NO955074L - 1-substituted istain and oxindole derivatives as inhibitors of acetylcholinesterase - Google Patents

1-substituted istain and oxindole derivatives as inhibitors of acetylcholinesterase

Info

Publication number
NO955074L
NO955074L NO955074A NO955074A NO955074L NO 955074 L NO955074 L NO 955074L NO 955074 A NO955074 A NO 955074A NO 955074 A NO955074 A NO 955074A NO 955074 L NO955074 L NO 955074L
Authority
NO
Norway
Prior art keywords
lower alkyl
hydrogen
compounds
substituted
istain
Prior art date
Application number
NO955074A
Other languages
Norwegian (no)
Other versions
NO955074D0 (en
Inventor
Bernard Robin Boar
Dennis Mark O'shea
Ian David Tomlinson
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO955074D0 publication Critical patent/NO955074D0/en
Publication of NO955074L publication Critical patent/NO955074L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Nye forbindelser som har den generelle formel (1) (1) hvor: n er 3, 4, 5, 6 eller 7; X representerer en eller flere substituenter uavhengig valgt fra hydrogen, lavere alkyl, aryl, lavere alkoksy, halogen, trifluormetyl, nitro, -NHCOR hvor R er lavere alkyl eller aryl, -NRjR2 hvor Rj og R2 uavhengig er hydrogen eller lavere alkyl eller sammen danner en ring, eller cykloalkyl, cykloalkenyl eller bicyklo- alkyl hver eventuelt ytterligere substituert med lavere alkyl; Y er I^CO eller hvor R3 og R$ uavhengig er hydrogen, lavere alkyl, lavere alkoksy eller sammen danner en syklisk acetal; Z er lavere alkyl; og W representerer en eller flere substituenter uavhengig valgt fra hydrogen, lavere alkyl. lavere alkoksy eller halogen; stereo- og optiske isomerer og racemater derav hvor slike isomerer forekommer, samt farmasøytisk akseptable syreaddisjonssalter derav og solvater derav, som har terapeutisk aktivitet; mellomprodukter for deres fremstilling; , fremgangsmåter for deres fremstilling; farmasøytiske preparater inneholdende nevnte ' forbindelser; og medisinsk anvendelse av nevnte forbindelser.New compounds having the general formula (1) (1) wherein: n is 3, 4, 5, 6 or 7; X represents one or more substituents independently selected from hydrogen, lower alkyl, aryl, lower alkoxy, halogen, trifluoromethyl, nitro, -NHCOR where R is lower alkyl or aryl, -NR 2 R 2 where R 1 and R 2 are independently hydrogen or lower alkyl or together form a ring, or cycloalkyl, cycloalkenyl or bicycloalkyl each optionally further substituted with lower alkyl; Y is 1 CO or wherein R 3 and R 5 are independently hydrogen, lower alkyl, lower alkoxy or together form a cyclic acetal; Z is lower alkyl; and W represents one or more substituents independently selected from hydrogen, lower alkyl. lower alkoxy or halogen; stereo and optical isomers and racemates thereof where such isomers occur, as well as pharmaceutically acceptable acid addition salts thereof and solvates thereof, which have therapeutic activity; intermediates for their manufacture; , processes for their preparation; pharmaceutical preparations containing said compounds; and the medical use of said compounds.

NO955074A 1993-06-16 1995-12-14 1-substituted istain and oxindole derivatives as inhibitors of acetylcholinesterase NO955074L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE19939302080A SE9302080D0 (en) 1993-06-16 1993-06-16 NEW COMPOUNDS
PCT/SE1994/000448 WO1994029272A1 (en) 1993-06-16 1994-05-13 1-substituted isatin and oxindole derivatives as inhibitors of acetylcholinesterase

Publications (2)

Publication Number Publication Date
NO955074D0 NO955074D0 (en) 1995-12-14
NO955074L true NO955074L (en) 1996-02-07

Family

ID=20390305

Family Applications (1)

Application Number Title Priority Date Filing Date
NO955074A NO955074L (en) 1993-06-16 1995-12-14 1-substituted istain and oxindole derivatives as inhibitors of acetylcholinesterase

Country Status (9)

Country Link
EP (1) EP0703901A1 (en)
JP (1) JPH08511515A (en)
AU (1) AU7010894A (en)
CA (1) CA2164119A1 (en)
FI (1) FI956074A0 (en)
IS (1) IS4167A (en)
NO (1) NO955074L (en)
SE (1) SE9302080D0 (en)
WO (1) WO1994029272A1 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9103752D0 (en) * 1991-12-18 1991-12-18 Astra Ab NEW COMPOUNDS
US6906090B1 (en) * 1998-03-06 2005-06-14 Astrazeneca Ab Compositions and methods for treating mycobacterial diseases
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
KR100648869B1 (en) 1998-09-30 2007-02-28 다케다 야쿠힌 고교 가부시키가이샤 Drugs for improving vesical excretory strength
US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
US6417214B1 (en) 1999-05-04 2002-07-09 Wyeth 3,3-substituted indoline derivatives
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6462032B1 (en) 1999-05-04 2002-10-08 Wyeth Cyclic regimens utilizing indoline derivatives
US6407101B1 (en) 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
US6391907B1 (en) 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6358947B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods
US6319912B1 (en) 1999-05-04 2001-11-20 American Home Products Corporation Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6380178B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6339098B1 (en) 1999-05-04 2002-01-15 American Home Products Corporation 2,1-benzisothiazoline 2,2-dioxides
US6399593B1 (en) 1999-05-04 2002-06-04 Wyeth Cyclic regimens using cyclic urea and cyclic amide derivatives
US6306851B1 (en) 1999-05-04 2001-10-23 American Home Products Corporation Cyclocarbamate and cyclic amide derivatives
US6444668B1 (en) 1999-05-04 2002-09-03 Wyeth Combination regimens using progesterone receptor modulators
US6423699B1 (en) 1999-05-04 2002-07-23 American Home Products Corporation Combination therapies using benzimidazolones
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6498154B1 (en) 1999-05-04 2002-12-24 Wyeth Cyclic regimens using quinazolinone and benzoxazine derivatives
US6329416B1 (en) 1999-05-04 2001-12-11 American Home Products Corporation Combination regimens using 3,3-substituted indoline derivatives
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
US7186745B2 (en) 2001-03-06 2007-03-06 Astrazeneca Ab Indolone derivatives having vascular damaging activity
TW200508197A (en) 2003-03-31 2005-03-01 Ucb Sa Indolone-acetamide derivatives, processes for preparing them and their uses
EP1756071B1 (en) 2004-05-27 2009-08-26 UCB Pharma S.A. Benzoxazolone derivatives, processes for preparing them and their uses
WO2006008067A1 (en) * 2004-07-22 2006-01-26 Ucb, S.A. Indolone derivatives, processes for preparing them and their uses
GT200500185A (en) 2004-08-09 2006-04-10 PROGESTERONE RECEIVER MODULATORS UNDERSTANDING PIRROL-OXINDOL DERIVATIVES AND THEIR USES
WO2010090680A1 (en) * 2008-12-15 2010-08-12 Wyeth Llc Substituted oxindole cb2 agonists
WO2011100373A1 (en) 2010-02-09 2011-08-18 The Johns Hopkins University Methods and compositions for improving cognitive function
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
MX362886B (en) 2012-12-13 2019-02-22 H Lundbeck As Compositions comprising vortioxetine and donepezil.
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
JP6433482B2 (en) 2013-03-15 2018-12-05 エージンバイオ， インコーポレイテッド Methods and compositions for improving cognitive function
CN104530065A (en) * 2013-05-13 2015-04-22 江西科技师范大学 1-N acyl substituent indolone derivative application
CN103242332B (en) * 2013-05-13 2015-11-04 江西科技师范大学 1-N acyl substituted indolone derivatives
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH491106A (en) * 1964-06-11 1970-05-31 Ciba Geigy Process for the production of new thiosemicarbazones

Also Published As

Publication number Publication date
JPH08511515A (en) 1996-12-03
EP0703901A1 (en) 1996-04-03
SE9302080D0 (en) 1993-06-16
IS4167A (en) 1994-12-17
FI956074A (en) 1995-12-18
AU7010894A (en) 1995-01-03
WO1994029272A1 (en) 1994-12-22
CA2164119A1 (en) 1994-12-22
NO955074D0 (en) 1995-12-14
FI956074A0 (en) 1995-12-18

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