FI956074A - Asetyylikolinesteraasin inhibiittoreina toimivia 1-asemasta substituoituja isatiini- ja oksindolijohdannaisia - Google Patents
Asetyylikolinesteraasin inhibiittoreina toimivia 1-asemasta substituoituja isatiini- ja oksindolijohdannaisia Download PDFInfo
- Publication number
- FI956074A FI956074A FI956074A FI956074A FI956074A FI 956074 A FI956074 A FI 956074A FI 956074 A FI956074 A FI 956074A FI 956074 A FI956074 A FI 956074A FI 956074 A FI956074 A FI 956074A
- Authority
- FI
- Finland
- Prior art keywords
- acetylcholinesterase inhibitors
- oxindole derivatives
- substituted isatin
- derivatives acting
- acting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE19939302080A SE9302080D0 (sv) | 1993-06-16 | 1993-06-16 | New compounds |
PCT/SE1994/000448 WO1994029272A1 (en) | 1993-06-16 | 1994-05-13 | 1-substituted isatin and oxindole derivatives as inhibitors of acetylcholinesterase |
Publications (2)
Publication Number | Publication Date |
---|---|
FI956074A0 FI956074A0 (fi) | 1995-12-18 |
FI956074A true FI956074A (fi) | 1995-12-18 |
Family
ID=20390305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI956074A FI956074A (fi) | 1993-06-16 | 1995-12-18 | Asetyylikolinesteraasin inhibiittoreina toimivia 1-asemasta substituoituja isatiini- ja oksindolijohdannaisia |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0703901A1 (fi) |
JP (1) | JPH08511515A (fi) |
AU (1) | AU7010894A (fi) |
CA (1) | CA2164119A1 (fi) |
FI (1) | FI956074A (fi) |
IS (1) | IS4167A (fi) |
NO (1) | NO955074L (fi) |
SE (1) | SE9302080D0 (fi) |
WO (1) | WO1994029272A1 (fi) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9103752D0 (sv) * | 1991-12-18 | 1991-12-18 | Astra Ab | New compounds |
WO1999044608A1 (en) | 1998-03-06 | 1999-09-10 | Astrazeneca Ab | New use |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
KR100639543B1 (ko) | 1998-09-30 | 2006-10-31 | 다케다 야쿠힌 고교 가부시키가이샤 | 방광 배출력 개선제 |
US6358948B1 (en) | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
US6358947B1 (en) | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Tetracyclic progesterone receptor modulator compounds and methods |
US6380235B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Benzimidazolones and analogues |
US6369056B1 (en) | 1999-05-04 | 2002-04-09 | American Home Products Corporation | Cyclic urea and cyclic amide derivatives |
US6417214B1 (en) | 1999-05-04 | 2002-07-09 | Wyeth | 3,3-substituted indoline derivatives |
US6306851B1 (en) | 1999-05-04 | 2001-10-23 | American Home Products Corporation | Cyclocarbamate and cyclic amide derivatives |
US6329416B1 (en) | 1999-05-04 | 2001-12-11 | American Home Products Corporation | Combination regimens using 3,3-substituted indoline derivatives |
US6462032B1 (en) | 1999-05-04 | 2002-10-08 | Wyeth | Cyclic regimens utilizing indoline derivatives |
US6423699B1 (en) | 1999-05-04 | 2002-07-23 | American Home Products Corporation | Combination therapies using benzimidazolones |
US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
US6339098B1 (en) | 1999-05-04 | 2002-01-15 | American Home Products Corporation | 2,1-benzisothiazoline 2,2-dioxides |
US6498154B1 (en) | 1999-05-04 | 2002-12-24 | Wyeth | Cyclic regimens using quinazolinone and benzoxazine derivatives |
US6319912B1 (en) | 1999-05-04 | 2001-11-20 | American Home Products Corporation | Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides |
US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
US6399593B1 (en) | 1999-05-04 | 2002-06-04 | Wyeth | Cyclic regimens using cyclic urea and cyclic amide derivatives |
US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
US6380178B1 (en) | 1999-05-04 | 2002-04-30 | American Home Products Corporation | Cyclic regimens using cyclocarbamate and cyclic amide derivatives |
US6444668B1 (en) | 1999-05-04 | 2002-09-03 | Wyeth | Combination regimens using progesterone receptor modulators |
US6355648B1 (en) | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
US7186745B2 (en) | 2001-03-06 | 2007-03-06 | Astrazeneca Ab | Indolone derivatives having vascular damaging activity |
TW200508197A (en) | 2003-03-31 | 2005-03-01 | Ucb Sa | Indolone-acetamide derivatives, processes for preparing them and their uses |
WO2005118561A1 (en) * | 2004-05-27 | 2005-12-15 | Ucb, S.A. | Benzoxazolone derivatives, processes for preparing them and their uses |
DE602005023755D1 (de) * | 2004-07-22 | 2010-11-04 | Ucb Pharma Sa | Indolonderivate, verfahren zu deren herstellung und deren anwendungen |
GT200500185A (es) | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
WO2010090680A1 (en) * | 2008-12-15 | 2010-08-12 | Wyeth Llc | Substituted oxindole cb2 agonists |
EP2533645B1 (en) | 2010-02-09 | 2016-07-27 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
CN104853755B (zh) | 2012-12-13 | 2017-08-22 | H.隆德贝克有限公司 | 包含沃替西汀和多奈哌齐的组合物 |
US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
EP2968220B1 (en) | 2013-03-15 | 2021-05-05 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
CN103242332B (zh) * | 2013-05-13 | 2015-11-04 | 江西科技师范大学 | 1-n酰基取代吲哚酮衍生物 |
CN104530065A (zh) * | 2013-05-13 | 2015-04-22 | 江西科技师范大学 | 1-n酰基取代吲哚酮衍生物的应用 |
US10925834B2 (en) | 2015-05-22 | 2021-02-23 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH491106A (de) * | 1964-06-11 | 1970-05-31 | Ciba Geigy | Verfahren zur Herstellung von neuen Thiosemicarbazonen |
-
1993
- 1993-06-16 SE SE19939302080A patent/SE9302080D0/xx unknown
-
1994
- 1994-05-13 EP EP94919032A patent/EP0703901A1/en not_active Withdrawn
- 1994-05-13 AU AU70108/94A patent/AU7010894A/en not_active Abandoned
- 1994-05-13 CA CA002164119A patent/CA2164119A1/en not_active Abandoned
- 1994-05-13 WO PCT/SE1994/000448 patent/WO1994029272A1/en not_active Application Discontinuation
- 1994-05-13 JP JP7501642A patent/JPH08511515A/ja active Pending
- 1994-05-18 IS IS4167A patent/IS4167A/is unknown
-
1995
- 1995-12-14 NO NO955074A patent/NO955074L/no unknown
- 1995-12-18 FI FI956074A patent/FI956074A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1994029272A1 (en) | 1994-12-22 |
FI956074A0 (fi) | 1995-12-18 |
AU7010894A (en) | 1995-01-03 |
IS4167A (is) | 1994-12-17 |
NO955074D0 (no) | 1995-12-14 |
CA2164119A1 (en) | 1994-12-22 |
JPH08511515A (ja) | 1996-12-03 |
NO955074L (no) | 1996-02-07 |
SE9302080D0 (sv) | 1993-06-16 |
EP0703901A1 (en) | 1996-04-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI956074A (fi) | Asetyylikolinesteraasin inhibiittoreina toimivia 1-asemasta substituoituja isatiini- ja oksindolijohdannaisia | |
FI974436A (fi) | Substituoituja N-(indoli-2-karbonyyli)-glysiiniamideja ja -johdannaisia glykogeenifosforylaasi-inhibiittoreina | |
IL120699A0 (en) | Indole derivatives and pharmaceutical compositions containing them | |
DK43193A (da) | Indolderivater | |
GB9921054D0 (en) | Indole and indoline derivatives as 5-ht6-selective ligands | |
NZ299693A (en) | 1,4-dioxino derivatives of indole and quinoline; pharmaceutical compositions | |
PL341400A1 (en) | Derivatives of indole as inhibitors of factor xa | |
ZA9711376B (en) | Indole or dihydroindole derivatives | |
FI954734A0 (fi) | Indolijohdannaiset 5HT1A ja/tai 5-HT2 ligandeina | |
EP0707581A1 (en) | INDOLINE DERIVATIVES AS 5 HT2C ANTAGONISTS | |
NO961475D0 (no) | Indol-derivater | |
DE69707659T2 (de) | Isatinderivate als acetylcholinesterase-inhibitoren und analgetika | |
PL341318A1 (en) | Derivatives of indole useful in treating oesteoporosis | |
GB9420287D0 (en) | 3-substituted heterocyclic indoles as inhibitors of HIV reverse transcriptase | |
DK0725061T3 (da) | Substituerede indolderivater | |
AU5715494A (en) | N-substituted indole derivative | |
IL119844A (en) | Substituted indole derivatives and pharmaceutical compositions containing them | |
SI0892796T1 (en) | Isatin derivatives as acetylcholinesterase inhibitors and analgesics | |
FI982654A (fi) | Hermoja suojaava indoloni ja siihen läheisesti liittyvät johdannaiset | |
DE59605373D1 (de) | Substituierte Indol-Derivate | |
ZA936050B (en) | Condensed indole derivatives as 5HT 2c and 5HT 2b antagonists | |
NO951241D0 (no) | Forbedret indolbiosyntese |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |