HRP20120605T1 - Postupci sinteze 9-supstituiranog minociklina - Google Patents
Postupci sinteze 9-supstituiranog minociklina Download PDFInfo
- Publication number
- HRP20120605T1 HRP20120605T1 HRP20120605AT HRP20120605T HRP20120605T1 HR P20120605 T1 HRP20120605 T1 HR P20120605T1 HR P20120605A T HRP20120605A T HR P20120605AT HR P20120605 T HRP20120605 T HR P20120605T HR P20120605 T1 HRP20120605 T1 HR P20120605T1
- Authority
- HR
- Croatia
- Prior art keywords
- minocycline
- conditions
- substituted
- substituted minocycline
- compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 7
- 229960004023 minocycline Drugs 0.000 title claims 11
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical class C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 title claims 8
- 230000002194 synthesizing effect Effects 0.000 title abstract 2
- -1 tetracycline compound Chemical class 0.000 claims abstract 9
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims abstract 8
- 229910052763 palladium Inorganic materials 0.000 claims abstract 4
- 239000003054 catalyst Substances 0.000 claims abstract 3
- 238000006268 reductive amination reaction Methods 0.000 claims abstract 3
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims abstract 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910002091 carbon monoxide Inorganic materials 0.000 claims abstract 2
- 238000007327 hydrogenolysis reaction Methods 0.000 claims abstract 2
- 229910000077 silane Inorganic materials 0.000 claims abstract 2
- 238000006243 chemical reaction Methods 0.000 claims 3
- 229910002666 PdCl2 Inorganic materials 0.000 claims 2
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical group Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- XOJNEFQLMRCOMS-UHFFFAOYSA-N ditert-butyl(phenyl)phosphane Chemical compound CC(C)(C)P(C(C)(C)C)C1=CC=CC=C1 XOJNEFQLMRCOMS-UHFFFAOYSA-N 0.000 claims 1
- MUJIDPITZJWBSW-UHFFFAOYSA-N palladium(2+) Chemical compound [Pd+2] MUJIDPITZJWBSW-UHFFFAOYSA-N 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 abstract 5
- 229960002180 tetracycline Drugs 0.000 abstract 5
- 229930101283 tetracycline Natural products 0.000 abstract 5
- 235000019364 tetracycline Nutrition 0.000 abstract 5
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94838507P | 2007-07-06 | 2007-07-06 | |
| US6035108P | 2008-06-10 | 2008-06-10 | |
| PCT/US2008/008355 WO2009009042A1 (en) | 2007-07-06 | 2008-07-07 | Methods for synthesizing substituted tetracycline compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120605T1 true HRP20120605T1 (hr) | 2012-09-30 |
Family
ID=39926392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120605AT HRP20120605T1 (hr) | 2007-07-06 | 2012-07-23 | Postupci sinteze 9-supstituiranog minociklina |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9522872B2 (ru) |
| EP (2) | EP2192111A3 (ru) |
| JP (2) | JP2010532759A (ru) |
| KR (1) | KR20100042276A (ru) |
| CN (2) | CN101784517A (ru) |
| AT (1) | ATE555079T1 (ru) |
| AU (2) | AU2008275701B2 (ru) |
| BR (2) | BRPI0823405A2 (ru) |
| CA (1) | CA2693376A1 (ru) |
| DK (1) | DK2176216T3 (ru) |
| EA (2) | EA201070048A1 (ru) |
| ES (1) | ES2386926T3 (ru) |
| HK (1) | HK1139386A1 (ru) |
| HR (1) | HRP20120605T1 (ru) |
| IL (1) | IL204133A0 (ru) |
| PT (1) | PT2176216E (ru) |
| WO (1) | WO2009009042A1 (ru) |
| ZA (2) | ZA201000034B (ru) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP2298323A3 (en) * | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP2284150A3 (en) * | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP1848685A1 (en) | 2005-02-04 | 2007-10-31 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| JP2009502809A (ja) * | 2005-07-21 | 2009-01-29 | パラテック ファーマシューティカルズ インコーポレイテッド | １０−置換テトラサイクリンおよびその使用方法 |
| JP2009543544A (ja) * | 2006-05-15 | 2009-12-10 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を調節する方法 |
| KR101538175B1 (ko) * | 2006-12-21 | 2015-07-20 | 파라테크 파마슈티컬스, 인크. | 박테리아, 바이러스 및 기생충 감염의 치료를 위한 테트라시클린 유도체 |
| US8513223B2 (en) | 2006-12-21 | 2013-08-20 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| JP2010523684A (ja) | 2007-04-12 | 2010-07-15 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法 |
| EP2144870A2 (en) * | 2007-04-27 | 2010-01-20 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| EP2262754A4 (en) | 2008-03-05 | 2012-03-14 | Paratek Pharm Innc | MINOCYCLINE COMPOUNDS AND METHODS OF USE THEREOF |
| US20100022483A1 (en) * | 2008-04-14 | 2010-01-28 | Paratek Pharmaceuticals, Inc. | Substituted Tetracycline Compounds |
| EP2341771A4 (en) * | 2008-09-19 | 2012-08-15 | Paratek Pharm Innc | TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED THERAPEUTIC METHODS |
| CN102596898B (zh) * | 2009-08-28 | 2016-01-27 | 四相制药公司 | 四环素类化合物 |
| WO2012065028A2 (en) | 2010-11-11 | 2012-05-18 | Concert Pharmaceuticals Inc. | Substituted tetracyclines |
| NZ705849A (en) | 2012-08-31 | 2018-06-29 | Tetraphase Pharmaceuticals Inc | Tetracycline compounds |
| DK3529236T3 (da) | 2016-10-19 | 2024-05-13 | Tetraphase Pharmaceuticals Inc | Krystalformer af eravacyclin |
| MX2019005070A (es) | 2016-11-01 | 2019-09-23 | Paratek Pharm Innc | Compuestos de 9-aminometil minociclina y su uso en el tratamiento de neumonía bacteriana adquirida en la comunidad (cabp). |
| CN115380022A (zh) * | 2018-04-06 | 2022-11-22 | 帕拉特克药品公司 | 萨瑞环素盐酸盐的制造方法 |
| PT117254B (pt) | 2021-05-26 | 2024-04-18 | Hovione Farm S A | Método de síntese de compostos 9-aminometil tetraciclinas |
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| US2820824A (en) | 1957-04-15 | 1958-01-21 | American Cyanamid Co | Purification of neutral tetracycline |
| US2980584A (en) | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3062717A (en) | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3165531A (en) | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
| US3454697A (en) | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
| US3304227A (en) | 1965-07-15 | 1967-02-14 | Loyal E Loveless | Antibiotic-containing animal feed |
| NL6607516A (ru) | 1966-05-31 | 1967-12-01 | ||
| DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
| US3876699A (en) | 1969-10-01 | 1975-04-08 | Squibb & Sons Inc | Purification of tetracycline antibiotic |
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| CA2672722C (en) | 1999-09-14 | 2013-11-05 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| US8106225B2 (en) | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
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| US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
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| EP1534300A4 (en) | 2002-07-12 | 2008-04-23 | Paratek Pharm Innc | TETRACYCLINE COMPOUNDS SUBSTITUTED IN 3, 10, AND 12A |
| US6846938B2 (en) * | 2002-07-29 | 2005-01-25 | Eastman Kodak Company | Water-compatible epoxy compounds containing sulfonate or thiosulfate moieties |
| WO2004091513A2 (en) | 2003-04-10 | 2004-10-28 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| JP4738333B2 (ja) | 2003-07-09 | 2011-08-03 | パラテック ファーマシューティカルズ インコーポレイテッド | ９−アミノメチルテトラサイクリン化合物のプロドラッグ |
| EP2298323A3 (en) | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP1716101A1 (en) | 2004-01-15 | 2006-11-02 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
| WO2005075439A1 (en) * | 2004-02-03 | 2005-08-18 | Astrazeneca Ab | Quinazoline derivatives |
| JP4625652B2 (ja) * | 2004-05-13 | 2011-02-02 | 東ソー株式会社 | ２−ぺルフルオロアルキルアクリル酸エステルの製造方法 |
| NZ553267A (en) * | 2004-07-27 | 2010-09-30 | Sgx Pharmaceuticals Inc | Pyrrolo-pyridine kinase modulators |
| EP2284150A3 (en) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP2301916A3 (en) | 2004-10-25 | 2011-09-28 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| EP1848685A1 (en) | 2005-02-04 | 2007-10-31 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| JP2009502809A (ja) | 2005-07-21 | 2009-01-29 | パラテック ファーマシューティカルズ インコーポレイテッド | １０−置換テトラサイクリンおよびその使用方法 |
| DK1934238T3 (en) * | 2005-08-24 | 2017-09-18 | Melinta Therapeutics Inc | TRIAZOL COMPOUNDS AND METHODS FOR THE PREPARATION AND USE OF THESE |
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| KR101538175B1 (ko) * | 2006-12-21 | 2015-07-20 | 파라테크 파마슈티컬스, 인크. | 박테리아, 바이러스 및 기생충 감염의 치료를 위한 테트라시클린 유도체 |
| EP2144870A2 (en) | 2007-04-27 | 2010-01-20 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
-
2008
- 2008-07-07 EP EP10154210A patent/EP2192111A3/en not_active Ceased
- 2008-07-07 CA CA2693376A patent/CA2693376A1/en not_active Abandoned
- 2008-07-07 EA EA201070048A patent/EA201070048A1/ru unknown
- 2008-07-07 AT AT08826197T patent/ATE555079T1/de active
- 2008-07-07 BR BRPI0823405-1A patent/BRPI0823405A2/pt not_active IP Right Cessation
- 2008-07-07 KR KR1020107002676A patent/KR20100042276A/ko not_active Application Discontinuation
- 2008-07-07 CN CN200880105304A patent/CN101784517A/zh active Pending
- 2008-07-07 WO PCT/US2008/008355 patent/WO2009009042A1/en active Application Filing
- 2008-07-07 PT PT08826197T patent/PT2176216E/pt unknown
- 2008-07-07 BR BRPI0813990-3A patent/BRPI0813990A2/pt not_active IP Right Cessation
- 2008-07-07 JP JP2010514886A patent/JP2010532759A/ja active Pending
- 2008-07-07 US US12/217,709 patent/US9522872B2/en active Active
- 2008-07-07 CN CN201010175452A patent/CN101811980A/zh active Pending
- 2008-07-07 DK DK08826197.9T patent/DK2176216T3/da active
- 2008-07-07 AU AU2008275701A patent/AU2008275701B2/en not_active Expired - Fee Related
- 2008-07-07 EP EP08826197A patent/EP2176216B1/en not_active Not-in-force
- 2008-07-07 ES ES08826197T patent/ES2386926T3/es active Active
- 2008-07-07 EA EA201070233A patent/EA201070233A1/ru unknown
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2010
- 2010-01-04 ZA ZA2010/00034A patent/ZA201000034B/en unknown
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- 2010-03-04 JP JP2010048260A patent/JP2011020996A/ja active Pending
- 2010-03-05 AU AU2010200845A patent/AU2010200845B2/en not_active Ceased
- 2010-06-25 HK HK10106266.2A patent/HK1139386A1/xx not_active IP Right Cessation
- 2010-12-01 ZA ZA2010/08646A patent/ZA201008646B/en unknown
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2012
- 2012-07-23 HR HRP20120605AT patent/HRP20120605T1/hr unknown
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2016
- 2016-11-15 US US15/351,700 patent/US20170283368A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PT2176216E (pt) | 2012-07-27 |
| AU2008275701B2 (en) | 2013-04-04 |
| ZA201008646B (en) | 2012-02-29 |
| KR20100042276A (ko) | 2010-04-23 |
| CN101811980A (zh) | 2010-08-25 |
| IL204133A0 (en) | 2011-07-31 |
| ES2386926T3 (es) | 2012-09-06 |
| CN101784517A (zh) | 2010-07-21 |
| EP2176216B1 (en) | 2012-04-25 |
| DK2176216T3 (da) | 2012-07-30 |
| US9522872B2 (en) | 2016-12-20 |
| EA201070048A1 (ru) | 2010-10-29 |
| JP2010532759A (ja) | 2010-10-14 |
| AU2010200845A1 (en) | 2010-04-01 |
| HK1139386A1 (en) | 2010-09-17 |
| US20170283368A1 (en) | 2017-10-05 |
| AU2010200845B2 (en) | 2013-01-17 |
| US20090156842A1 (en) | 2009-06-18 |
| BRPI0813990A2 (pt) | 2011-09-13 |
| EP2192111A3 (en) | 2010-10-06 |
| ZA201000034B (en) | 2011-10-26 |
| EA201070233A1 (ru) | 2010-08-30 |
| EP2192111A2 (en) | 2010-06-02 |
| EP2176216A1 (en) | 2010-04-21 |
| AU2008275701A1 (en) | 2009-01-15 |
| WO2009009042A1 (en) | 2009-01-15 |
| BRPI0823405A2 (pt) | 2012-12-25 |
| CA2693376A1 (en) | 2009-01-15 |
| ATE555079T1 (de) | 2012-05-15 |
| JP2011020996A (ja) | 2011-02-03 |
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