ES8303293A1 - Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (Z), their preparation and their use as medicines in the treatment of disorders of the central nervous system. - Google Patents
Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (Z), their preparation and their use as medicines in the treatment of disorders of the central nervous system.Info
- Publication number
- ES8303293A1 ES8303293A1 ES512842A ES512842A ES8303293A1 ES 8303293 A1 ES8303293 A1 ES 8303293A1 ES 512842 A ES512842 A ES 512842A ES 512842 A ES512842 A ES 512842A ES 8303293 A1 ES8303293 A1 ES 8303293A1
- Authority
- ES
- Spain
- Prior art keywords
- aryl
- atom
- alkyl group
- lower alkyl
- nervous system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Abstract
The present invention concerns new derivatives of 1-aryl 2-aminomethyl cyclopropane carboxamides (Z) of general formula I: < IMAGE > (I) in which: R represents a hydrogen or halogen atom, a lower alkyl group, a lower alkoxy group, or a hydroxy. nitro or amino group n represents the value 1 or 2 R1 and R2 represent a hydrogen atom, a lower alkyl group, an aryl or lower alkaryl group, possibly substituted, preferably in para position, by a halogen atom, preferably a chlorine atom R1 and R2 may also form a heterocycle having 5 or 6 members with the adjacent nitrogen atom R3 and R4 represent a hydrogen atom or a lower alkyl group R3 and R4 may also form with the adjacent nitrogen atom a heterocycle having 5 or 6 members, possibly containing an additional heteroatom selected from among nitrogen and oxygen, as well as their salts with therapeutically acceptable inorganic or organic acids, and their pharmaceutical compositions and use in the treatment of central nervous system disturbances, e.g., depression.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8112312A FR2508035A1 (en) | 1981-06-23 | 1981-06-23 | ARYL-1-AMINOMETHYL-2 CYCLOPROPANES CARBOXAMIDE (Z) DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8303293A1 true ES8303293A1 (en) | 1983-03-01 |
ES512842A0 ES512842A0 (en) | 1983-03-01 |
Family
ID=9259785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES512842A Granted ES512842A0 (en) | 1981-06-23 | 1982-06-04 | "PROCEDURE FOR PREPARING CARBOXAMIDIC DERIVATIVES". |
Country Status (11)
Country | Link |
---|---|
US (1) | US4478836A (en) |
EP (1) | EP0068999B1 (en) |
JP (1) | JPS584752A (en) |
AT (1) | ATE13422T1 (en) |
AU (1) | AU550774B2 (en) |
CA (1) | CA1202639A (en) |
DE (1) | DE3263734D1 (en) |
ES (1) | ES512842A0 (en) |
FR (1) | FR2508035A1 (en) |
LU (1) | LU90410I2 (en) |
ZA (1) | ZA824453B (en) |
Families Citing this family (67)
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FR2581059B1 (en) * | 1985-04-25 | 1988-04-22 | Pf Medicament | PROCESS FOR THE PREPARATION OF PHENYL-1 HYDROCHLORIDE DIETHYL AMINO CARBONYL-1 AMINOMETHYL-2 CYCLOPROPANE (Z) |
FR2581060B1 (en) * | 1985-04-25 | 1988-07-01 | Pf Medicament | INDUSTRIAL PROCESS FOR OBTAINING MIDALCIPRAN |
EP0747348A4 (en) * | 1994-02-22 | 1999-07-07 | Asahi Chemical Ind | Aminoalkylcyclopropane derivative |
CA2134038C (en) * | 1994-06-16 | 1997-06-03 | David Taiwai Wong | Potentiation of drug response |
EP0714663A3 (en) | 1994-11-28 | 1997-01-15 | Lilly Co Eli | Potentiation of drug response by a serotonin 1A receptor antagonist |
AU6776196A (en) * | 1995-08-16 | 1997-03-12 | Eli Lilly And Company | Potentiation of serotonin response |
FR2752732B1 (en) * | 1996-08-28 | 1998-11-20 | Pf Medicament | EXTENDED RELEASE GALENIC FORM OF MILNACIPRAN |
CN101921267A (en) * | 2001-10-12 | 2010-12-22 | 阿泽范药品公司 | Beta-lactam Hou Yejiayasu V 1aAntagonist |
US20040034101A1 (en) * | 2001-11-05 | 2004-02-19 | Cypress Bioscience, Inc. | Treatment and prevention of depression secondary to pain (DSP) |
US6635675B2 (en) | 2001-11-05 | 2003-10-21 | Cypress Bioscience, Inc. | Method of treating chronic fatigue syndrome |
US6602911B2 (en) * | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
WO2003090743A1 (en) * | 2002-04-24 | 2003-11-06 | Cypress Bioscience, Inc. | Prevention and treatment of functional somatic disorders, including stress-related disorders |
CA2503381A1 (en) * | 2002-10-25 | 2004-05-13 | Collegium Pharmaceutical, Inc. | Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof |
FR2851163B1 (en) | 2003-02-14 | 2007-04-27 | USE OF DEXTROGYAN ENANTIOMER OF MILNACIPRAN FOR THE PREPARATION OF A MEDICINAL PRODUCT | |
DE602004015257D1 (en) * | 2003-02-14 | 2008-09-04 | Pf Medicament | USE OF THE (1S, 2R) -MILNACIPRANE ENANTIOMER FOR THE MANUFACTURE OF A MEDICAMENT |
BRPI0409492A (en) * | 2003-04-18 | 2006-05-02 | Pharmacia & Up John Company Ll | combination therapies |
BRPI0413584A (en) | 2003-08-15 | 2006-10-17 | Lundbeck & Co As H | compound, pharmaceutical composition, use of a compound, and methods for treating disease and treating a disorder in the central nervous system |
AR045368A1 (en) * | 2003-08-15 | 2005-10-26 | Lundbeck & Co As H | DERIVATIVES OF CYCLOPROPYL AS ANTAGONISTS OF THE NK3 RECEIVER |
DK1691811T3 (en) | 2003-12-11 | 2014-10-20 | Sunovion Pharmaceuticals Inc | COMBINATION OF A SEDATIVE AND NEUROTRANSMITTER MODULATOR AND METHODS FOR IMPROVING SLEEP QUALITY AND TREATMENT OF DEPRESSION |
EP1737473A4 (en) * | 2004-04-19 | 2009-08-26 | Noven Therapeutics Llc | Lithium combinations, and uses related thereto |
JP2008534504A (en) | 2005-03-22 | 2008-08-28 | アゼヴァン ファーマスーティカルズ,インコーポレイテッド | Β-Lactamyl alkanoic acid for treating premenstrual disorders |
JP2008538573A (en) * | 2005-04-22 | 2008-10-30 | ワイス | Benzofuranyl alkanamine derivatives and their use as 5-HT2C agonists |
WO2006116170A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Dihydrobenzofuran derivatives and uses thereof |
AU2006239920A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Dihydrobenzofuran derivatives and uses thereof |
US8309128B2 (en) * | 2005-06-10 | 2012-11-13 | Pierre Fabre Medicament | Stabilized milnacipran formulation |
WO2007008758A2 (en) | 2005-07-08 | 2007-01-18 | Braincells, Inc. | Methods for identifying agents and conditions that modulate neurogenesis |
EP1910346B1 (en) * | 2005-07-19 | 2019-02-27 | Azevan Pharmaceuticals, Inc. | Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonist |
US20090203750A1 (en) * | 2005-08-24 | 2009-08-13 | Alan Kozikowski | 5-HT2C Receptor Agonists as Anorectic Agents |
US7994220B2 (en) * | 2005-09-28 | 2011-08-09 | Cypress Bioscience, Inc. | Milnacipran for the long-term treatment of fibromyalgia syndrome |
CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
EP1942879A1 (en) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20080319083A1 (en) * | 2006-01-27 | 2008-12-25 | Asahi Kasei Pharma Corporation | Medicine for transnasal administration |
AU2007208681B2 (en) * | 2006-01-27 | 2010-04-08 | Asahi Kasei Pharma Corporation | Medicine for transnasal administration |
FR2912057B1 (en) * | 2007-02-07 | 2009-04-17 | Sanofi Aventis Sa | PHARMACEUTICAL COMPOSITION COMPRISING SAREDUTANT AND A SELECTIVE SEROTONIN RECAPTURE INHIBITOR OR SEROTONIN / NOREPINEPHRINE RECAPTURE INHIBITOR |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
CN101410112A (en) * | 2006-03-24 | 2009-04-15 | 惠氏公司 | New therapeutic combinations for the treatment of depression |
JP2009536669A (en) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | Neurogenesis by angiotensin regulation |
JP2009536667A (en) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | 5HT receptor-mediated neurogenesis |
US7858611B2 (en) * | 2006-05-09 | 2010-12-28 | Braincells Inc. | Neurogenesis by modulating angiotensin |
TW200817003A (en) * | 2006-07-31 | 2008-04-16 | Sanofi Aventis | Pharmaceutical composition comprising, in combination, saredutant and a selective serotonin peuptake inhibitor or a serotonin/norepinephrine reuptake inhibitor |
AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
WO2008034032A2 (en) * | 2006-09-14 | 2008-03-20 | Azevan Pharmaceuticals, Inc. | Beta-lactam cannabinoid receptor modulators |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US20080167363A1 (en) * | 2006-12-28 | 2008-07-10 | Braincells, Inc | Modulation of Neurogenesis By Melatoninergic Agents |
US20080171750A1 (en) * | 2007-01-11 | 2008-07-17 | Braincells, Inc. | Modulation Of Neurogenesis With Use of Modafinil |
EP2114868A2 (en) * | 2007-02-28 | 2009-11-11 | Ranbaxy Laboratories Limited | Novel polymorphic forms of milnacipran hydrochloride |
WO2009023820A1 (en) * | 2007-08-16 | 2009-02-19 | Cypress Biosciences, Inc. | Improving the tolerability of a serotonin antagonist and a nsri, a snri or a rima by using them in combination |
US20090069431A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched milnacipran |
EP2288345B1 (en) | 2008-04-18 | 2015-06-10 | University College Dublin National University Of Ireland, Dublin | Psycho-pharmaceuticals |
WO2010021681A2 (en) * | 2008-08-18 | 2010-02-25 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
WO2010036773A1 (en) * | 2008-09-24 | 2010-04-01 | Concert Pharmaceuticals, Inc. | Deuterated l-aryl-2 -aminomethyl cyclopropane carboxyamide derivatives |
FR2941454B1 (en) | 2009-01-29 | 2011-04-01 | Pf Medicament | PROCESS FOR THE SYNTHESIS OF (1S, 2R) -MILNACIPRAN |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US20100274050A1 (en) * | 2009-04-23 | 2010-10-28 | Glenmark Generics Limited | Solid milnacipran and process for the preparation of the same |
US20100286260A1 (en) * | 2009-05-05 | 2010-11-11 | Forest Laboratories Holdings Ltd. | Milnacipran formulations |
CA2775091A1 (en) | 2009-08-05 | 2011-02-10 | Lupin Limited | Controlled release pharmaceutical compositions of milnacipran |
WO2011057176A1 (en) | 2009-11-06 | 2011-05-12 | Forest Laboratories Holding Limited | Novel crystalline forms of (1s,2r)-2-(amino methyl)-n,n-diethyl-1-phenyl cyclopropane carboxamide |
WO2011092065A1 (en) | 2010-01-29 | 2011-08-04 | Nicox S.A. | Nitric oxide releasing compounds for the treatment of neurophatic pain |
ES2662350T3 (en) | 2010-07-01 | 2018-04-06 | Azevan Pharmaceuticals, Inc. | Procedures for the treatment of posttraumatic stress disorder |
WO2012028922A2 (en) | 2010-08-30 | 2012-03-08 | Lupin Limited | Controlled release pharmaceutical compositions of milnacipran |
WO2012059933A1 (en) | 2010-11-03 | 2012-05-10 | Arch Pharmalabs Limited | A new process for preparing optically pure milnacipran and its pharmaceutically acceptable salts. |
EP2699539B1 (en) | 2011-04-21 | 2019-03-06 | Emory University | Cyclopropyl derivatives and methods of use |
WO2014009767A1 (en) | 2012-07-07 | 2014-01-16 | Micro Labs Limited | An improved process for the preparation of 1-aryl 2-aminomethyl cyclopropane carboxyamide (z) derivatives, their isomers and salts |
WO2014203277A2 (en) * | 2013-06-19 | 2014-12-24 | Msn Laboratories Private Limited | Process for the preparation of (1s,2r)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanearboxamide hydrochloride |
IN2013MU03122A (en) | 2013-09-30 | 2015-07-17 | Cadila Healthcare Ltd | |
FI3122743T3 (en) | 2014-03-28 | 2023-03-02 | Azevan Pharmaceuticals Inc | Compositions and methods for treating neurodegenerative diseases |
EP3681871A4 (en) | 2017-09-15 | 2021-05-26 | Azevan Pharmaceuticals, Inc. | Compositions and methods for treating brain injury |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA619080A (en) * | 1961-04-25 | The Upjohn Company | N-SUBSTITUTED-.alpha.-(TERTIARY-AMINOALKYL)-.alpha.-PHENYLACETAMIDES | |
CA570688A (en) * | 1959-02-17 | E. Speeter Merrill | Antispasmodic substituted amines | |
GB1415541A (en) | 1972-11-30 | 1975-11-26 | Hexachimie | 1-amino-methyl-2,2-diarylcyclopropanecarboxamide |
-
1981
- 1981-06-23 FR FR8112312A patent/FR2508035A1/en active Granted
-
1982
- 1982-06-04 ES ES512842A patent/ES512842A0/en active Granted
- 1982-06-21 EP EP82401129A patent/EP0068999B1/en not_active Expired
- 1982-06-21 DE DE8282401129T patent/DE3263734D1/en not_active Expired
- 1982-06-21 AT AT82401129T patent/ATE13422T1/en active
- 1982-06-22 AU AU85086/82A patent/AU550774B2/en not_active Expired
- 1982-06-22 US US06/390,810 patent/US4478836A/en not_active Expired - Lifetime
- 1982-06-22 CA CA000405651A patent/CA1202639A/en not_active Expired
- 1982-06-23 ZA ZA824453A patent/ZA824453B/en unknown
- 1982-06-23 JP JP57109097A patent/JPS584752A/en active Granted
-
1999
- 1999-06-30 LU LU90410C patent/LU90410I2/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU8508682A (en) | 1983-01-06 |
FR2508035A1 (en) | 1982-12-24 |
LU90410I2 (en) | 1999-08-31 |
EP0068999A1 (en) | 1983-01-05 |
AU550774B2 (en) | 1986-04-10 |
CA1202639A (en) | 1986-04-01 |
ATE13422T1 (en) | 1985-06-15 |
JPS584752A (en) | 1983-01-11 |
FR2508035B1 (en) | 1984-06-29 |
ZA824453B (en) | 1983-04-27 |
DE3263734D1 (en) | 1985-06-27 |
JPS6323186B2 (en) | 1988-05-16 |
ES512842A0 (en) | 1983-03-01 |
US4478836A (en) | 1984-10-23 |
EP0068999B1 (en) | 1985-05-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted |