NO955074L - 1-substituerte istain- og oksindolderivater som inhibitorer til acetylkolinesterase - Google Patents
1-substituerte istain- og oksindolderivater som inhibitorer til acetylkolinesteraseInfo
- Publication number
- NO955074L NO955074L NO955074A NO955074A NO955074L NO 955074 L NO955074 L NO 955074L NO 955074 A NO955074 A NO 955074A NO 955074 A NO955074 A NO 955074A NO 955074 L NO955074 L NO 955074L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- hydrogen
- compounds
- substituted
- istain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Abstract
Nye forbindelser som har den generelle formel (1) (1) hvor: n er 3, 4, 5, 6 eller 7; X representerer en eller flere substituenter uavhengig valgt fra hydrogen, lavere alkyl, aryl, lavere alkoksy, halogen, trifluormetyl, nitro, -NHCOR hvor R er lavere alkyl eller aryl, -NRjR2 hvor Rj og R2 uavhengig er hydrogen eller lavere alkyl eller sammen danner en ring, eller cykloalkyl, cykloalkenyl eller bicyklo- alkyl hver eventuelt ytterligere substituert med lavere alkyl; Y er I^CO eller hvor R3 og R$ uavhengig er hydrogen, lavere alkyl, lavere alkoksy eller sammen danner en syklisk acetal; Z er lavere alkyl; og W representerer en eller flere substituenter uavhengig valgt fra hydrogen, lavere alkyl. lavere alkoksy eller halogen; stereo- og optiske isomerer og racemater derav hvor slike isomerer forekommer, samt farmasøytisk akseptable syreaddisjonssalter derav og solvater derav, som har terapeutisk aktivitet; mellomprodukter for deres fremstilling; , fremgangsmåter for deres fremstilling; farmasøytiske preparater inneholdende nevnte ' forbindelser; og medisinsk anvendelse av nevnte forbindelser.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE19939302080A SE9302080D0 (sv) | 1993-06-16 | 1993-06-16 | New compounds |
PCT/SE1994/000448 WO1994029272A1 (en) | 1993-06-16 | 1994-05-13 | 1-substituted isatin and oxindole derivatives as inhibitors of acetylcholinesterase |
Publications (2)
Publication Number | Publication Date |
---|---|
NO955074D0 NO955074D0 (no) | 1995-12-14 |
NO955074L true NO955074L (no) | 1996-02-07 |
Family
ID=20390305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO955074A NO955074L (no) | 1993-06-16 | 1995-12-14 | 1-substituerte istain- og oksindolderivater som inhibitorer til acetylkolinesterase |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0703901A1 (no) |
JP (1) | JPH08511515A (no) |
AU (1) | AU7010894A (no) |
CA (1) | CA2164119A1 (no) |
FI (1) | FI956074A (no) |
IS (1) | IS4167A (no) |
NO (1) | NO955074L (no) |
SE (1) | SE9302080D0 (no) |
WO (1) | WO1994029272A1 (no) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9103752D0 (sv) * | 1991-12-18 | 1991-12-18 | Astra Ab | New compounds |
US6906090B1 (en) * | 1998-03-06 | 2005-06-14 | Astrazeneca Ab | Compositions and methods for treating mycobacterial diseases |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
KR100639543B1 (ko) | 1998-09-30 | 2006-10-31 | 다케다 야쿠힌 고교 가부시키가이샤 | 방광 배출력 개선제 |
US6498154B1 (en) | 1999-05-04 | 2002-12-24 | Wyeth | Cyclic regimens using quinazolinone and benzoxazine derivatives |
US6380235B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Benzimidazolones and analogues |
US6380178B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Cyclic regimens using cyclocarbamate and cyclic amide derivatives |
US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
US6358947B1 (en) | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Tetracyclic progesterone receptor modulator compounds and methods |
US6355648B1 (en) | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
US6417214B1 (en) | 1999-05-04 | 2002-07-09 | Wyeth | 3,3-substituted indoline derivatives |
US6462032B1 (en) | 1999-05-04 | 2002-10-08 | Wyeth | Cyclic regimens utilizing indoline derivatives |
US6391907B1 (en) * | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
US6319912B1 (en) | 1999-05-04 | 2001-11-20 | American Home Products Corporation | Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides |
US6444668B1 (en) | 1999-05-04 | 2002-09-03 | Wyeth | Combination regimens using progesterone receptor modulators |
US6423699B1 (en) | 1999-05-04 | 2002-07-23 | American Home Products Corporation | Combination therapies using benzimidazolones |
US6306851B1 (en) | 1999-05-04 | 2001-10-23 | American Home Products Corporation | Cyclocarbamate and cyclic amide derivatives |
US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
US6329416B1 (en) | 1999-05-04 | 2001-12-11 | American Home Products Corporation | Combination regimens using 3,3-substituted indoline derivatives |
US6399593B1 (en) | 1999-05-04 | 2002-06-04 | Wyeth | Cyclic regimens using cyclic urea and cyclic amide derivatives |
US6339098B1 (en) | 1999-05-04 | 2002-01-15 | American Home Products Corporation | 2,1-benzisothiazoline 2,2-dioxides |
US6369056B1 (en) | 1999-05-04 | 2002-04-09 | American Home Products Corporation | Cyclic urea and cyclic amide derivatives |
US6358948B1 (en) | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
JP2004529110A (ja) | 2001-03-06 | 2004-09-24 | アストラゼネカ アクチボラグ | 脈管損傷活性を有するインドール誘導体 |
TW200508197A (en) | 2003-03-31 | 2005-03-01 | Ucb Sa | Indolone-acetamide derivatives, processes for preparing them and their uses |
CA2567909A1 (en) | 2004-05-27 | 2005-12-15 | Ucb, S.A. | Benzoxazolone derivatives, processes for preparing them and their uses |
ATE482194T1 (de) | 2004-07-22 | 2010-10-15 | Ucb Pharma Sa | Indolonderivate, verfahren zu deren herstellung und deren anwendungen |
GT200500185A (es) | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
WO2010090680A1 (en) * | 2008-12-15 | 2010-08-12 | Wyeth Llc | Substituted oxindole cb2 agonists |
JP6082250B2 (ja) | 2010-02-09 | 2017-02-15 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 認知機能を改善するための方法および組成物 |
CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
ES2663680T3 (es) | 2012-12-13 | 2018-04-16 | H. Lundbeck A/S | Composiciones que comprenden vortioxetina y donepezilo |
CN105142623A (zh) | 2013-03-15 | 2015-12-09 | 艾吉因生物股份有限公司 | 用于改善认知功能的方法和组合物 |
WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
CN103242332B (zh) * | 2013-05-13 | 2015-11-04 | 江西科技师范大学 | 1-n酰基取代吲哚酮衍生物 |
CN104530065A (zh) * | 2013-05-13 | 2015-04-22 | 江西科技师范大学 | 1-n酰基取代吲哚酮衍生物的应用 |
NZ738682A (en) | 2015-05-22 | 2022-01-28 | Agenebio Inc | Extended release pharmaceutical compositions of levetiracetam |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH491106A (de) * | 1964-06-11 | 1970-05-31 | Ciba Geigy | Verfahren zur Herstellung von neuen Thiosemicarbazonen |
-
1993
- 1993-06-16 SE SE19939302080A patent/SE9302080D0/xx unknown
-
1994
- 1994-05-13 EP EP94919032A patent/EP0703901A1/en not_active Withdrawn
- 1994-05-13 JP JP7501642A patent/JPH08511515A/ja active Pending
- 1994-05-13 WO PCT/SE1994/000448 patent/WO1994029272A1/en not_active Application Discontinuation
- 1994-05-13 CA CA002164119A patent/CA2164119A1/en not_active Abandoned
- 1994-05-13 AU AU70108/94A patent/AU7010894A/en not_active Abandoned
- 1994-05-18 IS IS4167A patent/IS4167A/is unknown
-
1995
- 1995-12-14 NO NO955074A patent/NO955074L/no unknown
- 1995-12-18 FI FI956074A patent/FI956074A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FI956074A0 (fi) | 1995-12-18 |
JPH08511515A (ja) | 1996-12-03 |
NO955074D0 (no) | 1995-12-14 |
WO1994029272A1 (en) | 1994-12-22 |
CA2164119A1 (en) | 1994-12-22 |
SE9302080D0 (sv) | 1993-06-16 |
AU7010894A (en) | 1995-01-03 |
EP0703901A1 (en) | 1996-04-03 |
FI956074A (fi) | 1995-12-18 |
IS4167A (is) | 1994-12-17 |
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