HRP20120605T1 - Postupci sinteze 9-supstituiranog minociklina - Google Patents
Postupci sinteze 9-supstituiranog minociklina Download PDFInfo
- Publication number
- HRP20120605T1 HRP20120605T1 HRP20120605AT HRP20120605T HRP20120605T1 HR P20120605 T1 HRP20120605 T1 HR P20120605T1 HR P20120605A T HRP20120605A T HR P20120605AT HR P20120605 T HRP20120605 T HR P20120605T HR P20120605 T1 HRP20120605 T1 HR P20120605T1
- Authority
- HR
- Croatia
- Prior art keywords
- minocycline
- conditions
- substituted
- substituted minocycline
- compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 7
- 229960004023 minocycline Drugs 0.000 title claims 11
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical class C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 title claims 8
- 230000002194 synthesizing effect Effects 0.000 title abstract 2
- -1 tetracycline compound Chemical class 0.000 claims abstract 9
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims abstract 8
- 229910052763 palladium Inorganic materials 0.000 claims abstract 4
- 239000003054 catalyst Substances 0.000 claims abstract 3
- 238000006268 reductive amination reaction Methods 0.000 claims abstract 3
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims abstract 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910002091 carbon monoxide Inorganic materials 0.000 claims abstract 2
- 238000007327 hydrogenolysis reaction Methods 0.000 claims abstract 2
- 229910000077 silane Inorganic materials 0.000 claims abstract 2
- 238000006243 chemical reaction Methods 0.000 claims 3
- 229910002666 PdCl2 Inorganic materials 0.000 claims 2
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical group Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- XOJNEFQLMRCOMS-UHFFFAOYSA-N ditert-butyl(phenyl)phosphane Chemical compound CC(C)(C)P(C(C)(C)C)C1=CC=CC=C1 XOJNEFQLMRCOMS-UHFFFAOYSA-N 0.000 claims 1
- MUJIDPITZJWBSW-UHFFFAOYSA-N palladium(2+) Chemical compound [Pd+2] MUJIDPITZJWBSW-UHFFFAOYSA-N 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 abstract 5
- 229960002180 tetracycline Drugs 0.000 abstract 5
- 229930101283 tetracycline Natural products 0.000 abstract 5
- 235000019364 tetracycline Nutrition 0.000 abstract 5
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94838507P | 2007-07-06 | 2007-07-06 | |
| US6035108P | 2008-06-10 | 2008-06-10 | |
| PCT/US2008/008355 WO2009009042A1 (en) | 2007-07-06 | 2008-07-07 | Methods for synthesizing substituted tetracycline compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120605T1 true HRP20120605T1 (hr) | 2012-09-30 |
Family
ID=39926392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120605AT HRP20120605T1 (hr) | 2007-07-06 | 2012-07-23 | Postupci sinteze 9-supstituiranog minociklina |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9522872B2 (de) |
| EP (2) | EP2192111A3 (de) |
| JP (2) | JP2010532759A (de) |
| KR (1) | KR20100042276A (de) |
| CN (2) | CN101784517A (de) |
| AT (1) | ATE555079T1 (de) |
| AU (2) | AU2008275701B2 (de) |
| BR (2) | BRPI0823405A2 (de) |
| CA (1) | CA2693376A1 (de) |
| DK (1) | DK2176216T3 (de) |
| EA (2) | EA201070233A1 (de) |
| ES (1) | ES2386926T3 (de) |
| HK (1) | HK1139386A1 (de) |
| HR (1) | HRP20120605T1 (de) |
| IL (1) | IL204133A0 (de) |
| PT (1) | PT2176216E (de) |
| WO (1) | WO2009009042A1 (de) |
| ZA (2) | ZA201000034B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| CA2531728A1 (en) * | 2003-07-09 | 2005-02-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP2295419A3 (de) * | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclinverbindungen |
| JP2008530023A (ja) | 2005-02-04 | 2008-08-07 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の１１ａ，１２−誘導体 |
| CA2616224A1 (en) * | 2005-07-21 | 2007-02-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
| EP2026776A2 (de) * | 2006-05-15 | 2009-02-25 | Paratek Pharmaceuticals, Inc. | Verfahren zur regelung der genexpression oder genprodukte mithilfe von substituierten tetracyclinverbindungen |
| IL270446B2 (en) * | 2006-12-21 | 2023-10-01 | Paratek Pharm Innc | A tetracycline compound, a pharmaceutical preparation containing the tetracycline compound, and the tetracycline compound or the pharmaceutical preparation for the treatment of the tetracycline-responsive condition |
| EP3488853A1 (de) | 2006-12-21 | 2019-05-29 | Paratek Pharmaceuticals, Inc. | Substituierte tetracyclinverbindungen zur behandlung von entzündlichen hauterkrankungen |
| AU2008239606A1 (en) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| WO2008134048A2 (en) * | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| CA2717703A1 (en) | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Minocycline compounds and methods of use thereof |
| US20100022483A1 (en) * | 2008-04-14 | 2010-01-28 | Paratek Pharmaceuticals, Inc. | Substituted Tetracycline Compounds |
| EA201170425A1 (ru) * | 2008-09-19 | 2011-10-31 | Паратек Фармасьютикалс, Инк. | Тетрациклиновые соединения для лечения ревматоидного артрита и связанные с ними способы лечения |
| IN2012DN02502A (de) * | 2009-08-28 | 2015-08-28 | Tetraphase Pharmaceuticals Inc | |
| WO2012065028A2 (en) | 2010-11-11 | 2012-05-18 | Concert Pharmaceuticals Inc. | Substituted tetracyclines |
| SG10201801703RA (en) | 2012-08-31 | 2018-04-27 | Tetraphase Pharmaceuticals Inc | Tetracycline compounds |
| MA46567A (fr) | 2016-10-19 | 2019-08-28 | Tetraphase Pharmaceuticals Inc | Formes cristallines de l'éravacycline |
| WO2018085216A1 (en) | 2016-11-01 | 2018-05-11 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl minocycline compounds and use thereof in treating community-acquire bacterial pneumonia (cabp) |
| WO2019192614A1 (en) * | 2018-04-06 | 2019-10-10 | Paratek Pharmaceuticals, Inc. | Process for making sarecycline hydrochloride |
| PT117254B (pt) | 2021-05-26 | 2024-04-18 | Hovione Farm S A | Método de síntese de compostos 9-aminometil tetraciclinas |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2990331A (en) | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
| US2820824A (en) | 1957-04-15 | 1958-01-21 | American Cyanamid Co | Purification of neutral tetracycline |
| US2980584A (en) | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3062717A (en) | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3165531A (en) | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
| US3454697A (en) | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
| US3304227A (en) | 1965-07-15 | 1967-02-14 | Loyal E Loveless | Antibiotic-containing animal feed |
| NL6607516A (de) | 1966-05-31 | 1967-12-01 | ||
| DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
| US3876699A (en) | 1969-10-01 | 1975-04-08 | Squibb & Sons Inc | Purification of tetracycline antibiotic |
| US3957980A (en) | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
| DE2442829A1 (de) | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
| US4018889A (en) | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
| US4126680A (en) | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
| US4666897A (en) | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
| US4704383A (en) | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| USRE34656E (en) | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
| US4935412A (en) | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4925833A (en) | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
| US5308839A (en) | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
| JP3016587B2 (ja) | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
| US5770588A (en) | 1991-02-11 | 1998-06-23 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions of the prevention and treatment of root caries |
| US6756365B2 (en) | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US5258371A (en) | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
| US6043225A (en) | 1992-06-12 | 2000-03-28 | Board Of Regents Of The University Of Washington | Diagnosis and treatment of arterial chlamydial granuloma |
| DK0599397T3 (da) | 1992-11-17 | 1996-09-16 | Univ New York State Res Found | Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes |
| US5523297A (en) | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| US6043231A (en) | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| US5668122A (en) | 1993-07-28 | 1997-09-16 | Fife; Rose S. | Method to treat cancer with tetracyclines |
| AU1279095A (en) | 1994-02-17 | 1995-09-04 | Pfizer Inc. | 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
| US5843925A (en) | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
| JPH09227439A (ja) * | 1996-02-22 | 1997-09-02 | Teikoku Chem Ind Corp Ltd | アルデヒド化方法 |
| US5834449A (en) | 1996-06-13 | 1998-11-10 | The Research Foundation Of State University Of New York | Treatment of aortic and vascular aneurysms with tetracycline compounds |
| US5827840A (en) | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
| US5789395A (en) | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US5919774A (en) | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
| US5837696A (en) | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
| US5773430A (en) | 1997-03-13 | 1998-06-30 | Research Foundation Of State University Of New York | Serine proteinase inhibitory activity by hydrophobic tetracycline |
| US5929055A (en) | 1997-06-23 | 1999-07-27 | The Research Foundation Of State University Of New York | Therapeutic method for management of diabetes mellitus |
| WO1999037307A1 (en) | 1998-01-23 | 1999-07-29 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
| US6277061B1 (en) | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
| US6015804A (en) | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
| US5977091A (en) | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
| US5998390A (en) | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
| US8106225B2 (en) | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| US6849615B2 (en) | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| US6500812B2 (en) | 1999-09-14 | 2002-12-31 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| CA2383364C (en) * | 1999-09-14 | 2009-11-17 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| US6231894B1 (en) | 1999-10-21 | 2001-05-15 | Duke University | Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase |
| EP1250332A1 (de) * | 1999-12-17 | 2002-10-23 | Abbott Laboratories | Inhibitoren des interleukin-5 genausdrucks |
| AU3105801A (en) | 2000-01-24 | 2001-07-31 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| DE60129116T2 (de) | 2000-03-31 | 2008-03-13 | Trustees Of Tufts College, Medford | 7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen |
| EP1286954B1 (de) | 2000-05-15 | 2004-04-14 | Paratek Pharmaceuticals, Inc. | 7-substituierte kondensierte ring-tetrazyclin- verbindungen |
| AU2001268475A1 (en) | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US20050143353A1 (en) | 2000-07-07 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | 13-Substituted methacycline compounds |
| EP2289871A1 (de) | 2000-07-07 | 2011-03-02 | Paratek Pharmaceuticals, Inc. | 7-substituierte tetracyclinverbindungen |
| AU2001271556A1 (en) | 2000-07-07 | 2002-01-21 | Trustees Of Tufts College | 7,8 and 9-substituted tetracycline compounds |
| US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| AU8638801A (en) | 2000-07-07 | 2002-01-21 | Tufts College | 9-substituted minocycline compounds |
| EP1241160A1 (de) | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracyclinderivate und ihre Verwendung als Antibiotica |
| AU2002250331A1 (en) | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| EP2301914A1 (de) | 2001-03-13 | 2011-03-30 | Paratek Pharmaceuticals, Inc. | 7, 9-substituierte Tetracyclin-Verbindungen |
| WO2003055441A2 (en) | 2001-08-02 | 2003-07-10 | Paratek Pharmaceuticals, Inc. | Medicaments |
| US6908939B2 (en) * | 2001-12-21 | 2005-06-21 | Galderma Research & Development S.N.C. | Biaromatic ligand activators of PPARγ receptors |
| JP2003252803A (ja) * | 2002-03-01 | 2003-09-10 | Sumitomo Chem Co Ltd | 置換不飽和化合物の製造法 |
| EP2316450A1 (de) | 2002-03-08 | 2011-05-04 | Paratek Pharmaceuticals, Inc. | Aminomethyl-substituierte Tetracyclin-Verbindungen |
| AU2003218243B2 (en) * | 2002-03-21 | 2010-04-01 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| CA2492273C (en) | 2002-07-12 | 2013-02-05 | Paratek Pharmaceuticals, Inc. | 3, 10, and 12a substituted tetracycline compounds |
| US6846938B2 (en) * | 2002-07-29 | 2005-01-25 | Eastman Kodak Company | Water-compatible epoxy compounds containing sulfonate or thiosulfate moieties |
| WO2004091513A2 (en) | 2003-04-10 | 2004-10-28 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| EP2292590A3 (de) * | 2003-07-09 | 2012-05-02 | Paratek Pharmaceuticals, Inc. | Prodrugs aus 9-Aminomethyl-Tetracyclinverbindungen |
| CA2531728A1 (en) | 2003-07-09 | 2005-02-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| JP5010284B2 (ja) | 2004-01-15 | 2012-08-29 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の芳香族ａ環誘導体 |
| WO2005075439A1 (en) | 2004-02-03 | 2005-08-18 | Astrazeneca Ab | Quinazoline derivatives |
| JP4625652B2 (ja) * | 2004-05-13 | 2011-02-02 | 東ソー株式会社 | ２−ぺルフルオロアルキルアクリル酸エステルの製造方法 |
| KR20070053237A (ko) * | 2004-07-27 | 2007-05-23 | 에스지엑스 파마슈티컬스, 인코포레이티드 | 피롤로-피리딘 키나제 조절제 |
| EP2295419A3 (de) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclinverbindungen |
| WO2006047671A2 (en) | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| JP2008530023A (ja) | 2005-02-04 | 2008-08-07 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の１１ａ，１２−誘導体 |
| CA2616224A1 (en) | 2005-07-21 | 2007-02-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
| EP3290427A1 (de) * | 2005-08-24 | 2018-03-07 | Melinta Therapeutics, Inc. | Triazolverbindungen und verfahren zur herstellung und verwendung davon |
| EP2311814A1 (de) * | 2005-12-01 | 2011-04-20 | F. Hoffmann-La Roche AG | 2,4,5-Triphenylimidazolinderivate als Inhibitoren der Wechselwirkung zwischen P53 und MDM2-Proteinen zur Verwendung als Antikrebsmittel |
| IL270446B2 (en) * | 2006-12-21 | 2023-10-01 | Paratek Pharm Innc | A tetracycline compound, a pharmaceutical preparation containing the tetracycline compound, and the tetracycline compound or the pharmaceutical preparation for the treatment of the tetracycline-responsive condition |
| WO2008134048A2 (en) | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
-
2008
- 2008-07-07 BR BRPI0823405-1A patent/BRPI0823405A2/pt not_active IP Right Cessation
- 2008-07-07 AU AU2008275701A patent/AU2008275701B2/en not_active Expired - Fee Related
- 2008-07-07 KR KR1020107002676A patent/KR20100042276A/ko not_active Application Discontinuation
- 2008-07-07 CN CN200880105304A patent/CN101784517A/zh active Pending
- 2008-07-07 WO PCT/US2008/008355 patent/WO2009009042A1/en active Application Filing
- 2008-07-07 JP JP2010514886A patent/JP2010532759A/ja active Pending
- 2008-07-07 EA EA201070233A patent/EA201070233A1/ru unknown
- 2008-07-07 US US12/217,709 patent/US9522872B2/en active Active
- 2008-07-07 PT PT08826197T patent/PT2176216E/pt unknown
- 2008-07-07 EA EA201070048A patent/EA201070048A1/ru unknown
- 2008-07-07 CA CA2693376A patent/CA2693376A1/en not_active Abandoned
- 2008-07-07 DK DK08826197.9T patent/DK2176216T3/da active
- 2008-07-07 EP EP10154210A patent/EP2192111A3/de not_active Ceased
- 2008-07-07 EP EP08826197A patent/EP2176216B1/de not_active Not-in-force
- 2008-07-07 BR BRPI0813990-3A patent/BRPI0813990A2/pt not_active IP Right Cessation
- 2008-07-07 ES ES08826197T patent/ES2386926T3/es active Active
- 2008-07-07 AT AT08826197T patent/ATE555079T1/de active
- 2008-07-07 CN CN201010175452A patent/CN101811980A/zh active Pending
-
2010
- 2010-01-04 ZA ZA2010/00034A patent/ZA201000034B/en unknown
- 2010-02-24 IL IL204133A patent/IL204133A0/en unknown
- 2010-03-04 JP JP2010048260A patent/JP2011020996A/ja active Pending
- 2010-03-05 AU AU2010200845A patent/AU2010200845B2/en not_active Ceased
- 2010-06-25 HK HK10106266.2A patent/HK1139386A1/xx not_active IP Right Cessation
- 2010-12-01 ZA ZA2010/08646A patent/ZA201008646B/en unknown
-
2012
- 2012-07-23 HR HRP20120605AT patent/HRP20120605T1/hr unknown
-
2016
- 2016-11-15 US US15/351,700 patent/US20170283368A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PT2176216E (pt) | 2012-07-27 |
| BRPI0823405A2 (pt) | 2012-12-25 |
| BRPI0813990A2 (pt) | 2011-09-13 |
| DK2176216T3 (da) | 2012-07-30 |
| CN101811980A (zh) | 2010-08-25 |
| EP2176216A1 (de) | 2010-04-21 |
| EA201070048A1 (ru) | 2010-10-29 |
| AU2010200845A1 (en) | 2010-04-01 |
| JP2011020996A (ja) | 2011-02-03 |
| ZA201008646B (en) | 2012-02-29 |
| KR20100042276A (ko) | 2010-04-23 |
| US20170283368A1 (en) | 2017-10-05 |
| US20090156842A1 (en) | 2009-06-18 |
| ZA201000034B (en) | 2011-10-26 |
| EP2176216B1 (de) | 2012-04-25 |
| WO2009009042A1 (en) | 2009-01-15 |
| EA201070233A1 (ru) | 2010-08-30 |
| IL204133A0 (en) | 2011-07-31 |
| US9522872B2 (en) | 2016-12-20 |
| AU2008275701A1 (en) | 2009-01-15 |
| CA2693376A1 (en) | 2009-01-15 |
| HK1139386A1 (en) | 2010-09-17 |
| AU2008275701B2 (en) | 2013-04-04 |
| CN101784517A (zh) | 2010-07-21 |
| JP2010532759A (ja) | 2010-10-14 |
| AU2010200845B2 (en) | 2013-01-17 |
| ES2386926T3 (es) | 2012-09-06 |
| EP2192111A2 (de) | 2010-06-02 |
| EP2192111A3 (de) | 2010-10-06 |
| ATE555079T1 (de) | 2012-05-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20120605T1 (hr) | Postupci sinteze 9-supstituiranog minociklina | |
| EG24500A (en) | A catalyst & progress for the synthesis of C2- oxygenated by the hydrogenation of carbon monoxide | |
| Zhu et al. | Enantioselective hydrogenation of (Z)-and (E)-β-arylenamides catalyzed by rhodium complexes of monodentate chiral spiro phosphorous ligands: a new access to chiral β-arylisopropylamines | |
| Hao et al. | Air-stable and highly efficient indenyl-derived phosphine ligand: Application to Buchwald–Hartwig amination reactions | |
| Du et al. | N-Heterocyclic carbene-catalyzed hydroacylation of isatins with aldehydes: access to 3-acyloxy-1, 3-dihydro-2H-indol-2-ones | |
| Kang et al. | Catalytic enantioselective conjugate addition of aromatic amines to fumarate derivatives: asymmetric synthesis of aspartic acid derivatives | |
| Aydemir et al. | Synthesis and characterization of tris {2-(N, N-bis (diphenylphosphino) aminoethyl} amine derivatives: Application of a palladium (II) complex as a pre-catalyst in the Heck and Suzuki cross-coupling reactions | |
| Holton et al. | Regiocontrolled aromatic palladation | |
| Aydemir et al. | Synthesis and characterizations of N, N′‐bis (diphenylphosphino)‐2‐(aminomethyl) aniline derivatives: application of a palladium (II) complex as pre‐catalyst in Heck and Suzuki cross‐coupling reactions | |
| Pereira et al. | Binol derivative ligand immobilized onto silica: Alkyl-cyanohydrin synthesis via sequential hydroformylation/heterogeneous cyanosilylation reactions | |
| IL207020A (en) | The process for preparing biphenylanilides is converted | |
| CN114989031A (zh) | 一种二氧化碳和炔烃合成不饱和酰胺的制备方法 | |
| CN113563231B (zh) | 一种对位c-h烷基化芳胺及其制备方法 | |
| ES2784717T3 (es) | Complejos a base de rutenio | |
| Dupau et al. | Synthesis of optically active 2-aminotetraline derivatives via enantioselective ruthenium-catalyzed hydrogenation of ene carbamates | |
| ATE520647T1 (de) | Verfahren zur herstellung eines primären amins mit tertiärem alpha-c-atom durch umsetzung eines tertiären alkohols mit ammoniak | |
| KR20090055390A (ko) | 설파이드 화합물 및 유기 황-인듐 착물을 이용한설파이드화합물 제조방법 | |
| CN106478717A (zh) | 含三齿nnp配体的稀土金属受阻路易斯酸碱对的合成及其应用 | |
| CN103408450A (zh) | 一种苊并咪唑氮杂环卡宾烯丙基氯化钯化合物催化合成他米巴罗汀的方法 | |
| Qu et al. | Chelation controlled reductive amination of cyclic ketones to trans-4-methoxycyclohexylamines: 9-BBN reduction mediated with FeCl3 | |
| Hirata et al. | Chiral bifunctional organocatalysts bearing a 1, 3-propanediamine unit for the aza-MBH reaction | |
| CN110642737A (zh) | 一种酰胺取代的(e,e)-构型枝型共轭二烯衍生物及其制备方法 | |
| Ueda et al. | Synthesis of allylamides from allyl halides, carbon monoxide, and titanium–nitrogen complexes prepared from molecular nitrogen | |
| CN115304441B (zh) | 一种二氧化碳和烯烃合成酰胺的制备方法 | |
| CN113735730B (zh) | 一种酰基伯胺的制备方法 |