FI956074A - 1-Substituted isatin and oxindole derivatives acting as acetylcholinesterase inhibitors - Google Patents

1-Substituted isatin and oxindole derivatives acting as acetylcholinesterase inhibitors Download PDF

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Publication number
FI956074A
FI956074A FI956074A FI956074A FI956074A FI 956074 A FI956074 A FI 956074A FI 956074 A FI956074 A FI 956074A FI 956074 A FI956074 A FI 956074A FI 956074 A FI956074 A FI 956074A
Authority
FI
Finland
Prior art keywords
acetylcholinesterase inhibitors
oxindole derivatives
substituted isatin
derivatives acting
acting
Prior art date
Application number
FI956074A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI956074A0 (en
Inventor
Bernard Robin Boar
Dennis Mark O'shea
Ian David Tomlinson
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of FI956074A0 publication Critical patent/FI956074A0/en
Publication of FI956074A publication Critical patent/FI956074A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
FI956074A 1993-06-16 1995-12-18 1-Substituted isatin and oxindole derivatives acting as acetylcholinesterase inhibitors FI956074A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE19939302080A SE9302080D0 (en) 1993-06-16 1993-06-16 NEW COMPOUNDS
PCT/SE1994/000448 WO1994029272A1 (en) 1993-06-16 1994-05-13 1-substituted isatin and oxindole derivatives as inhibitors of acetylcholinesterase

Publications (2)

Publication Number Publication Date
FI956074A0 FI956074A0 (en) 1995-12-18
FI956074A true FI956074A (en) 1995-12-18

Family

ID=20390305

Family Applications (1)

Application Number Title Priority Date Filing Date
FI956074A FI956074A (en) 1993-06-16 1995-12-18 1-Substituted isatin and oxindole derivatives acting as acetylcholinesterase inhibitors

Country Status (9)

Country Link
EP (1) EP0703901A1 (en)
JP (1) JPH08511515A (en)
AU (1) AU7010894A (en)
CA (1) CA2164119A1 (en)
FI (1) FI956074A (en)
IS (1) IS4167A (en)
NO (1) NO955074L (en)
SE (1) SE9302080D0 (en)
WO (1) WO1994029272A1 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9103752D0 (en) * 1991-12-18 1991-12-18 Astra Ab NEW COMPOUNDS
DE69911380T2 (en) * 1998-03-06 2004-07-01 Astrazeneca Ab USE OF ISATIN AND OXINDOL DERIVATIVES FOR THE PRODUCTION OF MEDICINAL PRODUCTS FOR THE TREATMENT OF MYCOBACTERIAL DISEASES
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
WO2000018391A1 (en) 1998-09-30 2000-04-06 Takeda Chemical Industries, Ltd. Drugs for improving vesical excretory strength
US6358947B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6417214B1 (en) 1999-05-04 2002-07-09 Wyeth 3,3-substituted indoline derivatives
US6423699B1 (en) 1999-05-04 2002-07-23 American Home Products Corporation Combination therapies using benzimidazolones
US6319912B1 (en) 1999-05-04 2001-11-20 American Home Products Corporation Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
US6462032B1 (en) 1999-05-04 2002-10-08 Wyeth Cyclic regimens utilizing indoline derivatives
US6407101B1 (en) 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
US6391907B1 (en) * 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6380178B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6306851B1 (en) 1999-05-04 2001-10-23 American Home Products Corporation Cyclocarbamate and cyclic amide derivatives
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6399593B1 (en) 1999-05-04 2002-06-04 Wyeth Cyclic regimens using cyclic urea and cyclic amide derivatives
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6498154B1 (en) 1999-05-04 2002-12-24 Wyeth Cyclic regimens using quinazolinone and benzoxazine derivatives
US6339098B1 (en) 1999-05-04 2002-01-15 American Home Products Corporation 2,1-benzisothiazoline 2,2-dioxides
US6444668B1 (en) 1999-05-04 2002-09-03 Wyeth Combination regimens using progesterone receptor modulators
US6329416B1 (en) 1999-05-04 2001-12-11 American Home Products Corporation Combination regimens using 3,3-substituted indoline derivatives
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
US7186745B2 (en) 2001-03-06 2007-03-06 Astrazeneca Ab Indolone derivatives having vascular damaging activity
TW200508197A (en) 2003-03-31 2005-03-01 Ucb Sa Indolone-acetamide derivatives, processes for preparing them and their uses
JP4914346B2 (en) * 2004-05-27 2012-04-11 ユセベ ファルマ ソシエテ アノニム Benzoxazolone derivatives, methods for their preparation and uses thereof
JP4897679B2 (en) 2004-07-22 2012-03-14 ユセベ ファルマ ソシエテ アノニム INDORON DERIVATIVE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF
GT200500185A (en) 2004-08-09 2006-04-10 PROGESTERONE RECEIVER MODULATORS UNDERSTANDING PIRROL-OXINDOL DERIVATIVES AND THEIR USES
WO2010090680A1 (en) * 2008-12-15 2010-08-12 Wyeth Llc Substituted oxindole cb2 agonists
AU2011215870B2 (en) 2010-02-09 2016-01-28 The Johns Hopkins University Methods and compositions for improving cognitive function
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
RS56949B1 (en) 2012-12-13 2018-05-31 H Lundbeck As Compositions comprising vortioxetine and donepezil
CN105142623A (en) 2013-03-15 2015-12-09 艾吉因生物股份有限公司 Methods and compositions for improving cognitive function
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
CN104530065A (en) * 2013-05-13 2015-04-22 江西科技师范大学 1-N acyl substituent indolone derivative application
CN103242332B (en) * 2013-05-13 2015-11-04 江西科技师范大学 1-N acyl substituted indolone derivatives
CN112843005B (en) 2015-05-22 2023-02-21 艾吉因生物股份有限公司 Extended release pharmaceutical compositions of levetiracetam

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH491106A (en) * 1964-06-11 1970-05-31 Ciba Geigy Process for the production of new thiosemicarbazones

Also Published As

Publication number Publication date
IS4167A (en) 1994-12-17
WO1994029272A1 (en) 1994-12-22
CA2164119A1 (en) 1994-12-22
AU7010894A (en) 1995-01-03
NO955074D0 (en) 1995-12-14
NO955074L (en) 1996-02-07
FI956074A0 (en) 1995-12-18
EP0703901A1 (en) 1996-04-03
JPH08511515A (en) 1996-12-03
SE9302080D0 (en) 1993-06-16

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