HUP0200210A2 - Daganatellenes hatású kamptotecinszármazékok, eljárás előállításukra, és ezeket a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Daganatellenes hatású kamptotecinszármazékok, eljárás előállításukra, és ezeket a vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP0200210A2
HUP0200210A2 HU0200210A HUP0200210A HUP0200210A2 HU P0200210 A2 HUP0200210 A2 HU P0200210A2 HU 0200210 A HU0200210 A HU 0200210A HU P0200210 A HUP0200210 A HU P0200210A HU P0200210 A2 HUP0200210 A2 HU P0200210A2
Authority
HU
Hungary
Prior art keywords
group
preparation
camptothecin derivatives
substances
pharmaceutical compositions
Prior art date
Application number
HU0200210A
Other languages
English (en)
Inventor
Paolo Carminati
Lucio Merlini
Sergio Penco
Franco Zunino
Original Assignee
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Nazionale Per Lo Studio E La Cura Dei Tumori, Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Istituto Nazionale Per Lo Studio E La Cura Dei Tumori
Publication of HUP0200210A2 publication Critical patent/HUP0200210A2/hu
Publication of HUP0200210A3 publication Critical patent/HUP0200210A3/hu
Publication of HU229506B1 publication Critical patent/HU229506B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány új kamptotecin-származékokra, ezek előállítására,daganatgátló, vírusellenes és Plasmodium falciparum ellenihatóanyagokként való alkalmazásukra és ezeket az anyagokathatóanyagként tartalmazó gyógyászati készítményekre vonatkozik. Atalálmány szerinti vegyületek (I) általános képletében R1 jelentése -C(R5)-N-O(n)R4 képletű csoport, amelyben R4 jelentése adott esetbenszubsztituált alkil-, alkenil-, cikloalkil-, cikloalkilalkil-, aril-,arilalkil-, heterociklusos vagy heterocikloalkilcsoport; vagy adottesetben szubsztituált aroil- vagy arilszulfonilcsoport; vagy -(CH2)m-NR12-(CH2)p-NR13-(CH2)q-NH2 általános képletű poliaminoalkilcsoport,amelyben m és p jelentése 2-6 és q jelentése 0-6; és R12, valamint R13jelentése alkilcsoport; vagy 6-D-galaktozil-, 6-D-glükozil- és D-galaktopiranozilcsoport közül választott glikozilcsoport, ahol aglikozilcsoport adott esetben megfelelő ketálcsoporttal védettformában van; n értéke 1; R5 jelentése hidrogénatom; alkil-, alkenil-,cikloalkil-, cikloalkil-alkil- vagy arilcsoport; R2 és R3 jelentéseazonos vagy különböző, és jelentésük hidrogénatom, hidroxilcsoportvagy alkoxicsoport. Ó
HU0200210A 1999-03-09 2000-03-08 Camptothecin derivatives having antitumor activity, process for their preparation and pharmaceutical compositions containing them HU229506B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99830124A EP1044977B1 (en) 1999-03-09 1999-03-09 Camptothecin derivatives having antitumor activity
PCT/EP2000/001570 WO2000053607A1 (en) 1999-03-09 2000-03-08 Camptothecin derivatives having antitumor activity

Publications (3)

Publication Number Publication Date
HUP0200210A2 true HUP0200210A2 (hu) 2002-05-29
HUP0200210A3 HUP0200210A3 (en) 2004-03-29
HU229506B1 HU229506B1 (en) 2014-01-28

Family

ID=8243303

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0200210A HU229506B1 (en) 1999-03-09 2000-03-08 Camptothecin derivatives having antitumor activity, process for their preparation and pharmaceutical compositions containing them

Country Status (39)

Country Link
US (2) US6242457B1 (hu)
EP (1) EP1044977B1 (hu)
JP (1) JP4610743B2 (hu)
KR (1) KR100702085B1 (hu)
CN (1) CN1139592C (hu)
AR (1) AR022860A1 (hu)
AT (1) ATE216998T1 (hu)
AU (1) AU774174B2 (hu)
BG (1) BG65032B1 (hu)
BR (1) BR0008840B1 (hu)
CA (1) CA2362760C (hu)
CO (1) CO5180590A1 (hu)
CZ (1) CZ304465B6 (hu)
DE (1) DE69901379T2 (hu)
DK (1) DK1044977T3 (hu)
EA (1) EA003605B1 (hu)
EE (1) EE04679B1 (hu)
EG (1) EG23999A (hu)
ES (1) ES2175919T3 (hu)
HK (1) HK1031222A1 (hu)
HR (1) HRP20010667B1 (hu)
HU (1) HU229506B1 (hu)
IL (2) IL144958A0 (hu)
IS (1) IS2003B (hu)
ME (2) ME00017B (hu)
MX (1) MXPA01009081A (hu)
NO (1) NO328363B1 (hu)
NZ (1) NZ513393A (hu)
PE (1) PE20001485A1 (hu)
PL (1) PL222208B1 (hu)
PT (1) PT1044977E (hu)
RS (1) RS50405B (hu)
SI (1) SI1044977T1 (hu)
SK (1) SK287561B6 (hu)
TN (1) TNSN00045A1 (hu)
TR (1) TR200102603T2 (hu)
TW (1) TWI272272B (hu)
WO (1) WO2000053607A1 (hu)
ZA (1) ZA200107408B (hu)

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JP4790911B2 (ja) 1999-01-13 2011-10-12 アルケミア オンコロジー ピーティワイ リミテッド 薬物の効力を増強するための組成物および方法
US7105492B2 (en) * 1999-03-09 2006-09-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
FR2794123B1 (fr) * 1999-05-28 2001-07-27 Aventis Pharma Sa Preparation de derives de la camptothecine et de la nothapodytine
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
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ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.
ITRM20020305A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
RU2006137657A (ru) * 2004-03-26 2008-05-10 Новартис АГ (CH) Применение производных камптотецина для лечения пролиферативных заболеваний с использованием схемы лечения с фиксированной дозой
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ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
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GT200500310A (es) * 2004-11-19 2006-06-19 Compuestos organicos
PL1827437T3 (pl) 2004-12-15 2013-06-28 Sigma Tau Ind Farmaceuti Połączenia środków terapeutycznych do leczenia raka
CA2590756C (en) * 2004-12-21 2014-09-02 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Stereoselective process and crystalline forms of a camptothecin
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
AU2006270297B2 (en) 2005-07-14 2013-01-17 Wellstat Biologics Corporation Cancer treatment using viruses, fluoropyrimidines and camptothecins
AU2006274509B2 (en) * 2005-07-27 2012-01-19 Alchemia Oncology Pty Limited Therapeutic protocols using hyaluronan
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
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EA013877B1 (ru) * 2005-09-07 2010-08-30 Алкемиа Онколоджи Пти Лимитед Терапевтические композиции, содержащие гиалуроновую кислоту и терапевтические антитела, а также способы лечения
PL1962850T3 (pl) * 2005-12-21 2012-07-31 Sigma Tau Ind Farmaceuti Leczenie lekoopornych nowotworów
EP1989212B1 (en) 2006-02-17 2013-06-19 Cascade Prodrug Inc. Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs
EP1998809B1 (en) 2006-03-30 2014-06-25 Drais Pharmaceuticals, Inc. Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
AU2008210511A1 (en) * 2007-02-01 2008-08-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Pharmaceutical composition comprising a campothecin derivative
EP2120948A1 (en) * 2007-02-13 2009-11-25 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
CN101784277A (zh) * 2007-08-01 2010-07-21 希格马托制药工业公司 儿科肿瘤的治疗
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Also Published As

Publication number Publication date
CZ304465B6 (cs) 2014-05-21
IL144958A (en) 2009-08-03
ES2175919T3 (es) 2002-11-16
DK1044977T3 (da) 2002-07-08
CO5180590A1 (es) 2002-07-30
EA200100954A1 (ru) 2002-04-25
MEP4008A (xx) 2010-02-10
EE200100466A (et) 2002-12-16
SK11642001A3 (sk) 2002-01-07
AU3160400A (en) 2000-09-28
US6589939B2 (en) 2003-07-08
NO328363B1 (no) 2010-02-01
PT1044977E (pt) 2002-09-30
HU229506B1 (en) 2014-01-28
PL222208B1 (pl) 2016-07-29
MXPA01009081A (es) 2002-08-30
AR022860A1 (es) 2002-09-04
CN1139592C (zh) 2004-02-25
CZ20013077A3 (cs) 2002-01-16
TWI272272B (en) 2007-02-01
CA2362760C (en) 2009-08-18
CN1343209A (zh) 2002-04-03
NO20014128D0 (no) 2001-08-24
PL355094A1 (en) 2004-03-22
ZA200107408B (en) 2002-05-29
SK287561B6 (sk) 2011-02-04
BG105810A (en) 2002-06-28
EG23999A (en) 2008-03-19
ATE216998T1 (de) 2002-05-15
IS6031A (is) 2001-07-31
WO2000053607A1 (en) 2000-09-14
EE04679B1 (et) 2006-08-15
IL144958A0 (en) 2002-06-30
BR0008840A (pt) 2002-01-08
NO20014128L (no) 2001-08-24
KR20010102519A (ko) 2001-11-15
HRP20010667B1 (en) 2003-06-30
RS50405B (sr) 2009-12-31
HUP0200210A3 (en) 2004-03-29
JP4610743B2 (ja) 2011-01-12
ME00017B (me) 2010-06-10
DE69901379D1 (de) 2002-06-06
US6242457B1 (en) 2001-06-05
EP1044977B1 (en) 2002-05-02
YU64301A (sh) 2005-07-19
HK1031222A1 (en) 2001-06-08
TR200102603T2 (tr) 2002-01-21
KR100702085B1 (ko) 2007-04-02
TNSN00045A1 (fr) 2005-11-10
PE20001485A1 (es) 2000-12-07
HRP20010667A2 (en) 2002-08-31
JP2002539128A (ja) 2002-11-19
EA003605B1 (ru) 2003-06-26
DE69901379T2 (de) 2002-11-07
IS2003B (is) 2005-04-15
BG65032B1 (bg) 2006-12-29
AU774174B2 (en) 2004-06-17
SI1044977T1 (en) 2002-08-31
US20010008939A1 (en) 2001-07-19
NZ513393A (en) 2003-04-29
EP1044977A1 (en) 2000-10-18
BR0008840B1 (pt) 2011-12-27
CA2362760A1 (en) 2000-09-14

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