ATE32720T1 - 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung. - Google Patents

1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung.

Info

Publication number
ATE32720T1
ATE32720T1 AT83110044T AT83110044T ATE32720T1 AT E32720 T1 ATE32720 T1 AT E32720T1 AT 83110044 T AT83110044 T AT 83110044T AT 83110044 T AT83110044 T AT 83110044T AT E32720 T1 ATE32720 T1 AT E32720T1
Authority
AT
Austria
Prior art keywords
aryl
isochinolines
1alpha
pyrazino
hexahydro
Prior art date
Application number
AT83110044T
Other languages
English (en)
Inventor
Ronald C Griffith
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Application granted granted Critical
Publication of ATE32720T1 publication Critical patent/ATE32720T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT83110044T 1982-10-18 1983-10-07 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung. ATE32720T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/435,132 US4517187A (en) 1982-10-18 1982-10-18 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
EP83110044A EP0107825B1 (de) 1982-10-18 1983-10-07 1,3,4,6,7,11b-Hexahydro-7-aryl-2H-pyrazino(2,1-alpha)isochinoline als Zwischenprodukte und als pharmazeutische Verbindungen verwendbar und Methode zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE32720T1 true ATE32720T1 (de) 1988-03-15

Family

ID=23727113

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83110044T ATE32720T1 (de) 1982-10-18 1983-10-07 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung.

Country Status (14)

Country Link
US (1) US4517187A (de)
EP (1) EP0107825B1 (de)
JP (1) JPS5989680A (de)
KR (1) KR870000622B1 (de)
AT (1) ATE32720T1 (de)
AU (1) AU1955583A (de)
CA (1) CA1219874A (de)
DE (1) DE3375784D1 (de)
DK (1) DK477783A (de)
FI (1) FI833784A (de)
IL (1) IL69586A (de)
NO (1) NO833778L (de)
NZ (1) NZ205425A (de)
ZA (1) ZA836448B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4782058A (en) * 1985-04-26 1988-11-01 Pennwalt Corporation 1,3,4,6,7,11b-Hexahydro-6-phenyl-2H-pyrazino-(2,1-a)isoquinolines, for anti-histamine or anti-depression treatment
US4678791A (en) * 1985-05-07 1987-07-07 Pennwalt Corporation 6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression
US4772705A (en) * 1985-07-25 1988-09-20 Pennwalt Corporation Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazinol[2,1-a]isoquinolines
MX19222A (es) * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos
JP3287574B2 (ja) * 1994-09-30 2002-06-04 ファイザー・インク ２，７−置換オクタヒドロ−１ｈ−ピリド［１，２−ａ］ピラジン誘導体
CN106470994B (zh) * 2014-08-27 2019-09-24 豪夫迈·罗氏有限公司 用于治疗cns疾病的取代的吡嗪并[2,1-a]异喹啉衍生物
CA3159791A1 (en) * 2019-10-31 2021-05-06 Holosmedic Hexahydro-2h-pyrazino[1,2-a]pyrazine-6,9-dione derivatives and pharmaceutical compositions for prevention or treatment of cancer comprising same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1050901A (de) * 1964-02-06
US3684813A (en) * 1970-04-08 1972-08-15 Sterling Drug Inc Hexahydropyrazinoisoquinolines
US4162319A (en) * 1974-08-28 1979-07-24 Merck Patent Gesellschaft Mit Beschrankter Haftung Ring substituted pyrazino-isoquinoline derivatives and their preparation
DE2441261A1 (de) * 1974-08-28 1976-03-18 Merck Patent Gmbh Ringsubstituierte pyrazino-isochinolin-derivat und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
AU1955583A (en) 1984-05-03
FI833784A0 (fi) 1983-10-17
IL69586A0 (en) 1983-11-30
NO833778L (no) 1984-04-24
EP0107825A1 (de) 1984-05-09
EP0107825B1 (de) 1988-03-02
FI833784A (fi) 1984-04-19
JPS5989680A (ja) 1984-05-23
KR840006656A (ko) 1984-12-01
DK477783D0 (da) 1983-10-17
US4517187A (en) 1985-05-14
CA1219874A (en) 1987-03-31
KR870000622B1 (ko) 1987-03-26
ZA836448B (en) 1984-07-25
IL69586A (en) 1986-07-31
DK477783A (da) 1984-04-19
NZ205425A (en) 1986-05-09
DE3375784D1 (en) 1988-04-07

Similar Documents

Publication Publication Date Title
NO955074L (no) 1-substituerte istain- og oksindolderivater som inhibitorer til acetylkolinesterase
FR2639636B1 (fr) Nouveaux composes heterocycliques a activite anticonvulsivante, procede de preparation et compositions therapeutiques les contenant
FI870219A0 (fi) Hypoglykemiska tiazolidindioner.
FR2671348B1 (fr) Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
DE3462504D1 (de) Indole-3-carboxamide derivatives
FI946073A0 (fi) Vitamiini D-sarjan, 20-asemassa modifioituja johdannaisia, menetelmä tällaisten johdannaisten valmistamiseksi, menetelmässä käytettäviä välituotteita, mainittuja johdannaisia sisältäviä farmaseuttisia valmisteita ja johdannaisten käyttö lääkeaineiden valmistamiseen
ATE48602T1 (de) Beta-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
FI871322A (fi) Nya benzotiazinderivat.
FI894061A0 (fi) Menetelmä lääkeaineina käyttökelpoisten , -disubstituoitujen N-sykloalkyylialkyylibentsyyliamiinien valmistamiseksi ja niiden synteesivälituotteita
BR8200949A (pt) Imidazodiazepinas,substancias farmaceutica ativas,processo para a fabricacao de compostos,medicamentos,medicamento esquistossomicidamente ativo e uso de compostos
HUP0003577A2 (hu) Tetrahidro-gamma-karbolinok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
ATE32720T1 (de) 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1alpha)isochinoline als zwischenprodukte und als pharmazeutische verbindungen verwendbar und methode zu ihrer herstellung.
FI844333A0 (fi) 11-substituerade 5h,11h-pyrrolo/2,1-c/ /1,4/benzoxazepiner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
DZ1468A1 (fr) Composés nouveaux.
ATE150745T1 (de) 22-en-25-oxa-derivate in der vitamin d-reihe, verfahren zu ihrer herstellung, diese derivate enthaltenen pharmazeutische präparate sowie deren verwendung als arzneimittel
FR2508033B1 (de)
ATE12641T1 (de) Azepinindole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE24509T1 (de) Triazoloquinazolone und deren salze, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende zusammensetzungen.
PT861250E (pt) Derivados de amidina e de isotioureia como inibidores de oxido nitrico sintase
FR2766487B1 (fr) Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant
ES8600224A1 (es) Procedimiento de preparacion de nuevos derivados carbamiloxibenzoles
HUT46214A (en) Process for producing medical preparation suitable for treatment of peptic ulcer
ATE14308T1 (de) 4-aryloxy-1,2,3,4-tetrahydroisochinoline und zwischenprodukte, verfahren zu ihrer herstellung, diese verbindungen enthaltende pharmazeutische zusammensetzung und ihre verwendung als medikamente.
FR2766183B1 (fr) Medicaments contenant des polyhydroxybutylpyrazines, les polyhydroxybutylpyrazines nouvelles et leur preparation
ES2006165A6 (es) Procedimiento para la preparacion de derivados de 1,4-dihidropiridina y sus sales de adicion farmaceuticamente aceptables

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee