (en) * | 2000-03-21 | 2000-05-10 | Smithkline Beecham Plc | New use |
PL360439A1 (en) * | 2000-06-28 | 2004-09-06 | Astrazeneca Ab | Substituted quinazoline derivatives and their use as inhibitors |
US6610677B2 (en) * | 2000-09-15 | 2003-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
GB0124299D0 (en) * | 2001-10-10 | 2001-11-28 | Astrazeneca Ab | Crystal structure of enzyme and uses thereof |
ES2333702T3 (es) * | 2001-12-24 | 2010-02-26 | Astrazeneca Ab | Derivados de quinazolina sustituidos que actuan como unhibidores de cinasas aurora. |
US7105425B1 (en) * | 2002-05-16 | 2006-09-12 | Advanced Micro Devices, Inc. | Single electron devices formed by laser thermal annealing |
SI1578755T1 (sl) * | 2002-12-24 | 2007-12-31 | Astrazeneca Ab | Fosfonooksi kinazolinski derivati in njihova farmacevtska uporaba |
CA2522079A1 (en) * | 2003-04-16 | 2004-11-04 | Astrazeneca Ab | Quinazoline derivatives for treatment of cancer |
US20060135541A1 (en) * | 2003-06-02 | 2006-06-22 | Astrazeneca Ab | (3-((Quinazolin-4-yl) amino)-1h-pyrazol-1-yl)acetamide derivatives and related compounds as aurora kinase inhibitors for the treatment of proliferative diseases such as cancer |
EP1802608A1 (en) * | 2004-10-12 | 2007-07-04 | AstraZeneca AB | Quinazoline derivatives for use against cancer |
GB0427917D0 (en) * | 2004-12-21 | 2005-01-26 | Astrazeneca Ab | Chemical compounds |
WO2006129064A1 (en) * | 2005-05-28 | 2006-12-07 | Astrazeneca Ab | Quinazolines and their use as aurora kinase inhibitors |
GB0601215D0 (en) * | 2006-01-21 | 2006-03-01 | Astrazeneca Ab | Chemical compounds |
GB0609619D0 (en) * | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Combination |
GB0609617D0 (en) * | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Process & intermediate |
GB0609621D0 (en) * | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Novel co-crystal |
EP2231281A2 (en) * | 2007-12-12 | 2010-09-29 | AstraZeneca AB | Combination comprising a mek inhibitor and an aurora kinase inhibitor |
-
2002
- 2002-12-20 ES ES02788214T patent/ES2333702T3/es not_active Expired - Lifetime
- 2002-12-20 MX MXPA04006260A patent/MXPA04006260A/es active IP Right Grant
- 2002-12-20 PL PL371253A patent/PL211694B1/pl unknown
- 2002-12-20 CA CA2471577A patent/CA2471577C/en not_active Expired - Lifetime
- 2002-12-20 EP EP02788214A patent/EP1463506B1/en not_active Expired - Lifetime
- 2002-12-20 PT PT02788214T patent/PT1463506E/pt unknown
- 2002-12-20 UA UA20040706026A patent/UA82058C2/uk unknown
- 2002-12-20 CN CNB028283058A patent/CN100491372C/zh not_active Expired - Lifetime
- 2002-12-20 JP JP2003556068A patent/JP4498741B2/ja not_active Expired - Lifetime
- 2002-12-20 DE DE60234125T patent/DE60234125D1/de not_active Expired - Lifetime
- 2002-12-20 SI SI200230864T patent/SI1463506T1/sl unknown
- 2002-12-20 HU HU0402454A patent/HU229477B1/hu unknown
- 2002-12-20 IL IL16254102A patent/IL162541A0/xx unknown
- 2002-12-20 AT AT02788214T patent/ATE446093T1/de active
- 2002-12-20 NZ NZ533440A patent/NZ533440A/en not_active IP Right Cessation
- 2002-12-20 RU RU2004122926/04A patent/RU2323215C2/ru active
- 2002-12-20 KR KR1020047010003A patent/KR101029281B1/ko active IP Right Grant
- 2002-12-20 WO PCT/GB2002/005845 patent/WO2003055491A1/en active Application Filing
- 2002-12-20 BR BRPI0215312A patent/BRPI0215312B8/pt not_active IP Right Cessation
- 2002-12-20 AU AU2002353196A patent/AU2002353196B2/en not_active Expired
- 2002-12-20 US US10/499,684 patent/US7402585B2/en not_active Expired - Lifetime
- 2002-12-20 DK DK02788214T patent/DK1463506T3/da active
- 2002-12-23 AR ARP020105081A patent/AR038052A1/es active IP Right Grant
- 2002-12-23 MY MYPI20024859A patent/MY141739A/en unknown
- 2002-12-24 UY UY27604A patent/UY27604A1/es not_active Application Discontinuation
- 2002-12-24 TW TW091137139A patent/TWI335818B/zh not_active IP Right Cessation
-
2003
- 2003-01-28 SA SA03230531A patent/SA03230531B1/ar unknown
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2004
- 2004-06-21 IS IS7328A patent/IS2758B/is unknown
- 2004-06-22 ZA ZA2004/04923A patent/ZA200404923B/en unknown
- 2004-07-23 NO NO20043158A patent/NO328159B1/no not_active IP Right Cessation
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2005
- 2005-09-28 HK HK05108559.1A patent/HK1076598A1/xx not_active IP Right Cessation
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2008
- 2008-05-28 US US12/128,479 patent/US20090215770A1/en not_active Abandoned
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2009
- 2009-12-17 CY CY20091101316T patent/CY1109681T1/el unknown
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