ATE32720T1 - 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung. - Google Patents
1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung.Info
- Publication number
- ATE32720T1 ATE32720T1 AT83110044T AT83110044T ATE32720T1 AT E32720 T1 ATE32720 T1 AT E32720T1 AT 83110044 T AT83110044 T AT 83110044T AT 83110044 T AT83110044 T AT 83110044T AT E32720 T1 ATE32720 T1 AT E32720T1
- Authority
- AT
- Austria
- Prior art keywords
- aryl
- isochinolines
- 1alpha
- pyrazino
- hexahydro
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 aralkanoyl Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/435,132 US4517187A (en) | 1982-10-18 | 1982-10-18 | 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants |
| EP83110044A EP0107825B1 (de) | 1982-10-18 | 1983-10-07 | 1,3,4,6,7,11b-Hexahydro-7-aryl-2H-pyrazino(2,1-alpha)isochinoline als Zwischenprodukte und als pharmazeutische Verbindungen verwendbar und Methode zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE32720T1 true ATE32720T1 (de) | 1988-03-15 |
Family
ID=23727113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83110044T ATE32720T1 (de) | 1982-10-18 | 1983-10-07 | 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4517187A (de) |
| EP (1) | EP0107825B1 (de) |
| JP (1) | JPS5989680A (de) |
| KR (1) | KR870000622B1 (de) |
| AT (1) | ATE32720T1 (de) |
| AU (1) | AU1955583A (de) |
| CA (1) | CA1219874A (de) |
| DE (1) | DE3375784D1 (de) |
| DK (1) | DK477783A (de) |
| FI (1) | FI833784A7 (de) |
| IL (1) | IL69586A (de) |
| NO (1) | NO833778L (de) |
| NZ (1) | NZ205425A (de) |
| ZA (1) | ZA836448B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4782058A (en) * | 1985-04-26 | 1988-11-01 | Pennwalt Corporation | 1,3,4,6,7,11b-Hexahydro-6-phenyl-2H-pyrazino-(2,1-a)isoquinolines, for anti-histamine or anti-depression treatment |
| US4678791A (en) * | 1985-05-07 | 1987-07-07 | Pennwalt Corporation | 6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression |
| US4772705A (en) * | 1985-07-25 | 1988-09-20 | Pennwalt Corporation | Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazinol[2,1-a]isoquinolines |
| MX19222A (es) * | 1989-01-23 | 1993-12-01 | Pfizer | Agentes ansioliticos bis-aza-biciclicos |
| PL180899B1 (pl) * | 1994-09-30 | 2001-04-30 | Pfizer | Nowe pochodne 2,7-podstawionej oktahydro-1H-pirydo[1,2-a]pirazyny i środek farmaceutyczny je zawierający |
| CN106470994B (zh) * | 2014-08-27 | 2019-09-24 | 豪夫迈·罗氏有限公司 | 用于治疗cns疾病的取代的吡嗪并[2,1-a]异喹啉衍生物 |
| BR112022007998A2 (pt) * | 2019-10-31 | 2022-07-05 | Holosmedic | Novo composto e composição farmacêutica para prevenção ou tratamento de câncer que compreende os mesmos |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1050901A (de) * | 1964-02-06 | |||
| US3684813A (en) * | 1970-04-08 | 1972-08-15 | Sterling Drug Inc | Hexahydropyrazinoisoquinolines |
| US4162319A (en) * | 1974-08-28 | 1979-07-24 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Ring substituted pyrazino-isoquinoline derivatives and their preparation |
| DE2441261A1 (de) * | 1974-08-28 | 1976-03-18 | Merck Patent Gmbh | Ringsubstituierte pyrazino-isochinolin-derivat und verfahren zu ihrer herstellung |
-
1982
- 1982-10-18 US US06/435,132 patent/US4517187A/en not_active Expired - Fee Related
-
1983
- 1983-08-26 CA CA000435430A patent/CA1219874A/en not_active Expired
- 1983-08-29 IL IL69586A patent/IL69586A/xx unknown
- 1983-08-30 NZ NZ205425A patent/NZ205425A/en unknown
- 1983-08-31 ZA ZA836448A patent/ZA836448B/xx unknown
- 1983-09-26 AU AU19555/83A patent/AU1955583A/en not_active Abandoned
- 1983-10-07 EP EP83110044A patent/EP0107825B1/de not_active Expired
- 1983-10-07 DE DE8383110044T patent/DE3375784D1/de not_active Expired
- 1983-10-07 AT AT83110044T patent/ATE32720T1/de not_active IP Right Cessation
- 1983-10-13 JP JP58190025A patent/JPS5989680A/ja active Pending
- 1983-10-17 DK DK477783A patent/DK477783A/da not_active Application Discontinuation
- 1983-10-17 FI FI833784A patent/FI833784A7/fi not_active Application Discontinuation
- 1983-10-17 NO NO833778A patent/NO833778L/no unknown
- 1983-10-18 KR KR1019830004928A patent/KR870000622B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5989680A (ja) | 1984-05-23 |
| DE3375784D1 (en) | 1988-04-07 |
| EP0107825B1 (de) | 1988-03-02 |
| EP0107825A1 (de) | 1984-05-09 |
| AU1955583A (en) | 1984-05-03 |
| ZA836448B (en) | 1984-07-25 |
| NZ205425A (en) | 1986-05-09 |
| DK477783D0 (da) | 1983-10-17 |
| FI833784A7 (fi) | 1984-04-19 |
| DK477783A (da) | 1984-04-19 |
| NO833778L (no) | 1984-04-24 |
| KR870000622B1 (ko) | 1987-03-26 |
| KR840006656A (ko) | 1984-12-01 |
| US4517187A (en) | 1985-05-14 |
| CA1219874A (en) | 1987-03-31 |
| FI833784A0 (fi) | 1983-10-17 |
| IL69586A0 (en) | 1983-11-30 |
| IL69586A (en) | 1986-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |