DE60142473D1 - Intrakorporale medikamente zur photodynamischen behandlung von erkrankungen - Google Patents

Intrakorporale medikamente zur photodynamischen behandlung von erkrankungen

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Publication number
DE60142473D1
DE60142473D1 DE60142473T DE60142473T DE60142473D1 DE 60142473 D1 DE60142473 D1 DE 60142473D1 DE 60142473 T DE60142473 T DE 60142473T DE 60142473 T DE60142473 T DE 60142473T DE 60142473 D1 DE60142473 D1 DE 60142473D1
Authority
DE
Germany
Prior art keywords
intrakorporal
illnesses
medicaments
photodynamic treatment
photodynamic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60142473T
Other languages
English (en)
Inventor
H Craig Dees
Timothy Scott
Eric Wachter
Walter Fisher
John Smolik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Provectus Pharmatech Inc
Original Assignee
Provectus Pharmatech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Provectus Pharmatech Inc filed Critical Provectus Pharmatech Inc
Application granted granted Critical
Publication of DE60142473D1 publication Critical patent/DE60142473D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A61B2017/22062—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation to be filled with liquid
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    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22087—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance photodynamic
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    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/15—Inorganic acid or base [e.g., hcl, sulfuric acid, etc. ]
    • Y10T436/153333—Halogen containing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/19—Halogen containing
    • Y10T436/193333—In aqueous solution
DE60142473T 2000-03-24 2001-03-20 Intrakorporale medikamente zur photodynamischen behandlung von erkrankungen Expired - Lifetime DE60142473D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19180300P 2000-03-24 2000-03-24
US09/799,785 US7390668B2 (en) 1996-10-30 2001-03-06 Intracorporeal medicaments for photodynamic treatment of disease
PCT/US2001/008924 WO2001072301A1 (en) 2000-03-24 2001-03-20 Intracorporeal medicaments for photodynamic treatment of disease

Publications (1)

Publication Number Publication Date
DE60142473D1 true DE60142473D1 (de) 2010-08-12

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Family Applications (1)

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DE60142473T Expired - Lifetime DE60142473D1 (de) 2000-03-24 2001-03-20 Intrakorporale medikamente zur photodynamischen behandlung von erkrankungen

Country Status (15)

Country Link
US (6) US7390668B2 (de)
EP (1) EP1284727B1 (de)
JP (1) JP2003528143A (de)
KR (1) KR20030019329A (de)
CN (1) CN1423557A (de)
AR (1) AR028285A1 (de)
AT (1) ATE472325T1 (de)
AU (1) AU2001247615A1 (de)
BR (1) BR0109446A (de)
CA (1) CA2402187A1 (de)
DE (1) DE60142473D1 (de)
ES (1) ES2346289T3 (de)
IL (1) IL151689A0 (de)
MX (1) MXPA02009329A (de)
WO (1) WO2001072301A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7390668B2 (en) * 1996-10-30 2008-06-24 Provectus Pharmatech, Inc. Intracorporeal medicaments for photodynamic treatment of disease
US8974363B2 (en) * 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US7648695B2 (en) * 1998-08-06 2010-01-19 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US8557298B2 (en) * 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
ATE234114T1 (de) * 1999-01-15 2003-03-15 Light Sciences Corp Therapeutische zusammensetzungen fur knochenstoffwechselstörungen oder knochenmetastasen enthaltend einen photosensitizer und ein bisphosphonat
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
HU224941B1 (en) * 2001-08-10 2006-04-28 Bgi Innovacios Kft Phototerapy apparatus
CA2490692A1 (en) 2002-06-27 2004-01-08 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
DE10311027A1 (de) * 2003-03-13 2004-09-30 Siemens Ag Mess- und Simulationssystem für Werkzeug- oder Produktionsmaschinen
US20050053895A1 (en) 2003-09-09 2005-03-10 The Procter & Gamble Company Attention: Chief Patent Counsel Illuminated electric toothbrushes emitting high luminous intensity toothbrush
US20050059731A1 (en) * 2003-09-16 2005-03-17 Ceramoptec Industries, Inc. Erythrosin-based antimicrobial photodynamic therapy compound and its use
EP1753467B1 (de) * 2004-06-10 2013-01-09 Provectus Pharmatech, Inc. Diagnosemittel für positronenemissionsbildgebung unter verwendung von radioaktiv markierten halogenierten xanthenen und verfahren für positronenemissionsbildgebung mit radioaktiv markierten halogenierten xanthen-diagnosemitteln
US20060222592A1 (en) * 2005-04-05 2006-10-05 Clemens Burda Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications
CN103767886B (zh) 2005-11-09 2018-04-24 科洛斯科技公司 使牙齿增白的组合物及方法
US20090326435A1 (en) * 2006-05-02 2009-12-31 Green Medical, Inc. Systems and methods for treating superficial venous malformations like varicose or spider veins
US7465312B2 (en) 2006-05-02 2008-12-16 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US20070299431A1 (en) * 2006-05-02 2007-12-27 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US20080275432A1 (en) * 2006-05-11 2008-11-06 Ceramoptec Industries, Inc. Photodynamic foam composition and sclerosis treatment
JP2010500091A (ja) * 2006-08-09 2010-01-07 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 超音波によって生理的に有効な物質を活性化する装置及び方法、並びにカプセル
US20100266989A1 (en) 2006-11-09 2010-10-21 Klox Technologies Inc. Teeth whitening compositions and methods
US9358292B2 (en) 2007-04-08 2016-06-07 Immunolight, Llc Methods and systems for treating cell proliferation disorders
AU2016210665B2 (en) * 2007-04-08 2017-12-07 Immunolight, Llc Methods and systems for treating cell proliferation disorders
US20080291541A1 (en) * 2007-05-23 2008-11-27 3M Innovative Properties Company Light redirecting solar control film
AU2009311234B2 (en) 2008-11-07 2013-05-02 Klox Technologies Inc. Combination of an oxidant and a photoactivator for the healing of wounds
CN104721823A (zh) 2009-07-17 2015-06-24 克洛克斯科技公司 抗菌口腔组合物
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US9642687B2 (en) 2010-06-15 2017-05-09 The Procter & Gamble Company Methods for whitening teeth
FR2962436B1 (fr) * 2010-07-09 2012-12-14 Fabre Pierre Dermo Cosmetique Derives de xanthedediones pour le traitement des troubles de la pigmentation et du vieillissement cutane
BR112013022889B8 (pt) 2011-03-08 2022-12-20 Univ Laval Dispositivo centrípeto fluídico para testar componentes de um material biológico em um fluido, aparelho de teste e método de teste usando tal dispositivo centrípeto fluídico
US8630703B2 (en) * 2011-03-09 2014-01-14 Technion Research & Development Foundation Limited Treatment utilizing hydrophobic weak bases chemotherapeutic agents and illumination
US11116841B2 (en) * 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
US20130281913A1 (en) 2012-04-20 2013-10-24 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
WO2014042936A2 (en) 2012-09-14 2014-03-20 Valeant Pharmaceuticals International, Inc. Compositions and methods for teeth whitening
US20140276354A1 (en) 2013-03-14 2014-09-18 Klox Technologies Inc. Biophotonic materials and uses thereof
EP3016686A4 (de) 2013-07-03 2017-01-25 Klox Technologies Inc. Biophotonische zusammensetzungen mit einem chromophor und einem geliermittel zur behandlung von wunden
KR20160140716A (ko) 2014-04-01 2016-12-07 클록스 테크놀로지스 인크. 조직 필러 조성물 및 사용 방법
JP2018500468A (ja) 2014-10-31 2018-01-11 クロックス テクノロジーズ インコーポレイテッドＫｌｏｘ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． 光活性性の繊維および織物媒体
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
CA3072418A1 (en) * 2017-08-08 2019-02-14 Board Of Trustees Of Michigan State University Tunable luminescent organic salts for enhanced imaging and photodynamic therapy
MX2020011836A (es) 2018-05-16 2021-05-27 Provectus Pharmatech Inc Actividad antitumoral in vitro y xenoinjerto de un xanteno halogenado contra tumores solidos pediatricos refractarios.
US20220152413A1 (en) * 2019-03-04 2022-05-19 Photopill Medical Ltd. Method and device for gut microbiota manipulation
CN110498802B (zh) * 2019-07-03 2021-02-02 山西大学 一种二溴荧光素衍生物及其合成方法和应用
US11419844B2 (en) 2019-11-19 2022-08-23 Provectus Pharmatech, Inc. Halogenated xanthene composition and method for treating hematologic cancers
US11938182B2 (en) 2020-03-26 2024-03-26 Provectus Pharmatech, Inc. Halogenated xanthenes as vaccine adjuvants

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
EP0097012B2 (de) * 1982-06-10 1990-12-19 Jotun Polymer (UK) LTD. Photohärtbare Harze und ihre Verwendung
US4846789A (en) * 1982-07-19 1989-07-11 L. S. Van Landingham, Jr. Combatting internal parasites in warm blooded animals
US4490543A (en) 1982-11-12 1984-12-25 University Of Northern Iowa Foundation Low toxicity radiation sensitizer
US4599227A (en) 1983-11-07 1986-07-08 Wisconsin Alumni Research Foundation Injectable pharmaceutical preparation for the induction of multiple follicular growth
US4647578A (en) 1983-12-02 1987-03-03 Sterling Drug Inc. Phototoxic insecticidal compositions and method of use thereof
AU583854B2 (en) 1984-09-13 1989-05-11 Cytogen Corporation Antibody therapeutic agent conjugates
US4957481A (en) 1987-10-01 1990-09-18 U.S. Bioscience Photodynamic therapeutic technique
JPH0796669B2 (ja) * 1988-03-09 1995-10-18 日本化薬株式会社 変色性接着剤
US5053006A (en) 1988-04-19 1991-10-01 Watson Brant D Method for the permanent occlusion of arteries
US5177073A (en) * 1988-09-30 1993-01-05 Baylor Research Institute Therapeutic compositions derived from photoactive compounds
US4973848A (en) 1989-07-28 1990-11-27 J. Mccaughan Laser apparatus for concurrent analysis and treatment
US5149801A (en) 1990-11-21 1992-09-22 The Regents Of The University Of California Boronated porphyrin compounds
US5654423A (en) 1990-11-21 1997-08-05 Regents Of The University Of California Boronated metalloporphyrine and therapeutic methods
US5128139A (en) 1991-02-15 1992-07-07 Nu Skin International, Inc. Composition containing liposome-entrapped grapefruit seed extract and method for making
TW251236B (de) 1992-09-10 1995-07-11 Ciba Vision Ag
KR960009640B1 (ko) * 1992-10-16 1996-07-23 주식회사 태평양 헤어칼라린스 조성물
US5556992A (en) 1994-09-02 1996-09-17 Universite De Montreal Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias
US5837677A (en) * 1995-02-03 1998-11-17 Keystone Biomedical, Inc. Method for the treatment of cancer with Exochelins of Mycobacterium tuberculosis
US5576013A (en) 1995-03-21 1996-11-19 Eastern Virginia Medical School Treating vascular and neoplastic tissues
US5591422A (en) 1995-06-02 1997-01-07 Pharmacyclics, Inc. Texaphyrin complexes having improved functionalization
IT1275571B (it) * 1995-07-19 1997-08-07 Consiglio Nazionale Ricerche Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori
DE19602295C2 (de) 1996-01-23 2003-08-14 Deutsches Krebsforsch Verwendung eines Konjugats aus einer zur Fluoreszenz-fähigen Verbindung, Cyanurchlorid oder einem Derivat davon als Linker und einem Protein
US6162931A (en) 1996-04-12 2000-12-19 Molecular Probes, Inc. Fluorinated xanthene derivatives
ES2205215T3 (es) 1996-05-01 2004-05-01 The General Hospital Corporation Doing Business As Massachusetts General Hospital Inhibicion del crecimiento y erradicacion de tumores solidos usando un modulador de prolactina y un fotosensibilizador.
US6493570B1 (en) 1998-11-02 2002-12-10 Photogen, Inc. Method for improved imaging and photodynamic therapy
US5832931A (en) 1996-10-30 1998-11-10 Photogen, Inc. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US5829448A (en) 1996-10-30 1998-11-03 Photogen, Inc. Method for improved selectivity in photo-activation of molecular agents
US7353829B1 (en) * 1996-10-30 2008-04-08 Provectus Devicetech, Inc. Methods and apparatus for multi-photon photo-activation of therapeutic agents
US7390668B2 (en) * 1996-10-30 2008-06-24 Provectus Pharmatech, Inc. Intracorporeal medicaments for photodynamic treatment of disease
AU6665098A (en) * 1997-02-24 1998-09-09 Omd Devices Llc Silver halide material for optical memory devices with luminescent reading and methods for the treatment thereof
US5827186A (en) 1997-04-11 1998-10-27 Light Sciences Limited Partnership Method and PDT probe for minimizing CT and MRI image artifacts
US6514983B1 (en) * 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US8974363B2 (en) * 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US6034053A (en) 1998-07-13 2000-03-07 Wayne Hughes Institute EGF-isoflavone conjugates for the prevention of restenosis
US7648695B2 (en) * 1998-08-06 2010-01-19 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
WO2000007515A1 (en) * 1998-08-06 2000-02-17 Photogen, Inc. Improved method for targeted topical treatment of disease
WO2000025829A2 (en) 1998-10-29 2000-05-11 The General Hospital Corporation Radiodense compositions
US7384623B1 (en) * 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
KR20020020808A (ko) * 1999-08-13 2002-03-15 스무크 존 질병의 광역학적 치료를 위한 국부투여 약물 및 그 방법

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