DE60102815D1 - 7-substituierte kondensierte ring-tetrazyclin- verbindungen - Google Patents

7-substituierte kondensierte ring-tetrazyclin- verbindungen

Info

Publication number
DE60102815D1
DE60102815D1 DE60102815T DE60102815T DE60102815D1 DE 60102815 D1 DE60102815 D1 DE 60102815D1 DE 60102815 T DE60102815 T DE 60102815T DE 60102815 T DE60102815 T DE 60102815T DE 60102815 D1 DE60102815 D1 DE 60102815D1
Authority
DE
Germany
Prior art keywords
tetrazycline
compounds
condensed ring
substituted condensed
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60102815T
Other languages
English (en)
Inventor
L Nelson
Laura Mcintyre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Paratek Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc filed Critical Paratek Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60102815D1 publication Critical patent/DE60102815D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60102815T 2000-05-15 2001-05-10 7-substituierte kondensierte ring-tetrazyclin- verbindungen Expired - Lifetime DE60102815D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20415800P 2000-05-15 2000-05-15
PCT/US2001/015068 WO2001087824A2 (en) 2000-05-15 2001-05-10 7-substituted fused ring tetracycline compounds

Publications (1)

Publication Number Publication Date
DE60102815D1 true DE60102815D1 (de) 2004-05-19

Family

ID=22756861

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60102815T Expired - Lifetime DE60102815D1 (de) 2000-05-15 2001-05-10 7-substituierte kondensierte ring-tetrazyclin- verbindungen

Country Status (8)

Country Link
US (5) US6642270B2 (de)
EP (2) EP2308863A1 (de)
JP (2) JP2003533504A (de)
AT (1) ATE264295T1 (de)
AU (1) AU2001259701A1 (de)
CA (1) CA2409063A1 (de)
DE (1) DE60102815D1 (de)
WO (1) WO2001087824A2 (de)

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US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP2327686A3 (de) * 1999-09-14 2012-08-22 Trustees Of Tufts College Verfahren zur Herstellung von substituierten Tetracyclinen mit Übergangschemien auf Metallbasis
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
WO2001052858A1 (en) 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
BR0109725A (pt) * 2000-03-31 2003-02-04 Tufts College Composto de tetraciclina substituìdo, método para tratar um estado responsivo a tetraciclina em um mamìfero, composição farmacêutica, método para sintetizar um composto de tetraciclina 7- ou 9-substituìdo, e, intermediário reativo
AU2001259701A1 (en) * 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020128238A1 (en) * 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
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US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
MXPA03000056A (es) 2000-07-07 2003-07-14 Tufts College Compuestos de tetraciclina sustituidos en posicion 7.
BRPI0112269B8 (pt) 2000-07-07 2021-05-25 Paratek Pharm Innc composto de minociclina 9-aminometila substituída, e, composição farmacêutica
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AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
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WO2003079984A2 (en) * 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
JP4416652B2 (ja) * 2002-07-12 2010-02-17 パラテック ファーマシューティカルズ インコーポレイテッド ３、１０、および１２ａ置換されたテトラサイクリン化合物
CA2503446C (en) * 2002-10-24 2012-12-18 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate rna
JP2006511944A (ja) * 2002-12-20 2006-04-06 クリー　インコーポレイテッド 半導体メサ構造および導電性接合部を含む電子素子ならびに関連素子を形成する方法
CN1845897A (zh) * 2003-07-09 2006-10-11 帕拉特克药品公司 取代的四环素化合物
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CN103214409B (zh) 2004-05-21 2015-10-21 哈佛大学校长及研究员协会 四环素及其类似物的合成
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JP5583411B2 (ja) * 2006-12-21 2014-09-03 パラテック ファーマシューティカルズ インコーポレイテッド 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体
US7935687B2 (en) * 2007-04-12 2011-05-03 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
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TWI459947B (zh) * 2007-06-26 2014-11-11 Otsuka Pharma Co Ltd 苯并氮呯化合物及藥學製劑
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NZ586445A (en) 2007-11-29 2012-06-29 Actelion Pharmaceuticals Ltd Phosphonic acid derivates and their use as p2y12 receptor antagonists
JP2011513404A (ja) 2008-03-05 2011-04-28 パラテック ファーマシューティカルズ インコーポレイテッド ミノサイクリン化合物およびその使用方法
US20100022483A1 (en) * 2008-04-14 2010-01-28 Paratek Pharmaceuticals, Inc. Substituted Tetracycline Compounds
AP2011005631A0 (en) * 2008-09-19 2011-04-30 Paratek Pharmaceuticals Ind Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment.
JP5656399B2 (ja) * 2008-12-26 2015-01-21 大塚製薬株式会社 医薬及び医薬製剤
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
AU2011329854B2 (en) 2010-11-16 2017-03-30 University Of Southern California CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells
BR112019008897A2 (pt) 2016-11-01 2019-08-13 Paratek Pharm Innc método para tratar pneumonia bacteriana adquirida na comunidade.

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BRPI0112269B8 (pt) * 2000-07-07 2021-05-25 Paratek Pharm Innc composto de minociclina 9-aminometila substituída, e, composição farmacêutica
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Also Published As

Publication number Publication date
ATE264295T1 (de) 2004-04-15
US6642270B2 (en) 2003-11-04
US20060148765A1 (en) 2006-07-06
EP1286954B1 (de) 2004-04-14
US8288570B2 (en) 2012-10-16
EP2308863A1 (de) 2011-04-13
JP2013040173A (ja) 2013-02-28
JP2003533504A (ja) 2003-11-11
AU2001259701A1 (en) 2001-11-26
CA2409063A1 (en) 2001-11-22
WO2001087824A2 (en) 2001-11-22
US7893282B2 (en) 2011-02-22
US20110207951A1 (en) 2011-08-25
WO2001087824A3 (en) 2002-04-11
US20040048835A1 (en) 2004-03-11
US20020045602A1 (en) 2002-04-18
US7612053B2 (en) 2009-11-03
EP1286954A2 (de) 2003-03-05
US20080300424A1 (en) 2008-12-04

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