ATE555079T1 - Verfahren zur synthese von 9-substituiertem minocyclin - Google Patents

Verfahren zur synthese von 9-substituiertem minocyclin

Info

Publication number
ATE555079T1
ATE555079T1 AT08826197T AT08826197T ATE555079T1 AT E555079 T1 ATE555079 T1 AT E555079T1 AT 08826197 T AT08826197 T AT 08826197T AT 08826197 T AT08826197 T AT 08826197T AT E555079 T1 ATE555079 T1 AT E555079T1
Authority
AT
Austria
Prior art keywords
tetracycline compound
conditions
substituted tetracycline
reacting
synthesis
Prior art date
Application number
AT08826197T
Other languages
English (en)
Inventor
Farzaneh Seyedi
Tadeusz Warchol
Mark Grier
Original Assignee
Paratek Pharm Innc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharm Innc filed Critical Paratek Pharm Innc
Application granted granted Critical
Publication of ATE555079T1 publication Critical patent/ATE555079T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT08826197T 2007-07-06 2008-07-07 Verfahren zur synthese von 9-substituiertem minocyclin ATE555079T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94838507P 2007-07-06 2007-07-06
US6035108P 2008-06-10 2008-06-10
PCT/US2008/008355 WO2009009042A1 (en) 2007-07-06 2008-07-07 Methods for synthesizing substituted tetracycline compounds

Publications (1)

Publication Number Publication Date
ATE555079T1 true ATE555079T1 (de) 2012-05-15

Family

ID=39926392

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08826197T ATE555079T1 (de) 2007-07-06 2008-07-07 Verfahren zur synthese von 9-substituiertem minocyclin

Country Status (18)

Country Link
US (2) US9522872B2 (de)
EP (2) EP2192111A3 (de)
JP (2) JP2010532759A (de)
KR (1) KR20100042276A (de)
CN (2) CN101784517A (de)
AT (1) ATE555079T1 (de)
AU (2) AU2008275701B2 (de)
BR (2) BRPI0823405A2 (de)
CA (1) CA2693376A1 (de)
DK (1) DK2176216T3 (de)
EA (2) EA201070233A1 (de)
ES (1) ES2386926T3 (de)
HK (1) HK1139386A1 (de)
HR (1) HRP20120605T1 (de)
IL (1) IL204133A0 (de)
PT (1) PT2176216E (de)
WO (1) WO2009009042A1 (de)
ZA (2) ZA201000034B (de)

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* Cited by examiner, † Cited by third party
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EP1910273A2 (de) * 2005-07-21 2008-04-16 Paratek Pharmaceuticals, Inc. 10-substituierte tetracycline und verfahren zuderen herstellung
JP2009537139A (ja) * 2006-05-15 2009-10-29 パラテック ファーマシューティカルズ インコーポレイテッド 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を制御する方法
CA2892739A1 (en) 2006-12-21 2008-07-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
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AU2008239606A1 (en) 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
JP2010525069A (ja) 2007-04-27 2010-07-22 パラテック ファーマシューティカルズ インコーポレイテッド アミノアルキルテトラサイクリン化合物の合成方法および精製方法
WO2009111064A2 (en) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
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WO2010033939A1 (en) * 2008-09-19 2010-03-25 Paratek Pharmaceuticals, Inc. Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment
NO2470500T3 (de) * 2009-08-28 2018-03-03
WO2012065028A2 (en) 2010-11-11 2012-05-18 Concert Pharmaceuticals Inc. Substituted tetracyclines
BR112015004523B1 (pt) 2012-08-31 2020-08-04 Tetraphase Pharmaceuticals, Inc Compostos de tetraciclina, composições farmacêuticas e seus usos
SG11201903327PA (en) 2016-10-19 2019-05-30 Tetraphase Pharmaceuticals Inc Crystalline forms of eravacycline
US10383884B2 (en) 2016-11-01 2019-08-20 Paratek Pharmaceuticals, Inc. 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (CABP)
US20210017123A1 (en) * 2018-04-06 2021-01-21 Paratek Pharmaceuticals, Inc. Process for making sarecycline hydrochloride
PT117254B (pt) 2021-05-26 2024-04-18 Hovione Farm S A Método de síntese de compostos 9-aminometil tetraciclinas

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Also Published As

Publication number Publication date
EA201070048A1 (ru) 2010-10-29
PT2176216E (pt) 2012-07-27
US20170283368A1 (en) 2017-10-05
EP2176216A1 (de) 2010-04-21
AU2008275701A1 (en) 2009-01-15
AU2010200845A1 (en) 2010-04-01
US20090156842A1 (en) 2009-06-18
CA2693376A1 (en) 2009-01-15
BRPI0813990A2 (pt) 2011-09-13
CN101811980A (zh) 2010-08-25
HK1139386A1 (en) 2010-09-17
US9522872B2 (en) 2016-12-20
EP2192111A2 (de) 2010-06-02
AU2010200845B2 (en) 2013-01-17
KR20100042276A (ko) 2010-04-23
CN101784517A (zh) 2010-07-21
ZA201008646B (en) 2012-02-29
AU2008275701B2 (en) 2013-04-04
BRPI0823405A2 (pt) 2012-12-25
ES2386926T3 (es) 2012-09-06
DK2176216T3 (da) 2012-07-30
EA201070233A1 (ru) 2010-08-30
ZA201000034B (en) 2011-10-26
JP2010532759A (ja) 2010-10-14
EP2192111A3 (de) 2010-10-06
IL204133A0 (en) 2011-07-31
WO2009009042A1 (en) 2009-01-15
HRP20120605T1 (hr) 2012-09-30
EP2176216B1 (de) 2012-04-25
JP2011020996A (ja) 2011-02-03

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