EA200101224A1 - Производные пурина, способ их получения и содержащие их фармацевтические композиции - Google Patents

Производные пурина, способ их получения и содержащие их фармацевтические композиции

Info

Publication number
EA200101224A1
EA200101224A1 EA200101224A EA200101224A EA200101224A1 EA 200101224 A1 EA200101224 A1 EA 200101224A1 EA 200101224 A EA200101224 A EA 200101224A EA 200101224 A EA200101224 A EA 200101224A EA 200101224 A1 EA200101224 A1 EA 200101224A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
hydrogen
aryl
cycloalkyl
pharmaceutical compositions
Prior art date
Application number
EA200101224A
Other languages
English (en)
Other versions
EA005072B1 (ru
Inventor
Жан-Люк Асслен
Original Assignee
Авентис Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фарма С.А. filed Critical Авентис Фарма С.А.
Publication of EA200101224A1 publication Critical patent/EA200101224A1/ru
Publication of EA005072B1 publication Critical patent/EA005072B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom

Abstract

Изобретение относится к новым соединениям формулы I, в которой Z обозначает двухвалентный радикал -СН-, -SO-, -СО-, -COO-, -CONH- или -(CH)-NR-; n обозначает 0 или 1; Rобозначает водород, арил, -СН-арил, -SO-арил, -СО-арил, гетероциклический радикал, -СН-гетероциклический радикал, алкил и -SO-алкил; Rобозначает алкил, циклоалкил или гетероциклический радикал, содержащий кислород, серу или NR; Y обозначает кислород, серу или NR; Dи Dлибо выбирают из водорода, гидроксила, алкила, алкокси и NHR, либо образуют =O или =N-OR; Rобозначает водород, алкил или циклоалкил; Rобозначает водород, алкил, циклоалкил или арил; Rобозначает водород, алкил, циклоалкил или -COO-t-Bu; Rобозначает водород, галоген, гидроксил, алкил, алкокси или NHR; причем эти соединения существуют во всех изомерных формах и в виде солей; пригодным для использования в качестве лекарственных средств. Изобретение относится также к способу получения новых соединений и к фармацевтическим композициям, содержащим указанные соединения.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200101224A 1999-05-21 2000-05-18 Производные пурина, способ их получения и содержащие их фармацевтические композиции EA005072B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9906456A FR2793794B1 (fr) 1999-05-21 1999-05-21 Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
PCT/FR2000/001335 WO2000071543A1 (fr) 1999-05-21 2000-05-18 Derives de la purine, leur procede de preparation, et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
EA200101224A1 true EA200101224A1 (ru) 2002-10-31
EA005072B1 EA005072B1 (ru) 2004-10-28

Family

ID=9545846

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200101224A EA005072B1 (ru) 1999-05-21 2000-05-18 Производные пурина, способ их получения и содержащие их фармацевтические композиции

Country Status (33)

Country Link
US (2) US7122669B1 (ru)
EP (1) EP1183256B1 (ru)
JP (1) JP2003500407A (ru)
KR (1) KR100707895B1 (ru)
CN (1) CN1298719C (ru)
AP (1) AP1477A (ru)
AR (1) AR035317A1 (ru)
AT (1) ATE370951T1 (ru)
AU (1) AU4764500A (ru)
BR (1) BR0011282A (ru)
CA (1) CA2374714A1 (ru)
CZ (1) CZ20014163A3 (ru)
DE (1) DE60036102T2 (ru)
DK (1) DK1183256T3 (ru)
DZ (1) DZ3166A1 (ru)
EA (1) EA005072B1 (ru)
ES (1) ES2290033T3 (ru)
FR (1) FR2793794B1 (ru)
HU (1) HUP0201649A3 (ru)
IL (1) IL146441A0 (ru)
MA (1) MA26791A1 (ru)
MX (1) MXPA01011834A (ru)
NO (1) NO20015659L (ru)
NZ (1) NZ515556A (ru)
PL (1) PL352293A1 (ru)
PT (1) PT1183256E (ru)
SK (1) SK16722001A3 (ru)
TR (1) TR200103349T2 (ru)
TW (1) TWI284130B (ru)
UA (1) UA68441C2 (ru)
WO (1) WO2000071543A1 (ru)
YU (1) YU86601A (ru)
ZA (1) ZA200109602B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6479487B1 (en) * 1998-02-26 2002-11-12 Aventis Pharmaceuticals Inc. 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
US6413974B1 (en) * 1998-02-26 2002-07-02 Aventis Pharmaceuticals Inc. 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
US6969720B2 (en) 1999-03-17 2005-11-29 Amr Technology, Inc. Biaryl substituted purine derivatives as potent antiproliferative agents
CA2427338C (en) * 2000-10-31 2008-06-10 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
US6861524B2 (en) * 2000-10-31 2005-03-01 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion
US6667311B2 (en) 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
US6812232B2 (en) 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
WO2003031406A2 (en) * 2001-10-12 2003-04-17 Irm Llc Kinase inhibitor scaffolds and methods for their preparation
AU2003301407B2 (en) * 2002-10-15 2010-04-22 Irm Llc Compositions and methods for inducing osteogenesis
FR2851248B1 (fr) * 2003-02-18 2005-04-08 Aventis Pharma Sa Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
JP4976852B2 (ja) 2003-11-10 2012-07-18 ザ スクリプス リサーチ インスティチュート 細胞脱分化を誘導するための組成物および方法
EP1740587A4 (en) * 2004-04-02 2009-07-15 Adenosine Therapeutics Llc SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS
CZ302122B6 (cs) * 2009-01-28 2010-10-20 Univerzita Palackého v Olomouci Substituované deriváty 6-(2-aminobenzylamino)purinu, jejich použití jako léciva a prípravky tyto slouceniny obsahující
WO2012142029A2 (en) 2011-04-10 2012-10-18 Florida A&M University Serms for the treatment of estrogen receptor-mediated disorders
WO2015162518A1 (en) 2014-04-25 2015-10-29 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
JP2019533652A (ja) * 2016-09-30 2019-11-21 エスアールアイ インターナショナルＳＲＩ Ｉｎｔｅｒｎａｔｉｏｎａｌ がんを処置するための二重ｃｌｋ／ｃｄｋ１阻害剤
CZ308029B6 (cs) * 2017-03-20 2019-11-06 Univerzita PalackĂ©ho v Olomouci 2,6-Disubstituované-9-cyklopentyl-9H-puriny, jejich použití jako léčiva a farmaceutické přípravky

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4008858A1 (de) * 1990-03-20 1991-09-26 Hoechst Ag Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
EP0841810B1 (en) * 1991-12-05 2000-06-21 Texas Instruments Incorporated Method to improve a video signal
CA2084222C (en) * 1991-12-06 2004-04-06 David R. Borcherding Novel trans cyclopentanyl purine analogs useful as immunosuppressants
BR9611157A (pt) * 1995-11-01 1999-03-30 Novartis Ag Derivados de purina e processos para sua preparação
FR2741881B1 (fr) * 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
US6790958B2 (en) * 1996-08-02 2004-09-14 Robert T. Lum Purine inhibitors of cyclin dependent kinase 2 & IKBA
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
AU4920397A (en) * 1996-10-11 1998-05-11 Chiron Corporation Purine inhibitors of glycogen synthase kinase 3 (gsk3)
WO1999007705A1 (en) * 1997-08-07 1999-02-18 The Regents Of The University Of California Purine inhibitor of protein kinases, g proteins and polymerases
US6479487B1 (en) * 1998-02-26 2002-11-12 Aventis Pharmaceuticals Inc. 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
US6413974B1 (en) * 1998-02-26 2002-07-02 Aventis Pharmaceuticals Inc. 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
GB9903762D0 (en) * 1999-02-18 1999-04-14 Novartis Ag Organic compounds
FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion

Also Published As

Publication number Publication date
IL146441A0 (en) 2002-07-25
MXPA01011834A (es) 2002-04-17
FR2793794B1 (fr) 2001-07-27
ZA200109602B (en) 2003-01-29
HUP0201649A2 (en) 2002-08-28
AR035317A1 (es) 2004-05-12
WO2000071543A1 (fr) 2000-11-30
ES2290033T3 (es) 2008-02-16
NO20015659D0 (no) 2001-11-20
HUP0201649A3 (en) 2003-01-28
NO20015659L (no) 2002-01-18
KR100707895B1 (ko) 2007-04-17
AU4764500A (en) 2000-12-12
PL352293A1 (en) 2003-08-11
EP1183256B1 (fr) 2007-08-22
EP1183256A1 (fr) 2002-03-06
NZ515556A (en) 2003-08-29
UA68441C2 (en) 2004-08-16
TWI284130B (en) 2007-07-21
US20050187228A1 (en) 2005-08-25
EA005072B1 (ru) 2004-10-28
US7122669B1 (en) 2006-10-17
ATE370951T1 (de) 2007-09-15
CN1361780A (zh) 2002-07-31
KR20010113975A (ko) 2001-12-28
US7208598B2 (en) 2007-04-24
DE60036102D1 (de) 2007-10-04
AP1477A (en) 2005-10-19
DK1183256T3 (da) 2007-12-03
BR0011282A (pt) 2002-02-26
TR200103349T2 (tr) 2002-05-21
CZ20014163A3 (cs) 2002-10-16
AP2001002355A0 (en) 2001-12-31
CA2374714A1 (fr) 2000-11-30
DZ3166A1 (fr) 2000-11-30
SK16722001A3 (sk) 2003-01-09
FR2793794A1 (fr) 2000-11-24
PT1183256E (pt) 2007-11-13
CN1298719C (zh) 2007-02-07
YU86601A (sh) 2005-07-19
JP2003500407A (ja) 2003-01-07
MA26791A1 (fr) 2004-12-20
DE60036102T2 (de) 2008-05-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU