UY28736A1 - Derivados de quinazolina - Google Patents

Derivados de quinazolina

Info

Publication number
UY28736A1
UY28736A1 UY28736A UY28736A UY28736A1 UY 28736 A1 UY28736 A1 UY 28736A1 UY 28736 A UY28736 A UY 28736A UY 28736 A UY28736 A UY 28736A UY 28736 A1 UY28736 A1 UY 28736A1
Authority
UY
Uruguay
Prior art keywords
quinazoline
quinazoline derivatives
formula
derivatives
quinazoline derivative
Prior art date
Application number
UY28736A
Other languages
English (en)
Inventor
Christopher Thomas Halsall
Laurent Francois And Hennequin
Janet Elizabeth Pease
Benedicte Delouvrie
Craig Steven Harris
Peter Mark Smith
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34833782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY28736(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY28736A1 publication Critical patent/UY28736A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Un derivado de quinazolina de fórmula 1: en donde: R1, R2, R3, R3a, R4, R5, R5a, R6, R7, a, m y p son como se define en la descripción. También se reivindican composiciones farmacéuticas que contienen el derivado de quinazolina, el uso de los derivados de quinazolina como medicamentos y procesos para la preparación del derivado de quinazolina. The derivados de quinazolina de fórmula 1, son útiles en el tratamiento de trastornos hiperproliferativos, como el cáncer.
UY28736A 2004-02-03 2005-02-02 Derivados de quinazolina UY28736A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04290274 2004-02-03

Publications (1)

Publication Number Publication Date
UY28736A1 true UY28736A1 (es) 2005-09-30

Family

ID=34833782

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28736A UY28736A1 (es) 2004-02-03 2005-02-02 Derivados de quinazolina

Country Status (12)

Country Link
US (1) US7632840B2 (es)
EP (1) EP1713781B1 (es)
JP (1) JP5032851B2 (es)
CN (1) CN1914182B (es)
AR (1) AR047703A1 (es)
AT (1) ATE413389T1 (es)
DE (1) DE602005010824D1 (es)
ES (1) ES2315834T3 (es)
HK (1) HK1095590A1 (es)
TW (1) TW200529851A (es)
UY (1) UY28736A1 (es)
WO (1) WO2005075439A1 (es)

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MXPA06002963A (es) * 2003-09-16 2006-06-14 Astrazeneca Ab Derivados de quinazolina como inhibidores de cinasa de tirosina.
GB0321648D0 (en) * 2003-09-16 2003-10-15 Astrazeneca Ab Quinazoline derivatives
DE602004022180D1 (de) * 2003-09-16 2009-09-03 Astrazeneca Ab Chinazolinderivate
CA2541100A1 (en) * 2003-09-16 2005-03-24 Astrazenca Ab Quinazoline derivatives
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
GB0326459D0 (en) * 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
US20070232607A1 (en) * 2004-06-04 2007-10-04 Bradbury Robert H Quinazoline Derivatives as Erbb Receptor Tyrosine kinases
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GB0508717D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
GB0508715D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
WO2007034144A1 (en) * 2005-09-20 2007-03-29 Astrazeneca Ab 4- (ih-indazol-s-yl-amino)-quinazoline compounds as erbb receptor tyrosine kinase inhibitors for the treatment of cancer
WO2007034143A1 (en) * 2005-09-20 2007-03-29 Astrazeneca Ab Quinazoline derivatives as anticancer agents
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CN101321739A (zh) * 2005-12-02 2008-12-10 阿斯利康(瑞典)有限公司 用作erbB酪氨酸激酶抑制剂的喹唑啉衍生物
JP2010525069A (ja) 2007-04-27 2010-07-22 パラテック ファーマシューティカルズ インコーポレイテッド アミノアルキルテトラサイクリン化合物の合成方法および精製方法
ATE555079T1 (de) * 2007-07-06 2012-05-15 Paratek Pharm Innc Verfahren zur synthese von 9-substituiertem minocyclin
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BRPI0414489A8 (pt) * 2003-09-16 2019-01-15 Astrazeneca Ab derivado de quinazolina, composição farmacêutica, uso de um derivado de quinazolina, e, processo para a preparação de um derivado de quinazolina
GB0321648D0 (en) * 2003-09-16 2003-10-15 Astrazeneca Ab Quinazoline derivatives
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Also Published As

Publication number Publication date
EP1713781B1 (en) 2008-11-05
ES2315834T3 (es) 2009-04-01
JP5032851B2 (ja) 2012-09-26
US7632840B2 (en) 2009-12-15
DE602005010824D1 (de) 2008-12-18
ATE413389T1 (de) 2008-11-15
TW200529851A (en) 2005-09-16
US20070293490A1 (en) 2007-12-20
CN1914182B (zh) 2011-09-07
HK1095590A1 (en) 2007-05-11
CN1914182A (zh) 2007-02-14
WO2005075439A1 (en) 2005-08-18
EP1713781A1 (en) 2006-10-25
JP2007523072A (ja) 2007-08-16
AR047703A1 (es) 2006-02-08

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Effective date: 20120418