GB2006771A - Substituted Heterocyclic Compounds, their Preparation and Pharmaceutical Compositions Containing them - Google Patents

Substituted Heterocyclic Compounds, their Preparation and Pharmaceutical Compositions Containing them

Info

Publication number
GB2006771A
GB2006771A GB7840125A GB7840125A GB2006771A GB 2006771 A GB2006771 A GB 2006771A GB 7840125 A GB7840125 A GB 7840125A GB 7840125 A GB7840125 A GB 7840125A GB 2006771 A GB2006771 A GB 2006771A
Authority
GB
United Kingdom
Prior art keywords
alkyl
image
carbon atoms
formula
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7840125A
Other versions
GB2006771B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to GB7840125A priority Critical patent/GB2006771B/en
Publication of GB2006771A publication Critical patent/GB2006771A/en
Application granted granted Critical
Publication of GB2006771B publication Critical patent/GB2006771B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to compounds of the general formula <IMAGE> and physiologically acceptable salts and N-oxides, hydrates and bioprecursors thereof, in which R1 and R2 which may be the same or different each represent hydrogen, C1-8 alkyl, C4-8 cycloalkyl, C3-6 alkenyl, aralkyl with 1 to 4 carbon atoms in the alkyl residue or C1-8 alkyl interrupted by an oxygen atom or a group <IMAGE> in which R5 represents hydrogen or C1-8 alkyl, or R1 and R2 may together with the nitrogen atom to which they are attached, form a saturated monocyclic 5 to 7 membered heterocyclic ring which may additionally contain the heterofunction 0 or <IMAGE> R3 represents straight or branched chain C1-8 alkyl, alkoxyalkyl with 1 to 8 carbon atoms in each alkyl residue, C1-8 hydroxyalkyl, C1-8 alkoxycarbonyl, alkyl thioalkyl with 1 to 8 carbon atoms in each alkyl residue, halogen or aryl; R4 represents hydrogen, C1-8 alkyl, C3-6 alkenyl or alkoxyalkyl with 1 to 8 carbon atoms in each alkyl residue; X represents -O- or -S-; Y represents =S, =O, =NR6 or =CHNO2 where R6 represents hydrogen, nitro, cyano, C1-8 alkyl, aryl, C1-8 alkylsulphonyl or arylsulphonyl; m represents an integer from 2 to 4 inclusive; and n represents an integer which is 1 or 2, or additionally when X is -S- n may also be zero. The invention also relates to processes for the production of such compounds, pharmaceutical compositions containing them and certain novel intermediates used in their production, i.e. amines of the formula <IMAGE> and alcohols of the formula <IMAGE> The compounds of formula (I) show pharmacological activity as selective histamine H2-antagonists.
GB7840125A 1977-10-11 1978-10-11 Substituted heterocyclic compounds their preparation and pharmaceutical compositions containing them Expired GB2006771B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7840125A GB2006771B (en) 1977-10-11 1978-10-11 Substituted heterocyclic compounds their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4225677 1977-10-11
GB7840125A GB2006771B (en) 1977-10-11 1978-10-11 Substituted heterocyclic compounds their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
GB2006771A true GB2006771A (en) 1979-05-10
GB2006771B GB2006771B (en) 1982-10-20

Family

ID=26264870

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7840125A Expired GB2006771B (en) 1977-10-11 1978-10-11 Substituted heterocyclic compounds their preparation and pharmaceutical compositions containing them

Country Status (1)

Country Link
GB (1) GB2006771B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491586A (en) * 1980-06-05 1985-01-01 Glaxo Group Limited Amine derivatives
EP0454469A1 (en) * 1990-04-26 1991-10-30 Glaxo Group Limited Carboxylic acid derivatives
FR2728793A1 (en) * 1994-12-28 1996-07-05 Oreal Compsns. for treating sensitive skin

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491586A (en) * 1980-06-05 1985-01-01 Glaxo Group Limited Amine derivatives
EP0454469A1 (en) * 1990-04-26 1991-10-30 Glaxo Group Limited Carboxylic acid derivatives
US5229418A (en) * 1990-04-26 1993-07-20 Glaxo Group Limited Carboxylic acid derivatives
FR2728793A1 (en) * 1994-12-28 1996-07-05 Oreal Compsns. for treating sensitive skin
EP0729750A1 (en) * 1994-12-28 1996-09-04 L'oreal Use of an interleukin-1 antagonist and/or alpha-TNF antagonist in a cosmetic, pharmaceutical or dermatological composition, and the composition therefrom, possibly used in combination with a histamine antagonist
US5658581A (en) * 1994-12-28 1997-08-19 L'oreal Histamine antagonist, an interleukin-1 antagonist and/or a TNF alpha antagonist in a cosmetic, pharmaceutical or dermatological composition and composition obtained
US6277387B1 (en) 1994-12-28 2001-08-21 L'oreal Use of a histamine antagonist, an interleukin-1 antagonist and/or a TNF αantagonist in a cosmetic, pharmaceutical or dermatological composition and composition obtained

Also Published As

Publication number Publication date
GB2006771B (en) 1982-10-20

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Legal Events

Date Code Title Description
7732 Case decided by the comptroller ** patent revoked (sect. 73(2)/1977)