EA201070233A1 - Способы синтеза замещённых соединений тетрациклина (варианты) - Google Patents

Способы синтеза замещённых соединений тетрациклина (варианты)

Info

Publication number
EA201070233A1
EA201070233A1 EA201070233A EA201070233A EA201070233A1 EA 201070233 A1 EA201070233 A1 EA 201070233A1 EA 201070233 A EA201070233 A EA 201070233A EA 201070233 A EA201070233 A EA 201070233A EA 201070233 A1 EA201070233 A1 EA 201070233A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
tetracycline compound
conditions
substituted tetracycline
tetracycline
Prior art date
Application number
EA201070233A
Other languages
English (en)
Inventor
Фарзанех Сейеди
Тадеуш Уорчол
Марк Гриер
Original Assignee
Паратек Фармасьютикалс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Паратек Фармасьютикалс, Инк. filed Critical Паратек Фармасьютикалс, Инк.
Publication of EA201070233A1 publication Critical patent/EA201070233A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Способы синтеза карбоксальдегидзамещенного соединения тетрациклина, включающие такое взаимодействие реакционноспособного интермедиата тетрациклина с монооксидом углерода, палладиевым катализатором, фосфиновым лигандом, силаном и основанием при соответствующих условиях, при котором образуется карбоксальдегидзамещенное соединение тетрациклина. В качестве палладиевого катализатора используют PdCl(tBuPhP)[дихлорбис(ди--бутилфенилфосфин)палладий (II)] или PdClCDPEPhos) [хлорид бис(дифенилфосфинофенил)эфирпалладия (II)]. Реакционноспособный интермедиат тетрациклина содержит функциональные группы галогенов или трифлатов. Способы синтеза замещенного соединения тетрациклина, включающие превращение карбоксальдегидзамещенного соединения тетрациклина в условиях катализируемой палладием реакции сочетания, реакции гидрогенолиза и восстановительного аминирования.
EA201070233A 2007-07-06 2008-07-07 Способы синтеза замещённых соединений тетрациклина (варианты) EA201070233A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94838507P 2007-07-06 2007-07-06
US6035108P 2008-06-10 2008-06-10

Publications (1)

Publication Number Publication Date
EA201070233A1 true EA201070233A1 (ru) 2010-08-30

Family

ID=39926392

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201070233A EA201070233A1 (ru) 2007-07-06 2008-07-07 Способы синтеза замещённых соединений тетрациклина (варианты)
EA201070048A EA201070048A1 (ru) 2007-07-06 2008-07-07 Способы синтеза замещённых соединений тетрациклина (варианты)

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201070048A EA201070048A1 (ru) 2007-07-06 2008-07-07 Способы синтеза замещённых соединений тетрациклина (варианты)

Country Status (18)

Country Link
US (2) US9522872B2 (ru)
EP (2) EP2192111A3 (ru)
JP (2) JP2010532759A (ru)
KR (1) KR20100042276A (ru)
CN (2) CN101811980A (ru)
AT (1) ATE555079T1 (ru)
AU (2) AU2008275701B2 (ru)
BR (2) BRPI0823405A2 (ru)
CA (1) CA2693376A1 (ru)
DK (1) DK2176216T3 (ru)
EA (2) EA201070233A1 (ru)
ES (1) ES2386926T3 (ru)
HK (1) HK1139386A1 (ru)
HR (1) HRP20120605T1 (ru)
IL (1) IL204133A0 (ru)
PT (1) PT2176216E (ru)
WO (1) WO2009009042A1 (ru)
ZA (2) ZA201000034B (ru)

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NO2470500T3 (ru) * 2009-08-28 2018-03-03
WO2012065028A2 (en) 2010-11-11 2012-05-18 Concert Pharmaceuticals Inc. Substituted tetracyclines
LT2890673T (lt) 2012-08-31 2019-04-10 Tetraphase Pharmaceuticals, Inc. Tetraciklino junginiai
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Also Published As

Publication number Publication date
HRP20120605T1 (hr) 2012-09-30
ZA201000034B (en) 2011-10-26
KR20100042276A (ko) 2010-04-23
EA201070048A1 (ru) 2010-10-29
EP2192111A2 (en) 2010-06-02
PT2176216E (pt) 2012-07-27
CN101811980A (zh) 2010-08-25
EP2192111A3 (en) 2010-10-06
WO2009009042A1 (en) 2009-01-15
IL204133A0 (en) 2011-07-31
US20090156842A1 (en) 2009-06-18
CA2693376A1 (en) 2009-01-15
HK1139386A1 (en) 2010-09-17
AU2010200845B2 (en) 2013-01-17
ES2386926T3 (es) 2012-09-06
BRPI0813990A2 (pt) 2011-09-13
ZA201008646B (en) 2012-02-29
JP2011020996A (ja) 2011-02-03
AU2008275701B2 (en) 2013-04-04
EP2176216A1 (en) 2010-04-21
BRPI0823405A2 (pt) 2012-12-25
AU2008275701A1 (en) 2009-01-15
ATE555079T1 (de) 2012-05-15
EP2176216B1 (en) 2012-04-25
US20170283368A1 (en) 2017-10-05
JP2010532759A (ja) 2010-10-14
CN101784517A (zh) 2010-07-21
AU2010200845A1 (en) 2010-04-01
US9522872B2 (en) 2016-12-20
DK2176216T3 (da) 2012-07-30

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