UY28940A1 - Derivados de quinazolina - Google Patents

Derivados de quinazolina

Info

Publication number
UY28940A1
UY28940A1 UY28940A UY28940A UY28940A1 UY 28940 A1 UY28940 A1 UY 28940A1 UY 28940 A UY28940 A UY 28940A UY 28940 A UY28940 A UY 28940A UY 28940 A1 UY28940 A1 UY 28940A1
Authority
UY
Uruguay
Prior art keywords
quinazoline derivatives
tumors
medicament
inhibition
procedures
Prior art date
Application number
UY28940A
Other languages
English (en)
Inventor
Jason Grant Kettle
Robert Hugh Bradbury
Barlaam Bernard Christophe
Scott James Stewart
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY28940A1 publication Critical patent/UY28940A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

La invención se refiere a derivados de quinazolina de fórmula I: en donde cada uno de R1, R2, R3, R4, R5, R6, R7, X1, Q1, m y n adoptan cualquiera de los significados definidos en la memoria descriptiva; procedimientos para la preparación de los mismos, composiciones farmacéuticas que los contienen y su empleo en la fabricación de un medicamento para su utilización como un agente antiproliferativo en la prevención o tratamiento de tumores que son sensibles a la inhibición de las tirosinquinasas del receptor del erbB.
UY28940A 2004-06-04 2005-06-03 Derivados de quinazolina UY28940A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04291393 2004-06-04

Publications (1)

Publication Number Publication Date
UY28940A1 true UY28940A1 (es) 2006-01-31

Family

ID=34969245

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28940A UY28940A1 (es) 2004-06-04 2005-06-03 Derivados de quinazolina

Country Status (16)

Country Link
US (1) US20070232607A1 (es)
EP (1) EP1756088A1 (es)
JP (1) JP2008501675A (es)
KR (1) KR20070038500A (es)
CN (1) CN1993349A (es)
AR (1) AR049294A1 (es)
AU (1) AU2005250224A1 (es)
BR (1) BRPI0511741A (es)
CA (1) CA2567832A1 (es)
IL (1) IL179081A0 (es)
MX (1) MXPA06014125A (es)
NO (1) NO20066081L (es)
TW (1) TW200602328A (es)
UY (1) UY28940A1 (es)
WO (1) WO2005118572A1 (es)
ZA (1) ZA200609427B (es)

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GB0309009D0 (en) * 2003-04-22 2003-05-28 Astrazeneca Ab Quinazoline derivatives
GB0309850D0 (en) * 2003-04-30 2003-06-04 Astrazeneca Ab Quinazoline derivatives
GB0321648D0 (en) * 2003-09-16 2003-10-15 Astrazeneca Ab Quinazoline derivatives
US20070032513A1 (en) * 2003-09-16 2007-02-08 Hennequin Laurent F A Quinazoline derivatives
CN1882573A (zh) * 2003-09-16 2006-12-20 阿斯利康(瑞典)有限公司 作为酪氨酸激酶抑制剂的喹唑啉衍生物
WO2005026150A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
WO2005026156A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
GB0326459D0 (en) * 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
JP5032851B2 (ja) * 2004-02-03 2012-09-26 アストラゼネカ アクチボラグ キナゾリン誘導体
ATE501148T1 (de) * 2004-12-14 2011-03-15 Astrazeneca Ab Pyrazolopyrimidinverbindungen als antitumormittel
GB0504474D0 (en) * 2005-03-04 2005-04-13 Astrazeneca Ab Chemical compounds
GB0508717D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
GB0508715D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
ATE488513T1 (de) * 2005-09-20 2010-12-15 Astrazeneca Ab 4-(1h-indazol-5-ylamino)chinazolinverbindungen als inhibitoren der erbb-rezeptortyrosinkinase zur behandlung von krebs
EP1940825A1 (en) * 2005-09-20 2008-07-09 Astra Zeneca AB Quinazoline derivatives as anticancer agents
WO2007063291A1 (en) * 2005-12-02 2007-06-07 Astrazeneca Ab 4-anilino-substituted quinazoline derivatives as tyrosine kinase inhibitors
EP1960371B1 (en) * 2005-12-02 2009-09-16 AstraZeneca AB Quinazoleine derivatives used as inhibitors of erbb tyrosine kinase
ES2654847T3 (es) 2006-04-19 2018-02-15 Novartis Ag Compuestos de benzoxazol y benzotiazol sustituidos en 6-O y métodos para inhibir la señalización CSF-1R
AU2007303846B2 (en) 2006-10-04 2011-03-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as calcium receptor antagonists
EP2174938A1 (en) * 2006-10-12 2010-04-14 SuperGen, Inc. Quinoline derivatives for modulating DNA methylation
CA2682504C (en) * 2007-04-05 2012-10-30 Amgen Inc. Aurora kinase modulators and method of use
US7939546B2 (en) 2007-10-12 2011-05-10 Supergen, Inc. Quinoline derivatives for modulating DNA methylation
US7790746B2 (en) 2007-10-12 2010-09-07 Supergen, Inc. Quinoline derivatives for modulating DNA methylation
MX2010010151A (es) 2008-03-20 2010-10-25 Amgen Inc Moduladores de cinasa aurora y metodo de uso.
WO2010019473A1 (en) 2008-08-14 2010-02-18 Amgen Inc. Aurora kinase modulators and methods of use
CN105503835B (zh) * 2015-12-03 2018-04-24 中国人民解放军南京军区南京总医院 一种新型喹唑啉衍生物lu1510及其制备方法和应用
CN105541807B (zh) * 2015-12-03 2018-04-24 中国人民解放军南京军区南京总医院 一种新型喹唑啉衍生物lu1506及其制备方法和应用
CN105399733B (zh) * 2015-12-03 2018-04-24 中国人民解放军南京军区南京总医院 一种新型喹唑啉衍生物lu1504及其制备方法和应用
CN105503836B (zh) * 2015-12-03 2018-04-24 中国人民解放军南京军区南京总医院 一种新型喹唑啉衍生物lu1502及其制备方法和应用
CN106366020B (zh) * 2016-08-31 2018-12-11 京博农化科技股份有限公司 一种合成手性稻瘟酰胺的方法

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US4335127A (en) * 1979-01-08 1982-06-15 Janssen Pharmaceutica, N.V. Piperidinylalkyl quinazoline compounds, composition and method of use
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US20050043336A1 (en) * 2001-11-03 2005-02-24 Hennequin Laurent Francois Andre Quinazoline derivatives as antitumor agents
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TW200813014A (en) * 2002-03-28 2008-03-16 Astrazeneca Ab Quinazoline derivatives
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GB0309009D0 (en) * 2003-04-22 2003-05-28 Astrazeneca Ab Quinazoline derivatives
GB0309850D0 (en) * 2003-04-30 2003-06-04 Astrazeneca Ab Quinazoline derivatives
EP1660479A1 (en) * 2003-07-29 2006-05-31 Astrazeneca AB Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors
GB0317665D0 (en) * 2003-07-29 2003-09-03 Astrazeneca Ab Qinazoline derivatives
US20070032513A1 (en) * 2003-09-16 2007-02-08 Hennequin Laurent F A Quinazoline derivatives
CN1882573A (zh) * 2003-09-16 2006-12-20 阿斯利康(瑞典)有限公司 作为酪氨酸激酶抑制剂的喹唑啉衍生物
WO2005026150A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
GB0321648D0 (en) * 2003-09-16 2003-10-15 Astrazeneca Ab Quinazoline derivatives
CN1882570B (zh) * 2003-09-19 2010-12-08 阿斯利康(瑞典)有限公司 喹唑啉衍生物
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
BRPI0414735A (pt) * 2003-09-25 2006-11-21 Astrazeneca Ab derivado de quinazolina, composto, composição farmacêutica, uso de derivado de quinazolina, método para produzir um efeito anti-proliferativo em um animal de sangue quente, e, processo para a preparação de um derivado de quinazolina
GB0326459D0 (en) * 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
JP5032851B2 (ja) * 2004-02-03 2012-09-26 アストラゼネカ アクチボラグ キナゾリン誘導体

Also Published As

Publication number Publication date
AR049294A1 (es) 2006-07-12
US20070232607A1 (en) 2007-10-04
JP2008501675A (ja) 2008-01-24
NO20066081L (no) 2007-02-20
CA2567832A1 (en) 2005-12-15
ZA200609427B (en) 2008-08-27
WO2005118572A1 (en) 2005-12-15
IL179081A0 (en) 2007-03-08
KR20070038500A (ko) 2007-04-10
BRPI0511741A (pt) 2008-01-02
MXPA06014125A (es) 2007-01-31
CN1993349A (zh) 2007-07-04
TW200602328A (en) 2006-01-16
AU2005250224A1 (en) 2005-12-15
EP1756088A1 (en) 2007-02-28

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20160908