ATE455092T1 - Substituierte tetracyclin-verbindungen zur behandlung von malaria - Google Patents

Substituierte tetracyclin-verbindungen zur behandlung von malaria

Info

Publication number
ATE455092T1
ATE455092T1 AT02723955T AT02723955T ATE455092T1 AT E455092 T1 ATE455092 T1 AT E455092T1 AT 02723955 T AT02723955 T AT 02723955T AT 02723955 T AT02723955 T AT 02723955T AT E455092 T1 ATE455092 T1 AT E455092T1
Authority
AT
Austria
Prior art keywords
malaria
treatment
tetracycline compounds
substituted tetracycline
compounds
Prior art date
Application number
AT02723955T
Other languages
English (en)
Inventor
Michael Draper
Mark Nelson
Original Assignee
Paratek Pharm Innc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharm Innc filed Critical Paratek Pharm Innc
Application granted granted Critical
Publication of ATE455092T1 publication Critical patent/ATE455092T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
AT02723955T 2001-04-24 2002-04-24 Substituierte tetracyclin-verbindungen zur behandlung von malaria ATE455092T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28619301P 2001-04-24 2001-04-24
PCT/US2002/012935 WO2002085303A2 (en) 2001-04-24 2002-04-24 Substituted tetracycline compounds for the treatment of malaria

Publications (1)

Publication Number Publication Date
ATE455092T1 true ATE455092T1 (de) 2010-01-15

Family

ID=23097495

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02723955T ATE455092T1 (de) 2001-04-24 2002-04-24 Substituierte tetracyclin-verbindungen zur behandlung von malaria

Country Status (9)

Country Link
US (1) US20040092490A1 (de)
EP (2) EP1399414B1 (de)
JP (4) JP2004529927A (de)
AT (1) ATE455092T1 (de)
AU (2) AU2002254714C1 (de)
CA (1) CA2444899C (de)
DE (1) DE60235083D1 (de)
ES (1) ES2338994T3 (de)
WO (1) WO2002085303A2 (de)

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WO2001052858A1 (en) 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
IL151971A0 (en) * 2000-03-31 2003-04-10 Tufts College 7-and 9-carbamate, urea, thiourea, thiocarbabamate, and heteroaryl-amino substituted tetracycline compounds
AU2001259701A1 (en) * 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
MXPA03000055A (es) 2000-07-07 2003-07-14 Tufts College Compuestos de monociclina sustituidos en posicion 9..
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP2301914A1 (de) * 2001-03-13 2011-03-30 Paratek Pharmaceuticals, Inc. 7, 9-substituierte Tetracyclin-Verbindungen
US7045507B2 (en) 2001-03-14 2006-05-16 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
CA2444899C (en) * 2001-04-24 2011-06-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US8088820B2 (en) 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
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EP2481723A3 (de) * 2002-03-21 2013-02-13 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
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CA2502464A1 (en) * 2002-10-24 2004-05-06 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
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CN1845897A (zh) * 2003-07-09 2006-10-11 帕拉特克药品公司 取代的四环素化合物
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AU2012202559B2 (en) * 2004-05-21 2014-07-17 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
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JP2008518025A (ja) 2004-10-25 2008-05-29 パラテック ファーマシューティカルズ インコーポレイテッド ４−アミノテトラサイクリンおよびその使用の方法
EP2284153A3 (de) * 2004-10-25 2012-03-14 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
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AU2007235279B2 (en) 2006-04-07 2012-12-06 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
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US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
KR101538175B1 (ko) * 2006-12-21 2015-07-20 파라테크 파마슈티컬스, 인크. 박테리아, 바이러스 및 기생충 감염의 치료를 위한 테트라시클린 유도체
EP2225253B1 (de) 2007-11-29 2012-06-27 Actelion Pharmaceuticals Ltd. Phosphonsäurederivate und ihre verwendung als p2y12-rezeptorantagonisten
ES2655911T3 (es) 2008-08-08 2018-02-22 Tetraphase Pharmaceuticals, Inc. Compuestos de tetraciclina sustituidos con C7-fluoro
WO2010126607A2 (en) * 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
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PL2470500T3 (pl) 2009-08-28 2018-03-30 Tetraphase Pharmaceuticals, Inc. Związki tetracyklinowe
SG10201801703RA (en) 2012-08-31 2018-04-27 Tetraphase Pharmaceuticals Inc Tetracycline compounds
CN105001112B (zh) * 2015-06-30 2017-02-01 浦城正大生化有限公司 水溶性金霉素琥珀酸单酯盐及其制备方法
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RS62656B1 (sr) * 2017-07-04 2021-12-31 Sanofi Sa Etinilska jedinjenja, njihova priprema i njihova terapijska upotreba za lečenje malarije

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Also Published As

Publication number Publication date
AU2008255241B2 (en) 2012-06-28
US20040092490A1 (en) 2004-05-13
JP2013151540A (ja) 2013-08-08
EP1399414A2 (de) 2004-03-24
WO2002085303A3 (en) 2003-05-15
AU2002254714C1 (en) 2010-01-07
EP1399414A4 (de) 2006-03-22
CA2444899C (en) 2011-06-21
EP2186793A1 (de) 2010-05-19
AU2002254714B2 (en) 2008-09-11
JP2004529927A (ja) 2004-09-30
WO2002085303A2 (en) 2002-10-31
DE60235083D1 (de) 2010-03-04
AU2002254714B8 (en) 2008-10-02
AU2008255241A1 (en) 2009-01-08
CA2444899A1 (en) 2002-10-31
ES2338994T3 (es) 2010-05-14
JP2009221219A (ja) 2009-10-01
JP2013010806A (ja) 2013-01-17
EP1399414B1 (de) 2010-01-13

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