ATE555079T1 - Verfahren zur synthese von 9-substituiertem minocyclin - Google Patents
Verfahren zur synthese von 9-substituiertem minocyclinInfo
- Publication number
- ATE555079T1 ATE555079T1 AT08826197T AT08826197T ATE555079T1 AT E555079 T1 ATE555079 T1 AT E555079T1 AT 08826197 T AT08826197 T AT 08826197T AT 08826197 T AT08826197 T AT 08826197T AT E555079 T1 ATE555079 T1 AT E555079T1
- Authority
- AT
- Austria
- Prior art keywords
- tetracycline compound
- conditions
- substituted tetracycline
- reacting
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94838507P | 2007-07-06 | 2007-07-06 | |
US6035108P | 2008-06-10 | 2008-06-10 | |
PCT/US2008/008355 WO2009009042A1 (en) | 2007-07-06 | 2008-07-07 | Methods for synthesizing substituted tetracycline compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE555079T1 true ATE555079T1 (de) | 2012-05-15 |
Family
ID=39926392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08826197T ATE555079T1 (de) | 2007-07-06 | 2008-07-07 | Verfahren zur synthese von 9-substituiertem minocyclin |
Country Status (18)
Country | Link |
---|---|
US (2) | US9522872B2 (de) |
EP (2) | EP2192111A3 (de) |
JP (2) | JP2010532759A (de) |
KR (1) | KR20100042276A (de) |
CN (2) | CN101811980A (de) |
AT (1) | ATE555079T1 (de) |
AU (2) | AU2008275701B2 (de) |
BR (2) | BRPI0823405A2 (de) |
CA (1) | CA2693376A1 (de) |
DK (1) | DK2176216T3 (de) |
EA (2) | EA201070048A1 (de) |
ES (1) | ES2386926T3 (de) |
HK (1) | HK1139386A1 (de) |
HR (1) | HRP20120605T1 (de) |
IL (1) | IL204133A0 (de) |
PT (1) | PT2176216E (de) |
WO (1) | WO2009009042A1 (de) |
ZA (2) | ZA201000034B (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
EP2298322A3 (de) * | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclin-Verbindungen |
EP2284156A3 (de) * | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclin-Verbindungen |
US8088755B2 (en) * | 2005-02-04 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
US20070093455A1 (en) * | 2005-07-21 | 2007-04-26 | Paul Abato | 10-substituted tetracyclines and methods of use thereof |
JP2009537139A (ja) * | 2006-05-15 | 2009-10-29 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を制御する方法 |
ES2701725T3 (es) | 2006-12-21 | 2019-02-25 | Paratek Pharm Innc | Compuestos de tetraciclina sustituida para el tratamiento de trastornos inflamatorios de la piel |
CA2925939C (en) * | 2006-12-21 | 2019-10-01 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
CA2688725A1 (en) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
EP2216323A3 (de) | 2007-04-27 | 2010-12-29 | Paratek Pharmaceuticals, Inc. | Verfahren zur Synthetisierung und Reinigung von Aminoalkyl-Tetracyclinverbindungen |
US20090253660A1 (en) | 2008-03-05 | 2009-10-08 | Paratek Pharmaceuticals, Inc. | Minocycline Compounds and Methods of Use Thereof |
WO2009128913A1 (en) * | 2008-04-14 | 2009-10-22 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
CA2737470A1 (en) * | 2008-09-19 | 2010-03-25 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment |
WO2011025982A2 (en) * | 2009-08-28 | 2011-03-03 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
WO2012065028A2 (en) | 2010-11-11 | 2012-05-18 | Concert Pharmaceuticals Inc. | Substituted tetracyclines |
NZ740051A (en) | 2012-08-31 | 2019-09-27 | Tetraphase Pharmaceuticals Inc | Tetracycline compounds |
SG11201903327PA (en) | 2016-10-19 | 2019-05-30 | Tetraphase Pharmaceuticals Inc | Crystalline forms of eravacycline |
SG10201913599RA (en) | 2016-11-01 | 2020-02-27 | Paratek Pharm Innc | 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp) |
AU2019248350B2 (en) * | 2018-04-06 | 2023-07-27 | Almirall, Llc | Process for making sarecycline hydrochloride |
PT117254B (pt) | 2021-05-26 | 2024-04-18 | Hovione Farm S A | Método de síntese de compostos 9-aminometil tetraciclinas |
Family Cites Families (88)
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US2990331A (en) | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
US2820824A (en) * | 1957-04-15 | 1958-01-21 | American Cyanamid Co | Purification of neutral tetracycline |
US2980584A (en) | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
US3062717A (en) | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
US3165531A (en) | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
US3454697A (en) | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
US3304227A (en) * | 1965-07-15 | 1967-02-14 | Loyal E Loveless | Antibiotic-containing animal feed |
NL6607516A (de) | 1966-05-31 | 1967-12-01 | ||
DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
US3876699A (en) * | 1969-10-01 | 1975-04-08 | Squibb & Sons Inc | Purification of tetracycline antibiotic |
US3957980A (en) | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
DE2442829A1 (de) | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
US4018889A (en) | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
US4126680A (en) | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
US4666897A (en) * | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
US4704383A (en) * | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
USRE34656E (en) * | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
US4935412A (en) * | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
US4925833A (en) * | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
US5770588A (en) * | 1991-02-11 | 1998-06-23 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions of the prevention and treatment of root caries |
US6756365B2 (en) | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
US5258371A (en) * | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
US6043225A (en) * | 1992-06-12 | 2000-03-28 | Board Of Regents Of The University Of Washington | Diagnosis and treatment of arterial chlamydial granuloma |
CA2103189C (en) * | 1992-11-17 | 2005-05-03 | Lorne M. Golub | Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive collagen crosslinking during diabetes |
US5523297A (en) * | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US6043231A (en) * | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US5668122A (en) * | 1993-07-28 | 1997-09-16 | Fife; Rose S. | Method to treat cancer with tetracyclines |
CA2183565A1 (en) * | 1994-02-17 | 1995-08-24 | Wei-Guo Su | 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
US5843925A (en) * | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
JPH09227439A (ja) * | 1996-02-22 | 1997-09-02 | Teikoku Chem Ind Corp Ltd | アルデヒド化方法 |
US5834449A (en) * | 1996-06-13 | 1998-11-10 | The Research Foundation Of State University Of New York | Treatment of aortic and vascular aneurysms with tetracycline compounds |
US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
US5919774A (en) * | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
US5837696A (en) * | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
US5773430A (en) * | 1997-03-13 | 1998-06-30 | Research Foundation Of State University Of New York | Serine proteinase inhibitory activity by hydrophobic tetracycline |
US5929055A (en) * | 1997-06-23 | 1999-07-27 | The Research Foundation Of State University Of New York | Therapeutic method for management of diabetes mellitus |
IL137445A0 (en) | 1998-01-23 | 2001-07-24 | Tufts College | Pharmaceutically active compounds and methods of use thereof |
US6277061B1 (en) * | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
US6015804A (en) * | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
US5977091A (en) * | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
US5998390A (en) * | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
US6500812B2 (en) | 1999-09-14 | 2002-12-31 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
DE60027465T2 (de) | 1999-09-14 | 2007-02-01 | The Trustees Of Tufts College, Medford | Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien |
US8106225B2 (en) | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
US6849615B2 (en) | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
US6231894B1 (en) * | 1999-10-21 | 2001-05-15 | Duke University | Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase |
EP1250332A1 (de) * | 1999-12-17 | 2002-10-23 | Abbott Laboratories | Inhibitoren des interleukin-5 genausdrucks |
WO2001052858A1 (en) | 2000-01-24 | 2001-07-26 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
IL151971A0 (en) | 2000-03-31 | 2003-04-10 | Tufts College | 7-and 9-carbamate, urea, thiourea, thiocarbabamate, and heteroaryl-amino substituted tetracycline compounds |
US6642270B2 (en) | 2000-05-15 | 2003-11-04 | Paratek Pharmaceuticals, Inc. | 7-substituted fused ring tetracycline compounds |
US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US20020128238A1 (en) | 2000-06-16 | 2002-09-12 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
CN1450989A (zh) | 2000-07-07 | 2003-10-22 | 塔夫茨大学信托人 | 7-取代的四环素化合物 |
DE60144375D1 (de) | 2000-07-07 | 2011-05-19 | Trustees Of Tufts College Medford | 7-, 8- und 9-substitutierte tetracyclinverbindungen |
SI1301467T1 (sl) * | 2000-07-07 | 2007-02-28 | Tufts College | 9-substituirane minociklinske spojine |
US20050143353A1 (en) | 2000-07-07 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | 13-Substituted methacycline compounds |
WO2002072506A2 (en) | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
EP1241160A1 (de) | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracyclinderivate und ihre Verwendung als Antibiotica |
US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
DE60135387D1 (de) * | 2001-03-13 | 2008-09-25 | Paratek Pharm Innc | 7,9 substituierte tetracyclinverbindungen |
WO2003055441A2 (en) | 2001-08-02 | 2003-07-10 | Paratek Pharmaceuticals, Inc. | Medicaments |
US6908939B2 (en) * | 2001-12-21 | 2005-06-21 | Galderma Research & Development S.N.C. | Biaromatic ligand activators of PPARγ receptors |
JP2003252803A (ja) * | 2002-03-01 | 2003-09-10 | Sumitomo Chem Co Ltd | 置換不飽和化合物の製造法 |
CN102531948A (zh) | 2002-03-08 | 2012-07-04 | 帕拉特克药品公司 | 氨基-甲基取代的四环素类化合物 |
AU2003218243B2 (en) * | 2002-03-21 | 2010-04-01 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
KR101148415B1 (ko) | 2002-07-12 | 2012-05-21 | 파라테크 파마슈티컬스, 인크. | 3, 10, 및 12a 치환된 테트라시클린 화합물 |
US6846938B2 (en) * | 2002-07-29 | 2005-01-25 | Eastman Kodak Company | Water-compatible epoxy compounds containing sulfonate or thiosulfate moieties |
WO2004091513A2 (en) | 2003-04-10 | 2004-10-28 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
EP2298322A3 (de) * | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclin-Verbindungen |
US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
JP4738333B2 (ja) * | 2003-07-09 | 2011-08-03 | パラテック ファーマシューティカルズ インコーポレイテッド | 9−アミノメチルテトラサイクリン化合物のプロドラッグ |
CA2553510C (en) | 2004-01-15 | 2012-09-25 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
ES2315834T3 (es) | 2004-02-03 | 2009-04-01 | Astrazeneca Ab | Derivados de quinazolina. |
JP4625652B2 (ja) * | 2004-05-13 | 2011-02-02 | 東ソー株式会社 | 2−ぺルフルオロアルキルアクリル酸エステルの製造方法 |
AU2005269386A1 (en) * | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
EP2284156A3 (de) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclin-Verbindungen |
CA2585418A1 (en) * | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
US8088755B2 (en) | 2005-02-04 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
US20070093455A1 (en) | 2005-07-21 | 2007-04-26 | Paul Abato | 10-substituted tetracyclines and methods of use thereof |
JP5395432B2 (ja) * | 2005-08-24 | 2014-01-22 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | トリアゾール化合物ならびにこれを作製する方法および使用する方法 |
CN101316823B (zh) * | 2005-12-01 | 2013-05-22 | 霍夫曼-拉罗奇有限公司 | 用作抗癌剂的作为p53和MDM2蛋白之间相互作用的抑制剂的2,4,5-三苯基咪唑啉衍生物 |
CA2925939C (en) * | 2006-12-21 | 2019-10-01 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
EP2216323A3 (de) * | 2007-04-27 | 2010-12-29 | Paratek Pharmaceuticals, Inc. | Verfahren zur Synthetisierung und Reinigung von Aminoalkyl-Tetracyclinverbindungen |
-
2008
- 2008-07-07 BR BRPI0823405-1A patent/BRPI0823405A2/pt not_active IP Right Cessation
- 2008-07-07 AT AT08826197T patent/ATE555079T1/de active
- 2008-07-07 KR KR1020107002676A patent/KR20100042276A/ko not_active Application Discontinuation
- 2008-07-07 PT PT08826197T patent/PT2176216E/pt unknown
- 2008-07-07 EA EA201070048A patent/EA201070048A1/ru unknown
- 2008-07-07 EA EA201070233A patent/EA201070233A1/ru unknown
- 2008-07-07 JP JP2010514886A patent/JP2010532759A/ja active Pending
- 2008-07-07 CA CA2693376A patent/CA2693376A1/en not_active Abandoned
- 2008-07-07 CN CN201010175452A patent/CN101811980A/zh active Pending
- 2008-07-07 WO PCT/US2008/008355 patent/WO2009009042A1/en active Application Filing
- 2008-07-07 US US12/217,709 patent/US9522872B2/en active Active
- 2008-07-07 ES ES08826197T patent/ES2386926T3/es active Active
- 2008-07-07 DK DK08826197.9T patent/DK2176216T3/da active
- 2008-07-07 BR BRPI0813990-3A patent/BRPI0813990A2/pt not_active IP Right Cessation
- 2008-07-07 EP EP10154210A patent/EP2192111A3/de not_active Ceased
- 2008-07-07 EP EP08826197A patent/EP2176216B1/de not_active Not-in-force
- 2008-07-07 AU AU2008275701A patent/AU2008275701B2/en not_active Expired - Fee Related
- 2008-07-07 CN CN200880105304A patent/CN101784517A/zh active Pending
-
2010
- 2010-01-04 ZA ZA2010/00034A patent/ZA201000034B/en unknown
- 2010-02-24 IL IL204133A patent/IL204133A0/en unknown
- 2010-03-04 JP JP2010048260A patent/JP2011020996A/ja active Pending
- 2010-03-05 AU AU2010200845A patent/AU2010200845B2/en not_active Ceased
- 2010-06-25 HK HK10106266.2A patent/HK1139386A1/xx not_active IP Right Cessation
- 2010-12-01 ZA ZA2010/08646A patent/ZA201008646B/en unknown
-
2012
- 2012-07-23 HR HRP20120605AT patent/HRP20120605T1/hr unknown
-
2016
- 2016-11-15 US US15/351,700 patent/US20170283368A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2011020996A (ja) | 2011-02-03 |
JP2010532759A (ja) | 2010-10-14 |
ZA201008646B (en) | 2012-02-29 |
CN101784517A (zh) | 2010-07-21 |
WO2009009042A1 (en) | 2009-01-15 |
CA2693376A1 (en) | 2009-01-15 |
EP2176216B1 (de) | 2012-04-25 |
BRPI0813990A2 (pt) | 2011-09-13 |
EA201070048A1 (ru) | 2010-10-29 |
IL204133A0 (en) | 2011-07-31 |
PT2176216E (pt) | 2012-07-27 |
HRP20120605T1 (hr) | 2012-09-30 |
CN101811980A (zh) | 2010-08-25 |
HK1139386A1 (en) | 2010-09-17 |
EA201070233A1 (ru) | 2010-08-30 |
BRPI0823405A2 (pt) | 2012-12-25 |
US9522872B2 (en) | 2016-12-20 |
DK2176216T3 (da) | 2012-07-30 |
ZA201000034B (en) | 2011-10-26 |
US20090156842A1 (en) | 2009-06-18 |
EP2192111A3 (de) | 2010-10-06 |
EP2176216A1 (de) | 2010-04-21 |
ES2386926T3 (es) | 2012-09-06 |
AU2008275701A1 (en) | 2009-01-15 |
AU2010200845B2 (en) | 2013-01-17 |
AU2010200845A1 (en) | 2010-04-01 |
AU2008275701B2 (en) | 2013-04-04 |
US20170283368A1 (en) | 2017-10-05 |
EP2192111A2 (de) | 2010-06-02 |
KR20100042276A (ko) | 2010-04-23 |
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